<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ff822-1ad1-7e27-b34e-c80239a72a1e,g:7ff4e7b0-1bfd-4d24-981b-8cc28a17b1ca-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://mirumpharma.com/role/Cover" xlink:type="simple" xlink:href="mirm-20261103.xsd#Cover"/>
  <link:presentationLink xlink:role="http://mirumpharma.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019ff822-1ad1-79d0-80f6-691230e7f5b7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_DocumentType_019ff822-1ad1-79d0-80f6-691230e7f5b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019ff822-1ad1-7766-ba9c-a0b508eaefd0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_DocumentPeriodEndDate_019ff822-1ad1-7766-ba9c-a0b508eaefd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019ff822-1ad1-7b4c-9633-9d2862c6792c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityRegistrantName_019ff822-1ad1-7b4c-9633-9d2862c6792c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019ff822-1ad1-739c-8fc0-67439ef3179b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019ff822-1ad1-739c-8fc0-67439ef3179b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019ff822-1ad1-72b5-a1fc-252d00515800" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityFileNumber_019ff822-1ad1-72b5-a1fc-252d00515800" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019ff822-1ad1-70cb-a901-f40f136039b5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityTaxIdentificationNumber_019ff822-1ad1-70cb-a901-f40f136039b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019ff822-1ad1-7327-a7fc-e1d586741a8d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityAddressAddressLine1_019ff822-1ad1-7327-a7fc-e1d586741a8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019ff822-1ad1-7d88-8512-421410c084e1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityAddressCityOrTown_019ff822-1ad1-7d88-8512-421410c084e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019ff822-1ad1-79f0-be8b-fffc40af6824" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityAddressStateOrProvince_019ff822-1ad1-79f0-be8b-fffc40af6824" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019ff822-1ad1-7d53-b8a8-4bcb2f790e7c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityAddressPostalZipCode_019ff822-1ad1-7d53-b8a8-4bcb2f790e7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019ff822-1ad1-7031-a605-0dd6416445a1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_CityAreaCode_019ff822-1ad1-7031-a605-0dd6416445a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019ff822-1ad1-77c5-a927-c0152f2ca5e3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_LocalPhoneNumber_019ff822-1ad1-77c5-a927-c0152f2ca5e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019ff822-1ad1-730c-9842-6b4cc43cbe0f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_WrittenCommunications_019ff822-1ad1-730c-9842-6b4cc43cbe0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019ff822-1ad1-779b-a5c2-6b6739c8c4b6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_SolicitingMaterial_019ff822-1ad1-779b-a5c2-6b6739c8c4b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019ff822-1ad1-7c88-b1cf-2808b53f57d3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_PreCommencementTenderOffer_019ff822-1ad1-7c88-b1cf-2808b53f57d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019ff822-1ad1-7fb8-9f3c-c03fe2c7208a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019ff822-1ad1-7fb8-9f3c-c03fe2c7208a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019ff822-1ad1-7ec4-9141-14e1042fbf74" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_Security12bTitle_019ff822-1ad1-7ec4-9141-14e1042fbf74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019ff822-1ad1-7aca-8c00-70fa392fca4b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_TradingSymbol_019ff822-1ad1-7aca-8c00-70fa392fca4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019ff822-1ad1-7fe3-86a1-b9103a721d2e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_SecurityExchangeName_019ff822-1ad1-7fe3-86a1-b9103a721d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019ff822-1ad1-7ed9-b394-b4268e8cdf6d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityEmergingGrowthCompany_019ff822-1ad1-7ed9-b394-b4268e8cdf6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019ff822-1ad1-77a4-a4a1-8545398bb939" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_AmendmentFlag_019ff822-1ad1-77a4-a4a1-8545398bb939" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019ff822-1ad1-7ec8-8cf1-842fff4ab0c7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ff822-1ad1-7a2c-899a-22ff7bdadc36" xlink:to="loc_dei_EntityCentralIndexKey_019ff822-1ad1-7ec8-8cf1-842fff4ab0c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
