v3.26.3
Stockholders' Equity (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 714,564 $ 456,226 $ 527,165 $ 655,406 $ 702,981 $ 747,005 $ 527,165 $ 747,005
Balance, beginning (in shares)     66,549,442       66,549,442  
Shares issued under stock option and employee stock purchase plans 1,115 825 $ 327 774 63 202    
Shares issued in underwritten offering, net   323,832            
Stock-based compensation 10,974 8,408 8,523 8,801 9,191 9,316    
Unrealized (loss) gain on marketable securities (1,627) (1,224) (1,104) 426 (229) 254 $ (3,955) 451
Net loss (75,557) (73,503) (78,685) (67,044) (56,600) (53,796) (227,745) (177,440)
Balance, ending $ 649,469 714,564 456,226 598,363 655,406 702,981 $ 649,469 598,363
Balance, ending (in shares) 78,534,438           78,534,438  
Common Stock                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 79 $ 67 $ 67 $ 66 $ 66 $ 66 $ 67 $ 66
Balance, beginning (in shares) 78,500,173 66,568,971 66,549,442 66,394,241 66,384,191 66,374,549 66,549,442 66,374,549
Shares issued under stock option and employee stock purchase plans (in shares) 34,265 34,452 19,529 52,605 10,050 9,642    
Shares issued in underwritten offering, net   $ 12            
Shares issued in underwritten offering, net (in shares)   11,896,750            
Balance, ending $ 79 $ 79 $ 67 $ 66 $ 66 $ 66 $ 79 $ 66
Balance, ending (in shares) 78,534,438 78,500,173 66,568,971 66,446,846 66,394,241 66,384,191 78,534,438 66,446,846
Additional Paid-In Capital                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning $ 2,679,356 $ 2,346,303 $ 2,337,453 $ 2,317,621 $ 2,308,367 $ 2,298,849 $ 2,337,453 $ 2,298,849
Shares issued under stock option and employee stock purchase plans 1,115 825 327 774 63 202    
Shares issued in underwritten offering, net   323,820            
Stock-based compensation 10,974 8,408 8,523 8,801 9,191 9,316    
Balance, ending 2,691,445 2,679,356 2,346,303 2,327,196 2,317,621 2,308,367 2,691,445 2,327,196
Accumulated Other Comprehensive Income                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning 1,298 2,522 3,626 3,339 3,568 3,314 3,626 3,314
Unrealized (loss) gain on marketable securities (1,627) (1,224) (1,104) 426 (229) 254    
Balance, ending (329) 1,298 2,522 3,765 3,339 3,568 (329) 3,765
Accumulated Deficit                
Increase (Decrease) in Stockholders' Equity                
Balance, beginning (1,966,169) (1,892,666) (1,813,981) (1,665,620) (1,609,020) (1,555,224) (1,813,981) (1,555,224)
Net loss (75,557) (73,503) (78,685) (67,044) (56,600) (53,796)    
Balance, ending $ (2,041,726) $ (1,966,169) $ (1,892,666) $ (1,732,664) $ (1,665,620) $ (1,609,020) $ (2,041,726) $ (1,732,664)