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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Cash flows from operating activities:    
Net income $ 103,472 $ 76,408
Adjustments to reconcile net income to cash flows from operating activities:    
Deferred income tax 28,670 0
Share-based compensation 8,097 7,950
Amortization and depreciation 14,491 14,585
Foreign exchange (gain) loss on revaluation of Monoplant finance lease liability (2,605) 9,318
Net amortization of premiums and discounts on investments (6,141) (7,844)
Other, net (1,498) 4,852
Net changes in operating assets and liabilities:    
Accounts receivable, net (5,960) 5,816
Inventory 1,962 (5,565)
Prepaid expenses and other current assets (2,983) 940
Other noncurrent operating assets 0 730
Accounts payable (2,172) (2,973)
Accrued expenses and other liabilities (4,372) (17,777)
Deferred revenue 1,202 4,150
Operating lease liabilities (670) (600)
Cash flows from operating activities 131,493 89,990
Cash flows from investing activities:    
Proceeds from the sale and maturities of investments 297,650 348,785
Purchases of investments (415,164) (344,618)
Net cash and cash equivalents acquired in acquisition of Kezar 5,212 0
Purchases of property, equipment and intangible assets (63) (180)
Cash flows from investing activities (112,365) 3,987
Cash flows from financing activities:    
Purchase of common shares under Share Repurchase Plan (74,880) (98,156)
Payments of principal portion of Monoplant finance lease liability (10,902) (9,649)
Proceeds from issuance of common shares for equity awards 69,559 12,583
Payment of Net Cash Excess CVR to legacy Kezar shareholders (3,696) 0
Proceeds from issuance of common shares under ESPP 363 401
Tax withholding payments related to net settlements of equity awards (33,640) (9,400)
Cash flows from financing activities (53,196) (104,221)
Net decrease in cash, cash equivalents and restricted cash (34,068) (10,244)
Cash, cash equivalents and restricted cash, beginning of the period 80,213 83,433
Cash, cash equivalents and restricted cash, end of the period 46,145 73,189
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets:    
Cash and cash equivalents 45,792 72,889
Restricted cash 353 300
Total cash, cash equivalents and restricted cash 46,145 73,189
Supplemental cash flow information:    
Cash paid for taxes $ 2,356 $ 3,092