As filed with the Securities and Exchange Commission on November 5, 2026
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
under the
SECURITIES ACT OF 1933
mckessonlogoa04.jpg

McKESSON CORPORATION
(Exact Name of Registrant as Specified in Its Charter)
Delaware94-3207296
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)

6555 State Hwy 161
Irving, TX 75039
(Address, Including Zip Code, of Principal Executive Offices)

McKESSON CORPORATION DEFERRED COMPENSATION ADMINISTRATION PLAN III
MCKESSON CORPORATION SUPPLEMENTAL RETIREMENT SAVINGS PLAN
(Full Title of Plan)
Michele Lau
Executive Vice President and Chief Legal Officer
McKesson Corporation
6555 State Hwy 161
Irving, TX 75039

(972) 446-4800
(Name, Address and Telephone Number, Including Area Code, of Agent For Service)

Copy to:
Adam Kaminsky
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, New York 10017
(212) 450-4000 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer☐
Non-accelerated filer☐Smaller reporting company☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐                            





EXPLANATORY NOTE

This Registration Statement is being filed by McKesson Corporation (the “Registrant” or “Company”) in accordance with General Instruction E to Form S-8 to register an additional $100,000,000 of deferred compensation obligations issuable under the McKesson Corporation Deferred Compensation Administration Plan III, as amended and restated effective July 30, 2019 (the “DCAP III”) and an additional $50,000,000 of deferred compensation obligations issuable under the McKesson Corporation Supplemental Retirement Savings Plan, as amended and restated effective July 30, 2019 (the “SRSP”).

The contents of the Company’s Registration Statement on Form S-8 (No. 333-181119) filed with the Securities and Exchange Commission (the “Commission”) on May 3, 2012 and the Registration Statement on Form S-8 (No. 333-213488) filed with the Commission on September 2, 2016, each relating to the DCAP III, as well as the Company’s Registration Statement on Form S-8 (No. 333-249817) filed with the Commission on November 3, 2020 relating to the SRSP, as well as the Company's Registration Statement on Form S-8 (No. 333-273632) filed with the Commission on August 3, 2023, relating to the DCAP III and the SRSP, are incorporated by reference into this Registration Statement.

PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.    Incorporation of Certain Documents by Reference
The following documents previously filed or to be filed by the Registrant with the Commission are incorporated herein by reference in this Registration Statement:
(a)The Registrant’s Annual Report on Form 10-K for the fiscal year ended March 31, 2026 filed with the Commission on May 8, 2026, including the portions of the Registrant’s definitive proxy statement on Schedule 14A, filed with the Commission on June 12, 2026, specifically incorporated by reference in the Registrant’s Annual Report on Form 10-K;
(b)The Registrant's Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2026 filed with the Commission on August 5, 2026 and the Form 10-Q for the quarterly period ended September 30, 2026 filed with the Commission on November 4, 2026; and
(c)The Registrant’s Current Report on Form 8-K filed with the Commission on April 6, 2026, April 28, 2026, June 12, 2026, July 1, 2026, and July 24, 2026.

All reports and other documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) (other than Current Reports on Form 8-K furnished pursuant to Item 2.02 or Item 7.01 of Form 8-K, including any exhibits included with such information, unless otherwise indicated therein) after the date of this Registration Statement, but prior to the filing of a post-effective amendment that indicates that all securities offered hereby have been sold or that deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.






Item 8.    Exhibits

Unless otherwise indicated below as being incorporated herein by reference to another filing with the Commission, each of the following exhibits is filed herewith:

Exhibit
Number
Description of Document
5.1
10.1
10.2
23.1
23.2
24.1
Power of Attorney (included on signature page of this Registration Statement).
107

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Irving, Texas on November 5, 2026.


McKESSON CORPORATION
By:
/s/ Michele Lau
Michele Lau
Executive Vice President and Chief Legal Officer



POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Michele Lau and Saralisa Brau, and each of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts.





Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities indicated below on November 5, 2026.

Signature
Title
/s/ Brian S. TylerChief Executive Officer and Chair of the Board
Brian S. Tyler(Principal Executive Officer)
/s/ Kenny K. CheungExecutive Vice President and Chief Financial Officer
Kenny K. Cheung(Principal Financial Officer)
/s/ Napoleon B. Rutledge Jr.Senior Vice President and Controller
Napoleon B. Rutledge Jr.(Principal Accounting Officer)
/s/ Dominic J. CarusoDirector
Dominic J. Caruso
/s/ Lynne M. DoughtieDirector
Lynne M. Doughtie
/s/ W. Roy DunbarDirector
W. Roy Dunbar
/s/ Deborah Dunsire, M.D.Director
Deborah Dunsire, M.D.
/s/ Julie L. Gerberding, M.D., M.P.H.Director
Julie L. Gerberding, M.D., M.P.H.
/s/ James H. HintonDirector
James H. Hinton
/s/ Bradley E. LermanDirector
Bradley E. Lerman
/s/ Maria N. MartinezDirector
Maria N. Martinez
/s/ Kevin M. OzanDirector
Kevin M. Ozan
/s/ Kathleen Wilson-ThompsonDirector
Kathleen Wilson-Thompson




ATTACHMENTS / EXHIBITS

ATTACHMENTS / EXHIBITS

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EX-5.1

EX-23.2

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