Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Weighted-average common shares outstanding:
Anti-dilutive shares excluded from diluted net income (loss) per common share:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Trading Arrangement:
Trading Arrangement [Axis]
Maximum
Maximum [Member]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Title of 12(b) Security
Title of 12(b) Security
Document Fiscal Year Focus
Document Fiscal Year Focus
Leverage ratio
Debt Instrument, Covenant, Leverage Ratio, Maximum
Debt Instrument, Covenant, Leverage Ratio, Maximum
Base period maximum funding
Collaborative Arrangement, Base Period Maximum Funding
Collaborative Arrangement, Base Period Maximum Funding
Consideration payment for license
License Agreement, Consideration
License Agreement, Consideration
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Financial Instrument [Axis]
Financial Instrument [Axis]
Segment Reporting [Abstract]
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense
Intangible Asset, Finite-Lived, and Capitalized Cost, Software to be Sold, Leased, or Marketed, Estimated Amortization Expense [Table Text Block]
Common stock, no par value; shares authorized — 75,000; shares issued and outstanding — 51,044 and 50,620, respectively
Common Stock, Value, Issued
Payments on employees’ behalf for taxes related to vesting of restricted stock unit awards
Payment, Tax Withholding, Share-Based Payment Arrangement
Employee-related accruals
Employee-related Liabilities, Current
Leases
Lessee, Finance Leases [Text Block]
Line of credit
Line of Credit [Member]
Restatement Determination Date
Restatement Determination Date
Sales and maturities of investments
Proceeds from Sale, Maturity and Collection of Investments
Provision for excess and obsolete inventory
Inventory Write-down
Insurance reimbursement-related liabilities
Accrued Insurance, Current
Issuance of stock for restricted stock unit vesting (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Contract with Customer, Basis of Pricing [Domain]
Contract with Customer, Basis of Pricing [Domain]
Amendment Flag
Amendment Flag
Current liabilities:
Current
Liabilities, Current [Abstract]
Shares acquired, average cost per share (in USD per share)
Shares Acquired, Average Cost Per Share
Nexobrid
Revenue Not from Contract with Customer, Other
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Gross Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Schedule of Gross Unrealized Gains and Losses
Debt Securities, Available-for-Sale [Table Text Block]
Leases [Abstract]
Leases [Abstract]
Cost, Product and Service [Extensible List]
Cost, Product and Service [Extensible Enumeration]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Entity Address, State or Province
Entity Address, State or Province
Licensing Agreements
Licensing Agreements [Member]
Stock options granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
PEO Total Compensation Amount
PEO Total Compensation Amount
Non-current
Liabilities, Noncurrent [Abstract]
Basic (in shares)
Basic weighted-average common shares outstanding (in shares)
Weighted Average Number of Shares Outstanding, Basic
Amortization of premiums and discounts on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Provider or Facility
Provider or Facility [Member]
Provider or Facility [Member]
Number of reportable segments
Number of Reportable Segments
Total current liabilities
Liabilities, Current
Single Reportable Segment
Single Reportable Segment [Member]
Single Reportable Segment
Increase option for leverage ratio
Debt Instrument, Covenant, Increase Option, Leverage Ratio, Maximum
Debt Instrument, Covenant, Increase Option, Leverage Ratio, Maximum
Epicel
Epicel [Member]
Epicel [Member]
Entity Address, City or Town
Entity Address, City or Town
Restricted stock units granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Intangible assets, net
Total
Intangible Asset, Finite-Lived, after Accumulated Amortization
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Inventory:
Inventory, Net [Abstract]
Level 2
Fair Value, Inputs, Level 2 [Member]
Accumulated Amortization
Intangible Asset, Finite-Lived, Accumulated Amortization
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Maximum borrowing capacity
Line of Credit Facility, Maximum Borrowing Capacity
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Name of Property [Axis]
Name of Property [Axis]
Effect of Change in Accounting Estimate, Type [Domain]
Effect of Change in Accounting Estimate, Type [Domain]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Contract value
Collaborative Arrangement, Contract Value
Collaborative Arrangement, Contract Value
Additions to property and equipment included in accounts payable
Capital Expenditures Incurred but Not yet Paid
Schedule of Disaggregated Amounts that Comprise Selling, General and Administrative Expenses
Segment Reporting [Table Text Block]
Amortization of debt issuance costs
Amortization of Debt Issuance Costs
Remaining contractual maturity period
Debt Securities, Available-for-sale, Contractual Maturity Period
Debt Securities, Available-for-sale, Contractual Maturity Period
Unrealized (loss) gain on investments
Unrealized gain (loss) on investments
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Document Period End Date
Document Period End Date
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Net cash used in investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
Shareholders’ Equity
Equity [Text Block]
Security Exchange Name
Security Exchange Name
Debt instrument, term
Debt Instrument, Term
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Total liabilities
Liabilities, Fair Value Disclosure
Accumulated other comprehensive (loss) gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Shell Company
Entity Shell Company
Revenue, Product and Service [Extensible List]
Revenue, Product and Service [Extensible Enumeration]
Current portion of operating lease liabilities
Operating
Operating Lease, Liability, Current
Finance
Finance Lease, Right-of-Use Asset, after Accumulated Amortization
Schedule of Property and Equipment, Net
Property, Plant, and Equipment [Table Text Block]
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Marketable Securities [Table]
Marketable Securities [Table]
Net Income (Loss) Per Common Share
Earnings Per Share [Text Block]
Name
Outstanding Recovery, Individual Name
Net income (loss) per common share:
Earnings Per Share [Abstract]
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
Document Fiscal Period Focus
Document Fiscal Period Focus
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Total liabilities
Liabilities
Trading Symbol
Trading Symbol
Expenditures for property and equipment
Payments to Acquire Property, Plant, and Equipment
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Company Selected Measure Name
Company Selected Measure Name
Number of specialty pharmacies
Number of Contracted Specialty Pharmacies
Number of Contracted Specialty Pharmacies
Line of credit facility, commitment fee (in percent)
Line of Credit Facility, Commitment Fee Percentage
Credit Facility [Domain]
Credit Facility [Domain]
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Compensation Amount
Outstanding Recovery Compensation Amount
Individual:
Individual [Axis]
Diluted (in shares)
Diluted weighted-average common shares outstanding (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Accrued rebates
Accrued Rebates, Current
Accrued Rebates, Current
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Directly to consumer
Sales Channel, Directly to Consumer [Member]
Entity Emerging Growth Company
Entity Emerging Growth Company
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Property and equipment, net
Total property and equipment, net
Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization
Commercial paper
Commercial Paper [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Term of supply agreement
License Agreement, Supply Agreement Term
License Agreement, Supply Agreement Term
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Gross profit
Gross Profit
Revenue from Contract with Customer [Abstract]
Revenue from Contract with Customer [Abstract]
Less accumulated depreciation
Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, Accumulated Depreciation and Amortization
Award Timing Predetermined
Award Timing Predetermined [Flag]
Issuance of letters of credit
Letters of Credit Outstanding, Amount
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Level 1
Fair Value, Inputs, Level 1 [Member]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Area of real estate property
Area of Real Estate Property
Effect of dilutive stock options and restricted stock units (in shares)
Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements
Stock-based compensation expense
Shares Granted, Value, Share-Based Payment Arrangement, after Forfeiture
Renewal term of supply agreement
License Agreement, Supply Agreement Renewal Term
License Agreement, Supply Agreement Renewal Term
All Executive Categories
All Executive Categories [Member]
Allowance for doubtful accounts
Allowance for Credit Loss, Receivable, Other, Current
U.S. government securities
US Government Debt Securities [Member]
Shares repurchased and retired
Shares repurchased cost
Stock Repurchased and Retired During Period, Value
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Depreciation
Depreciation
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Selling and marketing
Selling and Marketing Expense
Right-of-use assets
Operating
Operating Lease, Right-of-Use Asset
Thereafter
Finite-Lived Intangible Asset, Expected Amortization, after Year Four
Finite-Lived Intangible Asset, Expected Amortization, after Year Four
Contract term (in years)
Collaborative Arrangement, Contract Term
Collaborative Arrangement, Contract Term
Schedule of Net Income (Loss) Per Common Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Segment Information
Segment Reporting [Text Block]
Investments
Investment in Debt and Equity Securities and Other Trading Assets [Text Block]
Outstanding borrowings
Long-Term Line of Credit
Minimum
Minimum [Member]
Change in estimate of uncollectible (percent)
Revenue, Revenue Recognized, Change in Uncollectible Analysis, Percentage
Revenue, Revenue Recognized, Change in Uncollectible Analysis, Percentage
Expiration Date
Trading Arrangement Expiration Date
Liabilities
Liabilities [Abstract]
Schedule of Disaggregation of Revenue
Disaggregation of Revenue [Table Text Block]
Income Statement Location [Axis]
Location, Statement of Income, Balance [Axis]
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Money market funds
Cash and Cash Equivalents, Fair Value Disclosure
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Net proceeds from common stock issuance
Proceeds from Issuance of Common Stock
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Useful Life (in years)
Intangible Asset, Finite-Lived, Useful Life
Number of commercial-stage products
Number Of Products
Number Of Products
Exercise Price
Award Exercise Price
MACI implants, kits, and instruments
Implants [Member]
Implants [Member]
Common stock repurchased but not yet settled
Common Stock Repurchased But Not Yet Settled
Common Stock Repurchased But Not Yet Settled
Recurring
Fair Value, Recurring [Member]
Segment Reporting [Line Items]
Segment Reporting [Line Items]
Authorized repurchase amount
Share Repurchase Program, Authorized, Amount
Document Quarterly Report
Document Quarterly Report
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Segments [Domain]
Segments [Domain]
Accrued expenses
Accrued Liabilities, Current [Abstract]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Revolving Credit Agreement
Debt Disclosure [Text Block]
Debt issuance costs, net
Debt Issuance Costs, Net
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Equity Component [Domain]
Equity Component [Domain]
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Adoption Date
Trading Arrangement Adoption Date
Counterparty Name [Domain]
Counterparty Name [Domain]
Total shareholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Total other income
Nonoperating Income (Expense)
ASSETS
Assets
Assets [Abstract]
25 Network Drive, Burlington, Massachusetts
25 Network Drive, Burlington, Massachusetts [Member]
25 Network Drive, Burlington, Massachusetts Member
Title
Trading Arrangement, Individual Title
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Supply agreement additional term
License Agreement, Supply Agreement, Optional Additional Term
License Agreement, Supply Agreement, Optional Additional Term
Insider Trading Policies and Procedures [Line Items]
Other
Proceeds from (Payment for) Other Financing Activity
Allowance for doubtful accounts
Accounts Receivable, Allowance for Credit Loss, Current
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Selling, general and administrative
Total selling, general and administrative expenses
Selling, General and Administrative Expense
Selected Balance Sheet Components
Supplemental Balance Sheet Disclosures [Text Block]
Contingent consideration
License Agreement, Contingent Consideration
License Agreement, Contingent Consideration
Letter of credit
Letter of Credit [Member]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Anti-dilutive shares excluded from diluted net income (loss) per common share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Entity Central Index Key
Entity Central Index Key
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Name of Property [Domain]
Name of Property [Domain]
Equity [Abstract]
Equity [Abstract]
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Net cash provided by operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Income Statement [Abstract]
Income Statement [Abstract]
Shareholders’ equity:
Equity, Attributable to Parent [Abstract]
Shares issued under the Employee Stock Purchase Plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Document Transition Report
Document Transition Report
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible List]
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]
Finance
Finance Lease, Liability, Noncurrent
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
Schedule of Finite-Lived Intangible Assets
Intangible Asset, Finite-Lived [Table Text Block]
Basis spread on variable rate (in percent)
Debt Instrument, Basis Spread on Variable Rate
Total leased assets
Right Of Use Asset
Right Of Use Asset
City Area Code
City Area Code
Variable Rate [Domain]
Variable Rate [Domain]
Total property and equipment, gross
Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, before Accumulated Depreciation and Amortization
Accumulated Other Comprehensive Gain (Loss)
AOCI Attributable to Parent [Member]
NexoBrid
NexoBrid [Member]
NexoBrid
All Individuals
All Individuals [Member]
Non-cash lease costs
Operating Lease, Right-of-Use Asset, Periodic Reduction
Name
Forgone Recovery, Individual Name
Balance Sheet Related Disclosures [Abstract]
Balance Sheet Related Disclosures [Abstract]
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Statement
Statement [Line Items]
Total assets
Assets
Stock options weighted average grant-date fair value (in USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Interest expense
Interest Expense, Nonoperating
Schedule of Non-Cash Stock-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Shares issued under the Employee Stock Purchase Plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Organization
Nature of Operations [Text Block]
PEO
PEO [Member]
Total leased liabilities
Lease Liability Noncurrent
Lease Liability Noncurrent
Corporate notes
Corporate Note Securities [Member]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Total non-cash stock-based compensation expense
Share-Based Payment Arrangement, Expense
Shares repurchased under repurchase program (in shares)
Shares repurchased under repurchase program (in shares)
Stock Repurchased and Retired During Period, Shares
Other long-term liabilities
Other Liabilities, Noncurrent
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Stock option exercises (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Investments
Investments
Restricted stock units weighted-average grant date fair value (in USD per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Accumulated Deficit
Retained Earnings [Member]
Operating lease liabilities
Operating
Operating Lease, Liability, Noncurrent
Total operating expenses
Operating Expenses
Revolving credit facility
Revolving Credit Facility [Member]
Money market funds
Money Market Funds [Member]
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Computer equipment and software
Computer Equipment And Computer Software Intangible Asset [Member]
Long lived, depreciable assets that are used in the creation, maintenance and utilization of information systems and the collection of computer programs and related data that provide instructions to a computer, for example, but not limited to, application program, control module or operating system, that perform one or more particular functions or tasks.
Increase (Decrease) in Shareholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Award Timing Disclosures [Line Items]
Corporate notes
Corporate Debt Securities [Member]
Diluted (in USD per share)
Diluted income (loss) per common share (in USD per share)
Earnings Per Share, Diluted
Entity Current Reporting Status
Entity Current Reporting Status
Net cash (used in) provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Total Shareholder Return Amount
Total Shareholder Return Amount
Restricted stock withheld for employee tax remittance
Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation
Schedule of Valuation of the Company's Investments and Financial Instruments that are Measured at Fair Value on a Recurring Basis
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Amortization of intangible assets
Intangible Asset, Finite-Lived, Amortization Expense
Intangible Asset, Finite-Lived [Line Items]
Intangible Asset, Finite-Lived [Line Items]
Research and development
Research and Development Expense
Adjustments to reconcile net income (loss) to net cash flows from operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Product sales, net
Revenue from Contract with Customer, Excluding Assessed Tax
Initial procurement funds
Collaborative Arrangement, Initial Procurement Funds
Collaborative Arrangement, Initial Procurement Funds
Financial Instruments [Domain]
Financial Instruments [Domain]
Intangible Asset, Finite-Lived, Class [Axis]
Intangible Asset, Finite-Lived, Class [Axis]
Stock option exercises
Stock Issued During Period, Value, Stock Options Exercised
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Underlying Securities
Award Underlying Securities Amount
Purchases of investments
Payments to Acquire Short-Term Investments
Revenue
Revenue from Contract with Customer [Text Block]
MediWound Ltd
MediWound Ltd [Member]
MediWound Ltd [Member]
Construction in process
Construction in Progress [Member]
Inventory
Increase (Decrease) in Inventories
Segment Reporting [Table]
Segment Reporting [Table]
Contract with Customer, Sales Channel [Axis]
Contract with Customer, Sales Channel [Axis]
Schedule of Related Party Transactions, by Related Party [Table]
Related Party Transaction [Table]
Finance Lease, Liability, Current, Statement of Financial Position [Extensible List]
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Investing activities:
Cash Provided by (Used in) Investing Activity, Continuing Operation [Abstract]
Change in revenue recognized due to 0.5% change in uncollectible percentage
Revenue, Revenue Recognized, Effect Of 0.5% Change In The Estimated Uncollectible Percentage, Amount
Revenue, Revenue Recognized, Effect Of 0.5% Change In The Estimated Uncollectible Percentage, Amount
Other current assets
Other Assets, Current
Operating activities:
Cash Provided by (Used in) Operating Activity, Continuing Operation [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Other income (expense):
Other Nonoperating Income (Expense) [Abstract]
All Trading Arrangements
All Trading Arrangements [Member]
Other Performance Measure, Amount
Other Performance Measure, Amount
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Income (loss) from operations
Operating Income (Loss)
Current Fiscal Year End Date
Current Fiscal Year End Date
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
Entity File Number
Entity File Number
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
U.S. Biomedical Advanced Research and Development Authority (BARDA)
U.S. Biomedical Advanced Research and Development Authority (BARDA) [Member]
U.S. Biomedical Advanced Research and Development Authority (BARDA)
Impairments of assets
Asset, Impairment Loss
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Dominick Colangelo [Member]
Dominick Colangelo
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Measure:
Measure [Axis]
Finished goods
Inventory, Finished Goods, Gross
Contract with Customer, Basis of Pricing [Axis]
Contract with Customer, Basis of Pricing [Axis]
Credit Losses
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Equity Components [Axis]
Equity Components [Axis]
Product and Service [Domain]
Product and Service [Domain]
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Entity Interactive Data Current
Entity Interactive Data Current
Variable Rate [Axis]
Variable Rate [Axis]
Finance
Finance Lease, Liability, Current
Deferred compensation plan liabilities
Deferred Compensation Liability, Current and Noncurrent
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Entity Small Business
Entity Small Business
Comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Termination Date
Trading Arrangement Termination Date
Restricted stock withheld for employee tax remittance (in shares)
Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation
Property and equipment, net:
Property, Plant, and Equipment [Line Items]
Property, Plant, and Equipment [Line Items]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Other current liabilities
Other Liabilities, Current
Other long-term assets
Other Assets, Noncurrent
Financing activities:
Cash Provided by (Used in) Financing Activity, Continuing Operation [Abstract]
Document Type
Document Type
Liabilities that are measured at fair value on a recurring basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Accrued expenses
Total accrued expenses
Accrued Liabilities, Current
Contract rate
Fixed-Price Contract [Member]
Fair Value as of Grant Date
Award Grant Date Fair Value
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Shares repurchased, remaining amount
Share Repurchase Program, Remaining Authorized, Amount
Arrangement Duration
Trading Arrangement Duration
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Local Phone Number
Local Phone Number
Work-in-process
Inventory, Work in Process, Gross
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Registrant Name
Entity Registrant Name
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
COMMITMENTS AND CONTINGENCIES (Note 13)
Commitments and Contingencies
Cost
Intangible Asset, Finite-Lived, before Accumulated Amortization
Total revenue
Revenues
Revenues
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible List]
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
2030
Intangible Asset, Finite-Lived, Estimated Amortization Expense, Year Four
Machinery and equipment
Machinery and Equipment [Member]
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Executive Category:
Executive Category [Axis]
Counterparty Name [Axis]
Counterparty Name [Axis]
Furniture, fixtures and office equipment
Furniture and Fixtures [Member]
LIABILITIES AND SHAREHOLDERS’ EQUITY
Liabilities and Equity [Abstract]
Intangible Asset, Finite-Lived, Class [Domain]
Intangible Asset, Finite-Lived, Class [Domain]
Inventory
Total inventory
Inventory, Net
Award Type [Domain]
Award Type [Domain]
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Finance lease expense (less than)
Finance Lease, Interest Expense
Fair Value Measurements
Fair Value Disclosures [Text Block]
Level 3
Fair Value, Inputs, Level 3 [Member]
Maximum contingent consideration
License Agreement, Contingent Consideration, Maximum
License Agreement, Contingent Consideration, Maximum
U.S. government agency bonds
US Government Agencies Debt Securities [Member]
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
2027
Intangible Asset, Finite-Lived, Estimated Amortization Expense, Year One
PEO Name
PEO Name
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Leasehold improvements
Leasehold Improvements [Member]
Other accrued expenses
Accrued Expenses, Other, Current
Represents other accrued expenses, current.
Property, Plant and Equipment, Type [Axis]
Long-Lived Asset, Class [Axis]
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Long-term investments
Debt Securities, Available-for-Sale, Noncurrent
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
Cash, cash equivalents, and restricted cash at beginning of period
Cash and cash equivalents at end of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Schedule of Finite-Lived Intangible Assets [Table]
Intangible Asset, Finite-Lived [Table]
Accounts payable
Increase (Decrease) in Accounts Payable
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Base rate
Base Rate [Member]
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Non-NEOs
Non-NEOs [Member]
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
2028
Intangible Asset, Finite-Lived, Estimated Amortization Expense, Year Two
Schedule of Inventory
Schedule of Inventory, Current [Table Text Block]
Leases
Lessee, Operating Leases [Text Block]
Long-Term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Basic (in USD per share)
Basic income (loss) per common share (in USD per share)
Earnings Per Share, Basic
Raw materials
Inventory, Raw Materials, Gross
Biopsy kits and instruments - direct bill
Biopsy Kits [Member]
Biopsy Kits [Member]
Repurchases of common stock
Payments for Repurchase of Common Stock
Total current assets
Assets, Current
Statistical Measurement [Axis]
Statistical Measurement [Axis]
Schedule of Operating and Finance Lease Assets and Liabilities
Assets And Liabilities, Leases [Table Text Block]
Assets And Liabilities, Leases [Table Text Block]
Insider Trading Arrangements [Line Items]
Award Type [Axis]
Award Type [Axis]
Short-term lease costs (less than)
Short-Term Lease, Cost
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Accounts receivable (net of allowance for doubtful accounts of $23 and $13, respectively)
Accounts Receivable, after Allowance for Credit Loss, Current
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Product and Service [Axis]
Product and Service [Axis]
Employee stock purchase plan and service-based stock options
Employee Stock And Employee Stock Option [Member]
Employee Stock And Employee Stock Option [Member]
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Common Stock
Common Stock [Member]
Estimated Fair Value
Debt securities, fair value
Debt Securities, Available-for-Sale
Effect of Change in Accounting Estimate, Type [Axis]
Effect of Change in Accounting Estimate, Type [Axis]
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
Cover [Abstract]
Cover [Abstract]
Equity Awards Adjustments
Equity Awards Adjustments [Member]
The BARDA Agreement
Collaborative Arrangement Disclosure [Text Block]
Total liabilities and shareholders’ equity
Liabilities and Equity
Operating lease liabilities
Increase (Decrease) In Lease Liabilities
Increase (Decrease) In Lease Liabilities
Stock options
Share-Based Payment Arrangement, Option [Member]
Segments [Axis]
Segments [Axis]
Other non-current assets and liabilities, net
Increase (Decrease) in Other Operating Liabilities
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Tabular List, Table
Tabular List [Table Text Block]
Milestone payments, assumed intangible assets
License Agreements, Milestone Payments, Assumed Intangible Assets
License Agreements, Milestone Payments, Assumed Intangible Assets
Purchases of intangible assets
Payments to Acquire Intangible Assets
Other (expense) income
Other Nonoperating Income (Expense)
2029
Intangible Asset, Finite-Lived, Estimated Amortization Expense, Year Three
Schedule of Accrued Expenses
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Remainder of 2026
Intangible Asset, Finite-Lived, Estimated Amortization Expense, Remainder of Fiscal Year
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Total MACI implants, kits, and instruments
MACI Implants And Kits [Member]
MACI Implants And Kits
General and administrative
General and Administrative Expense
Property, Plant and Equipment, Type [Domain]
Long-Lived Asset, Class [Domain]
Property, Plant, and Equipment [Table]
Property, Plant, and Equipment [Table]
Bonus-related compensation
Accrued Bonuses, Current
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Change in estimates related to prior periods
Change in Accounting Method Accounted for as Change in Estimate [Member]
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Credit Facility [Axis]
Credit Facility [Axis]
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Assets, fair value
Assets, Fair Value Disclosure
Name
Measure Name
Accounts payable
Accounts Payable, Current
Pay vs Performance Disclosure [Line Items]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Other
Other Noncash Income (Expense)
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Other current assets
Increase (Decrease) in Other Current Assets
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Entity Filer Category
Entity Filer Category
Short-term investments
Short-Term Investments
Through Intermediary
Sales Channel, Through Intermediary [Member]
Name
Trading Arrangement, Individual Name
Cash and cash equivalents
Cash and Cash Equivalent
Basis of Presentation
Basis of Accounting [Text Block]
Operating lease expense
Operating Lease, Expense
Company Selected Measure Amount
Company Selected Measure Amount
Investments, Debt and Equity Securities [Abstract]
Depreciation and amortization expense
Depreciation, Depletion and Amortization
SOFR
Secured Overnight Financing Rate (SOFR) [Member]
Sales threshold for first milestone
License Agreement, Initial Milestone, Sales
License Agreement, Initial Milestone, Sales
Contract with Customer, Sales Channel [Domain]
Contract with Customer, Sales Channel [Domain]
Current assets:
Assets, Current [Abstract]
Non-PEO NEO
Non-PEO NEO [Member]
Entity Address, Address Line One
Entity Address, Address Line One
Cost of product sales
Cost of Product and Service Sold
Award Timing Method
Award Timing Method [Text Block]
Net increase in cash, cash equivalents, and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Net Income (Loss) Attributable to Parent [Abstract]
Net Income (Loss) Attributable to Parent [Abstract]
Time-and-materials contract
Time-and-Materials Contract [Member]
Net income (loss)
Net income (loss)
Net (loss) income
Net income
Net Income (Loss) Attributable to Parent
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Balance Sheet Location [Axis]
Location, Statement of Financial Position, Balance [Axis]
Statement [Table]
Statement [Table]
Kevin McLaughlin [Member]
Kevin McLaughlin
Restatement Determination Date:
Restatement Determination Date [Axis]
NexoBrid License and Supply Agreements
License Agreement [Text Block]
License Agreement [Text Block]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Interest income
Investment Income, Interest
Accounts receivable
Increase (Decrease) in Receivables
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Product [Member]