The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abivax Common 00370M103 99,020 1,000 SH DFND 1 1,000 0 0
Agios Pharmaceutical, Inc. Common 00847X104 1,631,178 49,058 SH DFND 1 49,058 0 0
Alkermes PLC Common G01767105 4,637,879 114,459 SH DFND 1 114,459 0 0
AllianceBernstein Holding L.P. Common 01881G106 1,674,240 48,000 SH DFND 1 48,000 0 0
Alphabet Inc CL A Common 02079k305 103,224 300 SH DFND 1 300 0 0
Alphabet Inc-Cl C Common 02079K107 74,963 220 SH DFND 1 220 0 0
Alphabet Inc-Cl C Common 02079K107 31,075,488 91,200 SH DFND 1 91,200 0 0
Amazon.com Inc. Common 023135106 74,745 300 SH DFND 1 300 0 0
Apollo Global Management, Inc. Common 03769M106 26,113,500 225,000 SH DFND 1 225,000 0 0
Apple Inc. Common 037833100 830,552 2,494 SH DFND 1 2,494 0 0
Arcus Biosciences, Inc. Common 03969F109 2,589,225 100,241 SH DFND 1 100,241 0 0
Biogen Inc. Common 09062X103 451,760 2,000 SH DFND 1 2,000 0 0
Blackstone Group LP Common 09260d107 23,539 210 SH DFND 1 210 0 0
Bridgebio Pharma, Inc. Common 10806X102 6,580,000 100,000 SH DFND 1 100,000 0 0
Broadcom, Inc. Common 11135F101 249,345 710 SH DFND 1 710 0 0
Canadian Natural Resources Limited Common 136385101 655,120 13,918 SH DFND 1 13,918 0 0
CareDx, Inc. Common 14167L103 1,440,725 22,165 SH DFND 1 22,165 0 0
Cogent Biosciences Inc. Common 19240Q201 4,357,314 136,081 SH DFND 1 136,081 0 0
Collegium Pharmaceutical, Inc. Common 19459J104 850,980 39,000 SH DFND 1 39,000 0 0
Connect Biopharma Holdings Limited Common G23549101 461,853 419,866 SH DFND 1 419,866 0 0
Corteva, Inc. Common 22052L104 93,646 1,206 SH DFND 1 1,206 0 0
Cullinan Therapeutics, Inc. Common 230031106 1,463,914 95,369 SH DFND 1 95,369 0 0
Cybin Inc Common 23256X407 4,547,300 370,000 SH DFND 1 370,000 0 0
Danaher Corporation Common 235851102 39,879 180 SH DFND 1 180 0 0
DocGo, Inc. Common 256086109 1,067,806 2,670,850 SH DFND 1 2,670,850 0 0
Dow Inc. Common 260557103 33,213 1,206 SH DFND 1 1,206 0 0
DuPont de Nemours, Inc. Common 26614N102 489,296 3,767 SH DFND 1 3,767 0 0
Dyne Therapeutics, Inc. Common 26818M108 837,720 52,000 SH DFND 1 52,000 0 0
Eastern Bankshares Inc Common 27627N105 104,650 5,000 SH DFND 1 5,000 0 0
Edgewise Therapeutics, Inc. Common 28036F105 426,381 10,502 SH DFND 1 10,502 0 0
Enliven Therapeutics, Inc. Common 29337E102 1,324,959 28,904 SH DFND 1 28,904 0 0
FS KKR Capital Corp. Common 302635206 31,596 2,875 SH DFND 1 2,875 0 0
GE HealthCare Technologies Inc Common 36266G107 3,268 50 SH DFND 1 50 0 0
Insmed Incorporated Common 457669307 257,157 2,253 SH DFND 1 2,253 0 0
International Business Machines Common 459200101 471,090 2,142 SH DFND 1 2,142 0 0
Brightstar Lottery PLC Common G4863A108 24,975 2,500 SH DFND 1 2,500 0 0
Invivyd, Inc. Common 00534A102 87,010 100,000 SH DFND 1 100,000 0 0
Iovance Biotherapeutics, Inc. Common 462260100 17,265,300 1,165,000 SH DFND 1 1,165,000 0 0
iShares Biotechnology ETF Common 464287556 526,325 2,500 SH DFND 1 2,500 0 0
iShares Russell Mid-Cap Growth Common 464287481 95,688 695 SH DFND 1 695 0 0
Janus Henderson AAA CLO ETF Common 47103U845 4,720,358 93,528 SH DFND 1 93,528 0 0
Johnson & Johnson Common 478160104 244,090 922 SH DFND 1 922 0 0
Johnson & Johnson Common 478160104 529,480 2,000 SH DFND 1 2,000 0 0
JPMorgan Chase & Co. Common 46625H100 5,759,419 17,409 SH DFND 1 17,409 0 0
Kimberly-Clark Corporation Common 494368103 233,832 2,400 SH DFND 1 2,400 0 0
Kyndryl Holdings Inc. Common 50155Q100 4,819 428 SH DFND 1 428 0 0
LB Pharmaceuticals, Inc. Common 50180M108 654,955 17,065 SH DFND 1 17,065 0 0
Legacy Housing Corporation Common 52472M101 114,680 4,000 SH DFND 1 4,000 0 0
LPL Financial Holdings Inc. Common 52012V100 5,045,700 16,500 SH DFND 1 16,500 0 0
Madrigal Pharmaaceuticals, Inc. Common 558868105 1,814,256 3,600 SH DFND 1 3,600 0 0
Microsoft Corporation Common 594918104 820,640 1,600 SH DFND 1 1,600 0 0
Mineralys Therapeutics, Inc. Common 603170101 251,300 10,000 SH DFND 1 10,000 0 0
Mondelez International Inc. Common 609207105 173,460 3,000 SH DFND 1 3,000 0 0
Nuvectis Pharma, Inc. Common 67080T108 143,130 6,777 SH DFND 1 6,777 0 0
Nvidia Corp Common 67066G104 292,326 1,280 SH DFND 1 1,280 0 0
Occidental Petroleum Corporation Common 674599105 25,945 469 SH DFND 1 469 0 0
Occidential Pertro Wts exp. 8/3/27 Common 674599162 4,268 194 SH DFND 1 194 0 0
Orchestra Biomed Holdings, Inc. Common 68572M106 1,577,709 253,651 SH DFND 1 253,651 0 0
Oruka Therapeutics, Inc. Common 687604108 916,190 11,000 SH DFND 1 11,000 0 0
Pelthos Therapeutics, Inc. Common 171126204 370,700 17,644 SH DFND 1 17,644 0 0
Pfizer Inc. Common 717081103 922,251 32,337 SH DFND 1 32,337 0 0
Protagonist Therapeutics, Inc Common 74366E102 4,610,343 32,723 SH DFND 1 32,723 0 0
Quanta Services, Inc. Common 74762E102 113,082 176 SH DFND 1 176 0 0
Rain Enhancement Technologies Holdco Inc Common 75080J103 81,349 101,686 SH DFND 1 101,686 0 0
Relmada Therapeutics, Inc. Common 75955J402 1,809,600 480,000 SH DFND 1 480,000 0 0
Rezolute, Inc. Common 76200L309 660,901 159,638 SH DFND 1 159,638 0 0
Ryman Hospitality Properties, Inc. Common 78377T107 286,872 2,400 SH DFND 1 2,400 0 0
Salesforce, Inc. Common 79466L302 17,677 77 SH DFND 1 77 0 0
Solid Bioscience Inc. Common 83422E204 514,263 71,129 SH DFND 1 71,129 0 0
SPDR S&P Biotech ETF Common 78464A870 1,734,480 11,000 SH DFND 1 11,000 0 0
Spruce Biosciences, Inc. Common 85209E208 1,267,209 26,085 SH DFND 1 26,085 0 0
Starwood Property Trust, Inc. Common 85571B105 5,400 400 SH DFND 1 400 0 0
Syndax Pharmaceutical, Inc. Common 87164F105 8,051,927 428,294 SH DFND 1 428,294 0 0
TG Therapeutics, Inc. Common 88322Q108 3,337,819 59,839 SH DFND 1 59,839 0 0
Eldgridge BBB-B Common 81752T528 1,257,324 47,807 SH DFND 1 47,807 0 0
Thermo Fisher Scientific, Inc. Common 883556102 30,377 45 SH DFND 1 45 0 0
Travere Therapeutics, Inc. Common 89422G107 7,652,457 129,967 SH DFND 1 129,967 0 0
UnitedHealth Group Common 91324p102 20,924 57 SH DFND 1 57 0 0
United Rentals, Inc. Common 911363109 78,061 78 SH DFND 1 78 0 0
Viridian Therapeutics, Inc. Common 92790C104 3,932,690 191,000 SH DFND 1 191,000 0 0
Wabtec Corporation Common 929740108 1,723 6 SH DFND 1 6 0 0
Xeris Biopharma Holdings, Inc. Common 98422E103 9,587,724 1,002,900 SH DFND 1 1,002,900 0 0