<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fd856-926f-7829-b568-23b707d939e6,g:c65a78dd-df51-4018-8bf9-3b54e5b97f96-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="simple" xlink:href="pfe-20260927.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019fd856-95d4-79eb-af6c-6596bc95fd3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer_019fd856-95d4-7809-a39d-ad74ea4b78f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019fd856-95d4-79eb-af6c-6596bc95fd3d" xlink:to="loc_us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer_019fd856-95d4-7809-a39d-ad74ea4b78f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd856-95d4-7d1f-a06c-dd37236757de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019fd856-95d4-79eb-af6c-6596bc95fd3d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd856-95d4-7d1f-a06c-dd37236757de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd856-95d4-7adb-9b69-2799165ba044" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd856-95d4-7e03-8b62-fc98d38325a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd856-95d4-7adb-9b69-2799165ba044" xlink:to="loc_us-gaap_ProfitLoss_019fd856-95d4-7e03-8b62-fc98d38325a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019fd856-95d4-7c88-b746-c3e6a26e50fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd856-95d4-7adb-9b69-2799165ba044" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019fd856-95d4-7c88-b746-c3e6a26e50fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019fd856-95d4-7ca8-b5d3-e8e9d81d8560" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019fd856-95d4-7c54-8e27-79769bcd109c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019fd856-95d4-7ca8-b5d3-e8e9d81d8560" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019fd856-95d4-7c54-8e27-79769bcd109c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019fd856-95d4-738a-9e4a-03d9c0154511" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019fd856-95d4-7ca8-b5d3-e8e9d81d8560" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019fd856-95d4-738a-9e4a-03d9c0154511" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7513-b1db-32c2b2b4033d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-75e2-86b8-6d43ae8bc13a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7513-b1db-32c2b2b4033d" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-75e2-86b8-6d43ae8bc13a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019fd856-95d4-750f-a060-ffba85b90b67" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7513-b1db-32c2b2b4033d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019fd856-95d4-750f-a060-ffba85b90b67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fd856-95d4-7416-8505-6cfd6716a662" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fd856-95d4-7416-8505-6cfd6716a662" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd856-95d4-720c-9c34-5231b3baa432" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd856-95d4-720c-9c34-5231b3baa432" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fd856-95d4-78db-963d-7c1e18be735f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fd856-95d4-78db-963d-7c1e18be735f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction_019fd856-95d4-71fb-af73-15fcd22f67a5" xlink:href="pfe-20260927.xsd#pfe_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_pfe_AmortizationOfIntangibleAssetsNotAssociatedWithSingleFunction_019fd856-95d4-71fb-af73-15fcd22f67a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-95d4-7479-8f42-76c1350685cd" xlink:href="pfe-20260927.xsd#pfe_RestructuringChargesAndAcquisitionRelatedCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-95d4-7479-8f42-76c1350685cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-95d4-7983-a321-41b04dc43100" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-95d4-7983-a321-41b04dc43100" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019fd856-95d4-71f5-a92a-80287dba31f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019fd856-95d4-71f5-a92a-80287dba31f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019fd856-95d4-7240-8e90-c1fef086a692" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-95d4-7cd9-9315-2e2c1ba8a26c" xlink:to="loc_us-gaap_Revenues_019fd856-95d4-7240-8e90-c1fef086a692" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019fd856-95d4-75ca-8e8e-751c40922295" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019fd856-95d4-756f-8e17-7c0e2ae52a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019fd856-95d4-75ca-8e8e-751c40922295" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019fd856-95d4-756f-8e17-7c0e2ae52a1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019fd856-95d4-725e-889f-5662de3a83db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019fd856-95d4-75ca-8e8e-751c40922295" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019fd856-95d4-725e-889f-5662de3a83db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd856-95d4-7373-b927-5fe4fb1b6f86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7ac0-bf26-683af9ea6ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fd856-95d4-7373-b927-5fe4fb1b6f86" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7ac0-bf26-683af9ea6ed7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-95d4-7745-aebb-ca6d8c8d2d16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fd856-95d4-7373-b927-5fe4fb1b6f86" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-95d4-7745-aebb-ca6d8c8d2d16" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="simple" xlink:href="pfe-20260927.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_019fd856-95d4-71a9-ab72-4d4bf7833309" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_019fd856-95d4-7ef6-9ecc-a9ab9c9580ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_019fd856-95d4-71a9-ab72-4d4bf7833309" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_019fd856-95d4-7ef6-9ecc-a9ab9c9580ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentfromAOCIPensionandOtherPostretirementBenefitPlansforNetPriorServiceCostCreditbeforeTax_019fd856-95d4-78a8-8201-e1ff44e339df" xlink:href="pfe-20260927.xsd#pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentfromAOCIPensionandOtherPostretirementBenefitPlansforNetPriorServiceCostCreditbeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_019fd856-95d4-71a9-ab72-4d4bf7833309" xlink:to="loc_pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentfromAOCIPensionandOtherPostretirementBenefitPlansforNetPriorServiceCostCreditbeforeTax_019fd856-95d4-78a8-8201-e1ff44e339df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019fd856-95d4-7169-a187-aeb41ebe30df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_019fd856-95d4-7cf7-957e-e0756a982ca0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019fd856-95d4-7169-a187-aeb41ebe30df" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_019fd856-95d4-7cf7-957e-e0756a982ca0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_019fd856-95d4-7515-a631-5f657151bdc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019fd856-95d4-7169-a187-aeb41ebe30df" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_019fd856-95d4-7515-a631-5f657151bdc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7ea0-a1ff-a772605015a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd856-95d4-78be-86e0-1653f50986ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7ea0-a1ff-a772605015a3" xlink:to="loc_us-gaap_ProfitLoss_019fd856-95d4-78be-86e0-1653f50986ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7825-84c1-edb6d0222673" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7ea0-a1ff-a772605015a3" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7825-84c1-edb6d0222673" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd856-95d4-7b2b-a542-1d6f18a9e1ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7479-8a59-2d3413521f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd856-95d4-7b2b-a542-1d6f18a9e1ae" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7479-8a59-2d3413521f7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019fd856-95d4-76f3-863d-1ea77cac3eb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd856-95d4-7b2b-a542-1d6f18a9e1ae" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019fd856-95d4-76f3-863d-1ea77cac3eb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019fd856-95d4-7886-aa95-98f49bd0b41b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fd856-95d4-78db-8846-62e56d27188e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019fd856-95d4-7886-aa95-98f49bd0b41b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fd856-95d4-78db-8846-62e56d27188e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019fd856-95d4-7c45-93c9-9aa7b7bd115e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019fd856-95d4-7886-aa95-98f49bd0b41b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019fd856-95d4-7c45-93c9-9aa7b7bd115e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7d43-8f88-971c4f04f59d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7c6c-a063-47f06a5dec07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7d43-8f88-971c4f04f59d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7c6c-a063-47f06a5dec07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-95d4-7841-9020-68cbfefb8cc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7d43-8f88-971c4f04f59d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-95d4-7841-9020-68cbfefb8cc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7de5-a809-098eab2f4dab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019fd856-95d4-7a6d-a8f2-e647060e2447" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7de5-a809-098eab2f4dab" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019fd856-95d4-7a6d-a8f2-e647060e2447" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019fd856-95d4-7e11-b8cd-54f8a9dcce13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7de5-a809-098eab2f4dab" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019fd856-95d4-7e11-b8cd-54f8a9dcce13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_019fd856-95d4-7fda-bda0-bd6f1861ad4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7de5-a809-098eab2f4dab" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_019fd856-95d4-7fda-bda0-bd6f1861ad4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_019fd856-95d4-7c1d-8c92-c28598a5bdac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_019fd856-95d4-7de5-a809-098eab2f4dab" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_019fd856-95d4-7c1d-8c92-c28598a5bdac" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="pfe-20260927.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_019fd856-95d4-7686-a7bc-ce4b578d18f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_DebtCurrent_019fd856-95d4-7686-a7bc-ce4b578d18f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fd856-95d4-70e8-b852-d78973ae11a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fd856-95d4-70e8-b852-d78973ae11a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrent_019fd856-95d4-7e40-b48d-b8d541131a04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_DividendsPayableCurrent_019fd856-95d4-7e40-b48d-b8d541131a04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019fd856-95d4-7d8c-a4c5-886bdd2a8412" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_TaxesPayableCurrent_019fd856-95d4-7d8c-a4c5-886bdd2a8412" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd856-95d4-7d04-9ba0-f0b8e58960c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd856-95d4-7d04-9ba0-f0b8e58960c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019fd856-95d4-7735-b75c-f93c352a0c18" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-7a0a-8042-843f183e0948" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019fd856-95d4-7735-b75c-f93c352a0c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd856-95d4-79ed-91c2-f189e19419ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd856-95d4-7fbd-b2cd-a92b10a6359a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd856-95d4-79ed-91c2-f189e19419ff" xlink:to="loc_us-gaap_Liabilities_019fd856-95d4-7fbd-b2cd-a92b10a6359a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019fd856-95d4-7c91-8c78-639bc2378175" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd856-95d4-79ed-91c2-f189e19419ff" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019fd856-95d4-7c91-8c78-639bc2378175" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7b9b-8bf4-1eae4de6f07d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd856-95d4-79ed-91c2-f189e19419ff" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7b9b-8bf4-1eae4de6f07d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd856-95d4-7630-b2c2-c6428d5db1a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd856-95d4-7630-b2c2-c6428d5db1a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fd856-95d4-76a1-90f8-0a35d97b69be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019fd856-95d4-76a1-90f8-0a35d97b69be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd856-95d4-7aaa-8b4a-d63421b59320" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_us-gaap_InventoryNet_019fd856-95d4-7aaa-8b4a-d63421b59320" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019fd856-95d4-7b16-b328-35c766546628" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_us-gaap_OtherAssetsCurrent_019fd856-95d4-7b16-b328-35c766546628" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermInvestments_019fd856-95d4-7172-8dea-7f102f4f3186" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherShortTermInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_us-gaap_OtherShortTermInvestments_019fd856-95d4-7172-8dea-7f102f4f3186" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherTaxAssetsCurrent_019fd856-95d4-7c84-9d1d-d29778aa82f9" xlink:href="pfe-20260927.xsd#pfe_OtherTaxAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd856-95d4-7915-b408-181ecae9e601" xlink:to="loc_pfe_OtherTaxAssetsCurrent_019fd856-95d4-7c84-9d1d-d29778aa82f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-787e-b118-f3204cb4a875" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd856-95d4-7096-bcf4-7bd98798323b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-787e-b118-f3204cb4a875" xlink:to="loc_us-gaap_StockholdersEquity_019fd856-95d4-7096-bcf4-7bd98798323b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019fd856-95d4-72f1-825e-16ca7c1454d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-787e-b118-f3204cb4a875" xlink:to="loc_us-gaap_MinorityInterest_019fd856-95d4-72f1-825e-16ca7c1454d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-799a-bfdc-c9e34c55d4e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_LiabilitiesCurrent_019fd856-95d4-799a-bfdc-c9e34c55d4e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd856-95d4-7b55-9a0c-6032801e3d41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019fd856-95d4-7b55-9a0c-6032801e3d41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019fd856-95d4-738f-876b-25ac9d69b5eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019fd856-95d4-738f-876b-25ac9d69b5eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd856-95d4-72a5-bd01-345eeed5466d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd856-95d4-72a5-bd01-345eeed5466d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_019fd856-95d4-762b-a9ea-386a354c353f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilityForUncertainTaxPositionsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_019fd856-95d4-762b-a9ea-386a354c353f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_019fd856-95d4-72fe-aff0-a7073f756a5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd856-95d4-791e-8f8a-a50bb48589d5" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_019fd856-95d4-72fe-aff0-a7073f756a5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019fd856-95d4-7da2-8ade-5f0acb3c83e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:to="loc_us-gaap_CommonStockValue_019fd856-95d4-7da2-8ade-5f0acb3c83e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019fd856-95d4-7809-9e18-5f84c3625113" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019fd856-95d4-7809-9e18-5f84c3625113" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019fd856-95d4-7aed-a262-ab04b958355b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019fd856-95d4-7aed-a262-ab04b958355b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd856-95d4-7679-b09f-2e60a6c9684e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd856-95d4-7679-b09f-2e60a6c9684e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7ef6-801f-6ef6b4a30233" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd856-95d4-7f26-b848-b65341a6a6a7" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd856-95d4-7ef6-801f-6ef6b4a30233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd856-95d4-7c61-ade5-c617370a033c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_AssetsCurrent_019fd856-95d4-7c61-ade5-c617370a033c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermInvestments_019fd856-95d4-701f-a5b8-12497ed8fae2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLongTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_OtherLongTermInvestments_019fd856-95d4-701f-a5b8-12497ed8fae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd856-95d4-74c9-a301-4ecb1d187969" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd856-95d4-74c9-a301-4ecb1d187969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-95d4-7cdc-b030-3097ea8489b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-95d4-7cdc-b030-3097ea8489b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd856-95d4-7126-8d61-ae47509a8399" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_Goodwill_019fd856-95d4-7126-8d61-ae47509a8399" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DeferredTaxAssetsNetAndOtherTaxAssetsNoncurrent_019fd856-95d4-78cc-8254-ced7e80ba1c7" xlink:href="pfe-20260927.xsd#pfe_DeferredTaxAssetsNetAndOtherTaxAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_pfe_DeferredTaxAssetsNetAndOtherTaxAssetsNoncurrent_019fd856-95d4-78cc-8254-ced7e80ba1c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019fd856-95d4-7ba3-bc24-fd05f65d058c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd856-95d4-7367-b632-f6eb9d788500" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019fd856-95d4-7ba3-bc24-fd05f65d058c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="pfe-20260927.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fd856-95d4-7244-92aa-66f230d17ab7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fd856-95d4-7244-92aa-66f230d17ab7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd856-95d4-7230-9856-fbb436d87551" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd856-95d4-7230-9856-fbb436d87551" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_PaymentsForProceedsFromShortTermInvestmentsWithOriginalMaturitiesOfThreeMonthsOrLess_019fd856-95d4-78f5-9cbb-77a7c2713cb9" xlink:href="pfe-20260927.xsd#pfe_PaymentsForProceedsFromShortTermInvestmentsWithOriginalMaturitiesOfThreeMonthsOrLess"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_pfe_PaymentsForProceedsFromShortTermInvestmentsWithOriginalMaturitiesOfThreeMonthsOrLess_019fd856-95d4-78f5-9cbb-77a7c2713cb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfLongtermInvestments_019fd856-95d4-701d-85b9-2d4db66ea771" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionOfLongtermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfLongtermInvestments_019fd856-95d4-701d-85b9-2d4db66ea771" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019fd856-95d4-7e15-99a4-aec4e63852c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019fd856-95d4-7e15-99a4-aec4e63852c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfEquityMethodInvestments_019fd856-95d4-74eb-a164-1a190cf0032b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfEquityMethodInvestments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_ProceedsFromSaleOfEquityMethodInvestments_019fd856-95d4-74eb-a164-1a190cf0032b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_019fd856-95d4-7a9d-8f7c-c1af5315cbf6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_019fd856-95d4-7a9d-8f7c-c1af5315cbf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_019fd856-95d4-7ad8-b6b2-d17cfb7f0b4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-744b-a8a1-908fb4f475e7" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_019fd856-95d4-7ad8-b6b2-d17cfb7f0b4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_AssetWriteOffsAndAssetImpairmentCharges_019fd856-95d4-7a4e-93d8-4173ddb74e05" xlink:href="pfe-20260927.xsd#pfe_AssetWriteOffsAndAssetImpairmentCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_pfe_AssetWriteOffsAndAssetImpairmentCharges_019fd856-95d4-7a4e-93d8-4173ddb74e05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019fd856-95d4-74a7-be8b-2b6608838516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019fd856-95d4-74a7-be8b-2b6608838516" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_PensionAndOtherPostretirementBenefitContributionsNetOfPensionAndOtherPostretirementBenefitExpense_019fd856-95d4-79af-bf8e-70d494d27b22" xlink:href="pfe-20260927.xsd#pfe_PensionAndOtherPostretirementBenefitContributionsNetOfPensionAndOtherPostretirementBenefitExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_pfe_PensionAndOtherPostretirementBenefitContributionsNetOfPensionAndOtherPostretirementBenefitExpense_019fd856-95d4-79af-bf8e-70d494d27b22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019fd856-95d4-7602-9493-816e83f98c04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019fd856-95d4-7602-9493-816e83f98c04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019fd856-95d4-76ce-98c1-b3cbc1e1b785" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_ShareBasedCompensation_019fd856-95d4-76ce-98c1-b3cbc1e1b785" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapital_019fd856-95d4-72cf-98d9-349250a30e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingCapital"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapital_019fd856-95d4-72cf-98d9-349250a30e8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019fd856-95d4-7b89-801f-93bc4b0e7da7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019fd856-95d4-7b89-801f-93bc4b0e7da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7045-9c1f-6c77d82ba72f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_019fd856-95d4-7045-9c1f-6c77d82ba72f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_019fd856-95d4-798f-8003-f93b3bace7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-7db5-b765-3647110f6f99" xlink:to="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_019fd856-95d4-798f-8003-f93b3bace7d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_019fd856-95d4-7a3f-b921-fab023764426" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_019fd856-95d4-7a3f-b921-fab023764426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess_019fd856-95d4-7ce4-b476-820ea812b9a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess_019fd856-95d4-7ce4-b476-820ea812b9a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019fd856-95d4-7063-9316-8160ad8f4580" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019fd856-95d4-7063-9316-8160ad8f4580" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019fd856-95d4-7506-8c1f-dfd38786b608" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019fd856-95d4-7506-8c1f-dfd38786b608" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfOrdinaryDividends_019fd856-95d4-75ac-b2b7-19e17eb523a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfOrdinaryDividends"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_PaymentsOfOrdinaryDividends_019fd856-95d4-75ac-b2b7-19e17eb523a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019fd856-95d4-76b3-8660-bff719361e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7538-b7c7-70b79698039d" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019fd856-95d4-76b3-8660-bff719361e9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd856-95d4-7810-971e-8feeb866bcb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-792d-a91a-0834341db0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd856-95d4-7810-971e-8feeb866bcb9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd856-95d4-792d-a91a-0834341db0e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-7ec2-8836-81d0c49fe420" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd856-95d4-7810-971e-8feeb866bcb9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd856-95d4-7ec2-8836-81d0c49fe420" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7e4e-89a8-21a1bed19847" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd856-95d4-7810-971e-8feeb866bcb9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd856-95d4-7e4e-89a8-21a1bed19847" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd856-95d4-7b6b-a38c-4ca0d5c95a2b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd856-95d4-7810-971e-8feeb866bcb9" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd856-95d4-7b6b-a38c-4ca0d5c95a2b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandCostReductionProductivityInitiativesScheduleofAcquisitionsandCostReductionProductivityInitiativesDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandCostReductionProductivityInitiativesScheduleofAcquisitionsandCostReductionProductivityInitiativesDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/RestructuringChargesandOtherCostsAssociatedwithAcquisitionsandCostReductionProductivityInitiativesScheduleofAcquisitionsandCostReductionProductivityInitiativesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019fd856-9684-7689-89e0-21581e31f338" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_019fd856-9684-7d23-b7f5-405aaa446245" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeveranceCosts1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCharges_019fd856-9684-7689-89e0-21581e31f338" xlink:to="loc_us-gaap_SeveranceCosts1_019fd856-9684-7d23-b7f5-405aaa446245" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_RestructuringAssetImpairmentCharges_019fd856-9684-76c7-8216-55a78a286126" xlink:href="pfe-20260927.xsd#pfe_RestructuringAssetImpairmentCharges"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCharges_019fd856-9684-7689-89e0-21581e31f338" xlink:to="loc_pfe_RestructuringAssetImpairmentCharges_019fd856-9684-76c7-8216-55a78a286126" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessExitCosts1_019fd856-9684-7a7b-9da5-6c2173dce243" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessExitCosts1"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCharges_019fd856-9684-7689-89e0-21581e31f338" xlink:to="loc_us-gaap_BusinessExitCosts1_019fd856-9684-7a7b-9da5-6c2173dce243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:href="pfe-20260927.xsd#pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7fa9-ad39-8c2df3ea346e" xlink:href="pfe-20260927.xsd#pfe_RestructuringChargesAndAcquisitionRelatedCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:to="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7fa9-ad39-8c2df3ea346e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7c2b-95e7-9010ec192a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7c2b-95e7-9010ec192a3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019fd856-9684-782d-927d-48a30b757ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:to="loc_us-gaap_InventoryWriteDown_019fd856-9684-782d-927d-48a30b757ae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_019fd856-9684-7eba-85d5-1f73b087995d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveAcceleratedDepreciation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:to="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_019fd856-9684-7eba-85d5-1f73b087995d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_ImplementationCosts_019fd856-9684-7647-a662-b0187b869f00" xlink:href="pfe-20260927.xsd#pfe_ImplementationCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAcquisitionRelatedCostsandImplementationCosts_019fd856-9684-715e-952d-84b1244da988" xlink:to="loc_pfe_ImplementationCosts_019fd856-9684-7647-a662-b0187b869f00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7f6e-a585-ee07b35b7b6f" xlink:href="pfe-20260927.xsd#pfe_RestructuringChargesAndAcquisitionRelatedCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019fd856-9684-7395-b0c2-37875c6823ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7f6e-a585-ee07b35b7b6f" xlink:to="loc_us-gaap_RestructuringCharges_019fd856-9684-7395-b0c2-37875c6823ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_BusinessCombinationAcquisitionRelatedCostsTransactionCosts_019fd856-9684-7648-9286-7ec2eb130198" xlink:href="pfe-20260927.xsd#pfe_BusinessCombinationAcquisitionRelatedCostsTransactionCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7f6e-a585-ee07b35b7b6f" xlink:to="loc_pfe_BusinessCombinationAcquisitionRelatedCostsTransactionCosts_019fd856-9684-7648-9286-7ec2eb130198" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationIntegrationRelatedCosts_01a01ab9-57b2-7cd8-9a31-b4575f3a64b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationIntegrationRelatedCosts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_RestructuringChargesAndAcquisitionRelatedCosts_019fd856-9684-7f6e-a585-ee07b35b7b6f" xlink:to="loc_us-gaap_BusinessCombinationIntegrationRelatedCosts_01a01ab9-57b2-7cd8-9a31-b4575f3a64b5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/OtherIncomeDeductionsNetScheduleofOtherIncomeDeductionsNetDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#OtherIncomeDeductionsNetScheduleofOtherIncomeDeductionsNetDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/OtherIncomeDeductionsNetScheduleofOtherIncomeDeductionsNetDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRevenueExpenseNet_019fd856-9684-7e70-bf0b-99734505bf7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRevenueExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_InterestRevenueExpenseNet_019fd856-9684-7e70-bf0b-99734505bf7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019fd856-9684-7d13-9d7b-2ea82f821d64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019fd856-9684-7d13-9d7b-2ea82f821d64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent_019fd856-9684-72bc-97a0-5e5ee6e85ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_NetPeriodicDefinedBenefitsExpenseReversalOfExpenseExcludingServiceCostComponent_019fd856-9684-72bc-97a0-5e5ee6e85ff3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_019fd856-9684-7e72-82fc-896365d629d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_019fd856-9684-7e72-82fc-896365d629d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019fd856-9684-7f81-a231-90af346eef3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_AssetImpairmentCharges_019fd856-9684-7f81-a231-90af346eef3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherNonoperatingIncomeExpenseNet_019fd856-9684-713b-9477-071f123be860" xlink:href="pfe-20260927.xsd#pfe_OtherNonoperatingIncomeExpenseNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_pfe_OtherNonoperatingIncomeExpenseNet_019fd856-9684-713b-9477-071f123be860" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019fd856-9684-7a18-a099-8c685b54ecc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019fd856-9684-7a18-a099-8c685b54ecc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_019fd856-9684-790b-980a-42e7f74567ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_EquityMethodInvestmentRealizedGainLossOnDisposal_019fd856-9684-790b-980a-42e7f74567ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfOtherAssets_01a13fe7-2d37-7872-801f-265f5f1381f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfOtherAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_us-gaap_GainLossOnSaleOfOtherAssets_01a13fe7-2d37-7872-801f-265f5f1381f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_IncomeLossFromCollaborationsLicensingAgreementsAndSalesOfCompoundProductRights_01a13fe7-b911-75c2-89a9-70c89b8dae9f" xlink:href="pfe-20260927.xsd#pfe_IncomeLossFromCollaborationsLicensingAgreementsAndSalesOfCompoundProductRights"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-9684-7810-a393-f10289746ff8" xlink:to="loc_pfe_IncomeLossFromCollaborationsLicensingAgreementsAndSalesOfCompoundProductRights_01a13fe7-b911-75c2-89a9-70c89b8dae9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRevenueExpenseNet_019fd856-9684-7f75-afb9-2c72ccd5b0af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRevenueExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019fd856-9684-7b95-9658-4dd77c5580e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRevenueExpenseNet_019fd856-9684-7f75-afb9-2c72ccd5b0af" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019fd856-9684-7b95-9658-4dd77c5580e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_019fd856-9684-7ca7-8d26-96684c8b4312" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRevenueExpenseNet_019fd856-9684-7f75-afb9-2c72ccd5b0af" xlink:to="loc_us-gaap_InterestExpense_019fd856-9684-7ca7-8d26-96684c8b4312" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/OtherIncomeDeductionsNetScheduleofImpairedIntangibleAssetsDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#OtherIncomeDeductionsNetScheduleofImpairedIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/OtherIncomeDeductionsNetScheduleofImpairedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pfe_IntangibleAssetsFairValueDisclosure_019fd856-9684-7f3f-8f98-2f5168916d3e" xlink:href="pfe-20260927.xsd#pfe_IntangibleAssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillFairValueDisclosure_019fd856-9684-706c-9aed-7f98e2734b48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_IntangibleAssetsFairValueDisclosure_019fd856-9684-7f3f-8f98-2f5168916d3e" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillFairValueDisclosure_019fd856-9684-706c-9aed-7f98e2734b48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure_019fd856-9684-7725-aae7-13606bc18474" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_IntangibleAssetsFairValueDisclosure_019fd856-9684-7f3f-8f98-2f5168916d3e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure_019fd856-9684-7725-aae7-13606bc18474" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/TaxMattersScheduleofTaxProvisionBenefitonOtherComprehensiveIncomeLossDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#TaxMattersScheduleofTaxProvisionBenefitonOtherComprehensiveIncomeLossDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/TaxMattersScheduleofTaxProvisionBenefitonOtherComprehensiveIncomeLossDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect_019fd856-9684-7812-9837-449b7551f87a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax_019fd856-9684-7871-923f-3b26dae97fc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect_019fd856-9684-7812-9837-449b7551f87a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax_019fd856-9684-7871-923f-3b26dae97fc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax_019fd856-9684-7828-b822-5c5d196b688c" xlink:href="pfe-20260927.xsd#pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect_019fd856-9684-7812-9837-449b7551f87a" xlink:to="loc_pfe_OtherComprehensiveIncomeLossCurtailmentAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditTax_019fd856-9684-7828-b822-5c5d196b688c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-9684-7899-88ca-1b27376f4d66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_019fd856-9684-7302-8b2b-9b488737f6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-9684-7899-88ca-1b27376f4d66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_019fd856-9684-7302-8b2b-9b488737f6d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019fd856-9684-7180-89ea-d61ef71511b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-9684-7899-88ca-1b27376f4d66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019fd856-9684-7180-89ea-d61ef71511b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax_019fd856-9684-7732-b30b-1d29001d30e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-9684-7899-88ca-1b27376f4d66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax_019fd856-9684-7732-b30b-1d29001d30e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect_019fd856-9684-7a09-a97d-0b7ea49e70ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTax_019fd856-9684-7899-88ca-1b27376f4d66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBenefitPlanImprovementTaxEffect_019fd856-9684-7a09-a97d-0b7ea49e70ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax_019fd856-9684-783e-be01-608f2bb33092" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_019fd856-9684-7116-88f8-9aff94743d90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax_019fd856-9684-783e-be01-608f2bb33092" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_019fd856-9684-7116-88f8-9aff94743d90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_019fd856-9684-7327-8b77-9555928d335a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesTax_019fd856-9684-783e-be01-608f2bb33092" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_019fd856-9684-7327-8b77-9555928d335a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019fd856-9684-7157-9ab9-d3a7e8bcba19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_019fd856-9684-74d7-9dee-248d6995f13f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019fd856-9684-7157-9ab9-d3a7e8bcba19" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_019fd856-9684-74d7-9dee-248d6995f13f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax_019fd856-9684-7be5-aeea-f153de594b92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTax_019fd856-9684-7157-9ab9-d3a7e8bcba19" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax_019fd856-9684-7be5-aeea-f153de594b92" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities_019fd856-9684-7063-a983-6d880e000fa3" xlink:href="pfe-20260927.xsd#pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-749f-b107-b6d6bb5afdac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities_019fd856-9684-7063-a983-6d880e000fa3" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-749f-b107-b6d6bb5afdac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7fc3-92f5-edfeaaf8d25f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities_019fd856-9684-7063-a983-6d880e000fa3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7fc3-92f5-edfeaaf8d25f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LiabilitiesCurrentFairValueDisclosure_019fd856-9684-7fa4-b128-757859601565" xlink:href="pfe-20260927.xsd#pfe_LiabilitiesCurrentFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_019fd856-9684-7983-bfa0-ee93f6cf5d59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LiabilitiesCurrentFairValueDisclosure_019fd856-9684-7fa4-b128-757859601565" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_019fd856-9684-7983-bfa0-ee93f6cf5d59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019fd856-9684-71af-9a1d-f7ab3a0f6869" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LiabilitiesCurrentFairValueDisclosure_019fd856-9684-7fa4-b128-757859601565" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019fd856-9684-71af-9a1d-f7ab3a0f6869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherAssetsNoncurrentFairValueDisclosure_019fd856-9684-75ad-b59e-62680833b85f" xlink:href="pfe-20260927.xsd#pfe_OtherAssetsNoncurrentFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_019fd856-9684-7dd8-a862-7330ad3f778e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_OtherAssetsNoncurrentFairValueDisclosure_019fd856-9684-75ad-b59e-62680833b85f" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_019fd856-9684-7dd8-a862-7330ad3f778e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LifeSettlementContractsFairValueMethodCarryingAmount_019fd856-9684-7967-a0e8-d9ee3bde53cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LifeSettlementContractsFairValueMethodCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_OtherAssetsNoncurrentFairValueDisclosure_019fd856-9684-75ad-b59e-62680833b85f" xlink:to="loc_us-gaap_LifeSettlementContractsFairValueMethodCarryingAmount_019fd856-9684-7967-a0e8-d9ee3bde53cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments_019fd856-9684-7304-af1c-dcc31f146494" xlink:href="pfe-20260927.xsd#pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-721a-9dd3-2bae06f956cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments_019fd856-9684-7304-af1c-dcc31f146494" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-721a-9dd3-2bae06f956cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7022-9767-b04c20d96505" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments_019fd856-9684-7304-af1c-dcc31f146494" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7022-9767-b04c20d96505" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LiabilitiesNoncurrentFairValueDisclosure_019fd856-9684-7021-a8f2-a722879d7ecb" xlink:href="pfe-20260927.xsd#pfe_LiabilitiesNoncurrentFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_019fd856-9684-7f05-91ee-a96dfe1d9507" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LiabilitiesNoncurrentFairValueDisclosure_019fd856-9684-7021-a8f2-a722879d7ecb" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_019fd856-9684-7f05-91ee-a96dfe1d9507" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019fd856-9684-7249-96c3-a8000e470c60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_LiabilitiesNoncurrentFairValueDisclosure_019fd856-9684-7021-a8f2-a722879d7ecb" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019fd856-9684-7249-96c3-a8000e470c60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019fd856-9684-70e4-958a-0981d5211cfa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities_019fd856-9684-7136-9804-2b2ed58610fa" xlink:href="pfe-20260927.xsd#pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019fd856-9684-70e4-958a-0981d5211cfa" xlink:to="loc_pfe_ShorttermInvestmentsExcludingHeldToMaturitySecurities_019fd856-9684-7136-9804-2b2ed58610fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_019fd856-9684-737b-a70a-170ec96d04bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019fd856-9684-70e4-958a-0981d5211cfa" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_019fd856-9684-737b-a70a-170ec96d04bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments_019fd856-9684-73b0-9619-30888eb2f13a" xlink:href="pfe-20260927.xsd#pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019fd856-9684-70e4-958a-0981d5211cfa" xlink:to="loc_pfe_LongtermInvestmentsExcludingHeldToMaturitySecuritiesAndPrivateEquityInvestments_019fd856-9684-73b0-9619-30888eb2f13a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_OtherAssetsNoncurrentFairValueDisclosure_019fd856-9684-741e-a4ce-f01acdc0cdc4" xlink:href="pfe-20260927.xsd#pfe_OtherAssetsNoncurrentFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019fd856-9684-70e4-958a-0981d5211cfa" xlink:to="loc_pfe_OtherAssetsNoncurrentFairValueDisclosure_019fd856-9684-741e-a4ce-f01acdc0cdc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019fd856-9684-7e65-b517-6eae8ff19e53" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LiabilitiesCurrentFairValueDisclosure_019fd856-9684-7be1-9b9f-ff3adaf8cffc" xlink:href="pfe-20260927.xsd#pfe_LiabilitiesCurrentFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019fd856-9684-7e65-b517-6eae8ff19e53" xlink:to="loc_pfe_LiabilitiesCurrentFairValueDisclosure_019fd856-9684-7be1-9b9f-ff3adaf8cffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LiabilitiesNoncurrentFairValueDisclosure_019fd856-9684-74b5-a0d9-94a908de5d1f" xlink:href="pfe-20260927.xsd#pfe_LiabilitiesNoncurrentFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019fd856-9684-7e65-b517-6eae8ff19e53" xlink:to="loc_pfe_LiabilitiesNoncurrentFairValueDisclosure_019fd856-9684-74b5-a0d9-94a908de5d1f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsInvestmentsbyClassificationTypeDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsInvestmentsbyClassificationTypeDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsInvestmentsbyClassificationTypeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermInvestments_019fd856-9684-79a8-9549-1bc5399501bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019fd856-9684-7281-b00a-8da2c5c6849b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherShortTermInvestments_019fd856-9684-79a8-9549-1bc5399501bd" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019fd856-9684-7281-b00a-8da2c5c6849b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-7882-821b-e5d4a5238c6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherShortTermInvestments_019fd856-9684-79a8-9549-1bc5399501bd" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019fd856-9684-7882-821b-e5d4a5238c6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesCurrent_019fd856-9684-7b5e-9b37-8160cf162b51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherShortTermInvestments_019fd856-9684-79a8-9549-1bc5399501bd" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesCurrent_019fd856-9684-7b5e-9b37-8160cf162b51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLongTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFVNINoncurrent_019fd856-9684-7383-8d3a-d06d11ef594d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFVNINoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:to="loc_us-gaap_EquitySecuritiesFVNINoncurrent_019fd856-9684-7383-8d3a-d06d11ef594d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019fd856-9684-73b0-83d6-d9937dbb21c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019fd856-9684-73b0-83d6-d9937dbb21c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesNoncurrent_019fd856-9684-7a2c-ba0f-a69ce7c4d389" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesNoncurrent_019fd856-9684-7a2c-ba0f-a69ce7c4d389" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_PrivateEquityInvestments_019fd856-9684-7da4-b71c-a4f603647c26" xlink:href="pfe-20260927.xsd#pfe_PrivateEquityInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:to="loc_pfe_PrivateEquityInvestments_019fd856-9684-7da4-b71c-a4f603647c26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019fd856-9684-7d1a-8983-d21de3afab72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLongTermInvestments_019fd856-9684-7de3-99ab-896e389d4ea1" xlink:to="loc_us-gaap_EquityMethodInvestments_019fd856-9684-7d1a-8983-d21de3afab72" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsScheduleofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsScheduleofInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsScheduleofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7768-b711-ba10a8bea624" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fd856-9684-7f21-9863-497a2c82fbda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7768-b711-ba10a8bea624" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fd856-9684-7f21-9863-497a2c82fbda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fd856-9684-77f3-b554-c04b84584fd9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7768-b711-ba10a8bea624" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fd856-9684-77f3-b554-c04b84584fd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7896-9e09-154efe3a0679" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7768-b711-ba10a8bea624" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7896-9e09-154efe3a0679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesMaturitiesYearTwoThroughFiveFairValue_019fd856-9684-73d3-ad50-a36e2324c4c5" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesMaturitiesYearTwoThroughFiveFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7173-a81d-889191fafecb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesYearTwoThroughFiveFairValue_019fd856-9684-73d3-ad50-a36e2324c4c5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7173-a81d-889191fafecb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7cf2-a4fe-d323bdb68300" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesYearTwoThroughFiveFairValue_019fd856-9684-73d3-ad50-a36e2324c4c5" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7cf2-a4fe-d323bdb68300" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-7c75-a90b-a6fa1f5fe44a" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7ddd-81e3-d7a3448f9834" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-7c75-a90b-a6fa1f5fe44a" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019fd856-9684-7ddd-81e3-d7a3448f9834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-74b9-9db1-c8d875bb677d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-7c75-a90b-a6fa1f5fe44a" xlink:to="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-74b9-9db1-c8d875bb677d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity_019fd856-9684-7a21-963e-f2aca742dcc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-78b7-9ca6-0872e5a4b8c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity_019fd856-9684-7a21-963e-f2aca742dcc4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-78b7-9ca6-0872e5a4b8c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019fd856-9684-7ff1-8692-36e599d2cd4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity_019fd856-9684-7a21-963e-f2aca742dcc4" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019fd856-9684-7ff1-8692-36e599d2cd4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesMaturitiesNextTwelveMonthsFairValue_019fd856-9684-7960-be08-3c7fd8d77c79" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesMaturitiesNextTwelveMonthsFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-7abe-b576-208213350d84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesNextTwelveMonthsFairValue_019fd856-9684-7960-be08-3c7fd8d77c79" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-7abe-b576-208213350d84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-7f89-a1ad-170cff6e74f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesNextTwelveMonthsFairValue_019fd856-9684-7960-be08-3c7fd8d77c79" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-7f89-a1ad-170cff6e74f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-7647-b2ec-48b86aa09aab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019fd856-9684-75cf-b312-5e64a08ae028" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-7647-b2ec-48b86aa09aab" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019fd856-9684-75cf-b312-5e64a08ae028" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019fd856-9684-75c8-babc-fb0a0f7fd229" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-7647-b2ec-48b86aa09aab" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019fd856-9684-75c8-babc-fb0a0f7fd229" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019fd856-9684-78d7-af20-20f97a4013d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_019fd856-9684-7647-b2ec-48b86aa09aab" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_019fd856-9684-78d7-af20-20f97a4013d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss_019fd856-9684-7fed-975a-414931aacf0f" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019fd856-9684-72a5-bce0-e12c6b6462fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss_019fd856-9684-7fed-975a-414931aacf0f" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_019fd856-9684-72a5-bce0-e12c6b6462fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fd856-9684-7ccb-b7fc-5670f7c409a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss_019fd856-9684-7fed-975a-414931aacf0f" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fd856-9684-7ccb-b7fc-5670f7c409a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7b45-8265-b9d5558e1437" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-75d3-a823-24e028b80f2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7b45-8265-b9d5558e1437" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fd856-9684-75d3-a823-24e028b80f2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7966-95d9-184e71ad7aad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7b45-8265-b9d5558e1437" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fd856-9684-7966-95d9-184e71ad7aad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-7c85-8c5c-55a1c50eadae" xlink:href="pfe-20260927.xsd#pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019fd856-9684-7b45-8265-b9d5558e1437" xlink:to="loc_pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-7c85-8c5c-55a1c50eadae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesMaturitiesAfterYearFiveFairValue_019fd856-9684-77ce-9042-52f07efa519e" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesMaturitiesAfterYearFiveFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-719a-ace7-4ff18a914f1f" xlink:href="pfe-20260927.xsd#pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesAfterYearFiveFairValue_019fd856-9684-77ce-9042-52f07efa519e" xlink:to="loc_pfe_AvailableforsaleSecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-719a-ace7-4ff18a914f1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_HeldtomaturitySecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-7507-9fbc-a78abad78ddb" xlink:href="pfe-20260927.xsd#pfe_HeldtomaturitySecuritiesDebtMaturitiesAfterYearFiveFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesMaturitiesAfterYearFiveFairValue_019fd856-9684-77ce-9042-52f07efa519e" xlink:to="loc_pfe_HeldtomaturitySecuritiesDebtMaturitiesAfterYearFiveFairValue_019fd856-9684-7507-9fbc-a78abad78ddb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain_019fd856-9684-7aba-bfc4-703e32e322a1" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fd856-9684-7953-9f94-78f8acc3799f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain_019fd856-9684-7aba-bfc4-703e32e322a1" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fd856-9684-7953-9f94-78f8acc3799f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019fd856-9684-76a4-b558-7e13bda0e6c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain_019fd856-9684-7aba-bfc4-703e32e322a1" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_019fd856-9684-76a4-b558-7e13bda0e6c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsScheduleofInvestmentSecuritiesDetails_1" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsScheduleofInvestmentSecuritiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsScheduleofInvestmentSecuritiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-717a-adeb-b4df265afe86" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain_019fd856-9684-772f-a7f0-cdb26cfd3642" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-717a-adeb-b4df265afe86" xlink:to="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedGain_019fd856-9684-772f-a7f0-cdb26cfd3642" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss_019fd856-9684-7fe9-8bd1-835798aff030" xlink:href="pfe-20260927.xsd#pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-717a-adeb-b4df265afe86" xlink:to="loc_pfe_DebtSecuritiesAccumulatedGrossUnrealizedLoss_019fd856-9684-7fe9-8bd1-835798aff030" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity_019fd856-9684-78f2-ac52-7f40fdfb89a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_DebtSecuritiesAmortizedCostBasis_019fd856-9684-717a-adeb-b4df265afe86" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturity_019fd856-9684-78f2-ac52-7f40fdfb89a5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsInvestmentsUnrealizedGainsandLossesRelatedtoEquitySecuritiesDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsInvestmentsUnrealizedGainsandLossesRelatedtoEquitySecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsInvestmentsUnrealizedGainsandLossesRelatedtoEquitySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019fd856-9684-70c6-a37c-49b7aadfdf23" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_019fd856-9684-7bc1-b9da-e7142a8e3984" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019fd856-9684-70c6-a37c-49b7aadfdf23" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_019fd856-9684-7bc1-b9da-e7142a8e3984" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019fd856-9684-76f8-9638-b4ccb1478447" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019fd856-9684-70c6-a37c-49b7aadfdf23" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019fd856-9684-76f8-9638-b4ccb1478447" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsShorttermBorrowingsDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsShorttermBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsShorttermBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pfe_ShorttermDebtGross_019fd856-9684-7f10-b9d8-06e43a3de11f" xlink:href="pfe-20260927.xsd#pfe_ShorttermDebtGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermBorrowings_019fd856-9684-75a7-a943-45e2b7e10a56" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherShortTermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_ShorttermDebtGross_019fd856-9684-7f10-b9d8-06e43a3de11f" xlink:to="loc_us-gaap_OtherShortTermBorrowings_019fd856-9684-75a7-a943-45e2b7e10a56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_LongtermDebtCurrentMaturitiesExcludingNetFairValueAdjustmentsRelatedToHedgingAndPurchaseAccounting_019fd856-9684-7897-8fab-387e5fb1e406" xlink:href="pfe-20260927.xsd#pfe_LongtermDebtCurrentMaturitiesExcludingNetFairValueAdjustmentsRelatedToHedgingAndPurchaseAccounting"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pfe_ShorttermDebtGross_019fd856-9684-7f10-b9d8-06e43a3de11f" xlink:to="loc_pfe_LongtermDebtCurrentMaturitiesExcludingNetFairValueAdjustmentsRelatedToHedgingAndPurchaseAccounting_019fd856-9684-7897-8fab-387e5fb1e406" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_019fd856-9684-7cc8-8ede-f556ff82b151" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_ShorttermDebtGross_019fd856-9684-729a-b7c6-c6b1813172ac" xlink:href="pfe-20260927.xsd#pfe_ShorttermDebtGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtCurrent_019fd856-9684-7cc8-8ede-f556ff82b151" xlink:to="loc_pfe_ShorttermDebtGross_019fd856-9684-729a-b7c6-c6b1813172ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd856-9684-7b65-a9bb-1fe4efb98098" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtCurrent_019fd856-9684-7cc8-8ede-f556ff82b151" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd856-9684-7b65-a9bb-1fe4efb98098" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/FinancialInstrumentsLongTermDebtDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#FinancialInstrumentsLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/FinancialInstrumentsLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd856-9684-7b82-abea-4f814131b91e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd856-9684-701e-b60d-e8208948748d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019fd856-9684-7b82-abea-4f814131b91e" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fd856-9684-701e-b60d-e8208948748d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pfe_DebtInstrumentFairValueAdjustmentsHedgingAndPurchaseAccountingNoncurrent_019fd856-9684-783b-b9d0-ba937c519945" xlink:href="pfe-20260927.xsd#pfe_DebtInstrumentFairValueAdjustmentsHedgingAndPurchaseAccountingNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019fd856-9684-7b82-abea-4f814131b91e" xlink:to="loc_pfe_DebtInstrumentFairValueAdjustmentsHedgingAndPurchaseAccountingNoncurrent_019fd856-9684-783b-b9d0-ba937c519945" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd856-9684-7536-ac63-d5c14a286fef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019fd856-9684-7b82-abea-4f814131b91e" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd856-9684-7536-ac63-d5c14a286fef" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/OtherFinancialInformationInventoriesDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#OtherFinancialInformationInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/OtherFinancialInformationInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd856-9684-7479-9d39-24c200676ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd856-9684-7d0a-8342-aa08dac630a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd856-9684-7479-9d39-24c200676ce8" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd856-9684-7d0a-8342-aa08dac630a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd856-9684-73c8-b9c6-7f29a9054680" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd856-9684-7479-9d39-24c200676ce8" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd856-9684-73c8-b9c6-7f29a9054680" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_019fd856-9684-75ca-82c8-3952cbc3a0b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd856-9684-7479-9d39-24c200676ce8" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_019fd856-9684-75ca-82c8-3952cbc3a0b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7aa1-b554-3a9b554d23bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd856-9684-76b1-b4fb-774233d436e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7aa1-b554-3a9b554d23bd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd856-9684-76b1-b4fb-774233d436e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd856-9684-72a3-816a-3d15ce915e43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7aa1-b554-3a9b554d23bd" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd856-9684-72a3-816a-3d15ce915e43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd856-9684-72c6-8424-93045903b6c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd856-9684-71b4-9dd6-35353c6cacf7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd856-9684-72c6-8424-93045903b6c8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd856-9684-71b4-9dd6-35353c6cacf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd856-9684-777a-bd53-3f2390680f3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd856-9684-72c6-8424-93045903b6c8" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fd856-9684-777a-bd53-3f2390680f3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd856-9684-70ba-a3dd-8d331885cc97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd856-9684-7f5f-9800-8fe275993d04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd856-9684-70ba-a3dd-8d331885cc97" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd856-9684-7f5f-9800-8fe275993d04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd856-9684-7e02-b056-c83d7791c554" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd856-9684-70ba-a3dd-8d331885cc97" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd856-9684-7e02-b056-c83d7791c554" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail_1" xlink:type="simple" xlink:href="pfe-20260927.xsd#IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail_1"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/IdentifiableIntangibleAssetsNetandGoodwillScheduleofFinitelivedandIndefinitelivedIntangibleAssetsDetail_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7459-9998-457ebcc60b3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd856-9684-7992-8756-43e45e70c3d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7459-9998-457ebcc60b3b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd856-9684-7992-8756-43e45e70c3d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd856-9684-7690-b2e4-43c2610bace2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fd856-9684-7459-9998-457ebcc60b3b" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fd856-9684-7690-b2e4-43c2610bace2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/PensionandPostretirementBenefitPlansNetPeriodicBenefitCostDetail" xlink:type="simple" xlink:href="pfe-20260927.xsd#PensionandPostretirementBenefitPlansNetPeriodicBenefitCostDetail"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/PensionandPostretirementBenefitPlansNetPeriodicBenefitCostDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_019fd856-9684-7bdf-89e8-7f52c304ada2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_019fd856-9684-7bdf-89e8-7f52c304ada2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_019fd856-9684-7acf-970c-2938902ea6bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_019fd856-9684-7acf-970c-2938902ea6bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019fd856-9684-79bf-aaee-1888a98f39ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019fd856-9684-79bf-aaee-1888a98f39ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_019fd856-9684-706d-bfaf-16ad5fd06d05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_019fd856-9684-706d-bfaf-16ad5fd06d05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_019fd856-9684-7079-a8cb-b535a3c78f39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_019fd856-9684-7079-a8cb-b535a3c78f39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanCostOfProvidingSpecialOrContractualTerminationBenefitRecognizedDuringPeriod_019fd856-9684-7c41-b17f-95bbad37bc4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanCostOfProvidingSpecialOrContractualTerminationBenefitRecognizedDuringPeriod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanCostOfProvidingSpecialOrContractualTerminationBenefitRecognizedDuringPeriod_019fd856-9684-7c41-b17f-95bbad37bc4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_019fd856-9684-78e9-a679-ab5d0da49e4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fd856-9684-7ee5-ad2e-cd6bc44356ab" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_019fd856-9684-78e9-a679-ab5d0da49e4b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/EarningsPerCommonShareAttributabletoPfizerIncCommonShareholdersDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#EarningsPerCommonShareAttributabletoPfizerIncCommonShareholdersDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/EarningsPerCommonShareAttributabletoPfizerIncCommonShareholdersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019fd856-9684-74bf-8918-4ded4484c4d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-9684-73d2-9522-30fceb8964ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019fd856-9684-74bf-8918-4ded4484c4d9" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-9684-73d2-9522-30fceb8964ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersBasic_019fd856-9684-7ca2-bea6-f8afbcbf02d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019fd856-9684-74bf-8918-4ded4484c4d9" xlink:to="loc_us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersBasic_019fd856-9684-7ca2-bea6-f8afbcbf02d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019fd856-9684-743d-9212-a9d9e4705aa6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-9684-7b82-a340-116396fcbb1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019fd856-9684-743d-9212-a9d9e4705aa6" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_019fd856-9684-7b82-a340-116396fcbb1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersDiluted_019fd856-9684-7a54-94f0-b67c1b88c802" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersDiluted"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019fd856-9684-743d-9212-a9d9e4705aa6" xlink:to="loc_us-gaap_NetIncomeLossFromContinuingOperationsAvailableToCommonShareholdersDiluted_019fd856-9684-7a54-94f0-b67c1b88c802" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd856-9684-78d3-ae99-5c1986b1ef77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fd856-9684-7555-a52b-c052b5112e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd856-9684-78d3-ae99-5c1986b1ef77" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fd856-9684-7555-a52b-c052b5112e0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019fd856-9684-7af3-a2db-9d040e4757a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fd856-9684-78d3-ae99-5c1986b1ef77" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019fd856-9684-7af3-a2db-9d040e4757a5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.pfizer.com/role/SegmentGeographicandOtherRevenueInformationScheduleofSignificantBiopharmaSegmentExpensesDetails" xlink:type="simple" xlink:href="pfe-20260927.xsd#SegmentGeographicandOtherRevenueInformationScheduleofSignificantBiopharmaSegmentExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.pfizer.com/role/SegmentGeographicandOtherRevenueInformationScheduleofSignificantBiopharmaSegmentExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fd856-972a-781a-b217-14126b9579c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fd856-972a-781a-b217-14126b9579c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd856-972a-772d-958f-da2065e1e8ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd856-972a-772d-958f-da2065e1e8ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019fd856-972a-7291-89c9-694a9bf7d5bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019fd856-972a-7291-89c9-694a9bf7d5bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fd856-972a-7290-8ac8-e37f7bd1c6ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fd856-972a-7290-8ac8-e37f7bd1c6ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-972a-7026-8f07-f44b837407fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd856-972a-7026-8f07-f44b837407fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019fd856-972a-77d5-a977-564667c5f430" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd856-972a-70ae-a6e1-552e34fb3626" xlink:to="loc_us-gaap_Revenues_019fd856-972a-77d5-a977-564667c5f430" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
