Segment Reporting and Disaggregation of Relevant Expense Captions (Details) $ in Thousands |
3 Months Ended | 9 Months Ended | ||
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Sep. 30, 2026
USD ($)
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Sep. 30, 2025
USD ($)
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Sep. 30, 2026
USD ($)
segment
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Sep. 30, 2025
USD ($)
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| Segment Reporting [Abstract] | ||||
| Number of operating segments | segment | 1 | |||
| Number of reportable segments | segment | 1 | |||
| Research and development : | ||||
| Total research and development | $ 22,334 | $ 22,950 | $ 86,213 | $ 77,807 |
| General and administrative | 8,820 | 10,784 | 27,187 | 29,812 |
| Net loss | (28,815) | (26,691) | (106,453) | (101,844) |
| Adjustments for cash used in operations: | ||||
| Cash used in operations: | (102,899) | (94,307) | ||
| Reportable Segment | ||||
| Research and development : | ||||
| Azenosertib external development costs | 11,436 | 12,602 | 51,663 | 33,153 |
| Unallocated research and development expenses and discontinued programs | 10,898 | 10,348 | 34,550 | 44,654 |
| Total research and development | 22,334 | 22,950 | 86,213 | 77,807 |
| General and administrative | 8,820 | 10,784 | 27,187 | 29,812 |
| Other | 2,339 | 7,043 | 6,947 | 5,775 |
| Net loss | (28,815) | (26,691) | (106,453) | (101,844) |
| Adjustments for cash used in operations: | ||||
| Non-cash expenses | 3,216 | 898 | 9,659 | 15,281 |
| Changes in working capital | (7,108) | (1,170) | (6,105) | (7,744) |
| Cash used in operations: | $ (32,707) | $ (26,963) | $ (102,899) | $ (94,307) |
| X | ||||||||||
- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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| X | ||||||||||
- Definition Amount of increase (decrease) in asset and (increase) decrease in liability, used in operating activity in reconciling net income to reflect cash provided by (used in) operating activity when indirect cash flow method is applied. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of cash inflow (outflow) from operating activity, including, but not limited to, discontinued operation. Operating activity includes, but is not limited to, transaction, adjustment, and change in value not defined as investing or financing activity. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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| X | ||||||||||
- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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| X | ||||||||||
- Definition Number of segments reported by the entity. A reportable segment is a component of an entity for which there is an accounting requirement to report separate financial information on that component in the entity's financial statements. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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| X | ||||||||||
- Definition Amount of income (expense) included in net income that results in no cash inflow (outflow), classified as other. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition The amount of costs incurred under a research and development arrangement accounted for as a contract to perform research and development for others. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- References No definition available.
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- Definition Amount of other expense (income) and loss (gain) calculated as difference between segment revenue and separately disclosed expense category to arrive at segment profit (loss). Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Adjustments For Cash No definition available.
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- Definition Research and Development Expenses and Discontinued Programs No definition available.
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- Details
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