| Schedule of Significant Segment Expenses Regularly Provided to the CODM |
The following table presents certain significant segment expenses that are regularly provided to the CODM (in thousands):
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Three Months Ended September 30, |
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Nine Months Ended September 30, |
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|
2026 |
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2025 |
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|
2026 |
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|
2025 |
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Research and development expenses: |
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GlyphAllo direct research and development expenses |
$ |
10,189 |
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|
$ |
7,698 |
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|
$ |
31,283 |
|
|
$ |
15,757 |
|
GlyphAgo direct research and development expenses |
|
3,400 |
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|
|
4,214 |
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|
|
13,373 |
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|
|
8,185 |
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Glyph2BLSD direct research and development expenses |
|
3,173 |
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|
|
3,241 |
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|
|
5,372 |
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|
|
5,688 |
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Nonclinical and early discovery assets |
|
1,837 |
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|
|
978 |
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|
|
4,190 |
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|
|
2,766 |
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Personnel-related (including non-cash stock-based compensation expense of $1.0 million and $0.6 million for three months ended September 30, 2026 and 2025, respectively and $2.7 million and $1.7 million for nine months ended September 30, 2026 and 2025, respectively) |
|
4,651 |
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|
|
3,822 |
|
|
|
13,981 |
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|
|
10,693 |
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Other indirect research and development expenses |
|
641 |
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|
|
500 |
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|
|
1,740 |
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|
|
1,306 |
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Total research and development expenses |
|
23,891 |
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|
|
20,453 |
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|
|
69,939 |
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|
|
44,395 |
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General and administrative expenses: |
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Personnel-related (including non-cash stock-based compensation expense of $1.5 million and $1.2 million for three months ended September 30, 2026 and 2025, respectively and $39.1 million and $3.5 million for nine months ended September 30, 2026 and 2025, respectively) |
|
3,848 |
|
|
|
3,179 |
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|
|
46,140 |
|
|
|
9,440 |
|
Other general and administrative expenses(1) |
|
2,606 |
|
|
|
1,809 |
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|
|
7,616 |
|
|
|
6,260 |
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Total general and administrative expenses |
|
6,454 |
|
|
|
4,988 |
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|
|
53,756 |
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|
|
15,700 |
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Other segment items(2) |
|
(3,951 |
) |
|
|
(2,897 |
) |
|
|
(9,293 |
) |
|
|
(9,349 |
) |
Net loss |
$ |
26,394 |
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|
$ |
22,544 |
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|
$ |
114,402 |
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|
$ |
50,746 |
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(1)Other general and administrative expenses include professional fees, facilities, depreciation, IT, and other expenses. (2)Other segment items include interest income, net, research and development tax credit, income tax provision, and other income (expense), net.
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