<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a1340e-fc29-74aa-a5a5-12b80585a073,g:85ca9932-c153-4f6f-ab4f-4bc1e7b0d47c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.incannex.com.au/role/CondensedConsolidatedBalanceSheetsunaudited" xlink:type="simple" xlink:href="ixhl-20260930.xsd#CondensedConsolidatedBalanceSheetsunaudited"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/CondensedConsolidatedBalanceSheetsunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7354-b436-64889cb26ab7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a1340e-fcd8-768d-9025-a80d6c4c97ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7354-b436-64889cb26ab7" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a1340e-fcd8-768d-9025-a80d6c4c97ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a1340e-fcd8-7454-85cb-8c9d14a41304" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7354-b436-64889cb26ab7" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a1340e-fcd8-7454-85cb-8c9d14a41304" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_01a1340e-fcd8-7979-9297-57ee98c980cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7354-b436-64889cb26ab7" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_01a1340e-fcd8-7979-9297-57ee98c980cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a1340e-fcd8-7cc7-aa67-fb41a24969bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_01a1340e-fcd8-7db0-9d22-87fc44bea1a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a1340e-fcd8-7cc7-aa67-fb41a24969bb" xlink:to="loc_us-gaap_Liabilities_01a1340e-fcd8-7db0-9d22-87fc44bea1a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_01a1340e-fcd8-74f8-818a-50944848b7bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a1340e-fcd8-7cc7-aa67-fb41a24969bb" xlink:to="loc_us-gaap_CommitmentsAndContingencies_01a1340e-fcd8-74f8-818a-50944848b7bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-743e-917c-d5858662f683" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a1340e-fcd8-7cc7-aa67-fb41a24969bb" xlink:to="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-743e-917c-d5858662f683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_01a1340e-fcd8-7a36-adc9-a9907b207fd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7e5d-a185-150da55a7071" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a1340e-fcd8-7a36-adc9-a9907b207fd2" xlink:to="loc_us-gaap_AssetsCurrent_01a1340e-fcd8-7e5d-a185-150da55a7071" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01a1340e-fcd8-7a6b-abee-9e77fdc6adf7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a1340e-fcd8-7a36-adc9-a9907b207fd2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_01a1340e-fcd8-7a6b-abee-9e77fdc6adf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_01a1340e-fcd8-717f-afc8-631851b8b7ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a1340e-fcd8-7a36-adc9-a9907b207fd2" xlink:to="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_01a1340e-fcd8-717f-afc8-631851b8b7ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a1340e-fcd8-72d0-b109-ce7b2400c545" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a1340e-fcd8-7a36-adc9-a9907b207fd2" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a1340e-fcd8-72d0-b109-ce7b2400c545" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-7c3d-83de-640ed368a454" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-7c5f-a8f7-03aadae93962" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-7c3d-83de-640ed368a454" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-7c5f-a8f7-03aadae93962" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-7de3-b7f1-4db493f18dc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-7c3d-83de-640ed368a454" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-7de3-b7f1-4db493f18dc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a1340e-fcd8-799a-a9b1-c6cf1a2519e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-7c3d-83de-640ed368a454" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a1340e-fcd8-799a-a9b1-c6cf1a2519e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-790a-ad0c-ee0912654686" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_01a1340e-fcd8-77f3-9e78-d1ace722a0d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-790a-ad0c-ee0912654686" xlink:to="loc_us-gaap_CommonStockValue_01a1340e-fcd8-77f3-9e78-d1ace722a0d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_01a1340e-fcd8-79c7-92e9-e761e28da1fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-790a-ad0c-ee0912654686" xlink:to="loc_us-gaap_AdditionalPaidInCapital_01a1340e-fcd8-79c7-92e9-e761e28da1fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a1340e-fcd8-7f5d-b35a-5a532c68d263" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-790a-ad0c-ee0912654686" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a1340e-fcd8-7f5d-b35a-5a532c68d263" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a1340e-fcd8-724d-82e5-18b56f5619aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a1340e-fcd8-790a-ad0c-ee0912654686" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a1340e-fcd8-724d-82e5-18b56f5619aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_01a1340e-fcd8-7b88-a8b5-f87f5eb20f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-708f-8158-6fe0c849156e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_01a1340e-fcd8-7b88-a8b5-f87f5eb20f5d" xlink:to="loc_us-gaap_LiabilitiesCurrent_01a1340e-fcd8-708f-8158-6fe0c849156e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a1340e-fcd8-76b8-8ae0-607f097bcb7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_01a1340e-fcd8-7b88-a8b5-f87f5eb20f5d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a1340e-fcd8-76b8-8ae0-607f097bcb7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ixhl_WarrantLiabilityNoncurrent_01a1340e-fcd8-7b2c-adf0-2d720fceb53c" xlink:href="ixhl-20260930.xsd#ixhl_WarrantLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_01a1340e-fcd8-7b88-a8b5-f87f5eb20f5d" xlink:to="loc_ixhl_WarrantLiabilityNoncurrent_01a1340e-fcd8-7b2c-adf0-2d720fceb53c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossunaudited" xlink:type="simple" xlink:href="ixhl-20260930.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLossunaudited"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLossunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a1340e-fcd8-7466-8543-b55d320eac7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_01a1340e-fcd8-7ada-b20e-a96c207e7e36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_01a1340e-fcd8-7466-8543-b55d320eac7c" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_01a1340e-fcd8-7ada-b20e-a96c207e7e36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_01a1340e-fcd8-75d6-94cf-149e9970243b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_01a1340e-fcd8-7466-8543-b55d320eac7c" xlink:to="loc_us-gaap_OperatingExpenses_01a1340e-fcd8-75d6-94cf-149e9970243b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_01a1340e-fcd8-72b4-b8bb-62e9cc554fcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_01a1340e-fcd8-7f42-8192-0295a186f84c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_01a1340e-fcd8-72b4-b8bb-62e9cc554fcb" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_01a1340e-fcd8-7f42-8192-0295a186f84c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_01a1340e-fcd8-75b1-aa0b-240ef4c16a91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_01a1340e-fcd8-72b4-b8bb-62e9cc554fcb" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_01a1340e-fcd8-75b1-aa0b-240ef4c16a91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a1340e-fcd8-7709-8c0c-f9cefdb3435b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a1340e-fcd8-7194-af59-78fb87f9fbf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a1340e-fcd8-7709-8c0c-f9cefdb3435b" xlink:to="loc_us-gaap_NetIncomeLoss_01a1340e-fcd8-7194-af59-78fb87f9fbf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_01a1340e-fcd8-7793-a40c-a316d1dd5392" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a1340e-fcd8-7709-8c0c-f9cefdb3435b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_01a1340e-fcd8-7793-a40c-a316d1dd5392" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a1340e-fcd8-7068-9f6e-80d87e897a98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a1340e-fcd8-70d6-b766-66c3cc646216" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a1340e-fcd8-7068-9f6e-80d87e897a98" xlink:to="loc_us-gaap_OperatingIncomeLoss_01a1340e-fcd8-70d6-b766-66c3cc646216" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-7935-8199-aa95d1ac1647" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a1340e-fcd8-7068-9f6e-80d87e897a98" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-7935-8199-aa95d1ac1647" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ixhl_IncomeFromResearchAndDevelopmentIncentive_01a1340e-fcd8-734f-9d44-37f3bb710bd1" xlink:href="ixhl-20260930.xsd#ixhl_IncomeFromResearchAndDevelopmentIncentive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:to="loc_ixhl_IncomeFromResearchAndDevelopmentIncentive_01a1340e-fcd8-734f-9d44-37f3bb710bd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01a1340e-fcd8-7b83-adc0-35fdfd5d0716" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01a1340e-fcd8-7b83-adc0-35fdfd5d0716" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_01a1340e-fcd8-7215-afe0-63f02ac2aaab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:to="loc_us-gaap_InvestmentIncomeInterest_01a1340e-fcd8-7215-afe0-63f02ac2aaab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_01a1340e-fcd8-7a74-8aa8-8e023e864f08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_01a1340e-fcd8-7a74-8aa8-8e023e864f08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_01a1340e-fcd8-711a-8827-4eafa95c103d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_01a1340e-fcd8-79ec-8f96-b3abe45998d4" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_01a1340e-fcd8-711a-8827-4eafa95c103d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a1340e-fcd8-75c8-bf9f-99c178ec0b32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a1340e-fcd8-7f08-88e5-2f48ff3bd77c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a1340e-fcd8-75c8-bf9f-99c178ec0b32" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a1340e-fcd8-7f08-88e5-2f48ff3bd77c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_01a1340e-fcd8-7302-9738-4ab15408ba78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a1340e-fcd8-75c8-bf9f-99c178ec0b32" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_01a1340e-fcd8-7302-9738-4ab15408ba78" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/CondensedConsolidatedStatementsofCashFlowsunaudited" xlink:type="simple" xlink:href="ixhl-20260930.xsd#CondensedConsolidatedStatementsofCashFlowsunaudited"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/CondensedConsolidatedStatementsofCashFlowsunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a1af11-5ea6-7e6a-8cc5-55d030e25c34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_NetIncomeLoss_01a1af11-5ea6-7e6a-8cc5-55d030e25c34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_01a1af11-5ea6-7f76-82fd-fef3a359c098" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_DepreciationAndAmortization_01a1af11-5ea6-7f76-82fd-fef3a359c098" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_01a1af11-5ea6-7b2b-9795-dceb03920638" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_01a1af11-5ea6-7b2b-9795-dceb03920638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_01a1af11-5ea6-7ecc-9450-8d3756d07f3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_ShareBasedCompensation_01a1af11-5ea6-7ecc-9450-8d3756d07f3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_01a1af11-5ea6-7650-9f01-d5f658feded0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_01a1af11-5ea6-7650-9f01-d5f658feded0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOperating_01a1af11-5ea6-7dc4-ba7e-6be04e7e88d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeOperating"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_InterestIncomeOperating_01a1af11-5ea6-7dc4-ba7e-6be04e7e88d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_01a1af11-5ea6-7208-84f6-015cee61bc72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_01a1af11-5ea6-7208-84f6-015cee61bc72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ixhl_IncreaseDecreaseInResearchAndDevelopmentTaxIncentiveReceivable_01a1af11-5ea6-7380-a461-60a8cdedb093" xlink:href="ixhl-20260930.xsd#ixhl_IncreaseDecreaseInResearchAndDevelopmentTaxIncentiveReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_ixhl_IncreaseDecreaseInResearchAndDevelopmentTaxIncentiveReceivable_01a1af11-5ea6-7380-a461-60a8cdedb093" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a1af11-5ea6-787a-9daa-e4f3cf54be08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a1af11-5ea6-787a-9daa-e4f3cf54be08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_01a1cc81-32f9-7b25-9b22-97f9f28a7cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1af11-5ea6-7cc6-9172-8f6252b8ef85" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_01a1cc81-32f9-7b25-9b22-97f9f28a7cb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a1a3a3-62a2-7024-8a76-cfff66c91bdd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a1a3a3-62a3-7610-a828-89e7edba17b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a1a3a3-62a2-7024-8a76-cfff66c91bdd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a1a3a3-62a3-7610-a828-89e7edba17b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_01a1a3a3-62a3-755d-946a-2f0828607c8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a1a3a3-62a2-7024-8a76-cfff66c91bdd" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_01a1a3a3-62a3-755d-946a-2f0828607c8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a1340e-fcd8-7918-bbde-97aa09a63d20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a1340e-fcd8-7526-8430-cdc14efd657c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a1340e-fcd8-7918-bbde-97aa09a63d20" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a1340e-fcd8-7526-8430-cdc14efd657c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_01a1340e-fcd8-7b66-87ba-d58296eb4cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInterestInJointVenture"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a1340e-fcd8-7918-bbde-97aa09a63d20" xlink:to="loc_us-gaap_PaymentsToAcquireInterestInJointVenture_01a1340e-fcd8-7b66-87ba-d58296eb4cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_01a1340e-fcd8-7b82-8da6-c68176a6838d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1340e-fcd8-7e71-918e-43844eb300f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_01a1340e-fcd8-7b82-8da6-c68176a6838d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a1340e-fcd8-7e71-918e-43844eb300f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a1340e-fcd8-7419-9ca8-4ab4fef5e5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_01a1340e-fcd8-7b82-8da6-c68176a6838d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a1340e-fcd8-7419-9ca8-4ab4fef5e5b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a1340e-fcd8-7a5b-92b2-d2bf1b4742d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_01a1340e-fcd8-7b82-8da6-c68176a6838d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a1340e-fcd8-7a5b-92b2-d2bf1b4742d4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/PrepaidexpensesandothercurrentassetsDetails" xlink:type="simple" xlink:href="ixhl-20260930.xsd#PrepaidexpensesandothercurrentassetsDetails"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/PrepaidexpensesandothercurrentassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a1340e-fcd8-7781-bb09-4c87d8c789ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValueAddedTaxReceivableCurrent_01a1340e-fcd8-72eb-8476-67ce2a938577" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValueAddedTaxReceivableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a1340e-fcd8-7781-bb09-4c87d8c789ed" xlink:to="loc_us-gaap_ValueAddedTaxReceivableCurrent_01a1340e-fcd8-72eb-8476-67ce2a938577" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_01a1340e-fcd8-70ca-b1ed-e4fdc2cad143" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a1340e-fcd8-7781-bb09-4c87d8c789ed" xlink:to="loc_us-gaap_PrepaidInsurance_01a1340e-fcd8-70ca-b1ed-e4fdc2cad143" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/PropertyPlantandEquipmentnetScheduleofPropertyPlantandEquipmentnetDetails" xlink:type="simple" xlink:href="ixhl-20260930.xsd#PropertyPlantandEquipmentnetScheduleofPropertyPlantandEquipmentnetDetails"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/PropertyPlantandEquipmentnetScheduleofPropertyPlantandEquipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_01a1340e-fcd8-749e-96e1-d68320e14ae0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesGross_01a1340e-fcd8-73fa-aa9e-05ea205aba1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FurnitureAndFixturesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_01a1340e-fcd8-749e-96e1-d68320e14ae0" xlink:to="loc_us-gaap_FurnitureAndFixturesGross_01a1340e-fcd8-73fa-aa9e-05ea205aba1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01a1340e-fcd8-75f2-8196-d639011c8ba0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_01a1340e-fcd8-717f-a459-9dd3ded9c8c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_01a1340e-fcd8-75f2-8196-d639011c8ba0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_01a1340e-fcd8-717f-a459-9dd3ded9c8c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01a1340e-fcd8-771f-abc1-c2b456bc32ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_01a1340e-fcd8-75f2-8196-d639011c8ba0" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01a1340e-fcd8-771f-abc1-c2b456bc32ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/TradeandotherpayablesaccruedexpensesandothercurrentliabilitiesScheduleofTradeandOtherPayablesAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="ixhl-20260930.xsd#TradeandotherpayablesaccruedexpensesandothercurrentliabilitiesScheduleofTradeandOtherPayablesAccruedExpensesandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/TradeandotherpayablesaccruedexpensesandothercurrentliabilitiesScheduleofTradeandOtherPayablesAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-7ef6-8ee5-e91c339e43e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_01a1340e-fcd8-72fe-8959-91a43644fca8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-7ef6-8ee5-e91c339e43e4" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_01a1340e-fcd8-72fe-8959-91a43644fca8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_01a1340e-fcd8-70c7-9b5c-a10f822be179" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-7ef6-8ee5-e91c339e43e4" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_01a1340e-fcd8-70c7-9b5c-a10f822be179" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ixhl_TradeAndOtherPayablesAccruedExpensesAndOtherCurrentLiabilities_01a1340e-fcd8-7a94-b51d-24ce6eed94d0" xlink:href="ixhl-20260930.xsd#ixhl_TradeAndOtherPayablesAccruedExpensesAndOtherCurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-79d3-98d0-f2d2834c1981" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ixhl_TradeAndOtherPayablesAccruedExpensesAndOtherCurrentLiabilities_01a1340e-fcd8-7a94-b51d-24ce6eed94d0" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-79d3-98d0-f2d2834c1981" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-781e-8eda-832812055778" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ixhl_TradeAndOtherPayablesAccruedExpensesAndOtherCurrentLiabilities_01a1340e-fcd8-7a94-b51d-24ce6eed94d0" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_01a1340e-fcd8-781e-8eda-832812055778" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-7ea3-9c25-7eb90cb8f8c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_01a1340e-fcd8-77f5-a160-a346aadc5792" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-7ea3-9c25-7eb90cb8f8c7" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_01a1340e-fcd8-77f5-a160-a346aadc5792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a1340e-fcd8-7d02-b5f5-2b1738273cc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_01a1340e-fcd8-7ea3-9c25-7eb90cb8f8c7" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a1340e-fcd8-7d02-b5f5-2b1738273cc8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="ixhl-20260930.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-754f-8486-f3d35894cdc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_01a1340e-fcd8-7a0d-bcb4-e90a17c6b324" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-754f-8486-f3d35894cdc5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_01a1340e-fcd8-7a0d-bcb4-e90a17c6b324" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_01a1340e-fcd8-7c4b-bde4-4387aaf7fbe3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-754f-8486-f3d35894cdc5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_01a1340e-fcd8-7c4b-bde4-4387aaf7fbe3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incannex.com.au/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="ixhl-20260930.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.incannex.com.au/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-769b-a3e5-880602389e89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_01a1340e-fcd8-7904-bf6c-cba4d60135da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-769b-a3e5-880602389e89" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_01a1340e-fcd8-7904-bf6c-cba4d60135da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_01a1340e-fcd8-74ce-a3c0-768ca2ad09ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a1340e-fcd8-769b-a3e5-880602389e89" xlink:to="loc_us-gaap_OperatingLeaseLiability_01a1340e-fcd8-74ce-a3c0-768ca2ad09ea" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
