<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fec0d-b326-77fa-b5a4-2bed8b6ac635,g:6bf3c4e0-429b-42f0-972b-4715d2158d16-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.kenvue.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="kvue-20260927.xsd#CondensedConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019fec0d-b48d-7a50-80d8-bc25f622995d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019fec0d-b48d-7745-b520-40943c32d9da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019fec0d-b48d-7a50-80d8-bc25f622995d" xlink:to="loc_us-gaap_StatementTable_019fec0d-b48d-7745-b520-40943c32d9da" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b48d-7dd6-aee8-cb7c913c449b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019fec0d-b48d-7745-b520-40943c32d9da" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b48d-7dd6-aee8-cb7c913c449b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7dd6-aee8-cb7c913c449b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b48d-7dd6-aee8-cb7c913c449b" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7dd6-aee8-cb7c913c449b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b48d-7dd6-aee8-cb7c913c449b" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019fec0d-b48d-7561-a118-b37583ff586a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:to="loc_us-gaap_CommonStockMember_019fec0d-b48d-7561-a118-b37583ff586a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019fec0d-b48d-7958-8022-d4e6572ac06e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019fec0d-b48d-7958-8022-d4e6572ac06e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_019fec0d-b48d-78b8-b590-6cebf45ff46d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:to="loc_us-gaap_TreasuryStockCommonMember_019fec0d-b48d-78b8-b590-6cebf45ff46d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019fec0d-b48d-7550-b215-a33884edd7bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:to="loc_us-gaap_RetainedEarningsMember_019fec0d-b48d-7550-b215-a33884edd7bc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b48d-7b3f-bda5-03dd1ff6d09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b48d-7eff-aa8c-5071c798078f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b48d-7b3f-bda5-03dd1ff6d09c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019fec0d-b48d-7a50-80d8-bc25f622995d" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019fec0d-b48d-70b7-97ea-59cb18586ae3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019fec0d-b48d-70b7-97ea-59cb18586ae3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fec0d-b48d-7ab0-a646-e2ad684ca385" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_StockholdersEquity_019fec0d-b48d-7ab0-a646-e2ad684ca385" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019fec0d-b48d-7e33-9992-e613239d310a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_TreasuryStockCommonShares_019fec0d-b48d-7e33-9992-e613239d310a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fec0d-b48d-7659-885b-bf47d9d1b12d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_NetIncomeLoss_019fec0d-b48d-7659-885b-bf47d9d1b12d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fec0d-b48d-7dc2-9c51-eefdffe26c07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fec0d-b48d-7dc2-9c51-eefdffe26c07" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_019fec0d-b48d-7cce-be94-607be413808c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_DividendsCommonStockCash_019fec0d-b48d-7cce-be94-607be413808c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019fec0d-b48d-7262-95e3-15f4abee7649" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019fec0d-b48d-7262-95e3-15f4abee7649" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019fec0d-b48d-77b4-86bb-a5997f2be119" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019fec0d-b48d-77b4-86bb-a5997f2be119" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019fec0d-b48d-7f6a-ab2e-3ba3ab86dcbc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019fec0d-b48d-7f6a-ab2e-3ba3ab86dcbc" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_019fec0d-b48d-7bda-bb95-b47002c77af6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_019fec0d-b48d-7bda-bb95-b47002c77af6" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019fec0d-b48d-77d1-b425-5d3ec8c690de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019fec0d-b48d-7508-9a42-ee77a0f2e839" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019fec0d-b48d-77d1-b425-5d3ec8c690de" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019fec0d-b48d-7d3b-8b48-7fce99a2a79b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fec0d-b48d-72d6-9fb3-981ee59e740f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019fec0d-b48d-7126-a1e1-a3ce22b914e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019fec0d-b48d-7341-8d08-e5a74087ecee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019fec0d-b48d-7a05-bcb5-1866c6a9c6cd" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019fec0d-b48d-7341-8d08-e5a74087ecee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_NetEconomicBenefitArrangementsMember_019fec0d-b48d-72fe-8614-df38553b6b0f" xlink:href="kvue-20260927.xsd#kvue_NetEconomicBenefitArrangementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019fec0d-b48d-7341-8d08-e5a74087ecee" xlink:to="loc_kvue_NetEconomicBenefitArrangementsMember_019fec0d-b48d-72fe-8614-df38553b6b0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019fec0d-b48d-736b-913e-63d1d58a745c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019fec0d-b48d-736b-913e-63d1d58a745c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019fec0d-b48d-736b-913e-63d1d58a745c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019fec0d-b48d-736b-913e-63d1d58a745c" xlink:to="loc_us-gaap_RelatedPartyDomain_019fec0d-b48d-736b-913e-63d1d58a745c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019fec0d-b48d-7bbe-85a4-b1d0e46b3178" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019fec0d-b48d-736b-913e-63d1d58a745c" xlink:to="loc_us-gaap_RelatedPartyDomain_019fec0d-b48d-7bbe-85a4-b1d0e46b3178" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_019fec0d-b48d-7d1a-8cf0-77c25cec65d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019fec0d-b48d-7bbe-85a4-b1d0e46b3178" xlink:to="loc_us-gaap_ParentMember_019fec0d-b48d-7d1a-8cf0-77c25cec65d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019fec0d-b48d-71e7-b19c-8e195e26a479" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019fec0d-b48d-71e7-b19c-8e195e26a479" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fec0d-b48d-71e7-b19c-8e195e26a479_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019fec0d-b48d-71e7-b19c-8e195e26a479" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fec0d-b48d-71e7-b19c-8e195e26a479_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fec0d-b48d-7a2a-a45a-37ec47df48cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019fec0d-b48d-71e7-b19c-8e195e26a479" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fec0d-b48d-7a2a-a45a-37ec47df48cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_KenvueInc.Member_019fec0d-b48d-7ec1-9716-4057ed9a36b9" xlink:href="kvue-20260927.xsd#kvue_KenvueInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019fec0d-b48d-7a2a-a45a-37ec47df48cd" xlink:to="loc_kvue_KenvueInc.Member_019fec0d-b48d-7ec1-9716-4057ed9a36b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_019fec0d-b48d-7322-977e-4ab501398d5d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019fec0d-b48d-729d-8749-2c93f35e20d5" xlink:to="loc_dei_LegalEntityAxis_019fec0d-b48d-7322-977e-4ab501398d5d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019fec0d-b48d-7322-977e-4ab501398d5d_default" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_019fec0d-b48d-7322-977e-4ab501398d5d" xlink:to="loc_dei_EntityDomain_019fec0d-b48d-7322-977e-4ab501398d5d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019fec0d-b48d-7f38-a66c-eada88f5bfec" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_019fec0d-b48d-7322-977e-4ab501398d5d" xlink:to="loc_dei_EntityDomain_019fec0d-b48d-7f38-a66c-eada88f5bfec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_KimberlyClarkCorporationMember_019fec0d-b48d-764a-bd17-2d58ad684128" xlink:href="kvue-20260927.xsd#kvue_KimberlyClarkCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_019fec0d-b48d-7f38-a66c-eada88f5bfec" xlink:to="loc_kvue_KimberlyClarkCorporationMember_019fec0d-b48d-764a-bd17-2d58ad684128" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019fec0d-b48d-7cb6-8a09-a287b4495e4a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_NumberOfReportableSegments_019fec0d-b48d-7cb6-8a09-a287b4495e4a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019fec0d-b48d-755a-8419-855f917533f1" xlink:href="kvue-20260927.xsd#kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019fec0d-b48d-755a-8419-855f917533f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019fec0d-b48d-746a-92d8-c5667c0b06ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019fec0d-b48d-746a-92d8-c5667c0b06ff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_019fec0d-b48d-79d9-9b3e-96a1444273b6" xlink:href="kvue-20260927.xsd#kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_kvue_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_019fec0d-b48d-79d9-9b3e-96a1444273b6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected_019fec0d-b48d-72ab-a942-56a54bf1a040" xlink:href="kvue-20260927.xsd#kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_kvue_BusinessCombinationAcquireeOwnershipPercentageOfAcquirorExpected_019fec0d-b48d-72ab-a942-56a54bf1a040" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected_019fec0d-b48d-74bf-941f-e9582bb198f7" xlink:href="kvue-20260927.xsd#kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_kvue_BusinessCombinationVotingInterestsAcquiredPercentageExpected_019fec0d-b48d-74bf-941f-e9582bb198f7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fec0d-b48d-7dab-a61a-c3dfe52e786c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019fec0d-b48d-7dab-a61a-c3dfe52e786c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplierFinanceProgramObligationCurrent_019fec0d-b48d-7710-b8d4-9f3ea29ee7c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SupplierFinanceProgramObligationCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_SupplierFinanceProgramObligationCurrent_019fec0d-b48d-7710-b8d4-9f3ea29ee7c0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fec0d-b48d-7a13-8323-4a5a369da337" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fec0d-b48d-7a13-8323-4a5a369da337" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fec0d-b48d-7551-bdb8-e63375ce9e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019fec0d-b48d-7e76-bb0b-a419af5ea508" xlink:to="loc_us-gaap_NetIncomeLoss_019fec0d-b48d-7551-bdb8-e63375ce9e3a" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/DescriptionoftheCompanyandSummaryofSignificantAccountingPoliciesScheduleofSeparationRelatedCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b48d-7622-9469-43484225fdac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b48d-73b2-bebb-50578531a59d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b48d-7622-9469-43484225fdac" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b48d-73b2-bebb-50578531a59d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfExpenseAxis_019fec0d-b48d-789e-ad2c-680dca24aebd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NatureOfExpenseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b48d-73b2-bebb-50578531a59d" xlink:to="loc_us-gaap_NatureOfExpenseAxis_019fec0d-b48d-789e-ad2c-680dca24aebd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-789e-ad2c-680dca24aebd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019fec0d-b48d-789e-ad2c-680dca24aebd" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-789e-ad2c-680dca24aebd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-7139-a0a8-6c216e50dadb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019fec0d-b48d-789e-ad2c-680dca24aebd" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-7139-a0a8-6c216e50dadb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndOtherMember_019fec0d-b48d-778b-988b-a9ea544cdf6a" xlink:href="kvue-20260927.xsd#kvue_InformationTechnologyAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-7139-a0a8-6c216e50dadb" xlink:to="loc_kvue_InformationTechnologyAndOtherMember_019fec0d-b48d-778b-988b-a9ea544cdf6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LegalEntityNameChangeMember_019fec0d-b48d-7785-aa88-046e66963ab2" xlink:href="kvue-20260927.xsd#kvue_LegalEntityNameChangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019fec0d-b48d-7139-a0a8-6c216e50dadb" xlink:to="loc_kvue_LegalEntityNameChangeMember_019fec0d-b48d-7785-aa88-046e66963ab2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SeparationRelatedCosts_019fec0d-b48d-7867-97f4-0417134038c5" xlink:href="kvue-20260927.xsd#kvue_SeparationRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b48d-7622-9469-43484225fdac" xlink:to="loc_kvue_SeparationRelatedCosts_019fec0d-b48d-7867-97f4-0417134038c5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillIntangibleAssetsDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#IntangibleAssetsandGoodwillIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-7b31-8f12-531044a03e61" xlink:href="kvue-20260927.xsd#kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019fec0d-b48d-7bb2-8608-58e9375d0a76" xlink:href="kvue-20260927.xsd#kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-7b31-8f12-531044a03e61" xlink:to="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019fec0d-b48d-7bb2-8608-58e9375d0a76" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7828-b246-2ba17b3edd90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019fec0d-b48d-7bb2-8608-58e9375d0a76" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7828-b246-2ba17b3edd90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7828-b246-2ba17b3edd90_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7828-b246-2ba17b3edd90" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7828-b246-2ba17b3edd90_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7562-8358-e507567af61f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7828-b246-2ba17b3edd90" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7562-8358-e507567af61f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PatentsAndTrademarksMember_019fec0d-b48d-73a3-ae22-80a99ce0b1ac" xlink:href="kvue-20260927.xsd#kvue_PatentsAndTrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7562-8358-e507567af61f" xlink:to="loc_kvue_PatentsAndTrademarksMember_019fec0d-b48d-73a3-ae22-80a99ce0b1ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_019fec0d-b48d-7bee-acc4-4e61b8fb96ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7562-8358-e507567af61f" xlink:to="loc_us-gaap_CustomerRelationshipsMember_019fec0d-b48d-7bee-acc4-4e61b8fb96ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_019fec0d-b48d-7883-a1c7-2fb0780b84ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7562-8358-e507567af61f" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_019fec0d-b48d-7883-a1c7-2fb0780b84ac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7356-b71a-a2e50c304ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_kvue_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable_019fec0d-b48d-7bb2-8608-58e9375d0a76" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7356-b71a-a2e50c304ffa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7356-b71a-a2e50c304ffa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7356-b71a-a2e50c304ffa" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7356-b71a-a2e50c304ffa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7908-a35a-f626a524f285" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_019fec0d-b48d-7356-b71a-a2e50c304ffa" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7908-a35a-f626a524f285" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_019fec0d-b48d-757d-91da-ed442cdb0a28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7908-a35a-f626a524f285" xlink:to="loc_us-gaap_TrademarksMember_019fec0d-b48d-757d-91da-ed442cdb0a28" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_019fec0d-b48d-74ba-9583-f3d1c4bc5bb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_019fec0d-b48d-7908-a35a-f626a524f285" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_019fec0d-b48d-74ba-9583-f3d1c4bc5bb6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019fec0d-b48d-74eb-a105-154e1e77e835" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_kvue_FiniteLivedAndIndefiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-7b31-8f12-531044a03e61" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019fec0d-b48d-74eb-a105-154e1e77e835" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019fec0d-b48d-7e99-aa30-499ad429d382" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019fec0d-b48d-74eb-a105-154e1e77e835" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019fec0d-b48d-7e99-aa30-499ad429d382" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fec0d-b48d-79c7-9e94-d3ea7a8f6592" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019fec0d-b48d-7e99-aa30-499ad429d382" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fec0d-b48d-79c7-9e94-d3ea7a8f6592" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fec0d-b48d-74a2-b40d-b115accac997" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019fec0d-b48d-7e99-aa30-499ad429d382" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fec0d-b48d-74a2-b40d-b115accac997" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fec0d-b48d-7e71-99bb-97b9de0ec615" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019fec0d-b48d-7e99-aa30-499ad429d382" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fec0d-b48d-7e71-99bb-97b9de0ec615" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019fec0d-b48d-76df-8002-b39b3969d511" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019fec0d-b48d-74eb-a105-154e1e77e835" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019fec0d-b48d-76df-8002-b39b3969d511" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fec0d-b48d-741a-8c99-77af99b22042" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019fec0d-b48d-76df-8002-b39b3969d511" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019fec0d-b48d-741a-8c99-77af99b22042" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fec0d-b48d-7278-bc1a-01f6db174633" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwillAbstract_019fec0d-b48d-76df-8002-b39b3969d511" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fec0d-b48d-7278-bc1a-01f6db174633" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fec0d-b48d-7ec6-a4e9-914b46595cea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwillAbstract_019fec0d-b48d-74eb-a105-154e1e77e835" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019fec0d-b48d-7ec6-a4e9-914b46595cea" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#IntangibleAssetsandGoodwillNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019fec0d-b48d-7376-99ad-8477e17e4c91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019fec0d-b48d-7376-99ad-8477e17e4c91" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_019fec0d-b48d-7d50-b070-404d5ff7ad40" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019fec0d-b48d-7376-99ad-8477e17e4c91" xlink:to="loc_us-gaap_ReportingUnitAxis_019fec0d-b48d-7d50-b070-404d5ff7ad40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_019fec0d-b48d-7d50-b070-404d5ff7ad40_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReportingUnitAxis_019fec0d-b48d-7d50-b070-404d5ff7ad40" xlink:to="loc_us-gaap_ReportingUnitDomain_019fec0d-b48d-7d50-b070-404d5ff7ad40_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_019fec0d-b48d-7a4d-8669-0fd8c8eb933e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReportingUnitAxis_019fec0d-b48d-7d50-b070-404d5ff7ad40" xlink:to="loc_us-gaap_ReportingUnitDomain_019fec0d-b48d-7a4d-8669-0fd8c8eb933e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b48d-7a99-85d6-18c0bda7ea45" xlink:href="kvue-20260927.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReportingUnitDomain_019fec0d-b48d-7a4d-8669-0fd8c8eb933e" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b48d-7a99-85d6-18c0bda7ea45" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019fec0d-b48d-7171-8fb1-2f558ec93b13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019fec0d-b48d-7171-8fb1-2f558ec93b13" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fec0d-b48d-7d53-b9e1-668786ceb69d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fec0d-b48d-7d53-b9e1-668786ceb69d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_019fec0d-b48d-7f53-9655-77e3323782c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:to="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_019fec0d-b48d-7f53-9655-77e3323782c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment_019fec0d-b48d-7c95-a20f-dd1e2133118b" xlink:href="kvue-20260927.xsd#kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019fec0d-b48d-754a-bb88-6b9ab78d2155" xlink:to="loc_kvue_ReportingUnitIncreaseInDiscountRateThatWouldYieldImpairment_019fec0d-b48d-7c95-a20f-dd1e2133118b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/IntangibleAssetsandGoodwillGoodwillBySegmentDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#IntangibleAssetsandGoodwillGoodwillBySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/IntangibleAssetsandGoodwillGoodwillBySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_019fec0d-b48e-7289-971e-0df713470850" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_019fec0d-b48e-7045-8a5d-168d5082259d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_019fec0d-b48e-7289-971e-0df713470850" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_019fec0d-b48e-7045-8a5d-168d5082259d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b48e-7c6b-a1a7-2b716c947839" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_019fec0d-b48e-7045-8a5d-168d5082259d" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b48e-7c6b-a1a7-2b716c947839" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b48e-7c6b-a1a7-2b716c947839_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b48e-7c6b-a1a7-2b716c947839" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b48e-7c6b-a1a7-2b716c947839_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b48e-72d0-8463-f93758f82c65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b48e-7c6b-a1a7-2b716c947839" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b48e-72d0-8463-f93758f82c65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019fec0d-b48e-745a-b64a-03d6f669033f" xlink:href="kvue-20260927.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b48e-72d0-8463-f93758f82c65" xlink:to="loc_kvue_SelfCareMember_019fec0d-b48e-745a-b64a-03d6f669033f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b48e-7613-8abb-d2758e8cce43" xlink:href="kvue-20260927.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b48e-72d0-8463-f93758f82c65" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b48e-7613-8abb-d2758e8cce43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019fec0d-b48e-71bb-8c57-48cbd46593be" xlink:href="kvue-20260927.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b48e-72d0-8463-f93758f82c65" xlink:to="loc_kvue_EssentialHealthMember_019fec0d-b48e-71bb-8c57-48cbd46593be" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_019fec0d-b48e-7783-8d5b-2a92f6ee2436" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019fec0d-b48e-7289-971e-0df713470850" xlink:to="loc_us-gaap_GoodwillRollForward_019fec0d-b48e-7783-8d5b-2a92f6ee2436" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fec0d-b48e-7116-a5cb-7c11139a9da4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_019fec0d-b48e-7783-8d5b-2a92f6ee2436" xlink:to="loc_us-gaap_Goodwill_019fec0d-b48e-7116-a5cb-7c11139a9da4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_019fec0d-b48e-7c7c-b848-b62acdfd50e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_019fec0d-b48e-7783-8d5b-2a92f6ee2436" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_019fec0d-b48e-7c7c-b848-b62acdfd50e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fec0d-b48e-7357-b47e-85e8b0b38f22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/BorrowingsLongTermDebtDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#BorrowingsLongTermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/BorrowingsLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019fec0d-b48e-7b80-bf8c-0aa758c19528" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtInstrumentTable_019fec0d-b48e-7b80-bf8c-0aa758c19528" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019fec0d-b48e-7c72-9e63-9a412cded7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019fec0d-b48e-7b80-bf8c-0aa758c19528" xlink:to="loc_us-gaap_DebtInstrumentAxis_019fec0d-b48e-7c72-9e63-9a412cded7b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-7c72-9e63-9a412cded7b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fec0d-b48e-7c72-9e63-9a412cded7b1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-7c72-9e63-9a412cded7b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019fec0d-b48e-7c72-9e63-9a412cded7b1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A535NotesDue2026Member_019fec0d-b48e-7808-b2dc-3270f8b0e0fe" xlink:href="kvue-20260927.xsd#kvue_A535NotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A535NotesDue2026Member_019fec0d-b48e-7808-b2dc-3270f8b0e0fe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A505NotesDue2028Member_019fec0d-b48e-7beb-900d-3df3d45dd438" xlink:href="kvue-20260927.xsd#kvue_A505NotesDue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A505NotesDue2028Member_019fec0d-b48e-7beb-900d-3df3d45dd438" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A500NotesDue2030Member_019fec0d-b48e-73c6-b90b-b36ec4eaf219" xlink:href="kvue-20260927.xsd#kvue_A500NotesDue2030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A500NotesDue2030Member_019fec0d-b48e-73c6-b90b-b36ec4eaf219" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A4.85NotesDue2032Member_019fec0d-b533-78b2-a828-34bd7da8c767" xlink:href="kvue-20260927.xsd#kvue_A4.85NotesDue2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A4.85NotesDue2032Member_019fec0d-b533-78b2-a828-34bd7da8c767" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A490NotesDue2033Member_019fec0d-b533-7ea5-9fe0-3fbf55f05ea6" xlink:href="kvue-20260927.xsd#kvue_A490NotesDue2033Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A490NotesDue2033Member_019fec0d-b533-7ea5-9fe0-3fbf55f05ea6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A510NotesDue2043Member_019fec0d-b533-786b-8558-3c2b0c41aa13" xlink:href="kvue-20260927.xsd#kvue_A510NotesDue2043Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A510NotesDue2043Member_019fec0d-b533-786b-8558-3c2b0c41aa13" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A505NotesDue2053Member_019fec0d-b533-781a-895d-715d312a9593" xlink:href="kvue-20260927.xsd#kvue_A505NotesDue2053Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A505NotesDue2053Member_019fec0d-b533-781a-895d-715d312a9593" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A520NotesDue2063Member_019fec0d-b533-7ee3-8778-8dfe0b77a393" xlink:href="kvue-20260927.xsd#kvue_A520NotesDue2063Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019fec0d-b48e-75e0-a73c-cb134effd303" xlink:to="loc_kvue_A520NotesDue2063Member_019fec0d-b533-7ee3-8778-8dfe0b77a393" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019fec0d-b533-78b9-9dc3-6ea592c481ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019fec0d-b48e-7b80-bf8c-0aa758c19528" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019fec0d-b533-78b9-9dc3-6ea592c481ef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-78b9-9dc3-6ea592c481ef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fec0d-b533-78b9-9dc3-6ea592c481ef" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-78b9-9dc3-6ea592c481ef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-722e-9bd9-6b8861a1f820" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019fec0d-b533-78b9-9dc3-6ea592c481ef" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-722e-9bd9-6b8861a1f820" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_019fec0d-b533-7733-ab9e-b1000db9d5f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-722e-9bd9-6b8861a1f820" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_019fec0d-b533-7733-ab9e-b1000db9d5f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019fec0d-b533-72d1-80a1-c9d12c9ebdc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019fec0d-b533-722e-9bd9-6b8861a1f820" xlink:to="loc_us-gaap_SeniorNotesMember_019fec0d-b533-72d1-80a1-c9d12c9ebdc8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fec0d-b533-738b-9e48-4e20a66a547b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fec0d-b533-738b-9e48-4e20a66a547b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LongTermDebtGrossIncludingLeaseObligation_019fec0d-b533-7f7d-b035-47bef6efcf6f" xlink:href="kvue-20260927.xsd#kvue_LongTermDebtGrossIncludingLeaseObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_kvue_LongTermDebtGrossIncludingLeaseObligation_019fec0d-b533-7f7d-b035-47bef6efcf6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fec0d-b533-71ee-a1a5-a8848275044e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fec0d-b533-71ee-a1a5-a8848275044e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_019fec0d-b533-72ac-ba80-392c4353bbd9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_019fec0d-b533-72ac-ba80-392c4353bbd9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019fec0d-b533-76d9-b6bc-e6e6c9a51bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_LongTermDebtCurrent_019fec0d-b533-76d9-b6bc-e6e6c9a51bb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities_019fec0d-b533-7a30-90fc-c66693961e21" xlink:href="kvue-20260927.xsd#kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_kvue_LongTermDebtAndLeaseObligationExcludingCurrentMaturities_019fec0d-b533-7a30-90fc-c66693961e21" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesCurrent_019fec0d-b533-79ab-b8c0-cd828c5285df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_SeniorNotesCurrent_019fec0d-b533-79ab-b8c0-cd828c5285df" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaper_019fec0d-b533-7ec8-aa27-5d3de3b4214d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaper"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_CommercialPaper_019fec0d-b533-7ec8-aa27-5d3de3b4214d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent_019fec0d-b533-7380-a7cd-022082f85887" xlink:href="kvue-20260927.xsd#kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_kvue_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetCurrent_019fec0d-b533-7380-a7cd-022082f85887" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermBorrowings_019fec0d-b533-7963-94f4-2e23a7f914fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_OtherShortTermBorrowings_019fec0d-b533-7963-94f4-2e23a7f914fb" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_019fec0d-b533-706a-856a-d203bfbd7f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtCurrent_019fec0d-b533-706a-856a-d203bfbd7f2e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019fec0d-b533-7856-9375-e50bdd55c9bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019fec0d-b533-7856-9375-e50bdd55c9bc" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fec0d-b533-7ec3-8344-0728f1a6f72e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019fec0d-b533-7ec3-8344-0728f1a6f72e" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019fec0d-b533-712a-954c-1a9fd99f8eac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019fec0d-b533-7760-b296-41e7043eb4bf" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019fec0d-b533-712a-954c-1a9fd99f8eac" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossComponentsofAOCIDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#AccumulatedOtherComprehensiveLossComponentsofAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossComponentsofAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7b2c-bc2b-1a443dc5a1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7af8-97a4-07ad91829fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7b2c-bc2b-1a443dc5a1ea" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7af8-97a4-07ad91829fe9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7d5f-9c1f-d905fc01c927" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7af8-97a4-07ad91829fe9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7d5f-9c1f-d905fc01c927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7d5f-9c1f-d905fc01c927_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7d5f-9c1f-d905fc01c927" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7d5f-9c1f-d905fc01c927_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7fb2-b203-c004edbb60d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7d5f-9c1f-d905fc01c927" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7fb2-b203-c004edbb60d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b533-7ba0-a13d-3e4e90872b35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7fb2-b203-c004edbb60d2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b533-7ba0-a13d-3e4e90872b35" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019fec0d-b533-74ba-ab6a-aa9e170da49e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b533-7ba0-a13d-3e4e90872b35" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019fec0d-b533-74ba-ab6a-aa9e170da49e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019fec0d-b533-7dd6-b489-823f43d60a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b533-7ba0-a13d-3e4e90872b35" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019fec0d-b533-7dd6-b489-823f43d60a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019fec0d-b533-71ba-839e-f0cc2967fb80" xlink:href="kvue-20260927.xsd#kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019fec0d-b533-7ba0-a13d-3e4e90872b35" xlink:to="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019fec0d-b533-71ba-839e-f0cc2967fb80" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7b2c-bc2b-1a443dc5a1ea" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fec0d-b533-7953-bc87-0c8041ee7eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:to="loc_us-gaap_StockholdersEquity_019fec0d-b533-7953-bc87-0c8041ee7eaa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019fec0d-b533-74f4-bcbe-862118e1b32e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019fec0d-b533-74f4-bcbe-862118e1b32e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019fec0d-b533-7037-baee-a496ce1a1416" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019fec0d-b533-7037-baee-a496ce1a1416" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fec0d-b533-7358-9f46-9364bff0f7e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019fec0d-b533-7460-ac97-71b5e307635d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fec0d-b533-7358-9f46-9364bff0f7e8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fec0d-b533-7b75-b3dc-ebdfa8b7b0f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/AccumulatedOtherComprehensiveLossProvisionbenefitforTaxesAllocatedtoAOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7dad-946b-28fd773bdf8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7192-afb4-e8fd3e31be5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7dad-946b-28fd773bdf8a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7192-afb4-e8fd3e31be5f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7281-a20e-51f5e5f6d84b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019fec0d-b533-7192-afb4-e8fd3e31be5f" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7281-a20e-51f5e5f6d84b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7281-a20e-51f5e5f6d84b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7281-a20e-51f5e5f6d84b" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b533-7281-a20e-51f5e5f6d84b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019fec0d-b533-75bd-8641-57880106df56" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019fec0d-b533-7281-a20e-51f5e5f6d84b" xlink:to="loc_us-gaap_EquityComponentDomain_019fec0d-b533-75bd-8641-57880106df56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019fec0d-b533-7c93-91ee-694801e55016" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b533-75bd-8641-57880106df56" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019fec0d-b533-7c93-91ee-694801e55016" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019fec0d-b533-7899-8b57-725cf0371a10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b533-75bd-8641-57880106df56" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_019fec0d-b533-7899-8b57-725cf0371a10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019fec0d-b533-77c3-a7bd-1855cab5c640" xlink:href="kvue-20260927.xsd#kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019fec0d-b533-75bd-8641-57880106df56" xlink:to="loc_kvue_AccumulatedGainLossNetDerivativesAndHedgesParentMember_019fec0d-b533-77c3-a7bd-1855cab5c640" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_019fec0d-b533-764f-a15b-376448dde71f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019fec0d-b533-7dad-946b-28fd773bdf8a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_019fec0d-b533-764f-a15b-376448dde71f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#StockBasedCompensationStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019fec0d-b533-7b45-aa9e-49ecde09bfe5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019fec0d-b533-7b45-aa9e-49ecde09bfe5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-76bb-a6d6-cd98ca94e34a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019fec0d-b533-7b45-aa9e-49ecde09bfe5" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-76bb-a6d6-cd98ca94e34a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fec0d-b533-7371-aea4-6c53c85066c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fec0d-b533-7371-aea4-6c53c85066c1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails_1" xlink:type="simple" xlink:href="kvue-20260927.xsd#StockBasedCompensationStockBasedCompensationExpenseDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/StockBasedCompensationStockBasedCompensationExpenseDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019fec0d-b533-7b45-aa9e-49ecde09bfe5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019fec0d-b533-7b45-aa9e-49ecde09bfe5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fec0d-b533-7371-aea4-6c53c85066c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019fec0d-b533-721e-9ad8-dea49ec693bb" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019fec0d-b533-7371-aea4-6c53c85066c1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RelationshipwithJJScheduleofBalanceswithJJAffiliatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7c7b-a43a-8166a48678ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7c7b-a43a-8166a48678ee" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019fec0d-b533-719d-85c6-c8d990346881" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7c7b-a43a-8166a48678ee" xlink:to="loc_srt_CounterpartyNameAxis_019fec0d-b533-719d-85c6-c8d990346881" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-719d-85c6-c8d990346881_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019fec0d-b533-719d-85c6-c8d990346881" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-719d-85c6-c8d990346881_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7a6a-ac00-d2d5a75f4b7d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019fec0d-b533-719d-85c6-c8d990346881" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7a6a-ac00-d2d5a75f4b7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_JohnsonJohnsonMember_019fec0d-b533-719d-b7c2-555e40b2b762" xlink:href="kvue-20260927.xsd#kvue_JohnsonJohnsonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7a6a-ac00-d2d5a75f4b7d" xlink:to="loc_kvue_JohnsonJohnsonMember_019fec0d-b533-719d-b7c2-555e40b2b762" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fec0d-b533-7adf-81ec-99bb3142b0ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:to="loc_us-gaap_Liabilities_019fec0d-b533-7adf-81ec-99bb3142b0ff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fec0d-b533-7798-b20a-c2ebe276ea24" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:to="loc_us-gaap_Assets_019fec0d-b533-7798-b20a-c2ebe276ea24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fec0d-b533-7c73-8a41-f4a982eafb0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fec0d-b533-7c73-8a41-f4a982eafb0f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements_019fec0d-b533-75f6-bd54-c116866d43ef" xlink:href="kvue-20260927.xsd#kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7037-9565-0e644eacec1e" xlink:to="loc_kvue_SellingGeneralAndAdministrativeExpenseNetOfCostReimbursements_019fec0d-b533-75f6-bd54-c116866d43ef" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RelationshipwithJJNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RelationshipwithJJNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RelationshipwithJJNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7914-9973-d9c5d3ea1eb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7fd0-bb2b-6064cf9c2c15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7914-9973-d9c5d3ea1eb7" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7fd0-bb2b-6064cf9c2c15" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019fec0d-b533-7b42-b128-0af10f6a8c79" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019fec0d-b533-7fd0-bb2b-6064cf9c2c15" xlink:to="loc_srt_CounterpartyNameAxis_019fec0d-b533-7b42-b128-0af10f6a8c79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7b42-b128-0af10f6a8c79_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019fec0d-b533-7b42-b128-0af10f6a8c79" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7b42-b128-0af10f6a8c79_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7e4d-9d71-3045f150b554" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019fec0d-b533-7b42-b128-0af10f6a8c79" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7e4d-9d71-3045f150b554" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_JohnsonJohnsonMember_019fec0d-b533-7e73-a405-56afeb830f33" xlink:href="kvue-20260927.xsd#kvue_JohnsonJohnsonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019fec0d-b533-7e4d-9d71-3045f150b554" xlink:to="loc_kvue_JohnsonJohnsonMember_019fec0d-b533-7e73-a405-56afeb830f33" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_TransitionServicesAgreementServicesExited_019fec0d-b533-7aa9-876f-94792525a878" xlink:href="kvue-20260927.xsd#kvue_TransitionServicesAgreementServicesExited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019fec0d-b533-7914-9973-d9c5d3ea1eb7" xlink:to="loc_kvue_TransitionServicesAgreementServicesExited_019fec0d-b533-7aa9-876f-94792525a878" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-717a-b26f-f3002fd2dc88_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-717a-b26f-f3002fd2dc88_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-71d0-9669-5343cdca29f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-71d0-9669-5343cdca29f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-79a6-a9d2-56deea89f049" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-79a6-a9d2-56deea89f049" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7527-8419-a1d0cd719b9c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7527-8419-a1d0cd719b9c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019fec0d-b533-737e-aaa6-8ab53cfc2728" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019fec0d-b533-737e-aaa6-8ab53cfc2728" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019fec0d-b533-7f0a-af36-58786adc3572" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019fec0d-b533-7f0a-af36-58786adc3572" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019fec0d-b533-7063-953a-7bc64bb0b2f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019fec0d-b533-7063-953a-7bc64bb0b2f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019fec0d-b533-71d2-aefa-d3264e5e728c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019fec0d-b533-71d2-aefa-d3264e5e728c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentDetailAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:to="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019fec0d-b533-7c52-bc94-32ca6c902412" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019fec0d-b533-7c52-bc94-32ca6c902412" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019fec0d-b533-72d4-a8cd-d95f61a8d192" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019fec0d-b533-72d4-a8cd-d95f61a8d192" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7a10-a331-bfd17473a226" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7a10-a331-bfd17473a226" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesatFairValueDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-717a-b26f-f3002fd2dc88_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-717a-b26f-f3002fd2dc88_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-717a-b26f-f3002fd2dc88" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-71d0-9669-5343cdca29f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-71d0-9669-5343cdca29f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-79a6-a9d2-56deea89f049" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7bc2-9eed-b5207820daf9" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-79a6-a9d2-56deea89f049" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019fec0d-b533-7afb-84ad-338a94466d59" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7527-8419-a1d0cd719b9c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7527-8419-a1d0cd719b9c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019fec0d-b533-7527-8419-a1d0cd719b9c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019fec0d-b533-737e-aaa6-8ab53cfc2728" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019fec0d-b533-737e-aaa6-8ab53cfc2728" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019fec0d-b533-7f0a-af36-58786adc3572" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019fec0d-b533-7f0a-af36-58786adc3572" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019fec0d-b533-7063-953a-7bc64bb0b2f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019fec0d-b533-7dba-b06f-c318bf6ca0ab" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019fec0d-b533-7063-953a-7bc64bb0b2f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentDetailAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_019fec0d-b533-7bcd-9c80-bcd488f2516e" xlink:to="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019fec0d-b533-7c52-bc94-32ca6c902412" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAssetsAtFairValue_019fec0d-b533-7c52-bc94-32ca6c902412" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019fec0d-b533-72d4-a8cd-d95f61a8d192" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesLiabilitiesAtFairValue_019fec0d-b533-72d4-a8cd-d95f61a8d192" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7a10-a331-bfd17473a226" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentDetailAbstract_019fec0d-b533-7e59-89c1-89801ba291ed" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7a10-a331-bfd17473a226" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-778c-b109-5aa7ce094a14" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-778c-b109-5aa7ce094a14" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-778c-b109-5aa7ce094a14" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7a7c-8f27-1343d638df0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7a0a-bb2b-28fc3fd4cfd0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7a7c-8f27-1343d638df0b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-77ed-81bd-96aeeb5222d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7a7c-8f27-1343d638df0b" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-77ed-81bd-96aeeb5222d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019fec0d-b533-7458-b518-3752dc91c7ec" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-778c-b109-5aa7ce094a14" xlink:to="loc_srt_RangeAxis_019fec0d-b533-7458-b518-3752dc91c7ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fec0d-b533-7458-b518-3752dc91c7ec_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019fec0d-b533-7458-b518-3752dc91c7ec" xlink:to="loc_srt_RangeMember_019fec0d-b533-7458-b518-3752dc91c7ec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019fec0d-b533-7639-975d-2da993b8ea6b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019fec0d-b533-7458-b518-3752dc91c7ec" xlink:to="loc_srt_RangeMember_019fec0d-b533-7639-975d-2da993b8ea6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019fec0d-b533-7400-a319-e52d04f0e476" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fec0d-b533-7639-975d-2da993b8ea6b" xlink:to="loc_srt_MinimumMember_019fec0d-b533-7400-a319-e52d04f0e476" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019fec0d-b533-79fb-8fdb-857d61199a07" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019fec0d-b533-7639-975d-2da993b8ea6b" xlink:to="loc_srt_MaximumMember_019fec0d-b533-79fb-8fdb-857d61199a07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-7e87-aecb-101355525b74" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-778c-b109-5aa7ce094a14" xlink:to="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-7e87-aecb-101355525b74" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7e87-aecb-101355525b74_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-7e87-aecb-101355525b74" xlink:to="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7e87-aecb-101355525b74_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7d74-b671-2bfd756ec09e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-7e87-aecb-101355525b74" xlink:to="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7d74-b671-2bfd756ec09e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_019fec0d-b533-7a64-a8b6-c0e9862099e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7d74-b671-2bfd756ec09e" xlink:to="loc_us-gaap_NondesignatedMember_019fec0d-b533-7a64-a8b6-c0e9862099e2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019fec0d-b533-73f3-9328-3faa8f556bcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_019fec0d-b533-73f3-9328-3faa8f556bcb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019fec0d-b533-75be-8987-76a523562166" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019fec0d-b533-75be-8987-76a523562166" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_019fec0d-b533-74d3-851c-e0a42e90789d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:to="loc_us-gaap_DerivativeTermOfContract_019fec0d-b533-74d3-851c-e0a42e90789d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7033-a91b-ffa48eed99f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7701-85fc-b55398972947" xlink:to="loc_us-gaap_DerivativeInstrumentsInHedgesAtFairValueNet_019fec0d-b533-7033-a91b-ffa48eed99f8" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsNotionalAmountDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsNotionalAmountDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsNotionalAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-73e7-8e45-24a89c30ffe4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-77b7-aa7a-3e309113d4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-73e7-8e45-24a89c30ffe4" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-77b7-aa7a-3e309113d4a2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-729a-ba20-084a2d174b91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-77b7-aa7a-3e309113d4a2" xlink:to="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-729a-ba20-084a2d174b91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-729a-ba20-084a2d174b91_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-729a-ba20-084a2d174b91" xlink:to="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-729a-ba20-084a2d174b91_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7110-9bf6-fdafe01e8eec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_019fec0d-b533-729a-ba20-084a2d174b91" xlink:to="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7110-9bf6-fdafe01e8eec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019fec0d-b533-7420-9de7-d1535378ad7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7110-9bf6-fdafe01e8eec" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019fec0d-b533-7420-9de7-d1535378ad7b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_019fec0d-b533-79de-ab87-1ef54f323848" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019fec0d-b533-7110-9bf6-fdafe01e8eec" xlink:to="loc_us-gaap_NondesignatedMember_019fec0d-b533-79de-ab87-1ef54f323848" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019fec0d-b533-7c1d-a377-8edffe5132bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-77b7-aa7a-3e309113d4a2" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019fec0d-b533-7c1d-a377-8edffe5132bd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c1d-a377-8edffe5132bd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019fec0d-b533-7c1d-a377-8edffe5132bd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c1d-a377-8edffe5132bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c3b-bc6f-7908a65baf6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019fec0d-b533-7c1d-a377-8edffe5132bd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c3b-bc6f-7908a65baf6d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_019fec0d-b533-7d02-8f58-b2ff26593ab9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c3b-bc6f-7908a65baf6d" xlink:to="loc_us-gaap_CashFlowHedgingMember_019fec0d-b533-7d02-8f58-b2ff26593ab9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_019fec0d-b533-79e5-98c7-1c8e61a52f9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c3b-bc6f-7908a65baf6d" xlink:to="loc_us-gaap_FairValueHedgingMember_019fec0d-b533-79e5-98c7-1c8e61a52f9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_019fec0d-b533-7605-b42f-b062110efdc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019fec0d-b533-7c3b-bc6f-7908a65baf6d" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_019fec0d-b533-7605-b42f-b062110efdc4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7118-9361-1b105711e1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-77b7-aa7a-3e309113d4a2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7118-9361-1b105711e1a2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7118-9361-1b105711e1a2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7118-9361-1b105711e1a2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7118-9361-1b105711e1a2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75dc-9c2b-bec55c87e79c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7118-9361-1b105711e1a2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75dc-9c2b-bec55c87e79c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-7f1a-b6c4-670d9bbbd95a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75dc-9c2b-bec55c87e79c" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019fec0d-b533-7f1a-b6c4-670d9bbbd95a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-7e9a-a37b-9c8ae49dfd7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75dc-9c2b-bec55c87e79c" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_019fec0d-b533-7e9a-a37b-9c8ae49dfd7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_019fec0d-b533-7b51-8e79-1ae0e15880ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-73e7-8e45-24a89c30ffe4" xlink:to="loc_us-gaap_DerivativeNotionalAmount_019fec0d-b533-7b51-8e79-1ae0e15880ae" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-7008-a601-d0f2a7fb0e44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-7008-a601-d0f2a7fb0e44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7e10-a899-b2390968f860_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7e10-a899-b2390968f860_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019fec0d-b533-7931-ac96-1ce2445e24d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019fec0d-b533-7931-ac96-1ce2445e24d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7aee-9b0d-4c5323cc5f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7aee-9b0d-4c5323cc5f1b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019fec0d-b533-76a9-98a2-a9e66d8d6a16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019fec0d-b533-76a9-98a2-a9e66d8d6a16" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonForwardForeignExchangeContractsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-701f-bacb-496acf63322c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7e10-a899-b2390968f860_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7e10-a899-b2390968f860_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-7e10-a899-b2390968f860" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019fec0d-b533-7931-ac96-1ce2445e24d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-7368-b1f3-c242b4b71c5b" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019fec0d-b533-7931-ac96-1ce2445e24d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7aee-9b0d-4c5323cc5f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7aee-9b0d-4c5323cc5f1b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019fec0d-b533-76a9-98a2-a9e66d8d6a16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-7c7f-80a6-224b8730de0f" xlink:to="loc_us-gaap_ForeignCurrencyCashFlowHedgeGainLossReclassifiedToEarningsNet_019fec0d-b533-76a9-98a2-a9e66d8d6a16" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsSummaryofGainsandLossesonCrossCurrencySwapsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019fec0d-b533-70af-886c-69187cf22b94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019fec0d-b533-7089-b5ed-42361b676ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019fec0d-b533-70af-886c-69187cf22b94" xlink:to="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019fec0d-b533-7089-b5ed-42361b676ad2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-70eb-93a6-543d5e0c7ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019fec0d-b533-7089-b5ed-42361b676ad2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-70eb-93a6-543d5e0c7ad6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-70eb-93a6-543d5e0c7ad6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-70eb-93a6-543d5e0c7ad6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-70eb-93a6-543d5e0c7ad6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75f4-8920-a455bc7c099e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019fec0d-b533-70eb-93a6-543d5e0c7ad6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75f4-8920-a455bc7c099e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrencySwapMember_019fec0d-b533-7e19-8d51-e5a943d48a86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CurrencySwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019fec0d-b533-75f4-8920-a455bc7c099e" xlink:to="loc_us-gaap_CurrencySwapMember_019fec0d-b533-7e19-8d51-e5a943d48a86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7ece-bfbb-4532c45ebfc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019fec0d-b533-70af-886c-69187cf22b94" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019fec0d-b533-7ece-bfbb-4532c45ebfc5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsActivityDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-7852-a625-c3a8235862c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-7852-a625-c3a8235862c4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-7f11-a6fa-d6301ced650e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_019fec0d-b533-7852-a625-c3a8235862c4" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019fec0d-b533-7f11-a6fa-d6301ced650e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019fec0d-b533-757e-b60e-ea0e3e8272a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019fec0d-b533-757e-b60e-ea0e3e8272a4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails_1" xlink:type="simple" xlink:href="kvue-20260927.xsd#FairValueMeasurementsActivityDetails_1"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/FairValueMeasurementsActivityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_019fec0d-b533-7852-a625-c3a8235862c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:to="loc_us-gaap_DerivativeTable_019fec0d-b533-7852-a625-c3a8235862c4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019fec0d-b533-757e-b60e-ea0e3e8272a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019fec0d-b533-71af-a0c1-04b05e4fd3f3" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_019fec0d-b533-757e-b60e-ea0e3e8272a4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessProductCategoriesasaPercentofNetSalesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7df0-97e4-def1c810fda4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7df0-97e4-def1c810fda4" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_019fec0d-b533-75aa-af9b-43b921c38838" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_019fec0d-b533-75aa-af9b-43b921c38838" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019fec0d-b533-75aa-af9b-43b921c38838_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019fec0d-b533-75aa-af9b-43b921c38838" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019fec0d-b533-75aa-af9b-43b921c38838_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019fec0d-b533-7405-ba24-378c32dfe653" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019fec0d-b533-75aa-af9b-43b921c38838" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019fec0d-b533-7405-ba24-378c32dfe653" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductConcentrationRiskMember_019fec0d-b533-771a-b255-7b355c168d26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_019fec0d-b533-7405-ba24-378c32dfe653" xlink:to="loc_us-gaap_ProductConcentrationRiskMember_019fec0d-b533-771a-b255-7b355c168d26" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019fec0d-b533-79b2-8bd1-751fd9960195" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019fec0d-b533-79b2-8bd1-751fd9960195" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019fec0d-b533-79b2-8bd1-751fd9960195_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019fec0d-b533-79b2-8bd1-751fd9960195" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019fec0d-b533-79b2-8bd1-751fd9960195_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019fec0d-b533-73bd-bdd1-d04ae82a4bce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019fec0d-b533-79b2-8bd1-751fd9960195" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019fec0d-b533-73bd-bdd1-d04ae82a4bce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_019fec0d-b533-7db7-9936-26c4f9d3e44b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019fec0d-b533-73bd-bdd1-d04ae82a4bce" xlink:to="loc_us-gaap_SalesRevenueNetMember_019fec0d-b533-7db7-9936-26c4f9d3e44b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019fec0d-b533-7d31-a075-593087f924e7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:to="loc_srt_ProductOrServiceAxis_019fec0d-b533-7d31-a075-593087f924e7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7d31-a075-593087f924e7_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019fec0d-b533-7d31-a075-593087f924e7" xlink:to="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7d31-a075-593087f924e7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019fec0d-b533-7d31-a075-593087f924e7" xlink:to="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_CoughColdAndAllergyMember_019fec0d-b533-7ac1-a06b-fc63befcf38b" xlink:href="kvue-20260927.xsd#kvue_CoughColdAndAllergyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_CoughColdAndAllergyMember_019fec0d-b533-7ac1-a06b-fc63befcf38b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PainCareMember_019fec0d-b533-7684-bd1f-789ab9cc5897" xlink:href="kvue-20260927.xsd#kvue_PainCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_PainCareMember_019fec0d-b533-7684-bd1f-789ab9cc5897" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OtherSelfCareMember_019fec0d-b533-75eb-acf1-87cb09bb6f37" xlink:href="kvue-20260927.xsd#kvue_OtherSelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_OtherSelfCareMember_019fec0d-b533-75eb-acf1-87cb09bb6f37" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FaceAndBodyCareMember_019fec0d-b533-7302-aef8-c6c0838a12c4" xlink:href="kvue-20260927.xsd#kvue_FaceAndBodyCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_FaceAndBodyCareMember_019fec0d-b533-7302-aef8-c6c0838a12c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_HairSunAndOtherMember_019fec0d-b533-7a8b-950b-fe5bc1ef151c" xlink:href="kvue-20260927.xsd#kvue_HairSunAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_HairSunAndOtherMember_019fec0d-b533-7a8b-950b-fe5bc1ef151c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OralCareMember_019fec0d-b533-704d-a0b6-2d4fcb073150" xlink:href="kvue-20260927.xsd#kvue_OralCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_OralCareMember_019fec0d-b533-704d-a0b6-2d4fcb073150" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_BabyCareMember_019fec0d-b533-715c-b65a-4f4ea6970c70" xlink:href="kvue-20260927.xsd#kvue_BabyCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_BabyCareMember_019fec0d-b533-715c-b65a-4f4ea6970c70" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_OtherEssentialHealthMember_019fec0d-b533-707f-87a9-e7eb91b37d7e" xlink:href="kvue-20260927.xsd#kvue_OtherEssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019fec0d-b533-7ee2-bfe4-ddf4ab2d1dca" xlink:to="loc_kvue_OtherEssentialHealthMember_019fec0d-b533-707f-87a9-e7eb91b37d7e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7137-baac-0423548ecd4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7852-b031-6c01bb27df75" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7137-baac-0423548ecd4c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7137-baac-0423548ecd4c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7137-baac-0423548ecd4c" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7137-baac-0423548ecd4c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7a09-9610-1bd661680cb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7137-baac-0423548ecd4c" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7a09-9610-1bd661680cb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019fec0d-b533-7f8e-9a26-50c3b90eb956" xlink:href="kvue-20260927.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7a09-9610-1bd661680cb5" xlink:to="loc_kvue_SelfCareMember_019fec0d-b533-7f8e-9a26-50c3b90eb956" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-792b-ae25-8c1466c4ae54" xlink:href="kvue-20260927.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7a09-9610-1bd661680cb5" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-792b-ae25-8c1466c4ae54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019fec0d-b533-7812-bd80-d20d5acabe70" xlink:href="kvue-20260927.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7a09-9610-1bd661680cb5" xlink:to="loc_kvue_EssentialHealthMember_019fec0d-b533-7812-bd80-d20d5acabe70" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_019fec0d-b533-7298-95b7-38f4ef98aadf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7df0-97e4-def1c810fda4" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_019fec0d-b533-7298-95b7-38f4ef98aadf" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessSegmentNetSalesDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#SegmentsofBusinessSegmentNetSalesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessSegmentNetSalesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7551-a493-e89b8c019793" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7bcc-9786-68dd04dd4cd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7551-a493-e89b8c019793" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7bcc-9786-68dd04dd4cd2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7770-abc2-c9fa8e798cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7bcc-9786-68dd04dd4cd2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7770-abc2-c9fa8e798cb4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7770-abc2-c9fa8e798cb4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7770-abc2-c9fa8e798cb4" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7770-abc2-c9fa8e798cb4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7333-bb8f-f6340bde594a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7770-abc2-c9fa8e798cb4" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7333-bb8f-f6340bde594a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019fec0d-b533-75d0-acc9-ce92719d048f" xlink:href="kvue-20260927.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7333-bb8f-f6340bde594a" xlink:to="loc_kvue_SelfCareMember_019fec0d-b533-75d0-acc9-ce92719d048f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-7e90-b145-3688e29bbee2" xlink:href="kvue-20260927.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7333-bb8f-f6340bde594a" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-7e90-b145-3688e29bbee2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019fec0d-b533-7fb1-91f3-9cf49ee1ef6f" xlink:href="kvue-20260927.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7333-bb8f-f6340bde594a" xlink:to="loc_kvue_EssentialHealthMember_019fec0d-b533-7fb1-91f3-9cf49ee1ef6f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_019fec0d-b533-7721-9fc9-758dfc936eda" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-7bcc-9786-68dd04dd4cd2" xlink:to="loc_srt_ConsolidationItemsAxis_019fec0d-b533-7721-9fc9-758dfc936eda" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019fec0d-b533-7721-9fc9-758dfc936eda_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_019fec0d-b533-7721-9fc9-758dfc936eda" xlink:to="loc_srt_ConsolidationItemsDomain_019fec0d-b533-7721-9fc9-758dfc936eda_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_019fec0d-b533-7974-9403-66185ee9c49f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_019fec0d-b533-7721-9fc9-758dfc936eda" xlink:to="loc_srt_ConsolidationItemsDomain_019fec0d-b533-7974-9403-66185ee9c49f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_019fec0d-b533-759b-a5b4-61e355158731" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_019fec0d-b533-7974-9403-66185ee9c49f" xlink:to="loc_us-gaap_OperatingSegmentsMember_019fec0d-b533-759b-a5b4-61e355158731" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationRevenueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7551-a493-e89b8c019793" xlink:to="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fec0d-b533-7932-9910-f2c67a47a970" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fec0d-b533-7932-9910-f2c67a47a970" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_CostOfGoodsAndServicesSoldAdjusted_019fec0d-b533-701d-83d8-73728cf3d4fc" xlink:href="kvue-20260927.xsd#kvue_CostOfGoodsAndServicesSoldAdjusted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_CostOfGoodsAndServicesSoldAdjusted_019fec0d-b533-701d-83d8-73728cf3d4fc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019fec0d-b533-7dcc-9dcb-e8fbf2981829" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019fec0d-b533-7dcc-9dcb-e8fbf2981829" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_AdjustedOperatingIncome_019fec0d-b533-7e85-8cac-f21223c4400d" xlink:href="kvue-20260927.xsd#kvue_AdjustedOperatingIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_AdjustedOperatingIncome_019fec0d-b533-7e85-8cac-f21223c4400d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019fec0d-b533-75fb-b77b-508893ddf8bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_Depreciation_019fec0d-b533-75fb-b77b-508893ddf8bd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fec0d-b533-7b23-813c-fe30c2c292bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fec0d-b533-7b23-813c-fe30c2c292bf" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SeparationRelatedCosts_019fec0d-b533-7754-889e-1ff5d981aa88" xlink:href="kvue-20260927.xsd#kvue_SeparationRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_SeparationRelatedCosts_019fec0d-b533-7754-889e-1ff5d981aa88" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringAndOperatingModelOptimizationInitiatives_019fec0d-b533-7d30-b67e-11ac2a339b80" xlink:href="kvue-20260927.xsd#kvue_RestructuringAndOperatingModelOptimizationInitiatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_RestructuringAndOperatingModelOptimizationInitiatives_019fec0d-b533-7d30-b67e-11ac2a339b80" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_IncomeFromConversionOfShareBasedAwards_019fec0d-b533-73aa-a588-853811c866ee" xlink:href="kvue-20260927.xsd#kvue_IncomeFromConversionOfShareBasedAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_IncomeFromConversionOfShareBasedAwards_019fec0d-b533-73aa-a588-853811c866ee" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_FoundersShareBasedAwardsExpense_019fec0d-b533-7b0f-a3e6-8345444927de" xlink:href="kvue-20260927.xsd#kvue_FoundersShareBasedAwardsExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_FoundersShareBasedAwardsExpense_019fec0d-b533-7b0f-a3e6-8345444927de" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_PendingTransactionAndOtherRelatedCosts_019fec0d-b533-7cab-be2a-3cb4e3df338e" xlink:href="kvue-20260927.xsd#kvue_PendingTransactionAndOtherRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_PendingTransactionAndOtherRelatedCosts_019fec0d-b533-7cab-be2a-3cb4e3df338e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SaleAndLeasebackTransactionRelatedExpense_019fec0d-b533-7a16-aced-d3e29d7f6d90" xlink:href="kvue-20260927.xsd#kvue_SaleAndLeasebackTransactionRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_kvue_SaleAndLeasebackTransactionRelatedExpense_019fec0d-b533-7a16-aced-d3e29d7f6d90" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_019fec0d-b533-75bc-bd03-8de3832cdbb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_019fec0d-b533-75bc-bd03-8de3832cdbb3" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherGeneralExpense_019fec0d-b533-7bf3-82c9-04effd380416" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherGeneralExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_OtherGeneralExpense_019fec0d-b533-7bf3-82c9-04effd380416" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fec0d-b533-756f-af99-c59cc93aad7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fec0d-b533-756f-af99-c59cc93aad7f" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fec0d-b533-7975-9970-70b24b0e96e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019fec0d-b533-7975-9970-70b24b0e96e2" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fec0d-b533-7c7f-bdb7-6c36d2590ac9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019fec0d-b533-7c7f-bdb7-6c36d2590ac9" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fec0d-b533-75a8-adb7-83550c5fded8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationRevenueAbstract_019fec0d-b533-70f5-98c7-73c269cb534b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fec0d-b533-75a8-adb7-83550c5fded8" xlink:type="arc" order="18"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/SegmentsofBusinessDepreciationandAmortizationbySegmentDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#SegmentsofBusinessDepreciationandAmortizationbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/SegmentsofBusinessDepreciationandAmortizationbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7999-b685-220629353b72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-71bb-8ddf-37613ee87b35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7999-b685-220629353b72" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-71bb-8ddf-37613ee87b35" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7598-a57b-8e3e510c51c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019fec0d-b533-71bb-8ddf-37613ee87b35" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7598-a57b-8e3e510c51c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7598-a57b-8e3e510c51c5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7598-a57b-8e3e510c51c5" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7598-a57b-8e3e510c51c5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019fec0d-b533-7b19-9ddb-7e4a6bce88e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019fec0d-b533-7598-a57b-8e3e510c51c5" xlink:to="loc_us-gaap_SegmentDomain_019fec0d-b533-7b19-9ddb-7e4a6bce88e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SelfCareMember_019fec0d-b533-7b1b-9233-2121347c358e" xlink:href="kvue-20260927.xsd#kvue_SelfCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7b19-9ddb-7e4a6bce88e9" xlink:to="loc_kvue_SelfCareMember_019fec0d-b533-7b1b-9233-2121347c358e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-7dae-8037-eaa5696e4da1" xlink:href="kvue-20260927.xsd#kvue_SkinHealthAndBeautyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7b19-9ddb-7e4a6bce88e9" xlink:to="loc_kvue_SkinHealthAndBeautyMember_019fec0d-b533-7dae-8037-eaa5696e4da1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_EssentialHealthMember_019fec0d-b533-744c-beb9-498971831e32" xlink:href="kvue-20260927.xsd#kvue_EssentialHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019fec0d-b533-7b19-9ddb-7e4a6bce88e9" xlink:to="loc_kvue_EssentialHealthMember_019fec0d-b533-744c-beb9-498971831e32" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_DepreciationDepletionAndAmortizationAdjusted_019fec0d-b533-72e6-9a1d-3f05be272c8a" xlink:href="kvue-20260927.xsd#kvue_DepreciationDepletionAndAmortizationAdjusted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019fec0d-b533-7999-b685-220629353b72" xlink:to="loc_kvue_DepreciationDepletionAndAmortizationAdjusted_019fec0d-b533-72e6-9a1d-3f05be272c8a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-734b-97b4-d09dca015616" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-72c0-9564-81c72250265e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-734b-97b4-d09dca015616" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-72c0-9564-81c72250265e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7a3d-9785-5766cf721d83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-72c0-9564-81c72250265e" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7a3d-9785-5766cf721d83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7a3d-9785-5766cf721d83_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7a3d-9785-5766cf721d83" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7a3d-9785-5766cf721d83_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7b87-b894-bbdc9b34d3a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7a3d-9785-5766cf721d83" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7b87-b894-bbdc9b34d3a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019fec0d-b533-7727-81a7-570b15d13317" xlink:href="kvue-20260927.xsd#kvue_InformationTechnologyAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7b87-b894-bbdc9b34d3a2" xlink:to="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019fec0d-b533-7727-81a7-570b15d13317" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-7fd0-bcff-b124d28d8f2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7b87-b894-bbdc9b34d3a2" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-7fd0-bcff-b124d28d8f2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_019fec0d-b533-7309-89fc-76afcd9a04e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7b87-b894-bbdc9b34d3a2" xlink:to="loc_us-gaap_OtherRestructuringMember_019fec0d-b533-7309-89fc-76afcd9a04e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-79dc-b26c-8b8ed7a6750b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-72c0-9564-81c72250265e" xlink:to="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-79dc-b26c-8b8ed7a6750b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-79dc-b26c-8b8ed7a6750b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-79dc-b26c-8b8ed7a6750b" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-79dc-b26c-8b8ed7a6750b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7678-aab5-06ccf743148c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-79dc-b26c-8b8ed7a6750b" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7678-aab5-06ccf743148c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019fec0d-b533-7fe2-99ce-f95f19656401" xlink:href="kvue-20260927.xsd#kvue_A2024MultiYearRestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7678-aab5-06ccf743148c" xlink:to="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019fec0d-b533-7fe2-99ce-f95f19656401" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-741a-acef-694b87bd2de6" xlink:href="kvue-20260927.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7678-aab5-06ccf743148c" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-741a-acef-694b87bd2de6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019fec0d-b533-70e1-b4fd-e4e96568a876" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostCostIncurredToDate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-734b-97b4-d09dca015616" xlink:to="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_019fec0d-b533-70e1-b4fd-e4e96568a876" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019fec0d-b533-7f81-bf56-3e39bbcb098c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostExpectedCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-734b-97b4-d09dca015616" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_019fec0d-b533-7f81-bf56-3e39bbcb098c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringAndRelatedCostExpectedCostPercent_019fec0d-b533-7b59-9690-91f5d44d3f3f" xlink:href="kvue-20260927.xsd#kvue_RestructuringAndRelatedCostExpectedCostPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-734b-97b4-d09dca015616" xlink:to="loc_kvue_RestructuringAndRelatedCostExpectedCostPercent_019fec0d-b533-7b59-9690-91f5d44d3f3f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesSummaryofPretaxRestructuringExpensesandOtherChargesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7a4d-82e4-7d52bbce09d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7a4d-82e4-7d52bbce09d0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7481-90c2-b399a5b9b48e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7a4d-82e4-7d52bbce09d0" xlink:to="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7481-90c2-b399a5b9b48e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7481-90c2-b399a5b9b48e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7481-90c2-b399a5b9b48e" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7481-90c2-b399a5b9b48e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-70a8-8e68-c045cba185f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7481-90c2-b399a5b9b48e" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-70a8-8e68-c045cba185f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019fec0d-b533-7da6-90dc-d2daf4b0cbe8" xlink:href="kvue-20260927.xsd#kvue_A2024MultiYearRestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-70a8-8e68-c045cba185f9" xlink:to="loc_kvue_A2024MultiYearRestructuringInitiativeMember_019fec0d-b533-7da6-90dc-d2daf4b0cbe8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-7eb2-9a2f-94dacb0e2159" xlink:href="kvue-20260927.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-70a8-8e68-c045cba185f9" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-7eb2-9a2f-94dacb0e2159" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019fec0d-b533-7a9b-ba81-2ba2444d9447" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:to="loc_us-gaap_RestructuringCharges_019fec0d-b533-7a9b-ba81-2ba2444d9447" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fec0d-b533-76fc-8f5f-de5942dc762d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fec0d-b533-76fc-8f5f-de5942dc762d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fec0d-b533-70a1-a5ae-bd4b99575021" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fec0d-b533-70a1-a5ae-bd4b99575021" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7955-a95c-def8e0808d35" xlink:href="kvue-20260927.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-795f-9acd-24bbe16570e9" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7955-a95c-def8e0808d35" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesPretaxRestructuringExpensesandOtherChargesbyTypeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7370-8df0-dd9b524cf4b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-75c8-a279-808cf3bf9cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7370-8df0-dd9b524cf4b2" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-75c8-a279-808cf3bf9cf3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-76b1-83e8-6fb548586f16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-75c8-a279-808cf3bf9cf3" xlink:to="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-76b1-83e8-6fb548586f16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-76b1-83e8-6fb548586f16_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-76b1-83e8-6fb548586f16" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-76b1-83e8-6fb548586f16_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-71b9-8304-bd691198143a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-76b1-83e8-6fb548586f16" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-71b9-8304-bd691198143a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-7607-b349-4864cbf559ca" xlink:href="kvue-20260927.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-71b9-8304-bd691198143a" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-7607-b349-4864cbf559ca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7e7d-9477-b8b03815f463" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-75c8-a279-808cf3bf9cf3" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7e7d-9477-b8b03815f463" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7e7d-9477-b8b03815f463_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7e7d-9477-b8b03815f463" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7e7d-9477-b8b03815f463_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-728a-9da7-b334af2bfd83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-7e7d-9477-b8b03815f463" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-728a-9da7-b334af2bfd83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-75de-9221-0b0cefb583cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-728a-9da7-b334af2bfd83" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-75de-9221-0b0cefb583cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_ITAndProjectRelatedCostsMember_019fec0d-b533-7302-bfd0-55415b4b6f40" xlink:href="kvue-20260927.xsd#kvue_ITAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-728a-9da7-b334af2bfd83" xlink:to="loc_kvue_ITAndProjectRelatedCostsMember_019fec0d-b533-7302-bfd0-55415b4b6f40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_019fec0d-b533-7e50-a748-50f4ae7be32d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-728a-9da7-b334af2bfd83" xlink:to="loc_us-gaap_OtherRestructuringMember_019fec0d-b533-7e50-a748-50f4ae7be32d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7501-be05-9776edfc2a10" xlink:href="kvue-20260927.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7370-8df0-dd9b524cf4b2" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7501-be05-9776edfc2a10" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails" xlink:type="simple" xlink:href="kvue-20260927.xsd#RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails"/>
  <link:definitionLink xlink:role="http://www.kenvue.com/role/RestructuringExpensesandOperatingModelOptimizationInitiativesScheduleofRestructuringReserveDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7ead-8585-f4c2e8c2e9d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7f94-961a-628c35887a77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7ead-8585-f4c2e8c2e9d7" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7f94-961a-628c35887a77" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-75b2-8605-b6739985e4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7f94-961a-628c35887a77" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-75b2-8605-b6739985e4a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-75b2-8605-b6739985e4a2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-75b2-8605-b6739985e4a2" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-75b2-8605-b6739985e4a2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7d29-aeb7-c9d6b948d4bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_019fec0d-b533-75b2-8605-b6739985e4a2" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7d29-aeb7-c9d6b948d4bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-71cd-9c13-b75487edf887" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7d29-aeb7-c9d6b948d4bf" xlink:to="loc_us-gaap_EmployeeSeveranceMember_019fec0d-b533-71cd-9c13-b75487edf887" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019fec0d-b533-7b92-903f-4a02435fa122" xlink:href="kvue-20260927.xsd#kvue_InformationTechnologyAndProjectRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7d29-aeb7-c9d6b948d4bf" xlink:to="loc_kvue_InformationTechnologyAndProjectRelatedCostsMember_019fec0d-b533-7b92-903f-4a02435fa122" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_01a01abc-ee0b-71d5-86cb-50ffb267863d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_019fec0d-b533-7d29-aeb7-c9d6b948d4bf" xlink:to="loc_us-gaap_OtherRestructuringMember_01a01abc-ee0b-71d5-86cb-50ffb267863d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7ddb-a91e-bed0a2b92b6b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_019fec0d-b533-7f94-961a-628c35887a77" xlink:to="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7ddb-a91e-bed0a2b92b6b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7ddb-a91e-bed0a2b92b6b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7ddb-a91e-bed0a2b92b6b" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-7ddb-a91e-bed0a2b92b6b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-736e-87c6-407f2b12f21e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_019fec0d-b533-7ddb-a91e-bed0a2b92b6b" xlink:to="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-736e-87c6-407f2b12f21e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-754b-bb14-13ccdab426d3" xlink:href="kvue-20260927.xsd#kvue_A2026RestructuringInitiativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_019fec0d-b533-736e-87c6-407f2b12f21e" xlink:to="loc_kvue_A2026RestructuringInitiativeMember_019fec0d-b533-754b-bb14-13ccdab426d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_019fec0d-b533-7ead-8585-f4c2e8c2e9d7" xlink:to="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019fec0d-b533-7137-9487-9c312b143318" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:to="loc_us-gaap_RestructuringReserve_019fec0d-b533-7137-9487-9c312b143318" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7aa6-80fb-f156e492cceb" xlink:href="kvue-20260927.xsd#kvue_RestructuringCostsAndOtherCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:to="loc_kvue_RestructuringCostsAndOtherCharges_019fec0d-b533-7aa6-80fb-f156e492cceb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_019fec0d-b533-7e01-bf8c-a4433953675b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:to="loc_us-gaap_PaymentsForRestructuring_019fec0d-b533-7e01-bf8c-a4433953675b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveSettledWithoutCash2_019fec0d-b533-7e4d-9b65-fea401fcaf37" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveSettledWithoutCash2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_019fec0d-b533-787d-b0a1-3cc0e063ca61" xlink:to="loc_us-gaap_RestructuringReserveSettledWithoutCash2_019fec0d-b533-7e4d-9b65-fea401fcaf37" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_019fec0d-b533-7423-b557-c4e6b604e95a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
  </link:definitionLink>
</link:linkbase>
