<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fd8be-93f4-7507-b9e1-61c068514c28,g:6bb7be1b-7e6b-4441-bcf0-7ced326f10ce-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.amneal.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="amrx-20260930.xsd#ConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fd8be-9594-71ed-b38e-7d3c2791c5d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fd8be-9594-71ed-b38e-7d3c2791c5d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019fd8be-9594-7822-b1d1-76ddb31292a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019fd8be-9594-7822-b1d1-76ddb31292a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IncreaseDecreaseInTaxReceivableAgreementLiability_019fd8be-9594-7c7e-b45b-8f149a67fde7" xlink:href="amrx-20260930.xsd#amrx_IncreaseDecreaseInTaxReceivableAgreementLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:to="loc_amrx_IncreaseDecreaseInTaxReceivableAgreementLiability_019fd8be-9594-7c7e-b45b-8f149a67fde7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd8be-9594-7c8f-b9ce-e7b72d7a9d38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd8be-9594-7c8f-b9ce-e7b72d7a9d38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fd8be-9594-7d0f-8751-b8176c27307f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7647-8927-e96ba93e56e4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fd8be-9594-7d0f-8751-b8176c27307f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd8be-9594-7e78-b27f-f3daa148439e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8be-9594-7dbe-8d5a-f396a5b28a10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fd8be-9594-7e78-b27f-f3daa148439e" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8be-9594-7dbe-8d5a-f396a5b28a10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019fd8be-9594-7926-9150-06a047a074e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fd8be-9594-7e78-b27f-f3daa148439e" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019fd8be-9594-7926-9150-06a047a074e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fd8be-9594-7b71-b789-4bfbba19407a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_GrossProfit_019fd8be-9594-7b71-b789-4bfbba19407a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-9594-7e16-bb54-c394cffb54e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-9594-7e16-bb54-c394cffb54e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-9594-7e61-ab51-becbe1b78238" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-9594-7e61-ab51-becbe1b78238" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IntellectualPropertyLegalDevelopmentExpenses_019fd8be-9594-7bfb-b02a-7d899362a920" xlink:href="amrx-20260930.xsd#amrx_IntellectualPropertyLegalDevelopmentExpenses"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_amrx_IntellectualPropertyLegalDevelopmentExpenses_019fd8be-9594-7bfb-b02a-7d899362a920" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationAcquisitionRelatedAndIntegrationRelatedCostsExpense_019fd8be-9594-7ba1-a2be-ab7be3cfceec" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationAcquisitionRelatedAndIntegrationRelatedCostsExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_amrx_BusinessCombinationAcquisitionRelatedAndIntegrationRelatedCostsExpense_019fd8be-9594-7ba1-a2be-ab7be3cfceec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019fd8be-9594-78a4-a3f3-f1c8438ef0d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_RestructuringCharges_019fd8be-9594-78a4-a3f3-f1c8438ef0d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019fd8be-9594-79ed-8260-5560bb1d0738" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019fd8be-9594-79ed-8260-5560bb1d0738" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_ChargesForPropertyLossesAndAssociatedExpenses_019fd8be-9594-7056-9641-5953a36f532e" xlink:href="amrx-20260930.xsd#amrx_ChargesForPropertyLossesAndAssociatedExpenses"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_amrx_ChargesForPropertyLossesAndAssociatedExpenses_019fd8be-9594-7056-9641-5953a36f532e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_01a03c52-e1b9-7bc9-84d0-900f09e5e527" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_01a03c52-e1b9-7bc9-84d0-900f09e5e527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_01a03c52-e1b9-7f2c-86df-83da2b727275" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7d9a-98f5-e637a7d7c58d" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_01a03c52-e1b9-7f2c-86df-83da2b727275" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest_01a12f0c-e53d-764e-8ce5-f1d0925798c3" xlink:href="amrx-20260930.xsd#amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_01a12f0c-e53d-7ef7-bc9f-f5fef1961534" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest_01a12f0c-e53d-764e-8ce5-f1d0925798c3" xlink:to="loc_us-gaap_ProfitLoss_01a12f0c-e53d-7ef7-bc9f-f5fef1961534" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_01a12f0c-e53d-7efb-9b37-17a64d6dd9f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest_01a12f0c-e53d-764e-8ce5-f1d0925798c3" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_01a12f0c-e53d-7efb-9b37-17a64d6dd9f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8be-9594-7913-83fe-3f60346afa17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7441-829a-b757ded81f28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8be-9594-7913-83fe-3f60346afa17" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fd8be-9594-7441-829a-b757ded81f28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7b85-a678-2114fb434ca0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8be-9594-7913-83fe-3f60346afa17" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019fd8be-9594-7b85-a678-2114fb434ca0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fd8be-9594-7e41-8a4d-49cc5d803bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd8be-9594-7325-8f2a-6f4f13eafdd8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fd8be-9594-7e41-8a4d-49cc5d803bd7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd8be-9594-7325-8f2a-6f4f13eafdd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fd8be-9594-770a-a623-14276fcf59e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fd8be-9594-7e41-8a4d-49cc5d803bd7" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fd8be-9594-770a-a623-14276fcf59e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a154d0-9532-7c0d-bf43-0749a3d4fce0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AccretionOfRedeemableNoncontrollingInterest_01a1a823-1ebe-72c7-885f-94d7c097a808" xlink:href="amrx-20260930.xsd#amrx_AccretionOfRedeemableNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a154d0-9532-7c0d-bf43-0749a3d4fce0" xlink:to="loc_amrx_AccretionOfRedeemableNoncontrollingInterest_01a1a823-1ebe-72c7-885f-94d7c097a808" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest_01a154d0-9532-74eb-ac0a-58b216cc5151" xlink:href="amrx-20260930.xsd#amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a154d0-9532-7c0d-bf43-0749a3d4fce0" xlink:to="loc_amrx_NetIncomeLossAttributableToParentBeforeAccretionOfRedeemableNoncontrollingInterest_01a154d0-9532-74eb-ac0a-58b216cc5151" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/ConsolidatedStatementsofComprehensiveLossIncome" xlink:type="simple" xlink:href="amrx-20260930.xsd#ConsolidatedStatementsofComprehensiveLossIncome"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/ConsolidatedStatementsofComprehensiveLossIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8be-9594-74db-acbf-32347c92feb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd8be-9594-726e-a120-67eaa6e3e0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8be-9594-74db-acbf-32347c92feb6" xlink:to="loc_us-gaap_NetIncomeLoss_019fd8be-9594-726e-a120-67eaa6e3e0ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7bc3-a7e7-306ef398113d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8be-9594-74db-acbf-32347c92feb6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7bc3-a7e7-306ef398113d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7ab0-be8c-940ae949a7a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019fd8be-9594-720b-9ba1-d975adbfeef7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7ab0-be8c-940ae949a7a5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019fd8be-9594-720b-9ba1-d975adbfeef7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_019fd8be-9594-732a-ad71-669dd53ace05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7ab0-be8c-940ae949a7a5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_019fd8be-9594-732a-ad71-669dd53ace05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_019fd8be-9594-7aa2-a246-54d85149ae34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7ab0-be8c-940ae949a7a5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_019fd8be-9594-7aa2-a246-54d85149ae34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_019fd8be-9594-7800-ac2f-2820b96a3c12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeOtherNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd8be-9594-7ab0-be8c-940ae949a7a5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_019fd8be-9594-7800-ac2f-2820b96a3c12" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="amrx-20260930.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7673-95e8-473804b10993" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7673-95e8-473804b10993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7423-a1d0-a42d67ec04e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7423-a1d0-a42d67ec04e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fd8be-9594-7477-bd19-b6a909bd0028" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019fd8be-9594-7477-bd19-b6a909bd0028" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd8be-9594-79fa-a53f-fd8ab34203df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:to="loc_us-gaap_InventoryNet_019fd8be-9594-79fa-a53f-fd8ab34203df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9594-78f8-9d67-3dcb68cdc394" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8be-9594-7e05-a537-8bee9c4c33f7" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9594-78f8-9d67-3dcb68cdc394" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd8be-9594-76c7-b064-6068f3674391" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_AssetsCurrent_019fd8be-9594-76c7-b064-6068f3674391" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8be-9594-7fb2-ad50-aabb3b0fee44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8be-9594-7fb2-ad50-aabb3b0fee44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd8be-9594-706b-bbae-a79a3ff89c40" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_Goodwill_019fd8be-9594-706b-bbae-a79a3ff89c40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9594-752c-a274-d06b0a133d02" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9594-752c-a274-d06b0a133d02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd8be-9594-74d6-b46e-41530b499bd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd8be-9594-74d6-b46e-41530b499bd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019fd8be-9594-7ddc-a1ed-405ea721cc98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_019fd8be-9594-7ddc-a1ed-405ea721cc98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9594-76c4-8263-e71dbd73ae34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8be-9594-71ba-aa60-2f8859d99ea6" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9594-76c4-8263-e71dbd73ae34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9594-784e-9ebf-cbd56c6807dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9594-784e-9ebf-cbd56c6807dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019fd8be-9594-7ef9-b959-c1eca5acf7b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_LitigationReserveCurrent_019fd8be-9594-7ef9-b959-c1eca5acf7b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LinesOfCreditCurrent_019fd8be-9594-7ec7-a1b7-e032198334b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LinesOfCreditCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_LinesOfCreditCurrent_019fd8be-9594-7ec7-a1b7-e032198334b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019fd8be-9594-7e96-a690-bb35ec82cd1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_LongTermDebtCurrent_019fd8be-9594-7e96-a690-bb35ec82cd1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd8be-9594-723b-be40-3e3655495406" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd8be-9594-723b-be40-3e3655495406" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_019fd8be-9594-7a7b-bb6e-8848c8a6bc45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_019fd8be-9594-7a7b-bb6e-8848c8a6bc45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_01a1864d-baa8-763f-a95d-56e5a573a869" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-7f58-aa63-2fff341f7ab5" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_01a1864d-baa8-763f-a95d-56e5a573a869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd8be-9594-74a8-8693-2d6b78137df0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019fd8be-9594-74a8-8693-2d6b78137df0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd8be-9594-77d9-97d1-3db42963fd5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd8be-9594-77d9-97d1-3db42963fd5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019fd8be-9594-73d1-a530-689d206691cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019fd8be-9594-73d1-a530-689d206691cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveNoncurrent_019fd8be-9594-7cfb-8847-2ce2023b0c78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_LitigationReserveNoncurrent_019fd8be-9594-7cfb-8847-2ce2023b0c78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9594-7376-8ed4-33098ee87953" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9594-7376-8ed4-33098ee87953" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_01a03c5a-4546-7d8d-bbe0-52808894ade4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-74ab-a327-caf71d875ad6" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_01a03c5a-4546-7d8d-bbe0-52808894ade4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019fd8be-9594-7263-8c78-868002add5a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:to="loc_us-gaap_PreferredStockValue_019fd8be-9594-7263-8c78-868002add5a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019fd8be-9594-76b7-96e3-1cd3aa1202d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:to="loc_us-gaap_CommonStockValue_019fd8be-9594-76b7-96e3-1cd3aa1202d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019fd8be-9594-741a-bc72-b5a662e90d94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019fd8be-9594-741a-bc72-b5a662e90d94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd8be-9594-7272-bac5-f3425ddc3e4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd8be-9594-7272-bac5-f3425ddc3e4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd8be-9594-7007-a2f5-916045c451c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8be-9594-7832-b324-afacac9ec214" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd8be-9594-7007-a2f5-916045c451c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd8be-9594-71ff-8ab1-a83a6f1e2290" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd8be-9594-7276-a6e3-4ece1a1140a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd8be-9594-71ff-8ab1-a83a6f1e2290" xlink:to="loc_us-gaap_StockholdersEquity_019fd8be-9594-7276-a6e3-4ece1a1140a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019fd8be-9594-79e7-9a83-3258ed44277d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd8be-9594-71ff-8ab1-a83a6f1e2290" xlink:to="loc_us-gaap_MinorityInterest_019fd8be-9594-79e7-9a83-3258ed44277d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-796c-b17e-fdee5ebff764" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:to="loc_us-gaap_LiabilitiesCurrent_019fd8be-9594-796c-b17e-fdee5ebff764" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-770d-ba4b-51fef96c03e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_019fd8be-9594-770d-ba4b-51fef96c03e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019fd8be-9594-7e2d-bf12-d6cffa4c6eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019fd8be-9594-7e2d-bf12-d6cffa4c6eb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_019fd8be-9594-787e-93fb-522983bd0527" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountIncludingPortionAttributableToNoncontrollingInterests_019fd8be-9594-787e-93fb-522983bd0527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd8be-9594-7180-8160-ff9d8eda86b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8be-9594-70f0-be60-0816f0dbdacc" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd8be-9594-7180-8160-ff9d8eda86b3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="amrx-20260930.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-7a76-9abd-8280dea8f755" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7c23-8fcf-1bb7358d3e66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-7a76-9abd-8280dea8f755" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8be-9594-7c23-8fcf-1bb7358d3e66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019fd8be-9594-71cd-af73-b9e7e1d76dc3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-7a76-9abd-8280dea8f755" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019fd8be-9594-71cd-af73-b9e7e1d76dc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019fd8be-9594-76e5-9122-aefe809f4bdc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-7a76-9abd-8280dea8f755" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019fd8be-9594-76e5-9122-aefe809f4bdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_RepaymentsOfLongTermDebtRevolvingCreditFacilityAndFinancingLeaseObligations_019fd8be-9594-7b19-aa8a-b57daba0b3c6" xlink:href="amrx-20260930.xsd#amrx_RepaymentsOfLongTermDebtRevolvingCreditFacilityAndFinancingLeaseObligations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_amrx_RepaymentsOfLongTermDebtRevolvingCreditFacilityAndFinancingLeaseObligations_019fd8be-9594-7b19-aa8a-b57daba0b3c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_019fd8be-9594-7169-88da-3461a92b7de0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_019fd8be-9594-7169-88da-3461a92b7de0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_019fd8be-9594-7e73-b4a5-13c81eb8bfdd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_019fd8be-9594-7e73-b4a5-13c81eb8bfdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_019fd8be-9594-754d-bae6-46ebcefdb2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromLinesOfCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_ProceedsFromLinesOfCredit_019fd8be-9594-754d-bae6-46ebcefdb2f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019fd8be-9594-70d0-b7bc-fb351feb0081" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019fd8be-9594-70d0-b7bc-fb351feb0081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019fd8be-9594-7ec5-aa39-b38302724d03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019fd8be-9594-7ec5-aa39-b38302724d03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_TaxAndOtherDistributionToNoncontrollingInterestFinancingActivities_019fd8be-9594-70fe-9568-08a0363d39e7" xlink:href="amrx-20260930.xsd#amrx_TaxAndOtherDistributionToNoncontrollingInterestFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_amrx_TaxAndOtherDistributionToNoncontrollingInterestFinancingActivities_019fd8be-9594-70fe-9568-08a0363d39e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_ProceedsFromAllianceAndCollaborationAgreements_019fd8be-9594-7ff1-ab21-651fcb1108d0" xlink:href="amrx-20260930.xsd#amrx_ProceedsFromAllianceAndCollaborationAgreements"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_amrx_ProceedsFromAllianceAndCollaborationAgreements_019fd8be-9594-7ff1-ab21-651fcb1108d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_019fd8be-9594-7818-ba3d-e49c35fda037" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-750c-a74f-bcf35406830f" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_019fd8be-9594-7818-ba3d-e49c35fda037" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd8be-9594-723b-9b0e-7db109a251cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_ProfitLoss_019fd8be-9594-723b-9b0e-7db109a251cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts_019fd8be-9594-754c-8ac6-cdcb3e8f63f7" xlink:href="amrx-20260930.xsd#amrx_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_amrx_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtIssuanceCosts_019fd8be-9594-754c-8ac6-cdcb3e8f63f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_019fd8be-9594-78e1-9cf2-24f30a6e0f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_019fd8be-9594-78e1-9cf2-24f30a6e0f9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019fd8be-9594-7db2-8a78-fdb2e4d2d1b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019fd8be-9594-7db2-8a78-fdb2e4d2d1b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019fd8be-9594-74e8-a3ef-e40ff15ab1e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_ShareBasedCompensation_019fd8be-9594-74e8-a3ef-e40ff15ab1e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019fd8be-9594-7106-86fb-151e772c0607" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_InventoryWriteDown_019fd8be-9594-7106-86fb-151e772c0607" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019fd8be-9594-7963-a118-0f9a39b99476" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019fd8be-9594-7963-a118-0f9a39b99476" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd8be-9594-7c2b-955a-330571b63518" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd8be-9594-7c2b-955a-330571b63518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019fd8be-9594-703b-8b52-1417de2d2b61" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019fd8be-9594-703b-8b52-1417de2d2b61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019fd8be-9594-7dad-aced-a21a2a0deea6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019fd8be-9594-7dad-aced-a21a2a0deea6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_019fd8be-9594-7de4-8d63-8049d34d6d90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedParties"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInDueFromRelatedParties_019fd8be-9594-7de4-8d63-8049d34d6d90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019fd8be-9594-7a4f-8f3b-8a260ad62928" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019fd8be-9594-7a4f-8f3b-8a260ad62928" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDueToRelatedParties_019fd8be-9594-711f-80ea-ec201a78b4f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDueToRelatedParties"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_IncreaseDecreaseInDueToRelatedParties_019fd8be-9594-711f-80ea-ec201a78b4f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossReclassifiedToEarningsNet_019fd8be-9594-7be6-bf2f-cecea7d0bcc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRateCashFlowHedgeGainLossReclassifiedToEarningsNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossReclassifiedToEarningsNet_019fd8be-9594-7be6-bf2f-cecea7d0bcc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fd8be-9594-7c21-bdd2-288944979286" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019fd8be-9594-7c21-bdd2-288944979286" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_01a03c7f-775a-736e-b380-056062debebd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_01a03c7f-775a-736e-b380-056062debebd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_01a17d0b-b7b9-7c8b-8cbb-b2787369f4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_01a17d0b-b7b9-7c8b-8cbb-b2787369f4bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TangibleAssetImpairmentCharges_01a17d0b-b7b9-7848-a4d7-ae04083be4df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TangibleAssetImpairmentCharges"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_us-gaap_TangibleAssetImpairmentCharges_01a17d0b-b7b9-7848-a4d7-ae04083be4df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_NoncashPropertyLosses_01a17d0b-b7b9-7c66-9e52-50d2116fd433" xlink:href="amrx-20260930.xsd#amrx_NoncashPropertyLosses"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-79c1-ad94-8b2db3dc996a" xlink:to="loc_amrx_NoncashPropertyLosses_01a17d0b-b7b9-7c66-9e52-50d2116fd433" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8be-9594-779d-982a-016d0e20939b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-7b07-98c0-cab9fdbe485a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8be-9594-779d-982a-016d0e20939b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8be-9594-7b07-98c0-cab9fdbe485a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-7ccd-9859-e615944b2173" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8be-9594-779d-982a-016d0e20939b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-7ccd-9859-e615944b2173" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-77ca-8b47-62e0c16dc387" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8be-9594-779d-982a-016d0e20939b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8be-9594-77ca-8b47-62e0c16dc387" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-75cd-910c-8b6408587e84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8be-9594-779d-982a-016d0e20939b" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8be-9594-75cd-910c-8b6408587e84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019fd8be-9594-70ac-883c-3ec83c42c311" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019fd8be-9594-70ac-883c-3ec83c42c311" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd8be-9594-78dd-83f5-6d851cff5511" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd8be-9594-78dd-83f5-6d851cff5511" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_019fd8be-9594-7400-b7a4-2d23e815da34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_019fd8be-9594-7400-b7a4-2d23e815da34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_PaymentsToAcquirePropertyPlantAndEquipmentDeposits_019fd8be-9594-7e18-a564-39e6d4e973fb" xlink:href="amrx-20260930.xsd#amrx_PaymentsToAcquirePropertyPlantAndEquipmentDeposits"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:to="loc_amrx_PaymentsToAcquirePropertyPlantAndEquipmentDeposits_019fd8be-9594-7e18-a564-39e6d4e973fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_01a03c84-aac0-771a-9b19-19f6dcd4ae5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8be-9594-763d-87a0-87f136334c58" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_01a03c84-aac0-771a-9b19-19f6dcd4ae5a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/AcquisitionScheduleofPreliminaryConsiderationTransferredDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#AcquisitionScheduleofPreliminaryConsiderationTransferredDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/AcquisitionScheduleofPreliminaryConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_01a043d0-5602-7db5-9430-231a11310ecd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_01a043d0-5602-7db5-9430-231a11310ecd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_01a043d0-5602-705f-9c69-66e3c789118b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_01a043d0-5602-705f-9c69-66e3c789118b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred_01a043d0-5602-7a22-8c28-9f059c77020a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred_01a043d0-5602-7a22-8c28-9f059c77020a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationConsiderationTransferredRepaymentOfDebtObligations_01a043d0-5602-721c-bbe4-b75979558d45" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationConsiderationTransferredRepaymentOfDebtObligations"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_amrx_BusinessCombinationConsiderationTransferredRepaymentOfDebtObligations_01a043d0-5602-721c-bbe4-b75979558d45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationConsiderationTransferredReceivableFromSellersRelatedToPurchasePriceAdjustment_01a043d0-5602-7ec8-8d7b-2ec20ada3620" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationConsiderationTransferredReceivableFromSellersRelatedToPurchasePriceAdjustment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_amrx_BusinessCombinationConsiderationTransferredReceivableFromSellersRelatedToPurchasePriceAdjustment_01a043d0-5602-7ec8-8d7b-2ec20ada3620" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationship_01a043d0-5602-7124-88af-100caa05ac57" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationship"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a043d0-5602-757f-81af-8f91473d7dbc" xlink:to="loc_amrx_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationship_01a043d0-5602-7124-88af-100caa05ac57" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/AcquisitionScheduleofPreliminaryPurchasePriceAllocationfortheAcquisitionsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#AcquisitionScheduleofPreliminaryPurchasePriceAllocationfortheAcquisitionsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/AcquisitionScheduleofPreliminaryPurchasePriceAllocationfortheAcquisitionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedAccountsPayableAndAccruedExpenseCurrent_01a0437a-53fc-73a4-a152-2312275f4b22" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedLiabilityAssumedAccountsPayableAndAccruedExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:to="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedAccountsPayableAndAccruedExpenseCurrent_01a0437a-53fc-73a4-a152-2312275f4b22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityCurrent_01a0437a-53fc-7668-9ba9-e4c3f87cc763" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:to="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityCurrent_01a0437a-53fc-7668-9ba9-e4c3f87cc763" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_01a0437a-53fc-71b4-98e6-ceb27cbb093c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_01a0437a-53fc-71b4-98e6-ceb27cbb093c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityNoncurrent_01a0437a-53fc-712a-86f7-8a1f0c4d1daf" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:to="loc_amrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilityNoncurrent_01a0437a-53fc-712a-86f7-8a1f0c4d1daf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_01a0437a-53fc-72bc-94b2-ffec16afbebf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-53fc-7b22-805b-941d5005b907" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_01a0437a-53fc-72bc-94b2-ffec16afbebf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0437a-9368-7340-a1eb-75bd9e552bb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-9368-7738-b85d-76a58e0710e7" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0437a-9368-7340-a1eb-75bd9e552bb2" xlink:to="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-9368-7738-b85d-76a58e0710e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-9368-76a4-8b1d-d81cbdbfbd2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0437a-9368-7340-a1eb-75bd9e552bb2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0437a-9368-76a4-8b1d-d81cbdbfbd2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_01a0437a-26f8-7415-95eb-6a38579a5ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_01a0437a-26f8-7415-95eb-6a38579a5ea4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_01a0437a-26f8-78ca-b459-10b89bdc7da3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_01a0437a-26f8-78ca-b459-10b89bdc7da3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_01a0437a-26f8-7406-897f-33ab0609bd16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_01a0437a-26f8-7406-897f-33ab0609bd16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_01a0437a-26f8-71b6-9852-e4d05b8e70df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_01a0437a-26f8-71b6-9852-e4d05b8e70df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_01a0437a-26f8-7f63-af7e-c5518dba2b99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_01a0437a-26f8-7f63-af7e-c5518dba2b99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a0437a-26f8-7280-b6e9-c09f18826b83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a0437a-26f8-7280-b6e9-c09f18826b83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationRecognizedAssetAcquiredOperatingLeaseRightOfUseAsset_01a0437a-26f8-72e5-815b-6b53393d3864" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationRecognizedAssetAcquiredOperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_amrx_BusinessCombinationRecognizedAssetAcquiredOperatingLeaseRightOfUseAsset_01a0437a-26f8-72e5-815b-6b53393d3864" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_01a0437a-26f8-710e-9865-2c7c5777ae40" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_01a0437a-26f8-710e-9865-2c7c5777ae40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_01a17d2d-15df-750f-b4b0-86f9afd41ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_BusinessCombinationRecognizedAssetAcquiredAssetIncludingGoodwill_01a0437a-26f8-761d-9760-e69c34c5e776" xlink:to="loc_us-gaap_Goodwill_01a17d2d-15df-750f-b4b0-86f9afd41ff3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/AcquisitionScheduleofAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#AcquisitionScheduleofAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/AcquisitionScheduleofAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a05913-fb2f-7008-be8d-ccf69abcb224" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_01a05913-fb2f-7768-88b5-1ba76517c959" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a05913-fb2f-7008-be8d-ccf69abcb224" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_01a05913-fb2f-7768-88b5-1ba76517c959" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_01a05913-fb2f-70eb-ba67-48d0761e126d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a05913-fb2f-7008-be8d-ccf69abcb224" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_01a05913-fb2f-70eb-ba67-48d0761e126d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/IncomeTaxesScheduleofTaxReceivableAgreementDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#IncomeTaxesScheduleofTaxReceivableAgreementDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/IncomeTaxesScheduleofTaxReceivableAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreement_019fd8be-9623-7be4-932f-a312074a3713" xlink:href="amrx-20260930.xsd#amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreement"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementCurrent_019fd8be-9623-7189-b835-00cf229a3f09" xlink:href="amrx-20260930.xsd#amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreement_019fd8be-9623-7be4-932f-a312074a3713" xlink:to="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementCurrent_019fd8be-9623-7189-b835-00cf229a3f09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementNoncurrent_019fd8be-9623-7b46-a88e-614ce6ed47f9" xlink:href="amrx-20260930.xsd#amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreement_019fd8be-9623-7be4-932f-a312074a3713" xlink:to="loc_amrx_IncomeTaxLiabilitiesUnderTaxReceivableAgreementNoncurrent_019fd8be-9623-7b46-a88e-614ce6ed47f9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/LossEarningsperShareScheduleofBasicandDilutedLossEarningsperShareDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#LossEarningsperShareScheduleofBasicandDilutedLossEarningsperShareDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/LossEarningsperShareScheduleofBasicandDilutedLossEarningsperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd8be-9623-7c29-ab55-667690a7cc2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019fd8be-9623-7a08-afe3-7230123a1c30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd8be-9623-7c29-ab55-667690a7cc2e" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019fd8be-9623-7a08-afe3-7230123a1c30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fd8be-9623-70f2-a069-65265a8a2837" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd8be-9623-7c29-ab55-667690a7cc2e" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fd8be-9623-70f2-a069-65265a8a2837" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/TradeAccountsReceivableNetScheduleofTradeAccountsReceivableNetDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#TradeAccountsReceivableNetScheduleofTradeAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/TradeAccountsReceivableNetScheduleofTradeAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fd8be-9623-7bec-9762-d087566b1874" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_019fd8be-9623-7bdf-a97d-d252eab73bec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019fd8be-9623-7bec-9762-d087566b1874" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_019fd8be-9623-7bdf-a97d-d252eab73bec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d4d-840e-7c036f09cf45" xlink:href="amrx-20260930.xsd#amrx_AllowanceForAccountsReceivableCurrent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019fd8be-9623-7bec-9762-d087566b1874" xlink:to="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d4d-840e-7c036f09cf45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d3b-a4fe-b9bdd4af12c2" xlink:href="amrx-20260930.xsd#amrx_AllowanceForAccountsReceivableCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019fd8be-9623-7ad1-b990-245ec7eaa678" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d3b-a4fe-b9bdd4af12c2" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019fd8be-9623-7ad1-b990-245ec7eaa678" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_ContractChargeBacksAndSalesVolumeAllowancesCurrent_019fd8be-9623-7de1-a5b8-794c92e6fabd" xlink:href="amrx-20260930.xsd#amrx_ContractChargeBacksAndSalesVolumeAllowancesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d3b-a4fe-b9bdd4af12c2" xlink:to="loc_amrx_ContractChargeBacksAndSalesVolumeAllowancesCurrent_019fd8be-9623-7de1-a5b8-794c92e6fabd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_CashDiscountAllowancesCurrent_019fd8be-9623-72ac-8da8-cf580ad4870d" xlink:href="amrx-20260930.xsd#amrx_CashDiscountAllowancesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_AllowanceForAccountsReceivableCurrent_019fd8be-9623-7d3b-a4fe-b9bdd4af12c2" xlink:to="loc_amrx_CashDiscountAllowancesCurrent_019fd8be-9623-72ac-8da8-cf580ad4870d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/InventoriesDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd8be-9623-75ee-a807-fa8491f9f09a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd8be-9623-7f93-b1a5-35b4b21d2c13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8be-9623-75ee-a807-fa8491f9f09a" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd8be-9623-7f93-b1a5-35b4b21d2c13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd8be-9623-782f-91cf-8407ac6b4cb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8be-9623-75ee-a807-fa8491f9f09a" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd8be-9623-782f-91cf-8407ac6b4cb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd8be-9623-76a1-acb2-4e3bfa004edb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8be-9623-75ee-a807-fa8491f9f09a" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd8be-9623-76a1-acb2-4e3bfa004edb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#PrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/PrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019fd8be-9623-77d5-bfc3-4fbe1ff52ca1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019fd8be-9623-77d5-bfc3-4fbe1ff52ca1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_019fd8be-9623-7eb4-930f-adf86d203acc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_us-gaap_PrepaidInsurance_019fd8be-9623-7eb4-930f-adf86d203acc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_PrepaidRegulatoryFeesCurrent_019fd8be-9623-757d-98ab-aec57d2fcc33" xlink:href="amrx-20260930.xsd#amrx_PrepaidRegulatoryFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_amrx_PrepaidRegulatoryFeesCurrent_019fd8be-9623-757d-98ab-aec57d2fcc33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_IncomeAndOtherTaxesReceivable_019fd8be-9623-7082-9709-2650d2e8b293" xlink:href="amrx-20260930.xsd#amrx_IncomeAndOtherTaxesReceivable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_amrx_IncomeAndOtherTaxesReceivable_019fd8be-9623-7082-9709-2650d2e8b293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_019fd8be-9623-7495-820f-70a0493df7aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_us-gaap_PrepaidTaxes_019fd8be-9623-7495-820f-70a0493df7aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_019fd8be-9623-7ac1-b2cd-f5d2712dd6d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_019fd8be-9623-7ac1-b2cd-f5d2712dd6d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_ChargebacksReceivableCurrent_019fd8be-9623-717e-827d-dfb4ddf94373" xlink:href="amrx-20260930.xsd#amrx_ChargebacksReceivableCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_amrx_ChargebacksReceivableCurrent_019fd8be-9623-717e-827d-dfb4ddf94373" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent_019fd8be-9623-7e92-af04-5cf7457d7897" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent_019fd8be-9623-7e92-af04-5cf7457d7897" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AccruedRoyaltiesReceivableCurrent_019fd8be-9623-71ae-8c15-ed609d0f6301" xlink:href="amrx-20260930.xsd#amrx_AccruedRoyaltiesReceivableCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8be-9623-7840-bb18-23f862aedbe0" xlink:to="loc_amrx_AccruedRoyaltiesReceivableCurrent_019fd8be-9623-71ae-8c15-ed609d0f6301" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01a17d7f-601d-7a51-8b4c-aac7a7d783ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_01a17d7f-601d-747b-8c90-9af6b61fe63b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_01a17d7f-601d-7a51-8b4c-aac7a7d783ac" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_01a17d7f-601d-747b-8c90-9af6b61fe63b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01a17d7f-601d-7d05-a0c6-b64839190a39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_01a17d7f-601d-7a51-8b4c-aac7a7d783ac" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_01a17d7f-601d-7d05-a0c6-b64839190a39" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-740f-afe6-338cc44893ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd8be-9623-7030-bd83-c360f4f28900" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-740f-afe6-338cc44893ef" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd8be-9623-7030-bd83-c360f4f28900" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd8be-9623-72f2-831a-9e5028d06ab1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-740f-afe6-338cc44893ef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd8be-9623-72f2-831a-9e5028d06ab1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-7601-901d-d473ff8ae27d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd8be-9623-7b2a-9208-bd37f2864c88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-7601-901d-d473ff8ae27d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd8be-9623-7b2a-9208-bd37f2864c88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd8be-9623-73a3-9422-69b7ce5165a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-7601-901d-d473ff8ae27d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd8be-9623-73a3-9422-69b7ce5165a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd8be-9623-7e5d-a802-342d32a007ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd8be-9623-7402-8ec7-b3b01738109f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd8be-9623-7e5d-a802-342d32a007ce" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd8be-9623-7402-8ec7-b3b01738109f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd8be-9623-78be-9ce0-ed50e0d08bc9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd8be-9623-7e5d-a802-342d32a007ce" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd8be-9623-78be-9ce0-ed50e0d08bc9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails_1" xlink:type="simple" xlink:href="amrx-20260930.xsd#GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-70cf-9507-2372cf4e527d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-7cc4-8c5e-1914f1b4c7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-70cf-9507-2372cf4e527d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-7cc4-8c5e-1914f1b4c7a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd8be-9623-78bc-a377-f4084a4171f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd8be-9623-70cf-9507-2372cf4e527d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd8be-9623-78bc-a377-f4084a4171f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/GoodwillandOtherIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019fd8be-9623-75be-acf4-98c85f7e4871" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019fd8be-9623-75be-acf4-98c85f7e4871" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019fd8be-9623-7924-9e69-23dc75c1cb2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019fd8be-9623-7924-9e69-23dc75c1cb2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019fd8be-9623-7663-96a3-46ef37998f29" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019fd8be-9623-7663-96a3-46ef37998f29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019fd8be-9623-7283-9067-18b0fbed3bd0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019fd8be-9623-7283-9067-18b0fbed3bd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019fd8be-9623-785c-ae38-5b961df378ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019fd8be-9623-785c-ae38-5b961df378ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019fd8be-9623-747c-8d8e-d16b45eb4af1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019fd8be-9623-747c-8d8e-d16b45eb4af1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019fd8be-9623-7e6b-b434-c4f71ed8d50f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd8be-9623-78de-9e13-40a89d3274bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019fd8be-9623-7e6b-b434-c4f71ed8d50f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/OtherAssetsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#OtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/OtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_019fd8be-9623-783d-9ae3-85c10ddc637a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_019fd8be-9623-783d-9ae3-85c10ddc637a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsNoncurrent_019fd8be-9623-758d-8e24-34d68c6b1da7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepositsAssetsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_us-gaap_DepositsAssetsNoncurrent_019fd8be-9623-758d-8e24-34d68c6b1da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LongTermDepositsAndPrepaidExpensesNoncurrent_019fd8be-9623-772b-8825-17f2658320c7" xlink:href="amrx-20260930.xsd#amrx_LongTermDepositsAndPrepaidExpensesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_amrx_LongTermDepositsAndPrepaidExpensesNoncurrent_019fd8be-9623-772b-8825-17f2658320c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCosts_019fd8be-9623-7bf5-b76d-d8b94bc58a42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_us-gaap_DeferredCosts_019fd8be-9623-7bf5-b76d-d8b94bc58a42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019fd8be-9623-7334-becb-abc35ce64f31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019fd8be-9623-7334-becb-abc35ce64f31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_EquipmentDepositsNoncurrent_019fd8be-9623-7231-895e-4287edb3ea9f" xlink:href="amrx-20260930.xsd#amrx_EquipmentDepositsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_amrx_EquipmentDepositsNoncurrent_019fd8be-9623-7231-895e-4287edb3ea9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_019fd8be-9623-70b2-a7c1-9eb89140a6ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsMiscellaneousNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019fd8be-9623-7e39-b000-2c021aedb566" xlink:to="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_019fd8be-9623-70b2-a7c1-9eb89140a6ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#AccountsPayableandAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fd8be-9623-7985-98f6-3191cf992d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fd8be-9623-7985-98f6-3191cf992d9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AccruedSalesReturnsAllowanceCurrent_019fd8be-9623-72e4-a266-c125f138097d" xlink:href="amrx-20260930.xsd#amrx_AccruedSalesReturnsAllowanceCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_amrx_AccruedSalesReturnsAllowanceCurrent_019fd8be-9623-72e4-a266-c125f138097d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd8be-9623-756d-866e-73a0d8c3bfcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd8be-9623-756d-866e-73a0d8c3bfcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_AccruedSalesRebatesCurrent_019fd8be-9623-7c18-b6b9-a507ab1b41ae" xlink:href="amrx-20260930.xsd#amrx_AccruedSalesRebatesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_amrx_AccruedSalesRebatesCurrent_019fd8be-9623-7c18-b6b9-a507ab1b41ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_019fd8be-9623-7303-a729-828c33ffedd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_019fd8be-9623-7303-a729-828c33ffedd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019fd8be-9623-77ad-91ab-a2d1ce89bbd3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019fd8be-9623-77ad-91ab-a2d1ce89bbd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd8be-9623-7b97-bc74-ab4bba6f8ff9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd8be-9623-7b97-bc74-ab4bba6f8ff9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019fd8be-9623-7987-8223-ef129ed2e743" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019fd8be-9623-759e-a73e-a224b58f0ab4" xlink:to="loc_us-gaap_InterestPayableCurrent_019fd8be-9623-7987-8223-ef129ed2e743" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/DebtScheduleofLongTermDebtDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#DebtScheduleofLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/DebtScheduleofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019fd8be-9623-76ea-b0d1-22cadc70827e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019fd8be-9623-7e25-97a4-5d108114dc7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd8be-9623-76ea-b0d1-22cadc70827e" xlink:to="loc_us-gaap_LongTermDebtCurrent_019fd8be-9623-7e25-97a4-5d108114dc7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd8be-9623-757f-a6ea-1ed78da509b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd8be-9623-76ea-b0d1-22cadc70827e" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019fd8be-9623-757f-a6ea-1ed78da509b8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/DebtScheduleofLongTermDebtDetails_1" xlink:type="simple" xlink:href="amrx-20260930.xsd#DebtScheduleofLongTermDebtDetails_1"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/DebtScheduleofLongTermDebtDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019fd8be-9623-7edc-b29d-c21dc6277c54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8be-9623-7986-a91c-0281a7beb33e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd8be-9623-7edc-b29d-c21dc6277c54" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8be-9623-7986-a91c-0281a7beb33e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019fd8be-9623-7163-8e3b-1e0b8ab114ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd8be-9623-7edc-b29d-c21dc6277c54" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019fd8be-9623-7163-8e3b-1e0b8ab114ed" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/OtherLongTermLiabilitiesDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#OtherLongTermLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/OtherLongTermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9624-712a-9409-19b074ab886e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LongTermCompensationLiabilities_019fd8be-9624-76fd-b449-3b1ce15ec70e" xlink:href="amrx-20260930.xsd#amrx_LongTermCompensationLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9624-712a-9409-19b074ab886e" xlink:to="loc_amrx_LongTermCompensationLiabilities_019fd8be-9624-76fd-b449-3b1ce15ec70e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019fd8be-9624-72e6-892f-d104c06467c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSundryLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9624-712a-9409-19b074ab886e" xlink:to="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019fd8be-9624-72e6-892f-d104c06467c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019fd8be-9624-7153-85ce-f56b45069f44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8be-9624-712a-9409-19b074ab886e" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019fd8be-9624-7153-85ce-f56b45069f44" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/CommitmentandContingenciesScheduleofCashPaymentsDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#CommitmentandContingenciesScheduleofCashPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/CommitmentandContingenciesScheduleofCashPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementCashSettlement_019fd8be-9624-7677-8cbe-4739242ca02a" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementCashSettlement"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7cc4-a419-b7155b1f8129" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementCashSettlement_019fd8be-9624-7677-8cbe-4739242ca02a" xlink:to="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7cc4-a419-b7155b1f8129" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementImputedInterestAtWeightedAverageRate_019fd8be-9624-7e62-ab9a-7aeac2cd9803" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementImputedInterestAtWeightedAverageRate"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementCashSettlement_019fd8be-9624-7677-8cbe-4739242ca02a" xlink:to="loc_amrx_LitigationSettlementImputedInterestAtWeightedAverageRate_019fd8be-9624-7e62-ab9a-7aeac2cd9803" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidYearOne_019fd8be-9624-7f61-8b84-7b8a3d4e62ef" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidYearOne"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidYearOne_019fd8be-9624-7f61-8b84-7b8a3d4e62ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidYearTwo_019fd8be-9624-761b-8f15-e0691e11d657" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidYearTwo_019fd8be-9624-761b-8f15-e0691e11d657" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidYearThree_019fd8be-9624-7620-a405-d9ecf347001f" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidYearThree_019fd8be-9624-7620-a405-d9ecf347001f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidYearFour_019fd8be-9624-7f6b-b7a3-d8c31197fcb3" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidYearFour_019fd8be-9624-7f6b-b7a3-d8c31197fcb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidYearFive_019fd8be-9624-77fb-8a94-78f143e29424" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidYearFive_019fd8be-9624-77fb-8a94-78f143e29424" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LitigationSettlementToBePaidAfterYearFive_019fd8be-9624-7119-9cca-2763c9c9f768" xlink:href="amrx-20260930.xsd#amrx_LitigationSettlementToBePaidAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_amrx_LitigationSettlementToBePaidGross_019fd8be-9624-7948-9b77-4f9697b95497" xlink:to="loc_amrx_LitigationSettlementToBePaidAfterYearFive_019fd8be-9624-7119-9cca-2763c9c9f768" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/SegmentInformationScheduleofSellingGeneralandAdministrativeExpensesonaDepartmentalBasisDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#SegmentInformationScheduleofSellingGeneralandAdministrativeExpensesonaDepartmentalBasisDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/SegmentInformationScheduleofSellingGeneralandAdministrativeExpensesonaDepartmentalBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-96b3-7d0a-be9d-616702da23b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019fd8be-96b3-773f-8a29-aaf34040deae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-96b3-7d0a-be9d-616702da23b2" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019fd8be-96b3-773f-8a29-aaf34040deae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_CommercialOperationsAndSalesforceExpense_019fd8be-96b3-7048-8f35-839f766dfed6" xlink:href="amrx-20260930.xsd#amrx_CommercialOperationsAndSalesforceExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-96b3-7d0a-be9d-616702da23b2" xlink:to="loc_amrx_CommercialOperationsAndSalesforceExpense_019fd8be-96b3-7048-8f35-839f766dfed6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSellingGeneralAndAdministrativeExpense_019fd8be-96b3-7968-807b-7eaf5c47818d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-96b3-7d0a-be9d-616702da23b2" xlink:to="loc_us-gaap_OtherSellingGeneralAndAdministrativeExpense_019fd8be-96b3-7968-807b-7eaf5c47818d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketingAndAdvertisingExpense_019fd8be-96b3-74a0-9cd2-bed16b1a051a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketingAndAdvertisingExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8be-96b3-7d0a-be9d-616702da23b2" xlink:to="loc_us-gaap_MarketingAndAdvertisingExpense_019fd8be-96b3-74a0-9cd2-bed16b1a051a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/SegmentInformationScheduleofResearchandDevelopmentExpenseDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#SegmentInformationScheduleofResearchandDevelopmentExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/SegmentInformationScheduleofResearchandDevelopmentExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019fd8be-96b3-7ab0-a1dc-4626e0f8918f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019fd8be-96b3-7ab0-a1dc-4626e0f8918f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SuppliesExpense_019fd8be-96b3-75aa-891f-4aed9fbe1b49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SuppliesExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_us-gaap_SuppliesExpense_019fd8be-96b3-75aa-891f-4aed9fbe1b49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_ProductDevelopmentAndStudiesExpense_019fd8be-96b3-7236-a990-53e30ba06908" xlink:href="amrx-20260930.xsd#amrx_ProductDevelopmentAndStudiesExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_amrx_ProductDevelopmentAndStudiesExpense_019fd8be-96b3-7236-a990-53e30ba06908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_InLicensingAndUpfrontMilestones_019fd8be-96b3-77df-9fb5-20c8803f0a9b" xlink:href="amrx-20260930.xsd#amrx_InLicensingAndUpfrontMilestones"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_amrx_InLicensingAndUpfrontMilestones_019fd8be-96b3-77df-9fb5-20c8803f0a9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_FacilitiesCosts_019fd8be-96b3-7062-9d0e-47f10e3dec12" xlink:href="amrx-20260930.xsd#amrx_FacilitiesCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_amrx_FacilitiesCosts_019fd8be-96b3-7062-9d0e-47f10e3dec12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_RegulatoryFeesExpense_019fd8be-96b3-7386-895c-fc242052f043" xlink:href="amrx-20260930.xsd#amrx_RegulatoryFeesExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_amrx_RegulatoryFeesExpense_019fd8be-96b3-7386-895c-fc242052f043" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_BusinessCombinationResearchAndDevelopmentExpense_019fd8be-96b3-77d7-8485-618ec9e568c9" xlink:href="amrx-20260930.xsd#amrx_BusinessCombinationResearchAndDevelopmentExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_amrx_BusinessCombinationResearchAndDevelopmentExpense_019fd8be-96b3-77d7-8485-618ec9e568c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherResearchAndDevelopmentExpense_01a1c10e-b3d9-7d66-8f3f-808abee6656a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherResearchAndDevelopmentExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8be-96b3-7e21-8773-ae553d5ac64c" xlink:to="loc_us-gaap_OtherResearchAndDevelopmentExpense_01a1c10e-b3d9-7d66-8f3f-808abee6656a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="amrx-20260930.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7a52-9985-5c71f318a36c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_01a0f85e-e4e1-76cc-8a2f-e14d1e08c62b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7a52-9985-5c71f318a36c" xlink:to="loc_us-gaap_OperatingLeaseLiability_01a0f85e-e4e1-76cc-8a2f-e14d1e08c62b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_01a0f85e-e4e1-7bea-9fcc-9cfc8b0d628d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7a52-9985-5c71f318a36c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_01a0f85e-e4e1-7bea-9fcc-9cfc8b0d628d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amneal.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="amrx-20260930.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.amneal.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_01a0f85e-e4e1-76eb-b69d-366809d4aa32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_01a0f85e-e4e1-76eb-b69d-366809d4aa32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_01a0f85e-e4e1-7723-bacc-a047e7a728b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_01a0f85e-e4e1-7723-bacc-a047e7a728b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_01a0f85e-e4e1-7118-8657-2d98439db0d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_01a0f85e-e4e1-7118-8657-2d98439db0d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_01a0f85e-e4e1-7176-8de7-ac4c9a08fbbb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_01a0f85e-e4e1-7176-8de7-ac4c9a08fbbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_01a0f85e-e4e1-7e80-a11f-20ce9c4953ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_01a0f85e-e4e1-7e80-a11f-20ce9c4953ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_01a0f85e-e4e1-7c82-9df5-a7549d88f9a2" xlink:href="amrx-20260930.xsd#amrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_01a0f85e-e4e1-7d76-b19d-5551871e6ed1" xlink:to="loc_amrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_01a0f85e-e4e1-7c82-9df5-a7549d88f9a2" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
