Insider Trading Arrangements

3 Months Ended

Sep. 30, 2026

Name and Title

Type of Trading Arrangement

Action Taken (Date of Action)

Duration or End Date

Aggregate Numbers of Securities to be Sold(1)

Description of Trading Arrangement

Garry Neil, M.D., Chief Executive Officer

Trading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)

Modification (August 25, 2026)

June 30, 2027

90,000

Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan

Jennifer Riley, Chief Strategy Officer

Trading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)

Adoption (August 13, 2026)

May 30, 2027

29,800

Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan

Christopher Sullivan, Chief Financial Officer

Trading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)

Termination (September 17, 2026)

(3)

149,786(2)

Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan


(1)			Represents the maximum number of shares that may be sold pursuant to the 10b5-1 arrangement. The number of shares sold is dependent on the satisfaction of certain conditions as set forth in the trading plans.
(2)			These shares reflect the aggregate maximum of shares underlying vested stock options and RSUs, including 24,200 RSUs that are expected to vest during the term of the trading plan prior to expected share withholding or sell-to-cover to satisfy tax withholding obligations associated with the expected RSU vest.
(3)			The arrangement was originally scheduled to remain in effect through May 31, 2027 and was terminated on September 17, 2026, effective immediately.