v3.26.3
Segment Information (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2026
USD ($)
Jun. 30, 2026
USD ($)
Mar. 31, 2026
USD ($)
Sep. 30, 2025
USD ($)
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Sep. 30, 2026
USD ($)
segment
Sep. 30, 2025
USD ($)
Segment Reporting [Abstract]                
Number of operating segments | segment             1  
Number of reportable segments | segment             1  
Segment Reporting [Line Items]                
Product revenue, net $ 55,385     $ 12,880     $ 120,876 $ 34,061
PK activator (PYRUKYND®/AQVESME®) direct expenses - research and development (73,487)     (86,796)     (255,389) (251,479)
Total selling, general and administrative expenses (56,533)     (41,274)     (156,384) (128,670)
Net loss (65,045) $ (100,703) $ (99,111) (103,433) $ (112,020) $ (89,289) (264,859) (304,742)
Reportable Segment                
Segment Reporting [Line Items]                
PK activator (PYRUKYND®/AQVESME®) direct expenses - research and development (21,733)     (30,533)     (71,487) (81,663)
Compensation and related expenses - research and development (28,661)     (30,299)     (95,802) (90,883)
Total selling, general and administrative expenses (56,533)     (41,274)     (156,384) (128,670)
Other segment expenses (13,503)     (14,207)     (62,062) (37,587)
Net loss (65,045)     (103,433)     (264,859) (304,742)
Product revenue, net                
Segment Reporting [Line Items]                
Product revenue, net 55,385     12,880     120,876 34,061
Product revenue, net | United States                
Segment Reporting [Line Items]                
Product revenue, net 48,738     12,320     108,506 33,197
Product revenue, net | Rest of world                
Segment Reporting [Line Items]                
Product revenue, net 6,647     560     12,370 864
Product revenue, net | Reportable Segment | United States                
Segment Reporting [Line Items]                
Product revenue, net 48,738     12,320     108,506 33,197
Product revenue, net | Reportable Segment | Rest of world                
Segment Reporting [Line Items]                
Product revenue, net $ 6,647     $ 560     $ 12,370 $ 864