<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a05967-c0b9-707e-9a8a-cdea4ec5686c,g:d8b2a11c-26c2-4d61-8125-f3f4deb29506-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.vcel.com/role/CoverDocument" xlink:type="simple" xlink:href="vcel-20261105.xsd#CoverDocument"/>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CoverDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:href="vcel-20261105.xsd#vcel_CoverpageAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a05967-c0b9-7dd6-b1c9-5f0f45bcf350" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_Security12bTitle_01a05967-c0b9-7dd6-b1c9-5f0f45bcf350" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a05967-c0b9-72d3-919b-eff260b0680a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a05967-c0b9-72d3-919b-eff260b0680a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a05967-c0b9-781a-8e8d-b08b05e9bce7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_DocumentType_01a05967-c0b9-781a-8e8d-b08b05e9bce7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a05967-c0b9-733e-860b-a6236df486aa" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityFileNumber_01a05967-c0b9-733e-860b-a6236df486aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a05967-c0b9-752d-8b0c-ecb78081d1b1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a05967-c0b9-752d-8b0c-ecb78081d1b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a05967-c0b9-7aba-a5a6-ce0028c31fde" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityAddressAddressLine1_01a05967-c0b9-7aba-a5a6-ce0028c31fde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a05967-c0b9-74ce-bf61-ba90df4e7340" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityAddressCityOrTown_01a05967-c0b9-74ce-bf61-ba90df4e7340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a05967-c0b9-742b-aab5-18a62a72ce7f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityAddressStateOrProvince_01a05967-c0b9-742b-aab5-18a62a72ce7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a05967-c0b9-7bc2-b9c9-81c48f20c43c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityAddressPostalZipCode_01a05967-c0b9-7bc2-b9c9-81c48f20c43c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a05967-c0b9-71d2-8e5f-55bb29c4bd21" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_DocumentPeriodEndDate_01a05967-c0b9-71d2-8e5f-55bb29c4bd21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a05967-c0b9-78c6-94d4-bc6106ee2de5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityRegistrantName_01a05967-c0b9-78c6-94d4-bc6106ee2de5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a05967-c0b9-7ea6-88ad-453819da7539" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_CityAreaCode_01a05967-c0b9-7ea6-88ad-453819da7539" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a05967-c0b9-7661-a8c8-96a2979c183c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_LocalPhoneNumber_01a05967-c0b9-7661-a8c8-96a2979c183c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a05967-c0b9-7e57-bec4-1764de173aa2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_WrittenCommunications_01a05967-c0b9-7e57-bec4-1764de173aa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a05967-c0b9-7f2e-9217-265d4bc03036" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_SolicitingMaterial_01a05967-c0b9-7f2e-9217-265d4bc03036" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a05967-c0b9-72c8-aef5-c519a7458f73" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_PreCommencementTenderOffer_01a05967-c0b9-72c8-aef5-c519a7458f73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a05967-c0b9-7980-8e48-739c2f789463" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a05967-c0b9-7980-8e48-739c2f789463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a05967-c0b9-7378-a33c-0e92b3557ffc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a05967-c0b9-7378-a33c-0e92b3557ffc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a05967-c0b9-739b-879e-4f17745ff20f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_TradingSymbol_01a05967-c0b9-739b-879e-4f17745ff20f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a05967-c0b9-7cd9-b721-34a4521d9845" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-784e-b299-2a00e3cdb287" xlink:to="loc_dei_SecurityExchangeName_01a05967-c0b9-7cd9-b721-34a4521d9845" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.vcel.com/role/CoverNonprinting" xlink:type="simple" xlink:href="vcel-20261105.xsd#CoverNonprinting"/>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CoverNonprinting" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vcel_CoverpageAbstract_01a05967-c0b9-7b2b-b776-ef6ee0857290" xlink:href="vcel-20261105.xsd#vcel_CoverpageAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a05967-c0b9-77c3-9e54-6dfa571f94cf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-7b2b-b776-ef6ee0857290" xlink:to="loc_dei_EntityCentralIndexKey_01a05967-c0b9-77c3-9e54-6dfa571f94cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a05967-c0b9-7160-8127-0404a578ab40" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vcel_CoverpageAbstract_01a05967-c0b9-7b2b-b776-ef6ee0857290" xlink:to="loc_dei_AmendmentFlag_01a05967-c0b9-7160-8127-0404a578ab40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
