| Schedule of Significant Segment Expense Categories |
In addition, the CODM is regularly provided the significant segment expense categories included in the table below (in thousands), which are reviewed against budgeted expectations to assist in resource allocation decision-making.
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Three Months Ended
September 30, |
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Nine Months Ended
September 30, |
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2026 |
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2025 |
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2026 |
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2025 |
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Bitopertin program external expense |
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$ |
(6,992 |
) |
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$ |
(11,833 |
) |
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$ |
(24,998 |
) |
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$ |
(43,954 |
) |
Selcodebart (DISC-0974) program external expense |
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(8,422 |
) |
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(7,369 |
) |
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(28,885 |
) |
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(18,105 |
) |
DISC-3405 program external expense |
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(4,880 |
) |
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(11,910 |
) |
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(19,027 |
) |
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(15,486 |
) |
Other external research and development expense |
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(4,643 |
) |
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(4,095 |
) |
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(9,505 |
) |
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(9,030 |
) |
Internal and other research and development expense |
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(11,848 |
) |
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(10,704 |
) |
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(34,421 |
) |
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(26,597 |
) |
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Commercial expense |
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$ |
(4,117 |
) |
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$ |
(3,928 |
) |
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$ |
(15,634 |
) |
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$ |
(8,509 |
) |
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General and administrative expense |
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$ |
(8,654 |
) |
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$ |
(8,343 |
) |
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$ |
(25,791 |
) |
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$ |
(23,074 |
) |
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Stock-based compensation expense |
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$ |
(14,605 |
) |
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$ |
(9,514 |
) |
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$ |
(40,499 |
) |
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$ |
(24,297 |
) |
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Other segment items* |
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$ |
4,626 |
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$ |
5,375 |
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$ |
16,189 |
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$ |
17,399 |
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Net loss |
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$ |
(59,535 |
) |
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$ |
(62,321 |
) |
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$ |
(182,571 |
) |
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$ |
(151,653 |
) |
*Other segment items include interest income, interest expense, other (expense) income, and income tax expense as reported on the condensed consolidated statements of operations and comprehensive loss.
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