v3.26.3
Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (141,867) $ (395,064)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 8,383 8,782
(Accretion of discounts) amortization of premiums on investments, net (26) 7,925
Noncash lease expense 4,106 3,655
Change in fair value of equity investments 2,302 (4,335)
Change in estimated fair value of contingent consideration (1,120) 11,570
Payment of contingent consideration in excess of acquisition date fair value 0 (17,140)
Stock-based compensation 34,933 37,866
Non-cash restructuring, long-lived assets impairment and related charges 0 399
Other non-cash items, net 159 40
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (2,840) 10,152
Other assets 1,291 (3,924)
Accounts payable 1,652 2,042
Accrued liabilities and other liabilities (15,037) (22,828)
Operating lease liabilities (7,077) (5,045)
Net cash used in operating activities (115,141) (365,905)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Proceeds from sale of equipment 0 363
Purchases of long-lived assets (456) (4,484)
Purchases of investments (638,957) (630,512)
Maturities and sales of investments 498,665 858,353
Net cash (used in) provided by investing activities (140,748) 223,720
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from exercise of stock options 3,248 1,348
Proceeds from issuance of common stock under ESPP 1,356 1,757
Other financing activities 0 (359)
Net cash provided by financing activities 242,533 2,746
Net decrease in cash, cash equivalents and restricted cash and cash equivalents (13,356) (139,439)
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period 241,070 318,695
Cash, cash equivalents and restricted cash and cash equivalents at end of period 227,714 179,256
NONCASH INVESTING AND FINANCING ACTIVITIES:    
Obtaining a right-of-use asset in exchange for a lease liability 0 7,329
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:    
Net cash paid for income tax 184 2,266
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:    
Cash and cash equivalents 218,866 170,084
Restricted cash and cash equivalents, current 1,933 2,215
Restricted cash and cash equivalents, noncurrent 6,915 6,957
Total cash, cash equivalents and restricted cash and cash equivalents 227,714 179,256
Public Offering    
CASH FLOWS FROM FINANCING ACTIVITIES:    
Issuance of common stock related to a follow-on public offering, net of issuance costs 162,205 0
Astellas    
CASH FLOWS FROM FINANCING ACTIVITIES:    
Issuance of common stock related to a follow-on public offering, net of issuance costs $ 75,724 $ 0