v3.26.3
Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Astellas
Public Offering
Common Stock
Common Stock
Astellas
Common Stock
Public Offering
Additional Paid-in Capital
Additional Paid-in Capital
Astellas
Additional Paid-in Capital
Public Offering
Accumulated Other Comprehensive Loss
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2024       136,959,446              
Beginning balance at Dec. 31, 2024 $ 1,150,385     $ 14     $ 1,911,872     $ (1,717) $ (759,784)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Vesting of restricted common stock (in shares)       1,366,748              
Exercise of stock options (in shares)       298,060              
Exercise of stock options 1,348           1,348        
Issuance of common stock under employee stock purchase plan (in shares)       398,340              
Issuance of common stock under employee stock purchase plan 1,757           1,757        
Stock-based compensation 37,866           37,866        
Other comprehensive loss (194)                 (194)  
Net loss (395,064)                   (395,064)
Ending balance (in shares) at Sep. 30, 2025       139,022,594              
Ending balance at Sep. 30, 2025 796,098     $ 14     1,952,843     (1,911) (1,154,848)
Beginning balance (in shares) at Jun. 30, 2025       138,886,274              
Beginning balance at Jun. 30, 2025 947,472     $ 14     1,941,386     (2,221) (991,707)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Vesting of restricted common stock (in shares)       69,063              
Exercise of stock options (in shares)       67,257              
Exercise of stock options 101           101        
Stock-based compensation 11,356           11,356        
Other comprehensive loss 310                 310  
Net loss (163,141)                   (163,141)
Ending balance (in shares) at Sep. 30, 2025       139,022,594              
Ending balance at Sep. 30, 2025 $ 796,098     $ 14     1,952,843     (1,911) (1,154,848)
Beginning balance (in shares) at Dec. 31, 2025 139,474,954     139,474,954              
Beginning balance at Dec. 31, 2025 $ 765,276     $ 14     1,965,090     (2,057) (1,197,771)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost (in shares)         7,239,382 20,294,117          
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost   $ 75,724 $ 162,205   $ 1 $ 2   $ 75,723 $ 162,203    
Vesting of restricted common stock (in shares)       1,728,094              
Vesting of restricted common stock 0                    
Exercise of stock options (in shares)       429,249              
Exercise of stock options 3,248           3,248        
Issuance of common stock under employee stock purchase plan (in shares)       248,333              
Issuance of common stock under employee stock purchase plan 1,356           1,356        
Stock-based compensation 34,933           34,933        
Other comprehensive loss (4,839)                 (4,839)  
Net loss $ (141,867)                   (141,867)
Ending balance (in shares) at Sep. 30, 2026 169,414,129     169,414,129              
Ending balance at Sep. 30, 2026 $ 896,036     $ 17     2,242,553     (6,896) (1,339,638)
Beginning balance (in shares) at Jun. 30, 2026       169,185,671              
Beginning balance at Jun. 30, 2026 982,493     $ 17     2,230,464     (4,602) (1,243,386)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Vesting of restricted common stock (in shares)       47,966              
Vesting of restricted common stock 0                    
Exercise of stock options (in shares)       180,492              
Exercise of stock options 1,634           1,634        
Stock-based compensation 10,455           10,455        
Other comprehensive loss (2,294)                 (2,294)  
Net loss $ (96,252)                   (96,252)
Ending balance (in shares) at Sep. 30, 2026 169,414,129     169,414,129              
Ending balance at Sep. 30, 2026 $ 896,036     $ 17     $ 2,242,553     $ (6,896) $ (1,339,638)