<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a18988-0bda-7d10-8284-6d75f412d258,g:b77bf8cc-8701-419b-926a-8110916178cb-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://acumenpharm.com/role/Cover" xlink:type="simple" xlink:href="abos-20261030.xsd#Cover"/>
  <link:presentationLink xlink:role="http://acumenpharm.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a18988-0bda-7849-914b-d340c4b65b5d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_DocumentType_01a18988-0bda-7849-914b-d340c4b65b5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a18988-0bda-76ca-9376-a143bd6c588e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_DocumentPeriodEndDate_01a18988-0bda-76ca-9376-a143bd6c588e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a18988-0bda-7bda-9d4b-1c7d1cab0dee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityRegistrantName_01a18988-0bda-7bda-9d4b-1c7d1cab0dee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a18988-0bda-74e8-8400-28c60230f3a0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a18988-0bda-74e8-8400-28c60230f3a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a18988-0bda-70dd-b101-29b2b84273a2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityFileNumber_01a18988-0bda-70dd-b101-29b2b84273a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a18988-0bda-7b80-a0ac-954085944529" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a18988-0bda-7b80-a0ac-954085944529" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a18988-0bda-77cf-855d-635477ebb11a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityAddressAddressLine1_01a18988-0bda-77cf-855d-635477ebb11a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_01a18988-0bda-7a32-8745-ab395daba7c9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityAddressAddressLine2_01a18988-0bda-7a32-8745-ab395daba7c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a18988-0bda-754a-8c86-ba14057c825a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityAddressCityOrTown_01a18988-0bda-754a-8c86-ba14057c825a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a18988-0bda-7a7f-9136-a9fa9028159f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityAddressStateOrProvince_01a18988-0bda-7a7f-9136-a9fa9028159f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a18988-0bda-7b20-be3d-1b382a589a8a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityAddressPostalZipCode_01a18988-0bda-7b20-be3d-1b382a589a8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a18988-0bda-791a-990a-4bf44a23469d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_CityAreaCode_01a18988-0bda-791a-990a-4bf44a23469d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a18988-0bda-7ffb-b869-9f6eee153d4c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_LocalPhoneNumber_01a18988-0bda-7ffb-b869-9f6eee153d4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a18988-0bda-7f02-87de-7abe6a32b0e9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_WrittenCommunications_01a18988-0bda-7f02-87de-7abe6a32b0e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a18988-0bda-72c1-bb9b-0869d4f87e82" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_SolicitingMaterial_01a18988-0bda-72c1-bb9b-0869d4f87e82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a18988-0bda-7cb4-88a8-73d2a0ae4091" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_PreCommencementTenderOffer_01a18988-0bda-7cb4-88a8-73d2a0ae4091" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a18988-0bda-7c16-82ad-55b0c9a6b39d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a18988-0bda-7c16-82ad-55b0c9a6b39d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a18988-0bda-7b6e-81ce-3b3cc760286b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_Security12bTitle_01a18988-0bda-7b6e-81ce-3b3cc760286b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a18988-0bda-7701-9ed1-8fa1de1dfefe" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_TradingSymbol_01a18988-0bda-7701-9ed1-8fa1de1dfefe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a18988-0bda-74a6-8c31-8a816aaaa306" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_SecurityExchangeName_01a18988-0bda-74a6-8c31-8a816aaaa306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a18988-0bda-724f-9bde-2c7ce147e09d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a18988-0bda-724f-9bde-2c7ce147e09d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_01a18988-0bda-7b13-b516-bfdcefb2ab0a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityExTransitionPeriod_01a18988-0bda-7b13-b516-bfdcefb2ab0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a18988-0bda-74c8-a047-12fd395abdfa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_EntityCentralIndexKey_01a18988-0bda-74c8-a047-12fd395abdfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a18988-0bda-7175-aa90-81b95818ee85" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a18988-0bda-7c9a-a6c9-c1dcb84e7bc9" xlink:to="loc_dei_AmendmentFlag_01a18988-0bda-7175-aa90-81b95818ee85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
