| Schedule of Reconciliation of Segment Loss Before Income Taxes and Total Consolidated Loss Before Income Taxes |
The following table presents selected financial information with respect to the Company’s single operating segment for the three and nine months ended September 30, 2026 and 2025 (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | | Therapeutics Segment | | Three Months Ended September 30, | | Nine Months Ended September 30, | | | 2026 | | 2025 | | 2026 | | 2025 | | | | | | | | | | | | Product revenue, net | $ | 17,778 | | | $ | — | | | $ | 21,382 | | | $ | — | | | | Less: | | | | | | | | | | Cost of goods sold | 192 | | | — | | | 285 | | | — | | | | External research and development expenses - TV programs, including cost sharing | 43,574 | | | 35,157 | | | 122,457 | | | 119,209 | | | Other research and development expenses, including small molecule programs | 21,145 | | | 25,056 | | | 61,193 | | | 79,403 | | | Personnel related research and development expenses | 41,383 | | | 41,737 | | | 123,317 | | | 122,261 | | | | Total research and development expenses | 106,102 | | | 101,950 | | | 306,967 | | | 320,873 | | | Personnel related selling, general and administrative expenses | 22,502 | | | 22,079 | | | 67,987 | | | 60,932 | | | Other selling, general and administrative expenses | 14,983 | | | 13,405 | | | 39,292 | | | 36,172 | | | | Total selling, general and administrative expenses | 37,485 | | | 35,484 | | | 107,279 | | | 97,104 | | | | Intangible asset amortization | 750 | | | — | | | 1,500 | | | — | | | | Segment operating expenses | 144,529 | | | 137,434 | | | 416,031 | | | 417,977 | | | | | | | | | | | | | Segment loss from operations | (126,751) | | | (137,434) | | | (394,649) | | | (417,977) | | | | Gain on sale of priority review voucher, net | 194,000 | | | — | | | 194,000 | | | — | | | | Segment interest and other income, net | 2,877 | | | 10,532 | | | 14,775 | | | 33,986 | | | | Segment net income (loss) | $ | 70,126 | | | $ | (126,902) | | | $ | (185,874) | | | $ | (383,991) | | |
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