<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ffaf5-57be-771b-8916-7e2b947125b6,g:473e7e97-6513-4002-8c93-4c63c78de65f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://pelthos.com/role/Cover" xlink:type="simple" xlink:href="pths-20261112.xsd#Cover"/>
  <link:presentationLink xlink:role="http://pelthos.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019ffaf5-57be-7e66-8290-45529300b690" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_DocumentType_019ffaf5-57be-7e66-8290-45529300b690" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019ffaf5-57be-7687-baf7-2798d52534e6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_DocumentPeriodEndDate_019ffaf5-57be-7687-baf7-2798d52534e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019ffaf5-57be-7150-8d26-ac5ddc8026a1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityRegistrantName_019ffaf5-57be-7150-8d26-ac5ddc8026a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019ffaf5-57be-75fe-b61b-d49a86702b35" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019ffaf5-57be-75fe-b61b-d49a86702b35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019ffaf5-57be-7cb2-9f02-eeb7fdf03c22" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityFileNumber_019ffaf5-57be-7cb2-9f02-eeb7fdf03c22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019ffaf5-57be-7c7d-a4d5-8428d806d998" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityTaxIdentificationNumber_019ffaf5-57be-7c7d-a4d5-8428d806d998" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019ffaf5-57be-72af-8116-318f1a19feab" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityAddressAddressLine1_019ffaf5-57be-72af-8116-318f1a19feab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019ffaf5-57be-7ad8-b8c5-f601c95efa34" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityAddressAddressLine2_019ffaf5-57be-7ad8-b8c5-f601c95efa34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019ffaf5-57be-73f6-91bb-df0dbc464af9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityAddressCityOrTown_019ffaf5-57be-73f6-91bb-df0dbc464af9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019ffaf5-57be-715c-80d0-448896b9503d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityAddressStateOrProvince_019ffaf5-57be-715c-80d0-448896b9503d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019ffaf5-57be-7145-bc98-0ed1be47095d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityAddressPostalZipCode_019ffaf5-57be-7145-bc98-0ed1be47095d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019ffaf5-57be-7ac7-adeb-6d0fc3c45cee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_CityAreaCode_019ffaf5-57be-7ac7-adeb-6d0fc3c45cee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019ffaf5-57be-7045-b69e-8618bf43cdc5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_LocalPhoneNumber_019ffaf5-57be-7045-b69e-8618bf43cdc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019ffaf5-57be-78e0-a33e-b40e74b02567" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_WrittenCommunications_019ffaf5-57be-78e0-a33e-b40e74b02567" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019ffaf5-57be-7947-ae5c-1cd33127daf6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_SolicitingMaterial_019ffaf5-57be-7947-ae5c-1cd33127daf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019ffaf5-57be-7ce3-8ba4-edd5d30eb154" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_PreCommencementTenderOffer_019ffaf5-57be-7ce3-8ba4-edd5d30eb154" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019ffaf5-57be-7bb0-b90b-711fc03b4270" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019ffaf5-57be-7bb0-b90b-711fc03b4270" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019ffaf5-57be-763a-bf5b-93a09632c10b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_Security12bTitle_019ffaf5-57be-763a-bf5b-93a09632c10b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019ffaf5-57be-7b2a-a2ba-33d398afebf8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_TradingSymbol_019ffaf5-57be-7b2a-a2ba-33d398afebf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019ffaf5-57be-7669-b4c7-73c34afa3676" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_SecurityExchangeName_019ffaf5-57be-7669-b4c7-73c34afa3676" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019ffaf5-57be-7a7b-9a7a-571c1c361741" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityEmergingGrowthCompany_019ffaf5-57be-7a7b-9a7a-571c1c361741" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019ffaf5-57be-79e8-a48c-bcf51753b599" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityExTransitionPeriod_019ffaf5-57be-79e8-a48c-bcf51753b599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019ffaf5-57be-7364-832c-2ddb2511a6f5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_AmendmentFlag_019ffaf5-57be-7364-832c-2ddb2511a6f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019ffaf5-57be-7b66-88b3-e9ec1033f8d4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ffaf5-57be-7c34-bba1-3c8e610d5910" xlink:to="loc_dei_EntityCentralIndexKey_019ffaf5-57be-7b66-88b3-e9ec1033f8d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
