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  <xs:element id="iipr_LoansRecievableLineItems" abstract="true" name="LoansRecievableLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iipr_FinancingReceivableMaximumBorrowing" abstract="false" name="FinancingReceivableMaximumBorrowing" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_PaymentsOfDebtIssuanceCostsAdvisoryFees" abstract="false" name="PaymentsOfDebtIssuanceCostsAdvisoryFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_TermLoan1Member" abstract="true" name="TermLoan1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_TermLoan2Member" abstract="true" name="TermLoan2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_TermLoan3Member" abstract="true" name="TermLoan3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_TermLoan5Member" abstract="true" name="TermLoan5Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DebtInstrumentNumberOfExtensionOptions" abstract="false" name="DebtInstrumentNumberOfExtensionOptions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iipr_DebtInstrumentExtensionTerm" abstract="false" name="DebtInstrumentExtensionTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iipr_DebtInstrumentRestrictiveCovenantsMinimumNetWorth" abstract="false" name="DebtInstrumentRestrictiveCovenantsMinimumNetWorth" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_DebtInstrumentRestrictiveCovenantsMinimumLiquidAssets" abstract="false" name="DebtInstrumentRestrictiveCovenantsMinimumLiquidAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_LoanAndSecurityAgreementMember" abstract="true" name="LoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_IIPLifeScienceCreditFacilityMember" abstract="true" name="IIPLifeScienceCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_LineofCreditFacilityAccordionFeatureIncreaseLimit" abstract="false" name="LineofCreditFacilityAccordionFeatureIncreaseLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_DebtInstrumentCovenantDebtServiceCoverageRatioMinimum" abstract="false" name="DebtInstrumentCovenantDebtServiceCoverageRatioMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iipr_LongTermDebtMaturityAfterYearFour" abstract="false" name="LongTermDebtMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_SellerFinancedNoteMember" abstract="true" name="SellerFinancedNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_A2026OmnibusIncentivePlanMember" abstract="true" name="A2026OmnibusIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_CommitmentsRelatedToImprovementAllowancesMember" abstract="true" name="CommitmentsRelatedToImprovementAllowancesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_AmendedClassActionLawsuitMember" abstract="true" name="AmendedClassActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DerivativeActionLawsuitsMember" abstract="true" name="DerivativeActionLawsuitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DerivativeActionLawsuitMember" abstract="true" name="DerivativeActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_UnfundedCommitmentTotalExposureAmount" abstract="false" name="UnfundedCommitmentTotalExposureAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_CannabisPortfolioMember" abstract="true" name="CannabisPortfolioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_LifeSciencePortfolioMember" abstract="true" name="LifeSciencePortfolioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_PublicOfferingMember" abstract="true" name="PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_UnderwritersOverallotmentOptionMember" abstract="true" name="UnderwritersOverallotmentOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_AreaOfNewLeasesEntered" abstract="false" name="AreaOfNewLeasesEntered" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
