<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a020c3-d974-715e-b250-5f7c4522097d,g:40b1daea-3ec4-466c-9d6f-f50c4218351f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.alnylam.com/role/CoverPage" xlink:type="simple" xlink:href="alny-20260930.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a020c3-dab9-77be-87db-6ccbac644bc4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentType_01a020c3-dab9-77be-87db-6ccbac644bc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_01a020c3-dab9-79c7-817b-d0ff477f9cb6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentQuarterlyReport_01a020c3-dab9-79c7-817b-d0ff477f9cb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a020c3-dab9-711f-a47d-8ab5d2ff14c9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentPeriodEndDate_01a020c3-dab9-711f-a47d-8ab5d2ff14c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_01a020c3-dab9-71bf-84a8-8b77beee3fd9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentTransitionReport_01a020c3-dab9-71bf-84a8-8b77beee3fd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a020c3-dab9-7847-b507-0e2c101e2474" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityFileNumber_01a020c3-dab9-7847-b507-0e2c101e2474" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a020c3-dab9-7d19-8a26-aa0270ee038d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityRegistrantName_01a020c3-dab9-7d19-8a26-aa0270ee038d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a020c3-dab9-7d18-b1b5-98eec4c2dfe5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a020c3-dab9-7d18-b1b5-98eec4c2dfe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a020c3-dab9-767d-aeef-0db53103d1f6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a020c3-dab9-767d-aeef-0db53103d1f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a020c3-dab9-71f5-86f6-38a7a72f4629" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityAddressAddressLine1_01a020c3-dab9-71f5-86f6-38a7a72f4629" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_01a020c3-dab9-7fa7-81f7-cc54ee6e237c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityAddressAddressLine2_01a020c3-dab9-7fa7-81f7-cc54ee6e237c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a020c3-dab9-7fe1-b74f-752e56811b6d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityAddressCityOrTown_01a020c3-dab9-7fe1-b74f-752e56811b6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a020c3-dab9-7553-ac35-47c1341c2e5d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityAddressStateOrProvince_01a020c3-dab9-7553-ac35-47c1341c2e5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a020c3-dab9-7a26-a6f9-572f4c0439a8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityAddressPostalZipCode_01a020c3-dab9-7a26-a6f9-572f4c0439a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a020c3-dab9-7df1-9f7a-f83818a15024" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_CityAreaCode_01a020c3-dab9-7df1-9f7a-f83818a15024" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a020c3-dab9-7aaf-8257-3e4465e2204d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_LocalPhoneNumber_01a020c3-dab9-7aaf-8257-3e4465e2204d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a020c3-dab9-7427-9c39-478f6ea2cc04" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_Security12bTitle_01a020c3-dab9-7427-9c39-478f6ea2cc04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a020c3-dab9-7420-81a7-850f8fbf2d49" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_TradingSymbol_01a020c3-dab9-7420-81a7-850f8fbf2d49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a020c3-dab9-7ab8-b011-13db0a6b97aa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_SecurityExchangeName_01a020c3-dab9-7ab8-b011-13db0a6b97aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_01a020c3-dab9-7a87-a1e7-8cccf59ea08f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityCurrentReportingStatus_01a020c3-dab9-7a87-a1e7-8cccf59ea08f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_01a020c3-dab9-79d7-9703-3877b4e6488c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityInteractiveDataCurrent_01a020c3-dab9-79d7-9703-3877b4e6488c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_01a020c3-dab9-7e7a-97ba-61567d595059" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityFilerCategory_01a020c3-dab9-7e7a-97ba-61567d595059" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_01a020c3-dab9-7ebd-a1d0-28df95a60de7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntitySmallBusiness_01a020c3-dab9-7ebd-a1d0-28df95a60de7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a020c3-dab9-7d65-9edf-89d615fae9e2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a020c3-dab9-7d65-9edf-89d615fae9e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_01a020c3-dab9-77fa-babb-f68c53f012f1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityShellCompany_01a020c3-dab9-77fa-babb-f68c53f012f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_01a020c3-dab9-7c2e-a2cb-3e4a530f0eee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_01a020c3-dab9-7c2e-a2cb-3e4a530f0eee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a020c3-dab9-70c0-b7e4-904ad0cb47b2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_AmendmentFlag_01a020c3-dab9-70c0-b7e4-904ad0cb47b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_01a020c3-dab9-78ee-b70a-9fcdc7353587" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentFiscalYearFocus_01a020c3-dab9-78ee-b70a-9fcdc7353587" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_01a020c3-dab9-7156-aac1-66ac979efa17" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_CurrentFiscalYearEndDate_01a020c3-dab9-7156-aac1-66ac979efa17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_01a020c3-dab9-7694-81f1-25fbf67cee84" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_DocumentFiscalPeriodFocus_01a020c3-dab9-7694-81f1-25fbf67cee84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a020c3-dab9-7e1a-ae3b-f846a4300dc5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a020c3-dab9-796a-a0bd-0acd002512c9" xlink:to="loc_dei_EntityCentralIndexKey_01a020c3-dab9-7e1a-ae3b-f846a4300dc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-708b-b819-98a5f47a98bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-708b-b819-98a5f47a98bd" xlink:to="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a020c3-dab9-7a76-901c-b14dda424eec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a020c3-dab9-7a76-901c-b14dda424eec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_01a020c3-dab9-7b15-a8e8-98f1a25b7f98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_01a020c3-dab9-7b15-a8e8-98f1a25b7f98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-dab9-7298-9e58-af91163dddea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-dab9-7298-9e58-af91163dddea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_01a020c3-dab9-725a-aa29-f7f50a9c2f83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_InventoryNet_01a020c3-dab9-725a-aa29-f7f50a9c2f83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a020c3-dab9-7ca5-a53d-0a5bb4e78fa7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a020c3-dab9-7ca5-a53d-0a5bb4e78fa7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_01a020c3-dab9-7d05-bf8e-154b43a53327" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_01a020c3-dab9-7625-92e6-52928979f9de" xlink:to="loc_us-gaap_AssetsCurrent_01a020c3-dab9-7d05-bf8e-154b43a53327" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01a020c3-dab9-7bc3-bcd5-3e594abe6cde" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_01a020c3-dab9-7bc3-bcd5-3e594abe6cde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a020c3-dab9-78ab-8a16-400edafcaec1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a020c3-dab9-78ab-8a16-400edafcaec1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_01a020c3-dab9-7ea4-ae0d-1f0bb718cc99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_01a020c3-dab9-7ea4-ae0d-1f0bb718cc99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedInvestmentsNoncurrent_01a020c3-dab9-70c7-979f-bbc226561747" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedInvestmentsNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_RestrictedInvestmentsNoncurrent_01a020c3-dab9-70c7-979f-bbc226561747" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_01a020c3-dab9-7aed-a16e-8194de2bb301" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_01a020c3-dab9-7aed-a16e-8194de2bb301" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_01a020c3-dab9-7d1f-a789-9f4d24ee0230" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_01a020c3-dab9-7870-bfa1-a224ac1e5257" xlink:to="loc_us-gaap_Assets_01a020c3-dab9-7d1f-a789-9f4d24ee0230" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-708b-b819-98a5f47a98bd" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_01a020c3-dab9-71fd-9d94-a7e79f927e22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_AccountsPayableCurrent_01a020c3-dab9-71fd-9d94-a7e79f927e22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_01a020c3-dab9-7cd8-b4ae-bdb76f27d19c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_01a020c3-dab9-7cd8-b4ae-bdb76f27d19c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a020c3-dab9-7f6c-837c-e1518e9eeead" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a020c3-dab9-7f6c-837c-e1518e9eeead" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-dab9-7376-85c5-9de72a6078be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-dab9-7376-85c5-9de72a6078be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_01a12fa7-b36a-70e6-ade2-f590c40c640d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_01a12fa7-b36a-70e6-ade2-f590c40c640d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyAndDevelopmentFundingLiabilityCurrent_01a020c3-dab9-743b-8103-ddde3662527f" xlink:href="alny-20260930.xsd#alny_RoyaltyAndDevelopmentFundingLiabilityCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_alny_RoyaltyAndDevelopmentFundingLiabilityCurrent_01a020c3-dab9-743b-8103-ddde3662527f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01a020c3-dab9-7a79-ada1-6be484c5835b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_01a020c3-dab9-7325-a0c7-bb25c08c6745" xlink:to="loc_us-gaap_LiabilitiesCurrent_01a020c3-dab9-7a79-ada1-6be484c5835b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a020c3-dab9-779d-934b-1af677162201" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a020c3-dab9-779d-934b-1af677162201" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_01a020c3-dab9-7c17-805a-ac94c2609f2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_01a020c3-dab9-7c17-805a-ac94c2609f2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent_01a020c3-dab9-710b-aa4e-ac34aaf8c1d0" xlink:href="alny-20260930.xsd#alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent_01a020c3-dab9-710b-aa4e-ac34aaf8c1d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_01a020c3-dab9-777d-b70e-fc82b9d5dfcd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_01a020c3-dab9-777d-b70e-fc82b9d5dfcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_01a020c3-dab9-73be-9226-46a30edad3d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_Liabilities_01a020c3-dab9-73be-9226-46a30edad3d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_01a020c3-dab9-7687-a213-a3f7669fde04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_CommitmentsAndContingencies_01a020c3-dab9-7687-a213-a3f7669fde04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_01a020c3-dab9-714d-9451-7c12773be688" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_PreferredStockValue_01a020c3-dab9-714d-9451-7c12773be688" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_01a020c3-dab9-7c97-bd96-1dbd8507c39a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_CommonStockValue_01a020c3-dab9-7c97-bd96-1dbd8507c39a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_01a020c3-dab9-7cd4-a9f7-dfee5de26caf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_01a020c3-dab9-7cd4-a9f7-dfee5de26caf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a020c3-dab9-7ac6-9061-6d6ac85ecae0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a020c3-dab9-7ac6-9061-6d6ac85ecae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a020c3-dab9-7517-a44a-80ceded00daa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a020c3-dab9-7517-a44a-80ceded00daa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a020c3-dab9-759d-9c3f-c5576dfec0ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_01a020c3-dab9-7922-9102-d03782d6f82e" xlink:to="loc_us-gaap_StockholdersEquity_01a020c3-dab9-759d-9c3f-c5576dfec0ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a020c3-dab9-7e73-b417-6564c6ac4918" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_01a020c3-dab9-72ba-893c-a40bae9365a7" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a020c3-dab9-7e73-b417-6564c6ac4918" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_01a020c3-dab9-77b9-8d4d-cc09cbfdd9f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_01a020c3-dab9-77b9-8d4d-cc09cbfdd9f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_01a020c3-dab9-722a-a08c-bfc968aecc51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_01a020c3-dab9-722a-a08c-bfc968aecc51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_01a020c3-dab9-71dd-bd06-878020ac7b77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_PreferredStockSharesIssued_01a020c3-dab9-71dd-bd06-878020ac7b77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_01a020c3-dab9-70f9-bb88-559449222cdc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_01a020c3-dab9-70f9-bb88-559449222cdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-dab9-7676-bbbc-56ebf07ad943" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-dab9-7676-bbbc-56ebf07ad943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_01a020c3-dab9-7c63-88e5-b718eee134f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_01a020c3-dab9-7c63-88e5-b718eee134f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_01a020c3-dab9-7e8c-adc0-142e24de7dc3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_CommonStockSharesIssued_01a020c3-dab9-7e8c-adc0-142e24de7dc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-7b20-af7c-45797fb5634f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_01a020c3-dab9-7572-a518-ec8fcf638d78" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-7b20-af7c-45797fb5634f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSSINCOME" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSSINCOME"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSSINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_01a020c3-dab9-711c-a29d-1e44caf86f69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_01a020c3-dab9-7a13-9d3e-07a77f3fbbb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_01a020c3-dab9-711c-a29d-1e44caf86f69" xlink:to="loc_us-gaap_StatementTable_01a020c3-dab9-7a13-9d3e-07a77f3fbbb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-dab9-78b3-82a9-92f485445dfe" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-dab9-7a13-9d3e-07a77f3fbbb2" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-dab9-78b3-82a9-92f485445dfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-dab9-7a64-81dd-5fabe219e37e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-dab9-78b3-82a9-92f485445dfe" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-dab9-7a64-81dd-5fabe219e37e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_01a020c3-dab9-7fbb-af5c-ec47ec81ae65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-dab9-7a64-81dd-5fabe219e37e" xlink:to="loc_us-gaap_ProductMember_01a020c3-dab9-7fbb-af5c-ec47ec81ae65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborationsMember_01a020c3-dab9-7a49-bbc7-e408d7d50afd" xlink:href="alny-20260930.xsd#alny_CollaborationsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-dab9-7a64-81dd-5fabe219e37e" xlink:to="loc_alny_CollaborationsMember_01a020c3-dab9-7a49-bbc7-e408d7d50afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_01a020c3-dab9-70d4-a90d-85ac4756cd38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RoyaltyMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-dab9-7a64-81dd-5fabe219e37e" xlink:to="loc_us-gaap_RoyaltyMember_01a020c3-dab9-70d4-a90d-85ac4756cd38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-dab9-7a13-9d3e-07a77f3fbbb2" xlink:to="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_01a020c3-dab9-7600-97a4-9f2f5b86b146" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenuesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_RevenuesAbstract_01a020c3-dab9-7600-97a4-9f2f5b86b146" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-dab9-75e3-916f-0c064b1bc304" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_01a020c3-dab9-7600-97a4-9f2f5b86b146" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-dab9-75e3-916f-0c064b1bc304" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_01a020c3-dab9-7cb0-8081-929b83826180" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_01a020c3-dab9-7cb0-8081-929b83826180" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CostOfCollaborationManufacturingAndRoyalties_01a020c3-dab9-7ddd-a69f-143ad5cd9b48" xlink:href="alny-20260930.xsd#alny_CostOfCollaborationManufacturingAndRoyalties"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:to="loc_alny_CostOfCollaborationManufacturingAndRoyalties_01a020c3-dab9-7ddd-a69f-143ad5cd9b48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-dab9-7da9-a91e-4ff3dd0aba58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-dab9-7da9-a91e-4ff3dd0aba58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a020c3-dab9-7aba-a8dd-74cdc1acb11d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a020c3-dab9-7aba-a8dd-74cdc1acb11d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_01a020c3-dab9-78e7-b945-047a6099ab19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_01a020c3-dab9-7d02-9449-2db9ba4b9f22" xlink:to="loc_us-gaap_CostsAndExpenses_01a020c3-dab9-78e7-b945-047a6099ab19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a020c3-dab9-7a7c-bfba-5d59cfd94320" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_OperatingIncomeLoss_01a020c3-dab9-7a7c-bfba-5d59cfd94320" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_01a020c3-dab9-7367-b5a4-5195b674d423" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:to="loc_us-gaap_InterestExpenseNonoperating_01a020c3-dab9-7367-b5a4-5195b674d423" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_01a020c3-dab9-7380-8c3d-735406614b50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:to="loc_us-gaap_InvestmentIncomeInterest_01a020c3-dab9-7380-8c3d-735406614b50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InducedConversionOfConvertibleDebtExpense_01a04619-97f6-7d1e-a905-50ab8d27d42d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InducedConversionOfConvertibleDebtExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:to="loc_us-gaap_InducedConversionOfConvertibleDebtExpense_01a04619-97f6-7d1e-a905-50ab8d27d42d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_01a020c3-dab9-7e00-94aa-677aa654df9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_01a020c3-dab9-7e00-94aa-677aa654df9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_01a020c3-dab9-7302-a366-8bb83c435ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_01a020c3-dab9-7082-b6bf-a679b525e04e" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_01a020c3-dab9-7302-a366-8bb83c435ef5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a020c3-dab9-79ca-b26d-9b035511464a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a020c3-dab9-79ca-b26d-9b035511464a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_01a020c3-dab9-7d75-a037-33dd0dcc232a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_01a020c3-dab9-7d75-a037-33dd0dcc232a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-7e20-9e41-9487d7675865" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-7e20-9e41-9487d7675865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_01a020c3-dab9-7f90-868b-9fbbb53bed62" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_EarningsPerShareBasic_01a020c3-dab9-7f90-868b-9fbbb53bed62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_01a020c3-dab9-735b-99e2-3b49ec721ea3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_EarningsPerShareDiluted_01a020c3-dab9-735b-99e2-3b49ec721ea3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_01a020c3-dab9-7db2-abfe-af5178b8bfd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_01a020c3-dab9-7db2-abfe-af5178b8bfd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_01a020c3-dab9-7e2f-a551-fe4b3df87795" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_01a020c3-dab9-7e2f-a551-fe4b3df87795" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_01a020c3-dab9-78a9-8e8c-162a2ee2809b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAbstract"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-775d-b5e4-2f788d691bc0" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_01a020c3-dab9-78a9-8e8c-162a2ee2809b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-72ab-9d23-5c8333579e14" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_01a020c3-dab9-78a9-8e8c-162a2ee2809b" xlink:to="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-72ab-9d23-5c8333579e14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_01a020c3-dab9-78a9-8e8c-162a2ee2809b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_01a020c3-dab9-7766-9738-4013c0cb0a60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_01a020c3-dab9-7766-9738-4013c0cb0a60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_01a020c3-dab9-7a45-b497-cc1e4e1943df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_01a020c3-dab9-7a45-b497-cc1e4e1943df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_01a020c3-dab9-7564-b991-306dc70659a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_01a020c3-dab9-7564-b991-306dc70659a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-dab9-731a-aa7d-27890871fc3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_01a020c3-dab9-723e-9881-e8a47023769a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-dab9-731a-aa7d-27890871fc3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a020c3-dab9-78f3-bb86-0d8bf25af79f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_01a020c3-dab9-78a9-8e8c-162a2ee2809b" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a020c3-dab9-78f3-bb86-0d8bf25af79f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_01a020c3-dab9-7f09-b550-47a6c6f41327" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_01a020c3-dab9-7247-a58d-965b5116f954" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_01a020c3-dab9-7f09-b550-47a6c6f41327" xlink:to="loc_us-gaap_StatementTable_01a020c3-dab9-7247-a58d-965b5116f954" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-dab9-7726-b856-5038c46b75d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-dab9-7247-a58d-965b5116f954" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-dab9-7726-b856-5038c46b75d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-dab9-7726-b856-5038c46b75d4" xlink:to="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_01a020c3-dab9-7e51-94c0-2768424a6fba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:to="loc_us-gaap_CommonStockMember_01a020c3-dab9-7e51-94c0-2768424a6fba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_01a020c3-dab9-78c8-819f-a7dac830e95c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_01a020c3-dab9-78c8-819f-a7dac830e95c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-dab9-74a6-9d2d-f0554c9c7bcf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-dab9-74a6-9d2d-f0554c9c7bcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_01a020c3-dab9-72a8-8b12-b7dcb2966467" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_01a020c3-dab9-7f9f-ae4d-bd0d795dbbe9" xlink:to="loc_us-gaap_RetainedEarningsMember_01a020c3-dab9-72a8-8b12-b7dcb2966467" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_01a020c3-dab9-7608-b53b-1bb55ee60d10" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-dab9-7247-a58d-965b5116f954" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_01a020c3-dab9-7608-b53b-1bb55ee60d10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_01a020c3-dab9-7cae-a9c9-6db09d14b6ad" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_01a020c3-dab9-7608-b53b-1bb55ee60d10" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_01a020c3-dab9-7cae-a9c9-6db09d14b6ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_01a020c3-dab9-77eb-ba36-23b973d3ef03" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_01a020c3-dab9-7cae-a9c9-6db09d14b6ad" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_01a020c3-dab9-77eb-ba36-23b973d3ef03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_01a020c3-dab9-731f-ab63-323cf3fce65f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-dab9-7247-a58d-965b5116f954" xlink:to="loc_us-gaap_StatementLineItems_01a020c3-dab9-731f-ab63-323cf3fce65f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-dab9-731f-ab63-323cf3fce65f" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-7c7b-ba89-acbceda75995" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-7c7b-ba89-acbceda75995" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a020c3-dab9-798c-a917-d74dc5d7e0e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockholdersEquity_01a020c3-dab9-798c-a917-d74dc5d7e0e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_01a020c3-dab9-7725-8d95-01eb44421c99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_01a020c3-dab9-7725-8d95-01eb44421c99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_01a020c3-dab9-7dc9-8410-3e35a4012309" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_01a020c3-dab9-7dc9-8410-3e35a4012309" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_01a020c3-dab9-76b2-b908-e923a50a8928" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_01a020c3-dab9-76b2-b908-e923a50a8928" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross_01a020c3-dab9-7c5e-a9f7-7b2d107e3f41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross_01a020c3-dab9-7c5e-a9f7-7b2d107e3f41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_01a020c3-dab9-7980-b76e-c9038fe3845a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_01a020c3-dab9-7980-b76e-c9038fe3845a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_PaymentForOptionIndexedToEquity_01a04641-7565-7b5e-b3c9-0c20a9faa3b3" xlink:href="alny-20260930.xsd#alny_PaymentForOptionIndexedToEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_alny_PaymentForOptionIndexedToEquity_01a04641-7565-7b5e-b3c9-0c20a9faa3b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity_01a0462d-e56e-7553-a298-48d8418ae834" xlink:href="alny-20260930.xsd#alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity_01a0462d-e56e-7553-a298-48d8418ae834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-dab9-7719-9df3-4c0fe6190cb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-dab9-7719-9df3-4c0fe6190cb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-7695-9dab-e7ce869176ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_NetIncomeLoss_01a020c3-dab9-7695-9dab-e7ce869176ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-76bd-8ce3-e32ab0ae4615" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_01a020c3-dab9-76bd-8ce3-e32ab0ae4615" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a020c3-dab9-7c2e-b982-a0a633ee67e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a020c3-dab9-7c48-b8f1-4dc45ebf5bd1" xlink:to="loc_us-gaap_StockholdersEquity_01a020c3-dab9-7c2e-b982-a0a633ee67e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-706e-a3d5-a3518a5ca76e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-706e-a3d5-a3518a5ca76e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a020c3-db5e-7ab0-80eb-5fc93c5ec1f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-706e-a3d5-a3518a5ca76e" xlink:to="loc_us-gaap_NetIncomeLoss_01a020c3-db5e-7ab0-80eb-5fc93c5ec1f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-706e-a3d5-a3518a5ca76e" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_01a020c3-db5e-7954-b9b1-04297aa41314" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_01a020c3-db5e-7954-b9b1-04297aa41314" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NonCashInterestExpenseOnSaleOfFutureRoyalties_01a020c3-db5e-7225-9afc-3b96b15d3e05" xlink:href="alny-20260930.xsd#alny_NonCashInterestExpenseOnSaleOfFutureRoyalties"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_alny_NonCashInterestExpenseOnSaleOfFutureRoyalties_01a020c3-db5e-7225-9afc-3b96b15d3e05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_01a020c3-db5e-7d12-9023-4bd4efdcf9be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_ShareBasedCompensation_01a020c3-db5e-7d12-9023-4bd4efdcf9be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_01a020c3-db5e-7263-9064-0145c4834691" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_01a020c3-db5e-7263-9064-0145c4834691" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_01a04645-5e94-7850-aad1-d3c3c2b725d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_01a04645-5e94-7850-aad1-d3c3c2b725d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_01a020c3-db5e-756d-b689-04f0d2c89a77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_01a020c3-db5e-756d-b689-04f0d2c89a77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_01a020c3-db5e-7a6e-8318-8253ed738c87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_01a020c3-db5e-7a6e-8318-8253ed738c87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-7109-a573-cdf56ad98203" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_01a020c3-db5e-7f90-ad3c-ea517741af1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_01a020c3-db5e-7f90-ad3c-ea517741af1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_01a020c3-db5e-7525-a917-e52249fc0525" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_01a020c3-db5e-7525-a917-e52249fc0525" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_01a020c3-db5e-7486-b56e-e19ed85d3653" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_01a020c3-db5e-7486-b56e-e19ed85d3653" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a020c3-db5e-7f3e-9e3a-9eac809a2fa6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a020c3-db5e-7f3e-9e3a-9eac809a2fa6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_01a020c3-db5e-7c1c-9e92-4d0898cdab49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_01a020c3-db5e-7ac0-9b5b-678247562404" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_01a020c3-db5e-7c1c-9e92-4d0898cdab49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a020c3-db5e-7b68-b973-3110705dfeea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_01a020c3-db5e-706e-a3d5-a3518a5ca76e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a020c3-db5e-7b68-b973-3110705dfeea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a020c3-db5e-7265-aaf7-5b771e2b701c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a020c3-db5e-7265-aaf7-5b771e2b701c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_01a020c3-db5e-76b9-8fa3-38199991d706" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_01a020c3-db5e-76b9-8fa3-38199991d706" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_01a020c3-db5e-7ad6-b8f5-5f2a07e3c6d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_01a020c3-db5e-7ad6-b8f5-5f2a07e3c6d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfRestrictedInvestments_01a020c3-db5e-74e0-816a-3ab60c878696" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfRestrictedInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_ProceedsFromSaleOfRestrictedInvestments_01a020c3-db5e-74e0-816a-3ab60c878696" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_01a020c3-db5e-7189-8eed-eb756df4397e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireRestrictedInvestments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_01a020c3-db5e-7189-8eed-eb756df4397e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_01a020c3-db5e-76c1-8542-3fbc7ae7ea39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_01a020c3-db5e-76c1-8542-3fbc7ae7ea39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a020c3-db5e-7940-a47d-53aa8edcd3c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_01a020c3-db5e-7bf0-ac8d-ea00701ee9bb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a020c3-db5e-7940-a47d-53aa8edcd3c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_01a0465a-7ee3-7c6e-bba4-53e521c99100" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_01a0465a-7ee3-7c6e-bba4-53e521c99100" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_PaymentForOptionIndexedToEquity_01a0465a-7ee3-7202-b89d-9d4dcc374a9a" xlink:href="alny-20260930.xsd#alny_PaymentForOptionIndexedToEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_alny_PaymentForOptionIndexedToEquity_01a0465a-7ee3-7202-b89d-9d4dcc374a9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_01a0465a-7ee3-7c9a-857c-edb72102ca79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_01a0465a-7ee3-7c9a-857c-edb72102ca79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_01a0465a-7ee3-724f-af1b-a3e599f62517" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_01a0465a-7ee3-724f-af1b-a3e599f62517" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_01a020c3-db5e-7086-8316-c285d7e16366" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_01a020c3-db5e-7086-8316-c285d7e16366" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ProceedsFromSaleOfRoyaltiesInterest_01a1349c-944d-7f94-9074-c282a49b9642" xlink:href="alny-20260930.xsd#alny_ProceedsFromSaleOfRoyaltiesInterest"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_alny_ProceedsFromSaleOfRoyaltiesInterest_01a1349c-944d-7f94-9074-c282a49b9642" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RepaymentOfLiabilitiesRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFunding_01a020c3-db5e-79ff-af68-2c3e14da690c" xlink:href="alny-20260930.xsd#alny_RepaymentOfLiabilitiesRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFunding"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_alny_RepaymentOfLiabilitiesRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFunding_01a020c3-db5e-79ff-af68-2c3e14da690c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_01a020c3-db5e-7363-a2c9-e370815994cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_01a020c3-db5e-7363-a2c9-e370815994cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a020c3-db5e-76dd-a332-f4b3806e8010" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_01a020c3-db5e-7ebf-a208-ea26c8c57829" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a020c3-db5e-76dd-a332-f4b3806e8010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7651-9772-b527bed5b442" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7651-9772-b527bed5b442" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a020c3-db5e-72c1-838b-de71d32b0d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a020c3-db5e-72c1-838b-de71d32b0d4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7adf-91e7-79606a33c538" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7adf-91e7-79606a33c538" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7498-83f1-aa378c58a585" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-7498-83f1-aa378c58a585" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_01a020c3-db5e-7a09-ad69-608314dec734" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_01a020c3-db5e-7a09-ad69-608314dec734" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_01a020c3-db5e-78bc-a9e3-3716fbf2e759" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_01a020c3-db5e-7a09-ad69-608314dec734" xlink:to="loc_us-gaap_InterestPaidNet_01a020c3-db5e-78bc-a9e3-3716fbf2e759" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_01a020c3-db5e-7d7f-b54f-0316c39a9a0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxesPaidNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_01a020c3-db5e-7a09-ad69-608314dec734" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_01a020c3-db5e-7d7f-b54f-0316c39a9a0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_01a020c3-db5e-7a90-af9a-50f7b30c3497" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_01a020c3-db5e-7a09-ad69-608314dec734" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_01a020c3-db5e-7a90-af9a-50f7b30c3497" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_01a020c3-db5e-79d2-81fa-a5826fa68ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-dab9-78f6-a7db-49b49dfd45a6" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_01a020c3-db5e-79d2-81fa-a5826fa68ffd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_01a020c3-db5e-7027-b731-50ef841f745c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_01a020c3-db5e-79d2-81fa-a5826fa68ffd" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_01a020c3-db5e-7027-b731-50ef841f745c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYDEFICITParenthetical" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYDEFICITParenthetical"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYDEFICITParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_01a020c3-dab9-7ce6-a304-15f6ddd1dba2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_01a1416a-c089-7e09-ab71-1363f59919c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_01a020c3-dab9-7ce6-a304-15f6ddd1dba2" xlink:to="loc_us-gaap_StatementTable_01a1416a-c089-7e09-ab71-1363f59919c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_01a1416a-c089-70dd-b7bf-13b51f8df671" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a1416a-c089-7e09-ab71-1363f59919c4" xlink:to="loc_us-gaap_DebtInstrumentAxis_01a1416a-c089-70dd-b7bf-13b51f8df671" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01a1416a-c089-71c9-b86a-1558cedd96d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_01a1416a-c089-70dd-b7bf-13b51f8df671" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01a1416a-c089-71c9-b86a-1558cedd96d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2027Member_01a1416a-c089-7042-bcfe-1916973ab57f" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2027Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a1416a-c089-71c9-b86a-1558cedd96d7" xlink:to="loc_alny_ConvertibleSeniorNotesDue2027Member_01a1416a-c089-7042-bcfe-1916973ab57f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2028Member_01a1416a-c089-7e94-8078-a715bad7f335" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2028Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a1416a-c089-71c9-b86a-1558cedd96d7" xlink:to="loc_alny_ConvertibleSeniorNotesDue2028Member_01a1416a-c089-7e94-8078-a715bad7f335" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_01a1416a-c089-7270-81bd-2357f8f8a571" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a1416a-c089-7e09-ab71-1363f59919c4" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_01a1416a-c089-7270-81bd-2357f8f8a571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01a1416a-c089-733d-984a-acd03c05b539" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_01a1416a-c089-7270-81bd-2357f8f8a571" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01a1416a-c089-733d-984a-acd03c05b539" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_01a1416a-c089-7230-bde8-a677a52c256c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01a1416a-c089-733d-984a-acd03c05b539" xlink:to="loc_us-gaap_ConvertibleDebtMember_01a1416a-c089-7230-bde8-a677a52c256c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_01a1416a-c089-7425-a34a-429b2e4f5557" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a1416a-c089-7e09-ab71-1363f59919c4" xlink:to="loc_us-gaap_StatementLineItems_01a1416a-c089-7425-a34a-429b2e4f5557" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdateExtensibleList_01a020c3-dab9-77c5-9488-105b9dae88ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountingStandardsUpdateExtensibleList"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a1416a-c089-7425-a34a-429b2e4f5557" xlink:to="loc_us-gaap_AccountingStandardsUpdateExtensibleList_01a020c3-dab9-77c5-9488-105b9dae88ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a1416a-c089-77e2-a1bf-2ed360d4b3c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a1416a-c089-7425-a34a-429b2e4f5557" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a1416a-c089-77e2-a1bf-2ed360d4b3c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_01a1416a-c089-71e7-8821-711e202359e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a1416a-c089-7425-a34a-429b2e4f5557" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_01a1416a-c089-71e7-8821-711e202359e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSParenthetical" xlink:type="simple" xlink:href="alny-20260930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSParenthetical"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-db5e-79d6-a70d-a76b0b8fed1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_01a020c3-db5e-72cc-ab39-dbd5360c4de6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_01a020c3-db5e-79d6-a70d-a76b0b8fed1c" xlink:to="loc_us-gaap_StatementTable_01a020c3-db5e-72cc-ab39-dbd5360c4de6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7c43-a3d0-6b8214218c09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-db5e-72cc-ab39-dbd5360c4de6" xlink:to="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7c43-a3d0-6b8214218c09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7cd8-90f8-bb40ae3dd813" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7c43-a3d0-6b8214218c09" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7cd8-90f8-bb40ae3dd813" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-7c8d-b582-21498f5826a2" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2028Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7cd8-90f8-bb40ae3dd813" xlink:to="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-7c8d-b582-21498f5826a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2027Member_01a020c3-db5e-7994-8fe3-aaa77b5cb62f" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2027Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7cd8-90f8-bb40ae3dd813" xlink:to="loc_alny_ConvertibleSeniorNotesDue2027Member_01a020c3-db5e-7994-8fe3-aaa77b5cb62f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-787a-a66e-73ee4fad3ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-db5e-72cc-ab39-dbd5360c4de6" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-787a-a66e-73ee4fad3ae7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7571-8058-b4fafce2d92c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-787a-a66e-73ee4fad3ae7" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7571-8058-b4fafce2d92c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7ccf-99d6-790f3fd7b52c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7571-8058-b4fafce2d92c" xlink:to="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7ccf-99d6-790f3fd7b52c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_01a020c3-db5e-7ef4-967f-3249a6dd399b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_01a020c3-db5e-72cc-ab39-dbd5360c4de6" xlink:to="loc_us-gaap_StatementLineItems_01a020c3-db5e-7ef4-967f-3249a6dd399b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a020c3-db5e-7fac-9c9b-95b12398cbed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_01a020c3-db5e-7ef4-967f-3249a6dd399b" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a020c3-db5e-7fac-9c9b-95b12398cbed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NATUREOFBUSINESS" xlink:type="simple" xlink:href="alny-20260930.xsd#NATUREOFBUSINESS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NATUREOFBUSINESS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-74a1-9584-bb1a5e123549" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfOperations_01a020c3-db5e-757d-8cd4-344e654e0c38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NatureOfOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-74a1-9584-bb1a5e123549" xlink:to="loc_us-gaap_NatureOfOperations_01a020c3-db5e-757d-8cd4-344e654e0c38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATION" xlink:type="simple" xlink:href="alny-20260930.xsd#BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATION"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATION" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-73f8-96ae-6155d68b4193" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_01a020c3-db5e-7b10-90c5-5c14e0608a40" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-73f8-96ae-6155d68b4193" xlink:to="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_01a020c3-db5e-7b10-90c5-5c14e0608a40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETPRODUCTREVENUES" xlink:type="simple" xlink:href="alny-20260930.xsd#NETPRODUCTREVENUES"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETPRODUCTREVENUES" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7caf-bc22-1f1c98bcabaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_01a020c3-db5e-7267-9589-5f5e5100dd55" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7caf-bc22-1f1c98bcabaa" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_01a020c3-db5e-7267-9589-5f5e5100dd55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONS" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7472-999a-21c293bece0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_01a020c3-db5e-7a6f-8da7-4a16c986b6e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7472-999a-21c293bece0a" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_01a020c3-db5e-7a6f-8da7-4a16c986b6e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTS" xlink:type="simple" xlink:href="alny-20260930.xsd#FAIRVALUEMEASUREMENTS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7065-93c2-1ab51d37a877" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_01a020c3-db5e-7f60-a410-defebeb4ab05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7065-93c2-1ab51d37a877" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_01a020c3-db5e-7f60-a410-defebeb4ab05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIES" xlink:type="simple" xlink:href="alny-20260930.xsd#MARKETABLEDEBTSECURITIES"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIES" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-769e-8cdc-df223d73c015" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_InvestmentsInMarketableDebtSecuritiesDisclosureTextBlock_01a020c3-db5e-7992-8d4f-50cbdb0c0d7a" xlink:href="alny-20260930.xsd#alny_InvestmentsInMarketableDebtSecuritiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-769e-8cdc-df223d73c015" xlink:to="loc_alny_InvestmentsInMarketableDebtSecuritiesDisclosureTextBlock_01a020c3-db5e-7992-8d4f-50cbdb0c0d7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILS" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILS"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-792c-abd9-5d9b667a1e14" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_01a020c3-db5e-7226-944d-8bba23a51729" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-792c-abd9-5d9b667a1e14" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_01a020c3-db5e-7226-944d-8bba23a51729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCING" xlink:type="simple" xlink:href="alny-20260930.xsd#CONVERTIBLEDEBTANDOTHERFINANCING"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCING" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-7f2d-a23c-b7cdb727d654" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_01a020c3-db5e-7801-8717-53b0948d39a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-7f2d-a23c-b7cdb727d654" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_01a020c3-db5e-7801-8717-53b0948d39a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDING" xlink:type="simple" xlink:href="alny-20260930.xsd#LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDING"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDING" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7c57-a2c8-a203eb132060" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFundingTextBlock_01a020c3-db5e-734c-a093-54a4741bb935" xlink:href="alny-20260930.xsd#alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFundingTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7c57-a2c8-a203eb132060" xlink:to="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesAndDevelopmentFundingTextBlock_01a020c3-db5e-734c-a093-54a4741bb935" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/STOCKBASEDCOMPENSATION" xlink:type="simple" xlink:href="alny-20260930.xsd#STOCKBASEDCOMPENSATION"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/STOCKBASEDCOMPENSATION" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-701b-ac7f-fd90005679f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_01a020c3-db5e-730e-809f-3f534faaf149" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-701b-ac7f-fd90005679f6" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_01a020c3-db5e-730e-809f-3f534faaf149" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARE" xlink:type="simple" xlink:href="alny-20260930.xsd#NETINCOMELOSSPERCOMMONSHARE"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARE" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-793b-a1c4-8ebfe927dd83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_01a020c3-db5e-74a6-85a7-6015ba3daf42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-793b-a1c4-8ebfe927dd83" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_01a020c3-db5e-74a6-85a7-6015ba3daf42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="simple" xlink:href="alny-20260930.xsd#COMMITMENTSANDCONTINGENCIES"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_01a020c3-db5e-748e-af0b-fb262a1f6692" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_01a020c3-db5e-758b-90a9-88dce8ef8592" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_01a020c3-db5e-748e-af0b-fb262a1f6692" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_01a020c3-db5e-758b-90a9-88dce8ef8592" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/SEGMENTINFORMATION" xlink:type="simple" xlink:href="alny-20260930.xsd#SEGMENTINFORMATION"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/SEGMENTINFORMATION" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-794f-b19d-5afd94a909f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_01a020c3-db5e-70b0-994d-0086e133a969" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-794f-b19d-5afd94a909f0" xlink:to="loc_us-gaap_SegmentReportingDisclosureTextBlock_01a020c3-db5e-70b0-994d-0086e133a969" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/INCOMETAXES" xlink:type="simple" xlink:href="alny-20260930.xsd#INCOMETAXES"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/INCOMETAXES" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_01a12fb8-324c-7f60-8f33-daa4f37293b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_01a12fba-0773-717f-9a3f-d8c98ddcb454" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_01a12fb8-324c-7f60-8f33-daa4f37293b3" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_01a12fba-0773-717f-9a3f-d8c98ddcb454" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATIONPolicies" xlink:type="simple" xlink:href="alny-20260930.xsd#BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATIONPolicies"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/BASISOFPRESENTATIONANDPRINCIPLESOFCONSOLIDATIONPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-77bf-9048-7be638537ad9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_01a020c3-db5e-7d75-b6c0-a7e335c7864d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConsolidationPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-77bf-9048-7be638537ad9" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_01a020c3-db5e-7d75-b6c0-a7e335c7864d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_01a020c3-db5e-75ae-9adb-5a70f4b85af4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-77bf-9048-7be638537ad9" xlink:to="loc_us-gaap_UseOfEstimates_01a020c3-db5e-75ae-9adb-5a70f4b85af4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiquidityPolicyPolicyTextBlock_01a020c3-db5e-7c33-949d-69cc7cfa1621" xlink:href="alny-20260930.xsd#alny_LiquidityPolicyPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-77bf-9048-7be638537ad9" xlink:to="loc_alny_LiquidityPolicyPolicyTextBlock_01a020c3-db5e-7c33-949d-69cc7cfa1621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_01a020c3-db5e-7bf1-b6b2-10e20014bfbd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_01a020c3-db5e-77bf-9048-7be638537ad9" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_01a020c3-db5e-7bf1-b6b2-10e20014bfbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETPRODUCTREVENUESTables" xlink:type="simple" xlink:href="alny-20260930.xsd#NETPRODUCTREVENUESTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETPRODUCTREVENUESTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-71c8-b398-b10acbad2258" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_01a020c3-db5e-75e3-afd5-84376deb74bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-71c8-b398-b10acbad2258" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_01a020c3-db5e-75e3-afd5-84376deb74bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_SummaryOfProductRevenueAllowanceAndReserveCategoriesTableTableTextBlock_01a020c3-db5e-7477-bdd6-44ce36e7fa07" xlink:href="alny-20260930.xsd#alny_SummaryOfProductRevenueAllowanceAndReserveCategoriesTableTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-71c8-b398-b10acbad2258" xlink:to="loc_alny_SummaryOfProductRevenueAllowanceAndReserveCategoriesTableTableTextBlock_01a020c3-db5e-7477-bdd6-44ce36e7fa07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSTables" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7dab-a463-9441f008eec3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_01a020c3-db5e-7366-9aff-eea584727115" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7dab-a463-9441f008eec3" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_01a020c3-db5e-7366-9aff-eea584727115" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_01a020c3-db5e-7e83-ba30-b378651c026b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7dab-a463-9441f008eec3" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_01a020c3-db5e-7e83-ba30-b378651c026b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ScheduleOfAllocatedTransactionPriceTableTextBlock_01a020c3-db5e-767b-9543-c204b4c3251b" xlink:href="alny-20260930.xsd#alny_ScheduleOfAllocatedTransactionPriceTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7dab-a463-9441f008eec3" xlink:to="loc_alny_ScheduleOfAllocatedTransactionPriceTableTextBlock_01a020c3-db5e-767b-9543-c204b4c3251b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="simple" xlink:href="alny-20260930.xsd#FAIRVALUEMEASUREMENTSTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7822-bd14-32ad20a307cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_01a020c3-db5e-7e07-97af-c4a77fbd7c49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7822-bd14-32ad20a307cf" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_01a020c3-db5e-7e07-97af-c4a77fbd7c49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESTables" xlink:type="simple" xlink:href="alny-20260930.xsd#MARKETABLEDEBTSECURITIESTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-7730-bddb-00ee2ed2ae84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_01a020c3-db5e-708b-8c3a-59dfa3c8b85b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-7730-bddb-00ee2ed2ae84" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_01a020c3-db5e-708b-8c3a-59dfa3c8b85b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_01a020c3-db5e-7d5c-bf9a-edc86914ced2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-7730-bddb-00ee2ed2ae84" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_01a020c3-db5e-7d5c-bf9a-edc86914ced2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSTables" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILSTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-72de-925b-9fac1fcbadb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_01a020c3-db5e-7975-8774-c13180b8d120" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-72de-925b-9fac1fcbadb7" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_01a020c3-db5e-7975-8774-c13180b8d120" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashTableTableTextBlock_01a020c3-db5e-7d55-a64d-715e2d42ea04" xlink:href="alny-20260930.xsd#alny_ScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashTableTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-72de-925b-9fac1fcbadb7" xlink:to="loc_alny_ScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashTableTableTextBlock_01a020c3-db5e-7d55-a64d-715e2d42ea04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_01a020c3-db5e-77a9-b26c-59e2c8588e3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-72de-925b-9fac1fcbadb7" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_01a020c3-db5e-77a9-b26c-59e2c8588e3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGTables" xlink:type="simple" xlink:href="alny-20260930.xsd#LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7b96-aae8-73b0133cce6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_01a020c3-db5e-786a-8542-f34962383b30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7b96-aae8-73b0133cce6d" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_01a020c3-db5e-786a-8542-f34962383b30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ScheduleOfRoyaltyLiabilityTableTextBlock_01a020c3-db5e-71d6-88c5-c6cfdd655e70" xlink:href="alny-20260930.xsd#alny_ScheduleOfRoyaltyLiabilityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7b96-aae8-73b0133cce6d" xlink:to="loc_alny_ScheduleOfRoyaltyLiabilityTableTextBlock_01a020c3-db5e-71d6-88c5-c6cfdd655e70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/STOCKBASEDCOMPENSATIONTables" xlink:type="simple" xlink:href="alny-20260930.xsd#STOCKBASEDCOMPENSATIONTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/STOCKBASEDCOMPENSATIONTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-7e86-a4a2-d5b9249165f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock_01a020c3-db5e-7aa7-943c-833aa13dcf0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-7e86-a4a2-d5b9249165f7" xlink:to="loc_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock_01a020c3-db5e-7aa7-943c-833aa13dcf0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARETables" xlink:type="simple" xlink:href="alny-20260930.xsd#NETINCOMELOSSPERCOMMONSHARETables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARETables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7c34-b2e8-b0f0ae62b0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_01a020c3-db5e-7754-8ffb-a1e9099d6984" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7c34-b2e8-b0f0ae62b0a9" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_01a020c3-db5e-7754-8ffb-a1e9099d6984" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_01a020c3-db5e-7f6b-81d3-6a5a2996c5a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7c34-b2e8-b0f0ae62b0a9" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_01a020c3-db5e-7f6b-81d3-6a5a2996c5a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/SEGMENTINFORMATIONTables" xlink:type="simple" xlink:href="alny-20260930.xsd#SEGMENTINFORMATIONTables"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/SEGMENTINFORMATIONTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-76ed-a421-28a4cc9bba24" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_01a020c3-db5e-746d-8c45-edb861eccc1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-76ed-a421-28a4cc9bba24" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_01a020c3-db5e-746d-8c45-edb861eccc1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NATUREOFBUSINESSDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#NATUREOFBUSINESSDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NATUREOFBUSINESSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f90-8e96-e53f04afc431" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfProductsWithMarketingApproval_01a020c3-db5e-7c5b-8e36-1008f19e7f8c" xlink:href="alny-20260930.xsd#alny_NumberOfProductsWithMarketingApproval"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f90-8e96-e53f04afc431" xlink:to="loc_alny_NumberOfProductsWithMarketingApproval_01a020c3-db5e-7c5b-8e36-1008f19e7f8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfPartneredProducts_01a020c3-db5e-7cb5-a7c7-ecee3cd5557b" xlink:href="alny-20260930.xsd#alny_NumberOfPartneredProducts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f90-8e96-e53f04afc431" xlink:to="loc_alny_NumberOfPartneredProducts_01a020c3-db5e-7cb5-a7c7-ecee3cd5557b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfCommercializedProducts_01a020c3-db5e-7f9c-82a7-69b029dd37cd" xlink:href="alny-20260930.xsd#alny_NumberOfCommercializedProducts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f90-8e96-e53f04afc431" xlink:to="loc_alny_NumberOfCommercializedProducts_01a020c3-db5e-7f9c-82a7-69b029dd37cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETPRODUCTREVENUESScheduleofNetProductRevenuesDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETPRODUCTREVENUESScheduleofNetProductRevenuesDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETPRODUCTREVENUESScheduleofNetProductRevenuesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7a19-8bb9-3c499d72e308" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7911-b075-521d02d032a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7a19-8bb9-3c499d72e308" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7911-b075-521d02d032a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a020c3-db5e-7003-8a88-e251a9c17fc9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7911-b075-521d02d032a7" xlink:to="loc_srt_StatementGeographicalAxis_01a020c3-db5e-7003-8a88-e251a9c17fc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a020c3-db5e-7389-b29e-3066093570ae" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_01a020c3-db5e-7003-8a88-e251a9c17fc9" xlink:to="loc_srt_SegmentGeographicalDomain_01a020c3-db5e-7389-b29e-3066093570ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_01a020c3-db5e-7aa4-9313-45cede817854" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_US"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_01a020c3-db5e-7389-b29e-3066093570ae" xlink:to="loc_country_US_01a020c3-db5e-7aa4-9313-45cede817854" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_01a020c3-db5e-7d41-b201-090f1c4c389e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_EuropeMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_01a020c3-db5e-7389-b29e-3066093570ae" xlink:to="loc_srt_EuropeMember_01a020c3-db5e-7d41-b201-090f1c4c389e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NonUSOrEuropeMember_01a020c3-db5e-7f78-8acf-7fd35cc8ea0c" xlink:href="alny-20260930.xsd#alny_NonUSOrEuropeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_01a020c3-db5e-7389-b29e-3066093570ae" xlink:to="loc_alny_NonUSOrEuropeMember_01a020c3-db5e-7f78-8acf-7fd35cc8ea0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7248-9cb7-7c01571d400a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7911-b075-521d02d032a7" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7248-9cb7-7c01571d400a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7176-add1-c4a9c54cbc6e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7248-9cb7-7c01571d400a" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7176-add1-c4a9c54cbc6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_01a020c3-db5e-7841-a16f-01985ffb412d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7176-add1-c4a9c54cbc6e" xlink:to="loc_us-gaap_ProductMember_01a020c3-db5e-7841-a16f-01985ffb412d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_TTRMember_01a020c3-db5e-79dd-9ecc-a036e076fd00" xlink:href="alny-20260930.xsd#alny_TTRMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductMember_01a020c3-db5e-7841-a16f-01985ffb412d" xlink:to="loc_alny_TTRMember_01a020c3-db5e-79dd-9ecc-a036e076fd00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_AmvuttraMember_01a020c3-db5e-70cb-bb1e-2cfac63c7a9c" xlink:href="alny-20260930.xsd#alny_AmvuttraMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_TTRMember_01a020c3-db5e-79dd-9ecc-a036e076fd00" xlink:to="loc_alny_AmvuttraMember_01a020c3-db5e-70cb-bb1e-2cfac63c7a9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ONPATTROMember_01a020c3-db5e-799a-8e2a-249e7faaf5d9" xlink:href="alny-20260930.xsd#alny_ONPATTROMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_TTRMember_01a020c3-db5e-79dd-9ecc-a036e076fd00" xlink:to="loc_alny_ONPATTROMember_01a020c3-db5e-799a-8e2a-249e7faaf5d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RareMember_01a020c3-db5e-7aa0-90cb-b9257b33b2c1" xlink:href="alny-20260930.xsd#alny_RareMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductMember_01a020c3-db5e-7841-a16f-01985ffb412d" xlink:to="loc_alny_RareMember_01a020c3-db5e-7aa0-90cb-b9257b33b2c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_GIVLAARIMember_01a020c3-db5e-72ae-9302-84a071b54ccc" xlink:href="alny-20260930.xsd#alny_GIVLAARIMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RareMember_01a020c3-db5e-7aa0-90cb-b9257b33b2c1" xlink:to="loc_alny_GIVLAARIMember_01a020c3-db5e-72ae-9302-84a071b54ccc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OXLUMOMember_01a020c3-db5e-7874-b6bd-cda3dcfa0393" xlink:href="alny-20260930.xsd#alny_OXLUMOMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RareMember_01a020c3-db5e-7aa0-90cb-b9257b33b2c1" xlink:to="loc_alny_OXLUMOMember_01a020c3-db5e-7874-b6bd-cda3dcfa0393" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7da8-9c95-615e8c018dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7911-b075-521d02d032a7" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7da8-9c95-615e8c018dfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-737e-b891-a1fe692f442e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7da8-9c95-615e8c018dfb" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-737e-b891-a1fe692f442e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETPRODUCTREVENUESAdditionalInformationDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETPRODUCTREVENUESAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETPRODUCTREVENUESAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-75de-95e4-e9da111384b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-73c2-9941-66a27be170b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-75de-95e4-e9da111384b3" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-73c2-9941-66a27be170b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7953-b6a8-22c9e4c49520" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-73c2-9941-66a27be170b0" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7953-b6a8-22c9e4c49520" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7594-ae90-1a988cd93c78" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7953-b6a8-22c9e4c49520" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7594-ae90-1a988cd93c78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_01a020c3-db5e-756a-af49-8dffbc677888" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7594-ae90-1a988cd93c78" xlink:to="loc_us-gaap_ProductMember_01a020c3-db5e-756a-af49-8dffbc677888" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7086-91a8-d132c74c006c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-73c2-9941-66a27be170b0" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7086-91a8-d132c74c006c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-db5e-726a-8f66-77f2c018a0b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7086-91a8-d132c74c006c" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-db5e-726a-8f66-77f2c018a0b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETPRODUCTREVENUESScheduleofBalancesandActivityinEachProductRevenueAllowanceandReserveCategoryDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETPRODUCTREVENUESScheduleofBalancesandActivityinEachProductRevenueAllowanceandReserveCategoryDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETPRODUCTREVENUESScheduleofBalancesandActivityinEachProductRevenueAllowanceandReserveCategoryDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7134-93e6-6f57a32becfa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7991-8de9-bd922a6213c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_01a020c3-db5e-7134-93e6-6f57a32becfa" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7991-8de9-bd922a6213c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_01a020c3-db5e-7b8c-b675-efbc93ef69b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7991-8de9-bd922a6213c6" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_01a020c3-db5e-7b8c-b675-efbc93ef69b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_01a020c3-db5e-7cf4-990c-9a8fdbe63384" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_01a020c3-db5e-7b8c-b675-efbc93ef69b9" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_01a020c3-db5e-7cf4-990c-9a8fdbe63384" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ChargebacksAndRebatesMember_01a020c3-db5e-7cc9-abb7-7c3c8747eae7" xlink:href="alny-20260930.xsd#alny_ChargebacksAndRebatesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_01a020c3-db5e-7cf4-990c-9a8fdbe63384" xlink:to="loc_alny_ChargebacksAndRebatesMember_01a020c3-db5e-7cc9-abb7-7c3c8747eae7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OtherIncentivesAndAllowancesMember_01a020c3-db5e-7ce9-8dda-10cf48ae46f1" xlink:href="alny-20260930.xsd#alny_OtherIncentivesAndAllowancesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_01a020c3-db5e-7cf4-990c-9a8fdbe63384" xlink:to="loc_alny_OtherIncentivesAndAllowancesMember_01a020c3-db5e-7ce9-8dda-10cf48ae46f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7ec8-a5f2-baea67b5f02b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01a020c3-db5e-7991-8de9-bd922a6213c6" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7ec8-a5f2-baea67b5f02b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_01a020c3-db5e-7ec8-a5f2-baea67b5f02b" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_01a020c3-db5e-7a5e-8c95-68942452e210" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_01a020c3-db5e-7a5e-8c95-68942452e210" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ValuationAllowancesAndReservesProvisionRelatedToCurrentPeriodSales_01a020c3-db5e-7b43-8c0b-20deeee366f5" xlink:href="alny-20260930.xsd#alny_ValuationAllowancesAndReservesProvisionRelatedToCurrentPeriodSales"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_alny_ValuationAllowancesAndReservesProvisionRelatedToCurrentPeriodSales_01a020c3-db5e-7b43-8c0b-20deeee366f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ValuationAllowancesAndReservesProvisionRelatedToPriorPeriodSales_01a020c3-db5e-7f62-b069-96812269ef85" xlink:href="alny-20260930.xsd#alny_ValuationAllowancesAndReservesProvisionRelatedToPriorPeriodSales"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_alny_ValuationAllowancesAndReservesProvisionRelatedToPriorPeriodSales_01a020c3-db5e-7f62-b069-96812269ef85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ValuationAllowancesAndReservesSalesCreditPaymentCurrent_01a020c3-db5e-78d9-b7a7-5e145ea02bd3" xlink:href="alny-20260930.xsd#alny_ValuationAllowancesAndReservesSalesCreditPaymentCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_alny_ValuationAllowancesAndReservesSalesCreditPaymentCurrent_01a020c3-db5e-78d9-b7a7-5e145ea02bd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ValuationAllowancesAndReservesSalesCreditPaymentPrior_01a020c3-db5e-763a-86c3-1c80f9fce975" xlink:href="alny-20260930.xsd#alny_ValuationAllowancesAndReservesSalesCreditPaymentPrior"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_alny_ValuationAllowancesAndReservesSalesCreditPaymentPrior_01a020c3-db5e-763a-86c3-1c80f9fce975" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_01a020c3-db5e-7aea-baa2-6dde8785d362" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_01a020c3-db5e-7163-9d69-3d52612d634a" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_01a020c3-db5e-7aea-baa2-6dde8785d362" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSScheduleofRevenuefromCollaboratorsDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSScheduleofRevenuefromCollaboratorsDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSScheduleofRevenuefromCollaboratorsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7c55-a7af-cf8792112603" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-773c-94ab-f1ec3a0f1193" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7c55-a7af-cf8792112603" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-773c-94ab-f1ec3a0f1193" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7e5e-9a92-3e1fc89bfeeb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-773c-94ab-f1ec3a0f1193" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7e5e-9a92-3e1fc89bfeeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7570-a50c-287ee7f1614e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7e5e-9a92-3e1fc89bfeeb" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7570-a50c-287ee7f1614e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-732b-9f54-c851b88c204c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7570-a50c-287ee7f1614e" xlink:to="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-732b-9f54-c851b88c204c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-71c6-a4f9-415a469b17f0" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-773c-94ab-f1ec3a0f1193" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-71c6-a4f9-415a469b17f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-732a-9fa8-b17c313de567" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-71c6-a4f9-415a469b17f0" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-732a-9fa8-b17c313de567" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheMember_01a020c3-db5e-7b88-9b4e-13778645a4a8" xlink:href="alny-20260930.xsd#alny_RocheMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-732a-9fa8-b17c313de567" xlink:to="loc_alny_RocheMember_01a020c3-db5e-7b88-9b4e-13778645a4a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7b81-a554-f10c2a3af763" xlink:href="alny-20260930.xsd#alny_RegeneronPharmaceuticalsIncorporationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-732a-9fa8-b17c313de567" xlink:to="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7b81-a554-f10c2a3af763" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OtherCollaborationsMember_01a020c3-db5e-7bb8-be86-e252a4085228" xlink:href="alny-20260930.xsd#alny_OtherCollaborationsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-732a-9fa8-b17c313de567" xlink:to="loc_alny_OtherCollaborationsMember_01a020c3-db5e-7bb8-be86-e252a4085228" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-73c4-9f83-42140fe5daff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-773c-94ab-f1ec3a0f1193" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-73c4-9f83-42140fe5daff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7132-907b-a62561d2c3db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-73c4-9f83-42140fe5daff" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7132-907b-a62561d2c3db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSScheduleofBalanceofReceivablesandContractLiabilitiesRelatedtoCollaborationAgreementsDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSScheduleofBalanceofReceivablesandContractLiabilitiesRelatedtoCollaborationAgreementsDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSScheduleofBalanceofReceivablesandContractLiabilitiesRelatedtoCollaborationAgreementsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7144-9af3-9aaad3813822" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7a76-83a0-c6b28233b393" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7144-9af3-9aaad3813822" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7a76-83a0-c6b28233b393" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-717d-bb03-975829db7d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7a76-83a0-c6b28233b393" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-717d-bb03-975829db7d3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-79b9-9345-f277ee9862d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-717d-bb03-975829db7d3d" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-79b9-9345-f277ee9862d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-7f92-b002-7e3f39939130" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-79b9-9345-f277ee9862d2" xlink:to="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-7f92-b002-7e3f39939130" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-7156-a275-a6cdac381c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7a76-83a0-c6b28233b393" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-7156-a275-a6cdac381c7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-db5e-73d2-b58a-9e465ee4ffbd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-7156-a275-a6cdac381c7f" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_01a020c3-db5e-73d2-b58a-9e465ee4ffbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-db5e-7362-b46b-da683a5b5364" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-7156-a275-a6cdac381c7f" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-db5e-7362-b46b-da683a5b5364" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSAdditionalInformationDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f2b-bb30-4d5bcda6b4da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7f2b-bb30-4d5bcda6b4da" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73a3-8883-1299457c904c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73a3-8883-1299457c904c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7b57-bc9f-caa4edf324f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73a3-8883-1299457c904c" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7b57-bc9f-caa4edf324f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-70c8-a4e9-42c9df5ab61d" xlink:href="alny-20260930.xsd#alny_RocheCollaborationAndLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7b57-bc9f-caa4edf324f3" xlink:to="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-70c8-a4e9-42c9df5ab61d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_GlobalStrategicCollaborationMember_01a020c3-db5e-7f20-aa88-21c824da8be0" xlink:href="alny-20260930.xsd#alny_GlobalStrategicCollaborationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7b57-bc9f-caa4edf324f3" xlink:to="loc_alny_GlobalStrategicCollaborationMember_01a020c3-db5e-7f20-aa88-21c824da8be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-760e-846a-b323701a741b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-760e-846a-b323701a741b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-760e-846a-b323701a741b" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheMember_01a020c3-db5e-7ffd-995b-304bcc775927" xlink:href="alny-20260930.xsd#alny_RocheMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:to="loc_alny_RocheMember_01a020c3-db5e-7ffd-995b-304bcc775927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7bab-bec6-78fcb3a34538" xlink:href="alny-20260930.xsd#alny_RegeneronPharmaceuticalsIncorporationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:to="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7bab-bec6-78fcb3a34538" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_VirBiotechnologyInc.Member_01a020c3-db5e-7002-979c-ef5458d62528" xlink:href="alny-20260930.xsd#alny_VirBiotechnologyInc.Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:to="loc_alny_VirBiotechnologyInc.Member_01a020c3-db5e-7002-979c-ef5458d62528" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_InceptiveNucleicsIncMember_01a020c3-db5e-703a-bbf4-958a6bbee2cc" xlink:href="alny-20260930.xsd#alny_InceptiveNucleicsIncMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7470-afa5-c10ac33506f9" xlink:to="loc_alny_InceptiveNucleicsIncMember_01a020c3-db5e-703a-bbf4-958a6bbee2cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7c80-b8a2-993d32d39b7c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7c80-b8a2-993d32d39b7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7c80-b8a2-993d32d39b7c" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseMember_01a020c3-db5e-7ff4-a5f9-e854f5ead2f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LicenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:to="loc_us-gaap_LicenseMember_01a020c3-db5e-7ff4-a5f9-e854f5ead2f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_C5MonotherapyObligationMember_01a020c3-db5e-741e-9d90-53561bd6f15e" xlink:href="alny-20260930.xsd#alny_C5MonotherapyObligationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:to="loc_alny_C5MonotherapyObligationMember_01a020c3-db5e-741e-9d90-53561bd6f15e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ResearchServicesObligationMember_01a020c3-db5e-7ea2-89e3-3fc051ae7682" xlink:href="alny-20260930.xsd#alny_ResearchServicesObligationMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:to="loc_alny_ResearchServicesObligationMember_01a020c3-db5e-7ea2-89e3-3fc051ae7682" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborationsMember_01a020c3-db5e-7ddf-9123-b465dce8b8c2" xlink:href="alny-20260930.xsd#alny_CollaborationsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7e65-a9fe-ef506f265217" xlink:to="loc_alny_CollaborationsMember_01a020c3-db5e-7ddf-9123-b465dce8b8c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_01a020c3-db5e-7e4d-b281-04f7dc591b3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_01a020c3-db5e-7e4d-b281-04f7dc591b3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_01a020c3-db5e-7192-a472-28876c3ab0e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_01a020c3-db5e-7e4d-b281-04f7dc591b3b" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_01a020c3-db5e-7192-a472-28876c3ab0e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_FundingAtProgramInitiationMember_01a020c3-db5e-7f44-aa1f-45cc4aff2085" xlink:href="alny-20260930.xsd#alny_FundingAtProgramInitiationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_01a020c3-db5e-7192-a472-28876c3ab0e2" xlink:to="loc_alny_FundingAtProgramInitiationMember_01a020c3-db5e-7f44-aa1f-45cc4aff2085" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_FundingAtLeadCandidateIdentificationMember_01a020c3-db5e-750e-8d36-96992ccd40c4" xlink:href="alny-20260930.xsd#alny_FundingAtLeadCandidateIdentificationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_01a020c3-db5e-7192-a472-28876c3ab0e2" xlink:to="loc_alny_FundingAtLeadCandidateIdentificationMember_01a020c3-db5e-750e-8d36-96992ccd40c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_01a020c3-db5e-72b4-9dbe-6b4f3475cfb2" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_srt_RangeAxis_01a020c3-db5e-72b4-9dbe-6b4f3475cfb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a020c3-db5e-779d-b89e-dabd40adfc62" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_01a020c3-db5e-72b4-9dbe-6b4f3475cfb2" xlink:to="loc_srt_RangeMember_01a020c3-db5e-779d-b89e-dabd40adfc62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_01a020c3-db5e-7680-82c9-f069ce829746" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_01a020c3-db5e-779d-b89e-dabd40adfc62" xlink:to="loc_srt_MaximumMember_01a020c3-db5e-7680-82c9-f069ce829746" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-77b0-8ae0-fd6cefcb6c1e" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_01a020c3-db5e-7e60-97c8-38b755f7892e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_01a020c3-db5e-7e60-97c8-38b755f7892e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DevelopmentCostsPercentResponsible_01a020c3-db5e-70b9-b54f-f86fcf68bd75" xlink:href="alny-20260930.xsd#alny_DevelopmentCostsPercentResponsible"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_DevelopmentCostsPercentResponsible_01a020c3-db5e-70b9-b54f-f86fcf68bd75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ProfitAndLossSharingPercent_01a020c3-db5e-7c31-bec3-c85b80a567f3" xlink:href="alny-20260930.xsd#alny_ProfitAndLossSharingPercent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_ProfitAndLossSharingPercent_01a020c3-db5e-7c31-bec3-c85b80a567f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfPerformanceObligations_01a020c3-db5e-78f3-ba82-0367b5e57c51" xlink:href="alny-20260930.xsd#alny_NumberOfPerformanceObligations"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_NumberOfPerformanceObligations_01a020c3-db5e-78f3-ba82-0367b5e57c51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RevenueRecognitionPercentageOfActualReimbursement_01a020c3-db5e-7097-a725-23aeae168b55" xlink:href="alny-20260930.xsd#alny_RevenueRecognitionPercentageOfActualReimbursement"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_RevenueRecognitionPercentageOfActualReimbursement_01a020c3-db5e-7097-a725-23aeae168b55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_TransactionPrice_01a020c3-db5e-7a7a-8df1-e54b0b9b2b2b" xlink:href="alny-20260930.xsd#alny_TransactionPrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_TransactionPrice_01a020c3-db5e-7a7a-8df1-e54b0b9b2b2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_01a020c3-db5e-75b9-ae58-bfdccd2d4dc9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_01a020c3-db5e-75b9-ae58-bfdccd2d4dc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-db5e-757d-be97-fd0dc188bc10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-db5e-757d-be97-fd0dc188bc10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementUpfrontPayment_01a020c3-db5e-791b-9aff-11b7f916f832" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementUpfrontPayment"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_CollaborativeArrangementUpfrontPayment_01a020c3-db5e-791b-9aff-11b7f916f832" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_MaximumRoyaltiesAndCommercialMilestonePaymentsUponPotentialProductSale_01a020c3-db5e-7ac9-9cbb-1b163fdd078b" xlink:href="alny-20260930.xsd#alny_MaximumRoyaltiesAndCommercialMilestonePaymentsUponPotentialProductSale"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_MaximumRoyaltiesAndCommercialMilestonePaymentsUponPotentialProductSale_01a020c3-db5e-7ac9-9cbb-1b163fdd078b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborationAgreementDesignatedCandidatesPeriodAfterExpirationOfInitialResearchTerm_01a020c3-db5e-7d9f-9aa7-a3bcb0c75ccd" xlink:href="alny-20260930.xsd#alny_CollaborationAgreementDesignatedCandidatesPeriodAfterExpirationOfInitialResearchTerm"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_CollaborationAgreementDesignatedCandidatesPeriodAfterExpirationOfInitialResearchTerm_01a020c3-db5e-7d9f-9aa7-a3bcb0c75ccd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_MaximumAdditionalMilestonePaymentsToBeReceiveUponAchievementOfCertainCriteria_01a020c3-db5e-7ec2-accd-1cd2ce609cc6" xlink:href="alny-20260930.xsd#alny_MaximumAdditionalMilestonePaymentsToBeReceiveUponAchievementOfCertainCriteria"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_MaximumAdditionalMilestonePaymentsToBeReceiveUponAchievementOfCertainCriteria_01a020c3-db5e-7ec2-accd-1cd2ce609cc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_PotentialProceedsFromCollaborationArrangement_01a020c3-db5e-79d0-ad10-5e6ada28b7da" xlink:href="alny-20260930.xsd#alny_PotentialProceedsFromCollaborationArrangement"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_PotentialProceedsFromCollaborationArrangement_01a020c3-db5e-79d0-ad10-5e6ada28b7da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementMilestonePaymentsPerCollaborationProject_01a020c3-db5e-7917-a00a-fccdeae667ad" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementMilestonePaymentsPerCollaborationProject"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_CollaborativeArrangementMilestonePaymentsPerCollaborationProject_01a020c3-db5e-7917-a00a-fccdeae667ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyRate_01a020c3-db5e-7daf-836b-21f9357f9508" xlink:href="alny-20260930.xsd#alny_RoyaltyRate"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_RoyaltyRate_01a020c3-db5e-7daf-836b-21f9357f9508" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_PercentageOfMaximumRoyaltyPayments_01a020c3-db5e-7c6e-854c-c46718139af0" xlink:href="alny-20260930.xsd#alny_PercentageOfMaximumRoyaltyPayments"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_PercentageOfMaximumRoyaltyPayments_01a020c3-db5e-7c6e-854c-c46718139af0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_FixedConsideration_01a020c3-db5e-7ddb-9c8a-69a6cb4cf8f0" xlink:href="alny-20260930.xsd#alny_FixedConsideration"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_FixedConsideration_01a020c3-db5e-7ddb-9c8a-69a6cb4cf8f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfSeparatePrograms_01a134a2-22e5-7d19-bea3-4b75ea9f1d43" xlink:href="alny-20260930.xsd#alny_NumberOfSeparatePrograms"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_NumberOfSeparatePrograms_01a134a2-22e5-7d19-bea3-4b75ea9f1d43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-db5e-7f52-8eb2-2230f499af30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_01a020c3-db5e-7f52-8eb2-2230f499af30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7acb-9fbf-bc906c9a54d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7acb-9fbf-bc906c9a54d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborationAgreementInitialResearchTerm_01a020c3-db5e-7f81-839b-2b80300829e8" xlink:href="alny-20260930.xsd#alny_CollaborationAgreementInitialResearchTerm"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_CollaborationAgreementInitialResearchTerm_01a020c3-db5e-7f81-839b-2b80300829e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborationAgreementRightToTerminateWrittenAdvanceNoticePeriod_01a020c3-db5e-7e4d-86d9-775c3bbc5d90" xlink:href="alny-20260930.xsd#alny_CollaborationAgreementRightToTerminateWrittenAdvanceNoticePeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_alny_CollaborationAgreementRightToTerminateWrittenAdvanceNoticePeriod_01a020c3-db5e-7e4d-86d9-775c3bbc5d90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_01a020c3-db5e-7481-955b-49058d88f868" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77c8-a827-f6f2a7940d54" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_01a020c3-db5e-7481-955b-49058d88f868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSScheduleofTransactionPriceAllocatedDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSScheduleofTransactionPriceAllocatedDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSScheduleofTransactionPriceAllocatedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7374-ac19-512af3714cce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7374-ac19-512af3714cce" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7668-9200-de0a6bcba8df" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7668-9200-de0a6bcba8df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7899-b293-4432f41f30e8" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7668-9200-de0a6bcba8df" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7899-b293-4432f41f30e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LicenseObligationMember_01a020c3-db5e-769f-b365-6e7795d529ac" xlink:href="alny-20260930.xsd#alny_LicenseObligationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7899-b293-4432f41f30e8" xlink:to="loc_alny_LicenseObligationMember_01a020c3-db5e-769f-b365-6e7795d529ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DevelopmentServicesObligationMember_01a020c3-db5e-7f5a-a2b5-af3242cf2348" xlink:href="alny-20260930.xsd#alny_DevelopmentServicesObligationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7899-b293-4432f41f30e8" xlink:to="loc_alny_DevelopmentServicesObligationMember_01a020c3-db5e-7f5a-a2b5-af3242cf2348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_TechnologyTransferObligationMember_01a020c3-db5e-7143-a4db-fd04831ca1b2" xlink:href="alny-20260930.xsd#alny_TechnologyTransferObligationMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7899-b293-4432f41f30e8" xlink:to="loc_alny_TechnologyTransferObligationMember_01a020c3-db5e-7143-a4db-fd04831ca1b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7f98-b862-917c2dcaef9e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7f98-b862-917c2dcaef9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7070-8419-5104c0e6b9d1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7f98-b862-917c2dcaef9e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7070-8419-5104c0e6b9d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheMember_01a020c3-db5e-70f0-a67f-90fde5dba18a" xlink:href="alny-20260930.xsd#alny_RocheMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7070-8419-5104c0e6b9d1" xlink:to="loc_alny_RocheMember_01a020c3-db5e-70f0-a67f-90fde5dba18a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7ca0-a29a-a9e201f022a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7ca0-a29a-a9e201f022a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-73fb-8a39-1423b96253d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7ca0-a29a-a9e201f022a5" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-73fb-8a39-1423b96253d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-7a38-b64b-7106ee147d7d" xlink:href="alny-20260930.xsd#alny_RocheCollaborationAndLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-73fb-8a39-1423b96253d6" xlink:to="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-7a38-b64b-7106ee147d7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-708c-9124-6644ab022596" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7bd8-9058-e6c6c7c89ea2" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-708c-9124-6644ab022596" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_TransactionPrice_01a020c3-db5e-73ef-8e6d-bc1a29ec3d72" xlink:href="alny-20260930.xsd#alny_TransactionPrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-708c-9124-6644ab022596" xlink:to="loc_alny_TransactionPrice_01a020c3-db5e-73ef-8e6d-bc1a29ec3d72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSScheduleofNetRevenuesFromCollaborationsDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSScheduleofNetRevenuesFromCollaborationsDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSScheduleofNetRevenuesFromCollaborationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7223-849f-05edab6d639d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7223-849f-05edab6d639d" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7fab-82ae-4f118c27a71f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7fab-82ae-4f118c27a71f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7df8-8b07-bf35699fc64e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7fab-82ae-4f118c27a71f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7df8-8b07-bf35699fc64e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheMember_01a020c3-db5e-722d-add2-3bf40ccceb64" xlink:href="alny-20260930.xsd#alny_RocheMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7df8-8b07-bf35699fc64e" xlink:to="loc_alny_RocheMember_01a020c3-db5e-722d-add2-3bf40ccceb64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7318-a187-e46080066175" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7318-a187-e46080066175" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-77e3-a135-9998fa03f284" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7318-a187-e46080066175" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-77e3-a135-9998fa03f284" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LicenseObligationMember_01a057a0-6b53-7243-af68-15197b0c94ed" xlink:href="alny-20260930.xsd#alny_LicenseObligationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-77e3-a135-9998fa03f284" xlink:to="loc_alny_LicenseObligationMember_01a057a0-6b53-7243-af68-15197b0c94ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DevelopmentServicesObligationMember_01a020c3-db5e-7a82-b708-5145dac42ece" xlink:href="alny-20260930.xsd#alny_DevelopmentServicesObligationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-77e3-a135-9998fa03f284" xlink:to="loc_alny_DevelopmentServicesObligationMember_01a020c3-db5e-7a82-b708-5145dac42ece" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_01a020c3-db5e-7bfd-abeb-75ca601b537e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductAndServiceOtherMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-77e3-a135-9998fa03f284" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_01a020c3-db5e-7bfd-abeb-75ca601b537e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7268-be90-5877c438e849" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7268-be90-5877c438e849" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-77dd-9b56-4f3864772580" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7268-be90-5877c438e849" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-77dd-9b56-4f3864772580" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-785e-ba85-537862b1b6f4" xlink:href="alny-20260930.xsd#alny_RocheCollaborationAndLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-77dd-9b56-4f3864772580" xlink:to="loc_alny_RocheCollaborationAndLicenseAgreementMember_01a020c3-db5e-785e-ba85-537862b1b6f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77a3-a855-c0b75617eabc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ad2-8fd6-36a4771addb9" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77a3-a855-c0b75617eabc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7617-9e21-687f041f46c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-77a3-a855-c0b75617eabc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7617-9e21-687f041f46c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COLLABORATIONSScheduleofRevenueRecognizedunderCollaborationDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#COLLABORATIONSScheduleofRevenueRecognizedunderCollaborationDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COLLABORATIONSScheduleofRevenueRecognizedunderCollaborationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7a67-9304-a6c74103dab5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7a67-9304-a6c74103dab5" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7c44-8188-72a0964b557f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7c44-8188-72a0964b557f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ba9-a69e-dc98252fa1ef" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-7c44-8188-72a0964b557f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ba9-a69e-dc98252fa1ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7fb1-819f-e31f112f71f8" xlink:href="alny-20260930.xsd#alny_RegeneronPharmaceuticalsIncorporationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ba9-a69e-dc98252fa1ef" xlink:to="loc_alny_RegeneronPharmaceuticalsIncorporationMember_01a020c3-db5e-7fb1-819f-e31f112f71f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-734a-97be-b6a6cdb51312" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-734a-97be-b6a6cdb51312" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-734a-97be-b6a6cdb51312" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ResearchServicesObligationMember_01a020c3-db5e-7386-9fb7-4b7c5a065b1d" xlink:href="alny-20260930.xsd#alny_ResearchServicesObligationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:to="loc_alny_ResearchServicesObligationMember_01a020c3-db5e-7386-9fb7-4b7c5a065b1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_C5LicenseObligationMember_01a020c3-db5e-7c9e-9b8e-08cf1cbfc7ee" xlink:href="alny-20260930.xsd#alny_C5LicenseObligationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:to="loc_alny_C5LicenseObligationMember_01a020c3-db5e-7c9e-9b8e-08cf1cbfc7ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RegeneronTechnologyTransferObligationMember_01a020c3-db5e-7c5e-8a3f-7705590c5727" xlink:href="alny-20260930.xsd#alny_RegeneronTechnologyTransferObligationMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:to="loc_alny_RegeneronTechnologyTransferObligationMember_01a020c3-db5e-7c5e-8a3f-7705590c5727" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OtherLicenseProgramsMember_01a020c3-db5e-7211-9388-85a46ecfaccb" xlink:href="alny-20260930.xsd#alny_OtherLicenseProgramsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a23-ae75-238e31f50f35" xlink:to="loc_alny_OtherLicenseProgramsMember_01a020c3-db5e-7211-9388-85a46ecfaccb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73bc-9e9a-dae36f95e96f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73bc-9e9a-dae36f95e96f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-74dd-aa62-348391aceaf2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-73bc-9e9a-dae36f95e96f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-74dd-aa62-348391aceaf2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_GlobalStrategicCollaborationMember_01a020c3-db5e-77b8-b908-e0052a4c75a3" xlink:href="alny-20260930.xsd#alny_GlobalStrategicCollaborationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-74dd-aa62-348391aceaf2" xlink:to="loc_alny_GlobalStrategicCollaborationMember_01a020c3-db5e-77b8-b908-e0052a4c75a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-74d4-8f09-bb7be57e2129" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_01a020c3-db5e-7ed9-a743-ee93dbc14591" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-74d4-8f09-bb7be57e2129" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7ebc-a856-d066ec7d2d09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_01a020c3-db5e-74d4-8f09-bb7be57e2129" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a020c3-db5e-7ebc-a856-d066ec7d2d09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueofAssetsMeasuredonaRecurringBasisDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#FAIRVALUEMEASUREMENTSScheduleofFairValueofAssetsMeasuredonaRecurringBasisDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueofAssetsMeasuredonaRecurringBasisDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7b62-81f1-af7e3abaf07e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_01a020c3-db5e-7b62-81f1-af7e3abaf07e" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_01a020c3-db5e-7a25-8c7b-be6d36d57747" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_01a020c3-db5e-7a25-8c7b-be6d36d57747" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_01a020c3-db5e-7a25-8c7b-be6d36d57747" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_01a020c3-db5e-77a3-bfd2-cf8e5dd62cc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:to="loc_us-gaap_MoneyMarketFundsMember_01a020c3-db5e-77a3-bfd2-cf8e5dd62cc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7eab-be5c-0df8f93db7f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7eab-be5c-0df8f93db7f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7a15-8eba-9754f070b368" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:to="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7a15-8eba-9754f070b368" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-75dd-8883-0476a8bffb2f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_01a020c3-db5e-7244-a4e7-ef80b23cd6b1" xlink:to="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-75dd-8883-0476a8bffb2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a020c3-db5e-7d0e-b489-cf9ca3118697" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a020c3-db5e-7d0e-b489-cf9ca3118697" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a020c3-db5e-7f52-a24e-ad9ef963b0f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a020c3-db5e-7d0e-b489-cf9ca3118697" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a020c3-db5e-7f52-a24e-ad9ef963b0f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_01a020c3-db5e-73c1-8f1a-d4bc1c909e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a020c3-db5e-7f52-a24e-ad9ef963b0f9" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_01a020c3-db5e-73c1-8f1a-d4bc1c909e3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_01a020c3-db5e-7c13-8065-696d1be693ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a020c3-db5e-7f52-a24e-ad9ef963b0f9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_01a020c3-db5e-7c13-8065-696d1be693ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_01a020c3-db5e-716d-9770-210f8c3b0512" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a020c3-db5e-7f52-a24e-ad9ef963b0f9" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_01a020c3-db5e-716d-9770-210f8c3b0512" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7979-b969-861d307bb5a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7979-b969-861d307bb5a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7979-b969-861d307bb5a3" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7062-87e0-f1a89e5e7bb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7062-87e0-f1a89e5e7bb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_01a020c3-db5e-789b-b1d6-475df75e434e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_01a020c3-db5e-789b-b1d6-475df75e434e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7093-8366-52eb85cd4f12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:to="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7093-8366-52eb85cd4f12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-7f29-9d81-53519c399155" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:to="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-7f29-9d81-53519c399155" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalNotesMember_01a020c3-db5e-733d-8fb3-b896dc6ea2f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MunicipalNotesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-7042-a5f2-b0e5f3553e97" xlink:to="loc_us-gaap_MunicipalNotesMember_01a020c3-db5e-733d-8fb3-b896dc6ea2f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_01a1304c-3090-7210-a3fa-00f372a5f274" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_01a1304c-3090-7210-a3fa-00f372a5f274" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_01a1304c-3090-7f6e-8cea-ac99185d530a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_01a1304c-3090-7210-a3fa-00f372a5f274" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_01a1304c-3090-7f6e-8cea-ac99185d530a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_01a134a3-adb8-7213-b57c-9db00335a1a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_01a1304c-3090-7f6e-8cea-ac99185d530a" xlink:to="loc_us-gaap_CommercialPaperMember_01a134a3-adb8-7213-b57c-9db00335a1a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_01a1304c-3090-7ea3-9c11-1cb3d017782d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_01a1304c-3090-7ea3-9c11-1cb3d017782d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_01a1304c-3090-7ebe-ac4e-5155a5d3c707" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_01a1304c-3090-7ea3-9c11-1cb3d017782d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_01a1304c-3090-7ebe-ac4e-5155a5d3c707" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_01a1304c-3090-7e98-ac75-fe1e825305af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_01a1304c-3090-7ebe-ac4e-5155a5d3c707" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_01a1304c-3090-7e98-ac75-fe1e825305af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7941-ad0e-55d1ff5334e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-7d20-b1d1-5c6bce647e93" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7941-ad0e-55d1ff5334e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7941-ad0e-55d1ff5334e3" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a020c3-db5e-74fc-bc0a-46b36152f526" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a020c3-db5e-74fc-bc0a-46b36152f526" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01a020c3-db5e-77ed-9233-d345d041747c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01a020c3-db5e-77ed-9233-d345d041747c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_01a020c3-db5e-75b0-a902-f85bccd5fde9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_01a020c3-db5e-75b0-a902-f85bccd5fde9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_01a020c3-db5e-7d4c-b199-6d762d7f177c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01a020c3-db5e-7618-9254-7875711d9772" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_01a020c3-db5e-7d4c-b199-6d762d7f177c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESScheduleofMarketableDebtSecuritiesDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#MARKETABLEDEBTSECURITIESScheduleofMarketableDebtSecuritiesDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESScheduleofMarketableDebtSecuritiesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-7a13-9257-59533c2140c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_01a020c3-db5e-7a15-aedf-d489a4c5a552" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-7a13-9257-59533c2140c9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_01a020c3-db5e-7a15-aedf-d489a4c5a552" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7d25-8542-96688e4092cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_01a020c3-db5e-7a15-aedf-d489a4c5a552" xlink:to="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7d25-8542-96688e4092cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_01a020c3-db5e-7d25-8542-96688e4092cc" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7311-904e-1c9287f61e5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_01a020c3-db5e-7311-904e-1c9287f61e5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_01a020c3-db5e-755a-9595-3a86618e41ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_01a020c3-db5e-755a-9595-3a86618e41ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7575-8602-6d2b43cbe2c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:to="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_01a020c3-db5e-7575-8602-6d2b43cbe2c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-79d3-baa1-0f56bc90403b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:to="loc_us-gaap_CommercialPaperMember_01a020c3-db5e-79d3-baa1-0f56bc90403b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalNotesMember_01a020c3-db5e-7563-9843-b1efa9f6d116" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MunicipalNotesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_01a020c3-db5e-71fe-a995-d77e1fe30891" xlink:to="loc_us-gaap_MunicipalNotesMember_01a020c3-db5e-7563-9843-b1efa9f6d116" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_01a020c3-db5e-7a15-aedf-d489a4c5a552" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtSecuritiesAvailableForSaleAmortizedCostIncludingCashEquivalents_01a020c3-db5e-7590-a433-dba2e221ca4e" xlink:href="alny-20260930.xsd#alny_DebtSecuritiesAvailableForSaleAmortizedCostIncludingCashEquivalents"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:to="loc_alny_DebtSecuritiesAvailableForSaleAmortizedCostIncludingCashEquivalents_01a020c3-db5e-7590-a433-dba2e221ca4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxIncludingCashEquivalents_01a020c3-db5e-7ce0-b95b-f31020c6ac4d" xlink:href="alny-20260930.xsd#alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxIncludingCashEquivalents"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:to="loc_alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxIncludingCashEquivalents_01a020c3-db5e-7ce0-b95b-f31020c6ac4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxIncludingCashEquivalents_01a020c3-db5e-7af6-967c-b55fdeba0e21" xlink:href="alny-20260930.xsd#alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxIncludingCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:to="loc_alny_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxIncludingCashEquivalents_01a020c3-db5e-7af6-967c-b55fdeba0e21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents_01a020c3-db5e-71bb-ae3a-a282d47aa73d" xlink:href="alny-20260930.xsd#alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_01a020c3-db5e-7eb1-ae87-5dba685ceab3" xlink:to="loc_alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents_01a020c3-db5e-71bb-ae3a-a282d47aa73d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESScheduleofFairValueofMarketableDebtSecuritiesDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#MARKETABLEDEBTSECURITIESScheduleofFairValueofMarketableDebtSecuritiesDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/MARKETABLEDEBTSECURITIESScheduleofFairValueofMarketableDebtSecuritiesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-730f-935a-91fccb5c5651" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_01a020c3-db5e-7400-b6d8-2f8a92c46dc9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-730f-935a-91fccb5c5651" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_01a020c3-db5e-7400-b6d8-2f8a92c46dc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a020c3-db5e-7ca0-9663-b7eef1431519" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-730f-935a-91fccb5c5651" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a020c3-db5e-7ca0-9663-b7eef1431519" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents_01a020c3-db5e-7497-ad2b-d7680d35dbf6" xlink:href="alny-20260930.xsd#alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_01a020c3-db5e-730f-935a-91fccb5c5651" xlink:to="loc_alny_DebtSecuritiesAvailableForSaleIncludingCashEquivalents_01a020c3-db5e-7497-ad2b-d7680d35dbf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofInventoryDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILSScheduleofInventoryDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofInventoryDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-76f3-8752-af80917cef7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_01a020c3-db5e-7cab-933d-e1cc7780e980" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterials"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-76f3-8752-af80917cef7a" xlink:to="loc_us-gaap_InventoryRawMaterials_01a020c3-db5e-7cab-933d-e1cc7780e980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_01a020c3-db5e-7795-b0a1-8427e82222a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-76f3-8752-af80917cef7a" xlink:to="loc_us-gaap_InventoryWorkInProcess_01a020c3-db5e-7795-b0a1-8427e82222a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_01a020c3-db5e-7893-8d2d-b91f137605c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-76f3-8752-af80917cef7a" xlink:to="loc_us-gaap_InventoryFinishedGoods_01a020c3-db5e-7893-8d2d-b91f137605c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_InventoryCurrentAndNoncurrent_01a020c3-db5e-7a5f-8935-f48aeea69f22" xlink:href="alny-20260930.xsd#alny_InventoryCurrentAndNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-76f3-8752-af80917cef7a" xlink:to="loc_alny_InventoryCurrentAndNoncurrent_01a020c3-db5e-7a5f-8935-f48aeea69f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSNarrativeDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILSNarrativeDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSNarrativeDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-71fb-bf33-f717300fbc39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_01a020c3-db5e-7731-a0fb-51a9acf6a0c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-71fb-bf33-f717300fbc39" xlink:to="loc_us-gaap_InventoryNoncurrent_01a020c3-db5e-7731-a0fb-51a9acf6a0c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILSScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-75c9-bb4b-615644a633b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a020c3-db5e-7402-a927-f5b6ed4aadd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-75c9-bb4b-615644a633b0" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a020c3-db5e-7402-a927-f5b6ed4aadd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_01a020c3-db5e-7664-9894-38f232d17608" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-75c9-bb4b-615644a633b0" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_01a020c3-db5e-7664-9894-38f232d17608" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-75bb-b498-011538c0d50e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-75c9-bb4b-615644a633b0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a020c3-db5e-75bb-b498-011538c0d50e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofChangesinAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#OTHERBALANCESHEETDETAILSScheduleofChangesinAccumulatedOtherComprehensiveLossDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/OTHERBALANCESHEETDETAILSScheduleofChangesinAccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7b95-adef-d4a34bc12e27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_01a020c3-db5e-7b6a-a339-bb0a4608a836" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_01a020c3-db5e-7b95-adef-d4a34bc12e27" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_01a020c3-db5e-7b6a-a339-bb0a4608a836" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-db5e-72b6-9321-1481f394fff4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_01a020c3-db5e-7b6a-a339-bb0a4608a836" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-db5e-72b6-9321-1481f394fff4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a020c3-db5e-7f06-bad8-71fb94bafcbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a020c3-db5e-72b6-9321-1481f394fff4" xlink:to="loc_us-gaap_EquityComponentDomain_01a020c3-db5e-7f06-bad8-71fb94bafcbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_01a020c3-db5e-7f06-bad8-71fb94bafcbe" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_AccumulatedLossOnInvestmentInJointVentureMember_01a020c3-db5e-727c-b05e-876086fc1d5b" xlink:href="alny-20260930.xsd#alny_AccumulatedLossOnInvestmentInJointVentureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:to="loc_alny_AccumulatedLossOnInvestmentInJointVentureMember_01a020c3-db5e-727c-b05e-876086fc1d5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_01a020c3-db5e-7165-9778-bcd40cd3c266" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_01a020c3-db5e-7165-9778-bcd40cd3c266" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_01a020c3-db5e-7259-884e-eceaad36272f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_01a020c3-db5e-7259-884e-eceaad36272f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_01a020c3-db5e-7cf8-9ab1-c6932a0b9fbd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a020c3-db5e-7571-b8bc-f2a31bb01355" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_01a020c3-db5e-7cf8-9ab1-c6932a0b9fbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_01a020c3-db5e-74dc-9e90-5991fd140c45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_01a020c3-db5e-7b6a-a339-bb0a4608a836" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_01a020c3-db5e-74dc-9e90-5991fd140c45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_01a020c3-db5e-74dc-9e90-5991fd140c45" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a020c3-db5e-7e8e-8ee4-96f317dc0d12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:to="loc_us-gaap_StockholdersEquity_01a020c3-db5e-7e8e-8ee4-96f317dc0d12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_01a020c3-db5e-70d2-85ab-c5b9937e32db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_01a020c3-db5e-70d2-85ab-c5b9937e32db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_01a020c3-db5e-795a-9411-803f707d2bbd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_01a020c3-db5e-795a-9411-803f707d2bbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-db5e-726d-8fc5-653458dba845" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_01a020c3-db5e-726d-8fc5-653458dba845" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a020c3-db5e-7df1-b825-c249a5855631" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_01a020c3-db5e-7bc8-84a2-152132b55453" xlink:to="loc_us-gaap_StockholdersEquity_01a020c3-db5e-7df1-b825-c249a5855631" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGConvertibleSeniorNotesDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#CONVERTIBLEDEBTANDOTHERFINANCINGConvertibleSeniorNotesDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGConvertibleSeniorNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-759c-970f-eca3b97e0961" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-759c-970f-eca3b97e0961" xlink:to="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7db7-9bb0-a788d2570aea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:to="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7db7-9bb0-a788d2570aea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-779c-b480-de77fc2c0467" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7db7-9bb0-a788d2570aea" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-779c-b480-de77fc2c0467" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-74b0-aa92-0e4c689eeb43" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2028Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-779c-b480-de77fc2c0467" xlink:to="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-74b0-aa92-0e4c689eeb43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2028InitialAmountMember_01a020c3-db5e-7457-bf3b-89eeee0f571a" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2028InitialAmountMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-74b0-aa92-0e4c689eeb43" xlink:to="loc_alny_ConvertibleSeniorNotesDue2028InitialAmountMember_01a020c3-db5e-7457-bf3b-89eeee0f571a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2028AdditionalAmountMember_01a020c3-db5e-788b-a342-8370196b4abc" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2028AdditionalAmountMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ConvertibleSeniorNotesDue2028Member_01a020c3-db5e-74b0-aa92-0e4c689eeb43" xlink:to="loc_alny_ConvertibleSeniorNotesDue2028AdditionalAmountMember_01a020c3-db5e-788b-a342-8370196b4abc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2027Member_01a020c3-db5e-7f77-852e-dc2f43c51e39" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2027Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-779c-b480-de77fc2c0467" xlink:to="loc_alny_ConvertibleSeniorNotesDue2027Member_01a020c3-db5e-7f77-852e-dc2f43c51e39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConvertibleSeniorNotesDue2027AdditionalAmountMember_01a020c3-db5e-7de7-8901-b6f2b4b0ae19" xlink:href="alny-20260930.xsd#alny_ConvertibleSeniorNotesDue2027AdditionalAmountMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-779c-b480-de77fc2c0467" xlink:to="loc_alny_ConvertibleSeniorNotesDue2027AdditionalAmountMember_01a020c3-db5e-7de7-8901-b6f2b4b0ae19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtInstrumentConvertibleTermsOfConversionAxis_01a020c3-db5e-7e59-8638-3affc68c197e" xlink:href="alny-20260930.xsd#alny_DebtInstrumentConvertibleTermsOfConversionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:to="loc_alny_DebtInstrumentConvertibleTermsOfConversionAxis_01a020c3-db5e-7e59-8638-3affc68c197e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:href="alny-20260930.xsd#alny_DebtInstrumentConvertibleTermsOfConversionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_DebtInstrumentConvertibleTermsOfConversionAxis_01a020c3-db5e-7e59-8638-3affc68c197e" xlink:to="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtConversionTermsOneMember_01a020c3-db5e-7f36-ad3f-8633f315777f" xlink:href="alny-20260930.xsd#alny_DebtConversionTermsOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:to="loc_alny_DebtConversionTermsOneMember_01a020c3-db5e-7f36-ad3f-8633f315777f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtConversionTermsTwoMember_01a020c3-db5e-7a6e-902b-a7662dbaa202" xlink:href="alny-20260930.xsd#alny_DebtConversionTermsTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:to="loc_alny_DebtConversionTermsTwoMember_01a020c3-db5e-7a6e-902b-a7662dbaa202" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtConversionTermsThreeMember_01a020c3-db5e-7f76-9011-ae6ea12aa254" xlink:href="alny-20260930.xsd#alny_DebtConversionTermsThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:to="loc_alny_DebtConversionTermsThreeMember_01a020c3-db5e-7f76-9011-ae6ea12aa254" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtConversionTermsFourMember_01a020c3-db5e-767e-9cc2-cd54bcc17f78" xlink:href="alny-20260930.xsd#alny_DebtConversionTermsFourMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_DebtInstrumentConvertibleTermsOfConversionDomain_01a020c3-db5e-7dc7-942e-7b360154c8a0" xlink:to="loc_alny_DebtConversionTermsFourMember_01a020c3-db5e-767e-9cc2-cd54bcc17f78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7623-935f-d6cccb1dece8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7623-935f-d6cccb1dece8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7196-9a16-2c8ab8c968a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7623-935f-d6cccb1dece8" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7196-9a16-2c8ab8c968a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7358-bcf2-f6215728e031" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7196-9a16-2c8ab8c968a2" xlink:to="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7358-bcf2-f6215728e031" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7051-a71c-987448e888d6" xlink:to="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_01a020c3-db5e-77c9-b0b3-55023dd47a66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_01a020c3-db5e-77c9-b0b3-55023dd47a66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_01a020c3-db5e-7d3c-ad01-67984e145b82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_01a020c3-db5e-7d3c-ad01-67984e145b82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_01a020c3-db5e-793d-8251-1246b76652e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_01a020c3-db5e-793d-8251-1246b76652e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_01a020c3-db5e-7de1-93f1-af047f47d42b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_01a020c3-db5e-7de1-93f1-af047f47d42b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_01a020c3-db5e-7fed-a547-d7ee6fe3b2dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_01a020c3-db5e-7fed-a547-d7ee6fe3b2dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_01a020c3-db5e-767e-b23f-3b5ec0b2f4d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_01a020c3-db5e-767e-b23f-3b5ec0b2f4d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtInstrumentConvertiblePremiumPercentage_01a020c3-db5e-7301-8599-269c8a5433f2" xlink:href="alny-20260930.xsd#alny_DebtInstrumentConvertiblePremiumPercentage"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_alny_DebtInstrumentConvertiblePremiumPercentage_01a020c3-db5e-7301-8599-269c8a5433f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_01a020c3-db5e-7a7a-9e80-1987cbf04a3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_01a020c3-db5e-7a7a-9e80-1987cbf04a3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_01a020c3-db5e-7ea3-8197-b9c1de83c367" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_SharePrice_01a020c3-db5e-7ea3-8197-b9c1de83c367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_01a020c3-db5e-71e3-8abb-f3ecc677e84a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_01a020c3-db5e-71e3-8abb-f3ecc677e84a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentSinkingFundPayment_01a020c3-db5e-7dbb-acbb-e9e106fa7f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentSinkingFundPayment"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentSinkingFundPayment_01a020c3-db5e-7dbb-acbb-e9e106fa7f8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_01a020c3-db5e-7526-a961-914bbd44c416" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_LongTermDebt_01a020c3-db5e-7526-a961-914bbd44c416" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_01a020c3-db5e-7209-a5f7-60f808f0b208" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_01a020c3-db5e-7209-a5f7-60f808f0b208" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_01a020c3-db5e-71e4-a17b-8550be6269f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_LongTermDebtFairValue_01a020c3-db5e-71e4-a17b-8550be6269f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_01a020c3-db5e-7819-8e78-0fbaac5efa54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_01a020c3-db5e-7819-8e78-0fbaac5efa54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_01a020c3-db5e-7e51-b55b-c8564d1e833e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_01a020c3-db5e-7e51-b55b-c8564d1e833e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a020c3-db5e-708a-8420-77d0a50b348b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_01a020c3-db5e-708a-8420-77d0a50b348b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-db5e-73e8-9600-76c94a64b546" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-db5e-73e8-9600-76c94a64b546" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_01a020c3-db5e-7c7f-8e4c-89509df1f0c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentRepurchasedFaceAmount"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_01a020c3-db5e-7c7f-8e4c-89509df1f0c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_01a020c3-db5e-78b4-ac5c-6c887ad6de9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_InterestPaidNet_01a020c3-db5e-78b4-ac5c-6c887ad6de9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_01a020c3-db5e-7dce-b924-df247b94f069" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_01a020c3-db5e-7dce-b924-df247b94f069" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InducedConversionOfConvertibleDebtExpense_01a020c3-db5e-7143-8a03-9349a6583d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InducedConversionOfConvertibleDebtExpense"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_InducedConversionOfConvertibleDebtExpense_01a020c3-db5e-7143-8a03-9349a6583d7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_AdjustmentsToAdditionalPaidInCapitalRepurchaseOfConvertibleDebt_01a020c3-db5e-73f0-b5a1-45db9dc731bd" xlink:href="alny-20260930.xsd#alny_AdjustmentsToAdditionalPaidInCapitalRepurchaseOfConvertibleDebt"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_alny_AdjustmentsToAdditionalPaidInCapitalRepurchaseOfConvertibleDebt_01a020c3-db5e-73f0-b5a1-45db9dc731bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_01a020c3-db5e-7b21-bc31-2cf1de4cb4c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-705d-823f-6cedcc8a55a0" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_01a020c3-db5e-7b21-bc31-2cf1de4cb4c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGCappedCallTransactionsDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#CONVERTIBLEDEBTANDOTHERFINANCINGCappedCallTransactionsDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGCappedCallTransactionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-7b42-b0e9-55f4c66c64b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-7b42-b0e9-55f4c66c64b2" xlink:to="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_01a020c3-db5e-7e93-9a8d-41b9770e836b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_01a020c3-db5e-7e93-9a8d-41b9770e836b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_01a020c3-db5e-7c5e-81e9-2dfb9b2366ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_01a020c3-db5e-7e93-9a8d-41b9770e836b" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_01a020c3-db5e-7c5e-81e9-2dfb9b2366ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CallOptionMember_01a020c3-db5e-7a2e-9cdb-d3d8058a04fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CallOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_01a020c3-db5e-7c5e-81e9-2dfb9b2366ac" xlink:to="loc_us-gaap_CallOptionMember_01a020c3-db5e-7a2e-9cdb-d3d8058a04fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-790f-9c66-22a4504d2c98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:to="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-790f-9c66-22a4504d2c98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-721a-b58e-fda3c09ebbda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-790f-9c66-22a4504d2c98" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-721a-b58e-fda3c09ebbda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_A2022CappedCallTransactionsMember_01a020c3-db5e-7d0a-9812-fc6ae0f4d3ca" xlink:href="alny-20260930.xsd#alny_A2022CappedCallTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-721a-b58e-fda3c09ebbda" xlink:to="loc_alny_A2022CappedCallTransactionsMember_01a020c3-db5e-7d0a-9812-fc6ae0f4d3ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7ab1-abc9-00a9ddb35643" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7ab1-abc9-00a9ddb35643" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7cfa-a848-a346b382b18d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-7ab1-abc9-00a9ddb35643" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7cfa-a848-a346b382b18d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7aa5-b7d3-89171e49737a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-7cfa-a848-a346b382b18d" xlink:to="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-7aa5-b7d3-89171e49737a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-7a65-b601-532897e48000" xlink:to="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityStrikePrice1_01a020c3-db5e-7551-a556-d247a1c0f88b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OptionIndexedToIssuersEquityStrikePrice1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityStrikePrice1_01a020c3-db5e-7551-a556-d247a1c0f88b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity_01a020c3-db5e-7600-9ff1-a4e2b477dc8d" xlink:href="alny-20260930.xsd#alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:to="loc_alny_AdjustmentsToAdditionalPaidInCapitalOptionContractIndexedToEquity_01a020c3-db5e-7600-9ff1-a4e2b477dc8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCapPrice_01a020c3-db5e-7f07-aa6c-b7ca90427c7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeCapPrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:to="loc_us-gaap_DerivativeCapPrice_01a020c3-db5e-7f07-aa6c-b7ca90427c7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OptionIndexedToIssuersEquityPremiumOnStockPrice_01a020c3-db5e-75b0-9ca8-1c5186cc3476" xlink:href="alny-20260930.xsd#alny_OptionIndexedToIssuersEquityPremiumOnStockPrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:to="loc_alny_OptionIndexedToIssuersEquityPremiumOnStockPrice_01a020c3-db5e-75b0-9ca8-1c5186cc3476" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-db5e-7856-b269-3eedcc893484" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7a75-8b30-7e779e20957e" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_01a020c3-db5e-7856-b269-3eedcc893484" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGRevolvingCreditAgreementDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#CONVERTIBLEDEBTANDOTHERFINANCINGRevolvingCreditAgreementDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/CONVERTIBLEDEBTANDOTHERFINANCINGRevolvingCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-786b-9608-2daa24fd623a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_01a020c3-db5e-786b-9608-2daa24fd623a" xlink:to="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_01a020c3-db5e-7d6d-b105-81466c3a3d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_us-gaap_CreditFacilityAxis_01a020c3-db5e-7d6d-b105-81466c3a3d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_01a020c3-db5e-7c95-bd81-ebc574c22e04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_01a020c3-db5e-7d6d-b105-81466c3a3d5c" xlink:to="loc_us-gaap_CreditFacilityDomain_01a020c3-db5e-7c95-bd81-ebc574c22e04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_01a020c3-db5e-70de-8983-29a96dcdd1ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_01a020c3-db5e-7c95-bd81-ebc574c22e04" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_01a020c3-db5e-70de-8983-29a96dcdd1ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_01a020c3-db5e-7400-b4ac-58440cef0119" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LetterOfCreditMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_01a020c3-db5e-7c95-bd81-ebc574c22e04" xlink:to="loc_us-gaap_LetterOfCreditMember_01a020c3-db5e-7400-b4ac-58440cef0119" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7201-a1d5-88de1ff53cf5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7201-a1d5-88de1ff53cf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7980-93f1-f9e41fb49173" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_01a020c3-db5e-7201-a1d5-88de1ff53cf5" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7980-93f1-f9e41fb49173" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RevolvingCreditAgreementMember_01a020c3-db5e-7aa5-9fef-ac976bbde462" xlink:href="alny-20260930.xsd#alny_RevolvingCreditAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01a020c3-db5e-7980-93f1-f9e41fb49173" xlink:to="loc_alny_RevolvingCreditAgreementMember_01a020c3-db5e-7aa5-9fef-ac976bbde462" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-756a-8810-77a535a2937c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-756a-8810-77a535a2937c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-70ad-a615-2239cbff39a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_01a020c3-db5e-756a-8810-77a535a2937c" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-70ad-a615-2239cbff39a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_01a020c3-db5e-78be-aab8-2e778b2494d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01a020c3-db5e-70ad-a615-2239cbff39a9" xlink:to="loc_us-gaap_LineOfCreditMember_01a020c3-db5e-78be-aab8-2e778b2494d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_01a020c3-db5e-7fd5-b8f4-0021edee1f64" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_srt_RangeAxis_01a020c3-db5e-7fd5-b8f4-0021edee1f64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a020c3-db5e-70e1-9ce6-c82bfca67aeb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_01a020c3-db5e-7fd5-b8f4-0021edee1f64" xlink:to="loc_srt_RangeMember_01a020c3-db5e-70e1-9ce6-c82bfca67aeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_01a020c3-db5e-7b68-9ad1-54ac118970f8" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_01a020c3-db5e-70e1-9ce6-c82bfca67aeb" xlink:to="loc_srt_MinimumMember_01a020c3-db5e-7b68-9ad1-54ac118970f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_01a020c3-db5e-7859-bc0d-311c76e2aebe" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_01a020c3-db5e-70e1-9ce6-c82bfca67aeb" xlink:to="loc_srt_MaximumMember_01a020c3-db5e-7859-bc0d-311c76e2aebe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_01a020c3-db5e-7ac8-b06a-3b4f7e2fe50a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_us-gaap_VariableRateAxis_01a020c3-db5e-7ac8-b06a-3b4f7e2fe50a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_01a020c3-db5e-7edd-a52a-e552768f7a36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_01a020c3-db5e-7ac8-b06a-3b4f7e2fe50a" xlink:to="loc_us-gaap_VariableRateDomain_01a020c3-db5e-7edd-a52a-e552768f7a36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_01a020c3-db5e-77ed-ab8a-da4f226bfd54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BaseRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_01a020c3-db5e-7edd-a52a-e552768f7a36" xlink:to="loc_us-gaap_BaseRateMember_01a020c3-db5e-77ed-ab8a-da4f226bfd54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_01a020c3-db5e-7a8e-b809-4d5fcfd80390" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SecuredOvernightFinancingRateSofrMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_01a020c3-db5e-7edd-a52a-e552768f7a36" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_01a020c3-db5e-7a8e-b809-4d5fcfd80390" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_01a020c3-db5e-784e-8b85-5ae9abb8769d" xlink:to="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_01a020c3-db5e-7b65-8e22-10d2f7d8b03a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_01a020c3-db5e-7b65-8e22-10d2f7d8b03a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_01a020c3-db5e-7325-9a0d-b16f5125dea0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_01a020c3-db5e-7325-9a0d-b16f5125dea0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_01a020c3-db5e-7e6a-8309-d102329fd629" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_01a020c3-db5e-7e6a-8309-d102329fd629" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtInstrumentCovenantLiquidityRatioMinimum_01a020c3-db5e-7f29-a9c9-bb1324b48297" xlink:href="alny-20260930.xsd#alny_DebtInstrumentCovenantLiquidityRatioMinimum"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_alny_DebtInstrumentCovenantLiquidityRatioMinimum_01a020c3-db5e-7f29-a9c9-bb1324b48297" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DebtInstrumentCovenantInterestCoverageRatioMaximum_01a020c3-db5e-72bd-ac8c-8a020afe0243" xlink:href="alny-20260930.xsd#alny_DebtInstrumentCovenantInterestCoverageRatioMaximum"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_alny_DebtInstrumentCovenantInterestCoverageRatioMaximum_01a020c3-db5e-72bd-ac8c-8a020afe0243" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_01a020c3-db5e-711f-b8b1-42c8cfd80e8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCredit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_us-gaap_LineOfCredit_01a020c3-db5e-711f-b8b1-42c8cfd80e8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_01a020c3-db5e-745d-8fa8-2d38504ab257" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a020c3-db5e-7daa-8215-1b9a386d62af" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_01a020c3-db5e-745d-8fa8-2d38504ab257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGAdditionalInformationDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7581-8621-c89eb30d016e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:href="alny-20260930.xsd#alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7581-8621-c89eb30d016e" xlink:to="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-74d2-8501-ef785c841389" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-74d2-8501-ef785c841389" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-74d2-8501-ef785c841389" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_BlackstoneLifeSciencesMember_01a020c3-db5e-7aeb-9fd7-e5d29810ff51" xlink:href="alny-20260930.xsd#alny_BlackstoneLifeSciencesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:to="loc_alny_BlackstoneLifeSciencesMember_01a020c3-db5e-7aeb-9fd7-e5d29810ff51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_VutrisiranMember_01a020c3-db5e-7b9c-b8dc-1f9ffd608126" xlink:href="alny-20260930.xsd#alny_VutrisiranMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:to="loc_alny_VutrisiranMember_01a020c3-db5e-7b9c-b8dc-1f9ffd608126" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ZilebesrianMember_01a020c3-db5e-719a-9e6c-365970f23834" xlink:href="alny-20260930.xsd#alny_ZilebesrianMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:to="loc_alny_ZilebesrianMember_01a020c3-db5e-719a-9e6c-365970f23834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_BlackstoneGroupIncMember_01a020c3-db5e-7607-a38d-602e9e632535" xlink:href="alny-20260930.xsd#alny_BlackstoneGroupIncMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7ffa-a57b-84f0003be85e" xlink:to="loc_alny_BlackstoneGroupIncMember_01a020c3-db5e-7607-a38d-602e9e632535" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7720-aaef-32034c37c638" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7720-aaef-32034c37c638" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-7720-aaef-32034c37c638" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_VutrisiranAndZilebesiranMember_01a020c3-db5e-76bd-bcaf-c22392857ce6" xlink:href="alny-20260930.xsd#alny_VutrisiranAndZilebesiranMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_VutrisiranAndZilebesiranMember_01a020c3-db5e-76bd-bcaf-c22392857ce6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_HELIOSBPhase3ClinicalTrialMember_01a020c3-db5e-7500-9c1b-2653807f165d" xlink:href="alny-20260930.xsd#alny_HELIOSBPhase3ClinicalTrialMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_HELIOSBPhase3ClinicalTrialMember_01a020c3-db5e-7500-9c1b-2653807f165d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ALNAGTPhase2ClinicalTrialMember_01a020c3-db5e-7b5c-9bdc-6d977f9995e7" xlink:href="alny-20260930.xsd#alny_ALNAGTPhase2ClinicalTrialMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_ALNAGTPhase2ClinicalTrialMember_01a020c3-db5e-7b5c-9bdc-6d977f9995e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ALNAGTPhase3ClinicalTrialMember_01a020c3-db5e-79c1-b755-058c663d0268" xlink:href="alny-20260930.xsd#alny_ALNAGTPhase3ClinicalTrialMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_ALNAGTPhase3ClinicalTrialMember_01a020c3-db5e-79c1-b755-058c663d0268" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_VutrisiranMember_01a020c3-db5e-7615-aeee-71b8e63e763d" xlink:href="alny-20260930.xsd#alny_VutrisiranMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_VutrisiranMember_01a020c3-db5e-7615-aeee-71b8e63e763d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_DevelopmentMilestoneMember_01a020c3-db5e-7c3b-8f5c-44482fa392f7" xlink:href="alny-20260930.xsd#alny_DevelopmentMilestoneMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_DevelopmentMilestoneMember_01a020c3-db5e-7c3b-8f5c-44482fa392f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ZilebesrianMember_01a020c3-db5e-7292-b1f8-bc01d0eca18a" xlink:href="alny-20260930.xsd#alny_ZilebesrianMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7a88-b7c8-178324dd3f39" xlink:to="loc_alny_ZilebesrianMember_01a020c3-db5e-7292-b1f8-bc01d0eca18a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7633-b936-0751b3a96055" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7633-b936-0751b3a96055" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7d58-b986-7f2624d4f115" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7633-b936-0751b3a96055" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7d58-b986-7f2624d4f115" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-7109-a74b-420ece680c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7d58-b986-7f2624d4f115" xlink:to="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-7109-a74b-420ece680c4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_01a020c3-db5e-7941-9d3b-0943d1d3a795" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:to="loc_srt_StatementScenarioAxis_01a020c3-db5e-7941-9d3b-0943d1d3a795" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_01a020c3-db5e-7e43-958d-fd6ec1b65450" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementScenarioAxis_01a020c3-db5e-7941-9d3b-0943d1d3a795" xlink:to="loc_srt_ScenarioUnspecifiedDomain_01a020c3-db5e-7e43-958d-fd6ec1b65450" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_01a020c3-db5e-7544-9d5d-e8e29933dcd3" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioForecastMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ScenarioUnspecifiedDomain_01a020c3-db5e-7e43-958d-fd6ec1b65450" xlink:to="loc_srt_ScenarioForecastMember_01a020c3-db5e-7544-9d5d-e8e29933dcd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:href="alny-20260930.xsd#alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-749a-afdb-2c34a83a0cf3" xlink:to="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementMaximumFunding_01a020c3-db5e-7705-bed0-9e8462c87a84" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementMaximumFunding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementMaximumFunding_01a020c3-db5e-7705-bed0-9e8462c87a84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_NumberOfCardiometabolicPrograms_01a020c3-db5e-7b94-a0f1-84b4ff0aa6e1" xlink:href="alny-20260930.xsd#alny_NumberOfCardiometabolicPrograms"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_NumberOfCardiometabolicPrograms_01a020c3-db5e-7b94-a0f1-84b4ff0aa6e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementMilestonePayable_01a020c3-db5e-70c4-b442-fad94e4a6f8a" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementMilestonePayable"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementMilestonePayable_01a020c3-db5e-70c4-b442-fad94e4a6f8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementRoyaltiesPayablePercent_01a020c3-db5e-7043-ab14-743f499fee0a" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementRoyaltiesPayablePercent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementRoyaltiesPayablePercent_01a020c3-db5e-7043-ab14-743f499fee0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementRoyaltiesPayableTerm_01a020c3-db5e-77f8-a24d-9bece64b38f6" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementRoyaltiesPayableTerm"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementRoyaltiesPayableTerm_01a020c3-db5e-77f8-a24d-9bece64b38f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementFixedPaymentNumberOfQuarterlyPayments_01a020c3-db5e-7fff-9f2b-b15bacd4e208" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementFixedPaymentNumberOfQuarterlyPayments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementFixedPaymentNumberOfQuarterlyPayments_01a020c3-db5e-7fff-9f2b-b15bacd4e208" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementFixedPaymentTerm_01a020c3-db5e-7714-b0ac-33dac7e5c61c" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementFixedPaymentTerm"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementFixedPaymentTerm_01a020c3-db5e-7714-b0ac-33dac7e5c61c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_01a020c3-db5e-7a62-a0b9-ca905034e854" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_01a020c3-db5e-7a62-a0b9-ca905034e854" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyAndDevelopmentFundingLiabilityCurrent_01a020c3-db5e-7173-8416-27c389bb7e1a" xlink:href="alny-20260930.xsd#alny_RoyaltyAndDevelopmentFundingLiabilityCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyAndDevelopmentFundingLiabilityCurrent_01a020c3-db5e-7173-8416-27c389bb7e1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent_01a020c3-db5e-7bec-a8b7-3736e12b09ad" xlink:href="alny-20260930.xsd#alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyAndDevelopmentFundingLiabilityNoncurrent_01a020c3-db5e-7bec-a8b7-3736e12b09ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyAndDevelopmentFundingLiabilityFairValue_01a020c3-db5e-7da1-b2cb-cf0359ee9825" xlink:href="alny-20260930.xsd#alny_RoyaltyAndDevelopmentFundingLiabilityFairValue"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyAndDevelopmentFundingLiabilityFairValue_01a020c3-db5e-7da1-b2cb-cf0359ee9825" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementRoyaltiesAndCommercialMilestonesAcquiredByCollaboratorPercent_01a020c3-db5e-758b-b92a-fc99b4bd4a80" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementRoyaltiesAndCommercialMilestonesAcquiredByCollaboratorPercent"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementRoyaltiesAndCommercialMilestonesAcquiredByCollaboratorPercent_01a020c3-db5e-758b-b92a-fc99b4bd4a80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementCommercialMilestonesAcquiredByCollaboratorPercent_01a020c3-db5e-7893-9076-110454210fef" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementCommercialMilestonesAcquiredByCollaboratorPercent"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementCommercialMilestonesAcquiredByCollaboratorPercent_01a020c3-db5e-7893-9076-110454210fef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ExpectedRoyaltyInterestPayments_01a020c3-db5e-7f2c-baf5-95e582d49e0f" xlink:href="alny-20260930.xsd#alny_ExpectedRoyaltyInterestPayments"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_ExpectedRoyaltyInterestPayments_01a020c3-db5e-7f2c-baf5-95e582d49e0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CollaborativeArrangementConsiderationReceived_01a020c3-db5e-7f8e-b0c1-cbca8d4558db" xlink:href="alny-20260930.xsd#alny_CollaborativeArrangementConsiderationReceived"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_CollaborativeArrangementConsiderationReceived_01a020c3-db5e-7f8e-b0c1-cbca8d4558db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityInterestRate_01a020c3-db5e-70a7-980c-fd9d69968c77" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityInterestRate"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyLiabilityInterestRate_01a020c3-db5e-70a7-980c-fd9d69968c77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7197-abfb-72edd6fedb91" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityNoncurrent"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7197-abfb-72edd6fedb91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityClosingCosts_01a020c3-db5e-77bc-9d73-6b87787fa9e4" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityClosingCosts"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyLiabilityClosingCosts_01a020c3-db5e-77bc-9d73-6b87787fa9e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityFairValue_01a020c3-db5e-7cad-9389-96e2f76cd82c" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityFairValue"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-74e6-84f6-782db00ba7c6" xlink:to="loc_alny_RoyaltyLiabilityFairValue_01a020c3-db5e-7cad-9389-96e2f76cd82c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFairValueLiabilitiesDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFairValueLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFairValueLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-70f7-8d00-ae638911d7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-759f-bb8a-4ca013cac76f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-70f7-8d00-ae638911d7d1" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-759f-bb8a-4ca013cac76f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a020c3-db5e-757d-8997-3f987f7d73a7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-759f-bb8a-4ca013cac76f" xlink:to="loc_srt_ProductOrServiceAxis_01a020c3-db5e-757d-8997-3f987f7d73a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7f78-8603-557e2abd4d97" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_01a020c3-db5e-757d-8997-3f987f7d73a7" xlink:to="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7f78-8603-557e2abd4d97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_VutrisiranMember_01a020c3-db5e-727b-ac2e-542545a025af" xlink:href="alny-20260930.xsd#alny_VutrisiranMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7f78-8603-557e2abd4d97" xlink:to="loc_alny_VutrisiranMember_01a020c3-db5e-727b-ac2e-542545a025af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ZilebesrianMember_01a020c3-db5e-70dc-a652-c33625c4bec7" xlink:href="alny-20260930.xsd#alny_ZilebesrianMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_01a020c3-db5e-7f78-8603-557e2abd4d97" xlink:to="loc_alny_ZilebesrianMember_01a020c3-db5e-70dc-a652-c33625c4bec7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_01a020c3-db5e-71e8-8459-051ed732e2b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-759f-bb8a-4ca013cac76f" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_01a020c3-db5e-71e8-8459-051ed732e2b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_01a020c3-db5e-7a95-b1e8-26ec577c596d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_01a020c3-db5e-71e8-8459-051ed732e2b1" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_01a020c3-db5e-7a95-b1e8-26ec577c596d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ObligationsMember_01a020c3-db5e-70a0-9222-dcc80599e833" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ObligationsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_01a020c3-db5e-7a95-b1e8-26ec577c596d" xlink:to="loc_us-gaap_ObligationsMember_01a020c3-db5e-70a0-9222-dcc80599e833" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7b54-b4f5-53e8802c7015" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_01a020c3-db5e-759f-bb8a-4ca013cac76f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7b54-b4f5-53e8802c7015" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_01a020c3-db5e-7b54-b4f5-53e8802c7015" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_01a020c3-db5e-7a44-a04e-42538ac02766" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_01a020c3-db5e-7a44-a04e-42538ac02766" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterest_01a020c3-db5e-714a-acbd-93229c8be556" xlink:href="alny-20260930.xsd#alny_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:to="loc_alny_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterest_01a020c3-db5e-714a-acbd-93229c8be556" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_01a020c3-db5e-7761-8253-4731de785bb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_01a020c3-db5e-7761-8253-4731de785bb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityIssues_01a020c3-db5e-79d9-a8f7-cdf901997b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityIssues"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityIssues_01a020c3-db5e-79d9-a8f7-cdf901997b5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_01a020c3-db5e-786e-b42f-0150863560b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_01a020c3-db5e-79fb-9545-f4bc98941c22" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_01a020c3-db5e-786e-b42f-0150863560b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFutureRoyaltiesDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFutureRoyaltiesDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/LIABILITIESRELATEDTOTHESALEOFFUTUREROYALTIESANDDEVELOPMENTFUNDINGScheduleofFutureRoyaltiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7b7c-b09c-cf566d6c6284" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-7a82-b667-f8d4784f4aa4" xlink:href="alny-20260930.xsd#alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_01a020c3-db5e-7b7c-b09c-cf566d6c6284" xlink:to="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-7a82-b667-f8d4784f4aa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01a020c3-db5e-76fc-ab5c-37b6e9319525" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-7a82-b667-f8d4784f4aa4" xlink:to="loc_srt_CounterpartyNameAxis_01a020c3-db5e-76fc-ab5c-37b6e9319525" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7987-a053-300a4c9aa85f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_01a020c3-db5e-76fc-ab5c-37b6e9319525" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7987-a053-300a4c9aa85f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_BlackstoneGroupIncMember_01a020c3-db5e-756c-8998-a9f5e215442d" xlink:href="alny-20260930.xsd#alny_BlackstoneGroupIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01a020c3-db5e-7987-a053-300a4c9aa85f" xlink:to="loc_alny_BlackstoneGroupIncMember_01a020c3-db5e-756c-8998-a9f5e215442d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7702-8c4d-c97b1333cfe5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-7a82-b667-f8d4784f4aa4" xlink:to="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7702-8c4d-c97b1333cfe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7ef1-a330-a0de3a745eb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_01a020c3-db5e-7702-8c4d-c97b1333cfe5" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7ef1-a330-a0de3a745eb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-79e4-a9e3-a80b2fee0844" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_01a020c3-db5e-7ef1-a330-a0de3a745eb2" xlink:to="loc_us-gaap_CollaborativeArrangementMember_01a020c3-db5e-79e4-a9e3-a80b2fee0844" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-7a15-912f-b1dc51228391" xlink:href="alny-20260930.xsd#alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesTable_01a020c3-db5e-7a82-b667-f8d4784f4aa4" xlink:to="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-7a15-912f-b1dc51228391" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityRollforwardAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_LiabilityRelatedToTheSaleOfFutureRoyaltiesLineItems_01a020c3-db5e-7a15-912f-b1dc51228391" xlink:to="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7e97-99fc-7c33658798e3" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityNoncurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:to="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7e97-99fc-7c33658798e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityInterestExpenseIncludingAmortizationOfClosingCosts_01a020c3-db5e-7a1a-8ae2-b0182d82bf55" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityInterestExpenseIncludingAmortizationOfClosingCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:to="loc_alny_RoyaltyLiabilityInterestExpenseIncludingAmortizationOfClosingCosts_01a020c3-db5e-7a1a-8ae2-b0182d82bf55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityPayments_01a020c3-db5e-797a-8e27-b37f862d8b83" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityPayments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:to="loc_alny_RoyaltyLiabilityPayments_01a020c3-db5e-797a-8e27-b37f862d8b83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7876-a93c-76b19fe0c476" xlink:href="alny-20260930.xsd#alny_RoyaltyLiabilityNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_RoyaltyLiabilityRollforwardAbstract_01a020c3-db5e-778f-95a5-f32c0703d738" xlink:to="loc_alny_RoyaltyLiabilityNoncurrent_01a020c3-db5e-7876-a93c-76b19fe0c476" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/STOCKBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesIncludedOperatingCostsandExpenseDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#STOCKBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesIncludedOperatingCostsandExpenseDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/STOCKBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesIncludedOperatingCostsandExpenseDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-7560-8c88-4d88d4b8140f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_01a020c3-db5e-74a4-b29d-4b9beea7c3cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_01a020c3-db5e-7560-8c88-4d88d4b8140f" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_01a020c3-db5e-74a4-b29d-4b9beea7c3cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a020c3-db5e-7fcf-ac45-f4708e1826bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_01a020c3-db5e-74a4-b29d-4b9beea7c3cb" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a020c3-db5e-7fcf-ac45-f4708e1826bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01a020c3-db5e-7d74-a368-fe68dac02ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_01a020c3-db5e-74a4-b29d-4b9beea7c3cb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01a020c3-db5e-7d74-a368-fe68dac02ad2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_01a020c3-db5e-7542-9bc2-bea1bcc24959" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01a020c3-db5e-7d74-a368-fe68dac02ad2" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_01a020c3-db5e-7542-9bc2-bea1bcc24959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_01a020c3-db5e-721c-96d5-095d1dcc5c8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01a020c3-db5e-7d74-a368-fe68dac02ad2" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_01a020c3-db5e-721c-96d5-095d1dcc5c8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_01a020c3-db5e-79eb-bbfa-55b6e0c3b494" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_01a020c3-db5e-7d74-a368-fe68dac02ad2" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_01a020c3-db5e-79eb-bbfa-55b6e0c3b494" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofBasicandDilutedNetLossIncomePerShareDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETINCOMELOSSPERCOMMONSHAREScheduleofBasicandDilutedNetLossIncomePerShareDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofBasicandDilutedNetLossIncomePerShareDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-757e-bd8e-cd7afa8400e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7e6d-95c0-9f84754b39c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-757e-bd8e-cd7afa8400e8" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7e6d-95c0-9f84754b39c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_01a020c3-db5e-799a-8a8f-0ddb1dc4c34c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7e6d-95c0-9f84754b39c1" xlink:to="loc_us-gaap_AwardTypeAxis_01a020c3-db5e-799a-8a8f-0ddb1dc4c34c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01a020c3-db5e-7b21-8f9f-2b5bf22ab319" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_01a020c3-db5e-799a-8a8f-0ddb1dc4c34c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01a020c3-db5e-7b21-8f9f-2b5bf22ab319" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_01a020c3-db5e-770d-ab4c-249eee796345" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01a020c3-db5e-7b21-8f9f-2b5bf22ab319" xlink:to="loc_us-gaap_EmployeeStockOptionMember_01a020c3-db5e-770d-ab4c-249eee796345" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_01a020c3-db5e-7772-ab2c-1fd30de6ed4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01a020c3-db5e-7b21-8f9f-2b5bf22ab319" xlink:to="loc_us-gaap_RestrictedStockMember_01a020c3-db5e-7772-ab2c-1fd30de6ed4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_01a020c3-db5e-7c05-8d69-ad84d05c3100" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01a020c3-db5e-7b21-8f9f-2b5bf22ab319" xlink:to="loc_us-gaap_EmployeeStockMember_01a020c3-db5e-7c05-8d69-ad84d05c3100" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7e6d-95c0-9f84754b39c1" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a020c3-db5e-7f63-82f9-3a7edd329ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_NetIncomeLoss_01a020c3-db5e-7f63-82f9-3a7edd329ed7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_InterestOnConvertibleDebtAdjustment_01a020c3-db5e-75ed-8ffc-5b37cb26a367" xlink:href="alny-20260930.xsd#alny_InterestOnConvertibleDebtAdjustment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_alny_InterestOnConvertibleDebtAdjustment_01a020c3-db5e-75ed-8ffc-5b37cb26a367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_01a020c3-db5e-764e-aedc-5fc7775edbca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToParentDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_01a020c3-db5e-764e-aedc-5fc7775edbca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_01a020c3-db5e-7e23-a113-995801a03621" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_01a020c3-db5e-7e23-a113-995801a03621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DilutiveSecuritiesAbstract_01a020c3-db5e-7c50-850e-b2591529f820" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DilutiveSecuritiesAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_DilutiveSecuritiesAbstract_01a020c3-db5e-7c50-850e-b2591529f820" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_01a020c3-db5e-7e14-806a-7cd1f69e26c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DilutiveSecuritiesAbstract_01a020c3-db5e-7c50-850e-b2591529f820" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_01a020c3-db5e-7e14-806a-7cd1f69e26c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_01a020c3-db5e-7813-83e7-ca24b4298826" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DilutiveSecuritiesAbstract_01a020c3-db5e-7c50-850e-b2591529f820" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_01a020c3-db5e-7813-83e7-ca24b4298826" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_01a020c3-db5e-7c6a-9269-10717099eb4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_01a020c3-db5e-7c6a-9269-10717099eb4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_01a020c3-db5e-7f26-9488-88ccf5c259ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_EarningsPerShareBasic_01a020c3-db5e-7f26-9488-88ccf5c259ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_01a020c3-db5e-7f9f-8597-3800f66e527b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72a7-b1d7-12ed339fc8b7" xlink:to="loc_us-gaap_EarningsPerShareDiluted_01a020c3-db5e-7f9f-8597-3800f66e527b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofCommonShareEquivalentsExcludedfromCalculationofNetLossPerCommonShareDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETINCOMELOSSPERCOMMONSHAREScheduleofCommonShareEquivalentsExcludedfromCalculationofNetLossPerCommonShareDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofCommonShareEquivalentsExcludedfromCalculationofNetLossPerCommonShareDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7690-9793-6e8e1953c2ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7362-b374-a56821adaabf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7690-9793-6e8e1953c2ef" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7362-b374-a56821adaabf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-7dbb-8f1a-e720610c1ba4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7362-b374-a56821adaabf" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-7dbb-8f1a-e720610c1ba4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-7852-b3ba-138962f17d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-7dbb-8f1a-e720610c1ba4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-7852-b3ba-138962f17d7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_01a020c3-db5e-7672-8a18-442fb9993849" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-7852-b3ba-138962f17d7b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_01a020c3-db5e-7672-8a18-442fb9993849" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_01a020c3-db5e-7cd8-8be8-10284199f9c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-7852-b3ba-138962f17d7b" xlink:to="loc_us-gaap_RestrictedStockMember_01a020c3-db5e-7cd8-8be8-10284199f9c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-732f-8a07-7635eec7255e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-7852-b3ba-138962f17d7b" xlink:to="loc_us-gaap_ConvertibleDebtMember_01a020c3-db5e-732f-8a07-7635eec7255e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-7109-b14b-1cb72446861c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7362-b374-a56821adaabf" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-7109-b14b-1cb72446861c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01a020c3-db5e-7304-8ff1-be841062a5a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-7109-b14b-1cb72446861c" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01a020c3-db5e-7304-8ff1-be841062a5a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARENarrativeDetail" xlink:type="simple" xlink:href="alny-20260930.xsd#NETINCOMELOSSPERCOMMONSHARENarrativeDetail"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/NETINCOMELOSSPERCOMMONSHARENarrativeDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7caa-a0cf-ee00b2dc5899" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7851-8589-23fd092116a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_01a020c3-db5e-7caa-a0cf-ee00b2dc5899" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7851-8589-23fd092116a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-70f7-97b6-ea44469ff6a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7851-8589-23fd092116a3" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-70f7-97b6-ea44469ff6a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-75e7-9942-9988b87fcbfd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_01a020c3-db5e-70f7-97b6-ea44469ff6a9" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-75e7-9942-9988b87fcbfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_A2022And2025CappedCallTransactionsMember_01a020c3-db5e-7664-a1c1-462f2bf591a3" xlink:href="alny-20260930.xsd#alny_A2022And2025CappedCallTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_01a020c3-db5e-75e7-9942-9988b87fcbfd" xlink:to="loc_alny_A2022And2025CappedCallTransactionsMember_01a020c3-db5e-7664-a1c1-462f2bf591a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72c1-a929-fed8d7bbae44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_01a020c3-db5e-7851-8589-23fd092116a3" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72c1-a929-fed8d7bbae44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01a020c3-db5e-796a-ba1d-db42992263b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_01a020c3-db5e-72c1-a929-fed8d7bbae44" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01a020c3-db5e-796a-ba1d-db42992263b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/COMMITMENTSANDCONTINGENCIESDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#COMMITMENTSANDCONTINGENCIESDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/COMMITMENTSANDCONTINGENCIESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_01a020c3-db5e-73d1-8275-8d11bc7708f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_01a020c3-db5e-7beb-ac9b-514ad21a4495" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_01a020c3-db5e-73d1-8275-8d11bc7708f6" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_01a020c3-db5e-7beb-ac9b-514ad21a4495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/SEGMENTINFORMATIONNarrativeDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#SEGMENTINFORMATIONNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/SEGMENTINFORMATIONNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-7bbe-b71c-0e825e0e2458" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_01a020c3-db5e-750d-9558-b30739234d84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-7bbe-b71c-0e825e0e2458" xlink:to="loc_us-gaap_NumberOfOperatingSegments_01a020c3-db5e-750d-9558-b30739234d84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_01a020c3-db5e-72ae-9f2e-6d0569cc63eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-7bbe-b71c-0e825e0e2458" xlink:to="loc_us-gaap_NumberOfReportableSegments_01a020c3-db5e-72ae-9f2e-6d0569cc63eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/SEGMENTINFORMATIONScheduleofExpensesbySegmentDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#SEGMENTINFORMATIONScheduleofExpensesbySegmentDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/SEGMENTINFORMATIONScheduleofExpensesbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-7df8-a3a9-7eda31a97125" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_01a020c3-db5e-7df8-a3a9-7eda31a97125" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ResearchAndDevelopmentExpenseAxis_01a020c3-db5e-7a2c-a4ce-02fe39eae7a1" xlink:href="alny-20260930.xsd#alny_ResearchAndDevelopmentExpenseAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:to="loc_alny_ResearchAndDevelopmentExpenseAxis_01a020c3-db5e-7a2c-a4ce-02fe39eae7a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ResearchAndDevelopmentExpenseDomain_01a020c3-db5e-7f6f-a361-aed5d40ed110" xlink:href="alny-20260930.xsd#alny_ResearchAndDevelopmentExpenseDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ResearchAndDevelopmentExpenseAxis_01a020c3-db5e-7a2c-a4ce-02fe39eae7a1" xlink:to="loc_alny_ResearchAndDevelopmentExpenseDomain_01a020c3-db5e-7f6f-a361-aed5d40ed110" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ClinicalResearchAndOutsideServicesMember_01a020c3-db5e-76fb-b748-32e6f244c0fa" xlink:href="alny-20260930.xsd#alny_ClinicalResearchAndOutsideServicesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ResearchAndDevelopmentExpenseDomain_01a020c3-db5e-7f6f-a361-aed5d40ed110" xlink:to="loc_alny_ClinicalResearchAndOutsideServicesMember_01a020c3-db5e-76fb-b748-32e6f244c0fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CompensationAndRelatedMember_01a020c3-db5e-7b4d-b20e-1882fa369c31" xlink:href="alny-20260930.xsd#alny_CompensationAndRelatedMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ResearchAndDevelopmentExpenseDomain_01a020c3-db5e-7f6f-a361-aed5d40ed110" xlink:to="loc_alny_CompensationAndRelatedMember_01a020c3-db5e-7b4d-b20e-1882fa369c31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OccupancyAndAllOtherCostsMember_01a020c3-db5e-7fa2-b0a6-e25a1ba22d3d" xlink:href="alny-20260930.xsd#alny_OccupancyAndAllOtherCostsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_ResearchAndDevelopmentExpenseDomain_01a020c3-db5e-7f6f-a361-aed5d40ed110" xlink:to="loc_alny_OccupancyAndAllOtherCostsMember_01a020c3-db5e-7fa2-b0a6-e25a1ba22d3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_SellingGeneralAndAdministrativeExpenseAxis_01a020c3-db5e-7a14-bdf8-a928d9751db5" xlink:href="alny-20260930.xsd#alny_SellingGeneralAndAdministrativeExpenseAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:to="loc_alny_SellingGeneralAndAdministrativeExpenseAxis_01a020c3-db5e-7a14-bdf8-a928d9751db5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_SellingGeneralAndAdministrativeExpenseDomain_01a020c3-db5e-7b70-a9b4-9851434b4e56" xlink:href="alny-20260930.xsd#alny_SellingGeneralAndAdministrativeExpenseDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_SellingGeneralAndAdministrativeExpenseAxis_01a020c3-db5e-7a14-bdf8-a928d9751db5" xlink:to="loc_alny_SellingGeneralAndAdministrativeExpenseDomain_01a020c3-db5e-7b70-a9b4-9851434b4e56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_CompensationAndRelatedMember_01a020c3-db5e-793c-ae6f-7f7b4ccbf7ee" xlink:href="alny-20260930.xsd#alny_CompensationAndRelatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_SellingGeneralAndAdministrativeExpenseDomain_01a020c3-db5e-7b70-a9b4-9851434b4e56" xlink:to="loc_alny_CompensationAndRelatedMember_01a020c3-db5e-793c-ae6f-7f7b4ccbf7ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_ConsultingAndProfessionalServicesMember_01a020c3-db5e-778a-b65e-1e8984b6e207" xlink:href="alny-20260930.xsd#alny_ConsultingAndProfessionalServicesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_SellingGeneralAndAdministrativeExpenseDomain_01a020c3-db5e-7b70-a9b4-9851434b4e56" xlink:to="loc_alny_ConsultingAndProfessionalServicesMember_01a020c3-db5e-778a-b65e-1e8984b6e207" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_OccupancyAndAllOtherCostsMember_01a020c3-db5e-735b-87d2-417453bab94f" xlink:href="alny-20260930.xsd#alny_OccupancyAndAllOtherCostsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_alny_SellingGeneralAndAdministrativeExpenseDomain_01a020c3-db5e-7b70-a9b4-9851434b4e56" xlink:to="loc_alny_OccupancyAndAllOtherCostsMember_01a020c3-db5e-735b-87d2-417453bab94f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a020c3-db5e-7818-9467-288069ae5443" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a020c3-db5e-7818-9467-288069ae5443" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a020c3-db5e-7c3f-adc0-85966aad8d19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a020c3-db5e-7818-9467-288069ae5443" xlink:to="loc_us-gaap_SegmentDomain_01a020c3-db5e-7c3f-adc0-85966aad8d19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_SingleReportableSegmentMember_01a020c3-db5e-7a6e-94b8-387a60938283" xlink:href="alny-20260930.xsd#alny_SingleReportableSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_01a020c3-db5e-7c3f-adc0-85966aad8d19" xlink:to="loc_alny_SingleReportableSegmentMember_01a020c3-db5e-7a6e-94b8-387a60938283" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_01a020c3-db5e-753d-87b2-26cd3c043163" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a020c3-db5e-73ed-8406-a9857b7ef70a" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_01a020c3-db5e-753d-87b2-26cd3c043163" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-db5e-720a-b100-4d2c32b4ef76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a020c3-db5e-753d-87b2-26cd3c043163" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_01a020c3-db5e-720a-b100-4d2c32b4ef76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a020c3-db5e-7168-92d7-99bf0ba96482" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a020c3-db5e-753d-87b2-26cd3c043163" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a020c3-db5e-7168-92d7-99bf0ba96482" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.alnylam.com/role/INCOMETAXESDetails" xlink:type="simple" xlink:href="alny-20260930.xsd#INCOMETAXESDetails"/>
  <link:presentationLink xlink:role="http://www.alnylam.com/role/INCOMETAXESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_01a12fb8-324c-7f4d-9617-71b375a1ca8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_01a12fd5-f5e9-74b9-bff6-5fdd46e645d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_01a12fb8-324c-7f4d-9617-71b375a1ca8d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_01a12fd5-f5e9-74b9-bff6-5fdd46e645d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_01a12fd9-f134-7d88-bc71-35636fe825e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_01a12fb8-324c-7f4d-9617-71b375a1ca8d" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_01a12fd9-f134-7d88-bc71-35636fe825e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/AwardTimingDisclosure" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#AwardTimingDisclosure"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/AwardTimingDisclosure" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgDiscLineItems" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgDiscLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgMnpiDiscTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgMnpiDiscTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardTmgMnpiDiscTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgMethodTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgMethodTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardTmgMethodTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgPredtrmndFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgPredtrmndFlag"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardTmgPredtrmndFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgMnpiCnsdrdFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgMnpiCnsdrdFlag"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardTmgMnpiCnsdrdFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardTmgHowMnpiCnsdrdTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardTmgHowMnpiCnsdrdTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardTmgHowMnpiCnsdrdTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MnpiDiscTimedForCompValFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_MnpiDiscTimedForCompValFlag"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_MnpiDiscTimedForCompValFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardsCloseToMnpiDiscTableTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardsCloseToMnpiDiscTableTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardsCloseToMnpiDiscTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardsCloseToMnpiDiscTable" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardsCloseToMnpiDiscTable"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardsCloseToMnpiDiscTable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_IndividualAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_IndividualAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardsCloseToMnpiDiscTable" xlink:to="loc_ecd_IndividualAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_IndividualAxis" xlink:to="loc_ecd_AllIndividualsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardsCloseToMnpiDiscTable" xlink:to="loc_us-gaap_AwardTypeAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_EmployeeStockOptionMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockAppreciationRightsSARSMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockAppreciationRightsSARSMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_StockAppreciationRightsSARSMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardsCloseToMnpiDiscIndName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardsCloseToMnpiDiscIndName"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardsCloseToMnpiDiscIndName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardUndrlygSecuritiesAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardUndrlygSecuritiesAmt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardUndrlygSecuritiesAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardExrcPrice" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardExrcPrice"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardExrcPrice" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AwardGrantDateFairValue" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AwardGrantDateFairValue"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_AwardGrantDateFairValue" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_UndrlygSecurityMktPriceChngPct" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_UndrlygSecurityMktPriceChngPct"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AwardTmgDiscLineItems" xlink:to="loc_ecd_UndrlygSecurityMktPriceChngPct" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/ErrCompDisclosure" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ErrCompDisclosure"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/ErrCompDisclosure" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_RecoveryOfErrCompDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ErrCompRecoveryTable" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ErrCompRecoveryTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ErrCompRecoveryTable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_RestatementDateAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_RestatementDateAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_ErrCompRecoveryTable" xlink:to="loc_ecd_RestatementDateAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_IndividualAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_IndividualAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_ErrCompRecoveryTable" xlink:to="loc_ecd_IndividualAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_IndividualAxis" xlink:to="loc_ecd_AllIndividualsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonNeosMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonNeosMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ecd_NonNeosMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_RestatementDeterminationDate" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_RestatementDeterminationDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_RestatementDeterminationDate" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AggtErrCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AggtErrCompAmt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_AggtErrCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ErrCompAnalysisTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ErrCompAnalysisTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ErrCompAnalysisTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_StkPrcOrTsrEstimationMethodTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_StkPrcOrTsrEstimationMethodTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OutstandingAggtErrCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_OutstandingAggtErrCompAmt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_OutstandingAggtErrCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AggtErrCompNotYetDeterminedTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AggtErrCompNotYetDeterminedTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_AggtErrCompNotYetDeterminedTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryIndName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ForgoneRecoveryIndName"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ForgoneRecoveryIndName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryDueToExpenseOfEnforcementAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ForgoneRecoveryDueToExpenseOfEnforcementAmt"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ForgoneRecoveryDueToExpenseOfEnforcementAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryDueToViolationOfHomeCountryLawAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ForgoneRecoveryDueToViolationOfHomeCountryLawAmt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ForgoneRecoveryDueToViolationOfHomeCountryLawAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryDueToDisqualificationOfTaxBenefitsAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ForgoneRecoveryDueToDisqualificationOfTaxBenefitsAmt"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ForgoneRecoveryDueToDisqualificationOfTaxBenefitsAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_ForgoneRecoveryExplanationOfImpracticabilityTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OutstandingRecoveryIndName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_OutstandingRecoveryIndName"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_OutstandingRecoveryIndName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OutstandingRecoveryCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_OutstandingRecoveryCompAmt"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_OutstandingRecoveryCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_RestatementDoesNotRequireRecoveryTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_RestatementDoesNotRequireRecoveryTextBlock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_RecoveryOfErrCompDisclosureLineItems" xlink:to="loc_ecd_RestatementDoesNotRequireRecoveryTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#PvpDisclosure"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PayVsPerformanceDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PvpTable" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PvpTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PvpTable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ExecutiveCategoryAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ExecutiveCategoryAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PvpTable" xlink:to="loc_ecd_ExecutiveCategoryAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllExecutiveCategoriesMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllExecutiveCategoriesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_ExecutiveCategoryAxis" xlink:to="loc_ecd_AllExecutiveCategoriesMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeoMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllExecutiveCategoriesMember" xlink:to="loc_ecd_PeoMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonPeoNeoMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonPeoNeoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllExecutiveCategoriesMember" xlink:to="loc_ecd_NonPeoNeoMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_IndividualAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_IndividualAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PvpTable" xlink:to="loc_ecd_IndividualAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_IndividualAxis" xlink:to="loc_ecd_AllIndividualsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToCompAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AdjToCompAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PvpTable" xlink:to="loc_ecd_AdjToCompAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllAdjToCompMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AdjToCompAxis" xlink:to="loc_ecd_AllAdjToCompMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AggtChngPnsnValInSummryCompstnTblForAplblYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AggtChngPnsnValInSummryCompstnTblForAplblYrMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_ecd_AggtChngPnsnValInSummryCompstnTblForAplblYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AggtPnsnAdjsSvcCstMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AggtPnsnAdjsSvcCstMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_ecd_AggtPnsnAdjsSvcCstMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PnsnAdjsSvcCstMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PnsnAdjsSvcCstMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AggtPnsnAdjsSvcCstMember" xlink:to="loc_ecd_PnsnAdjsSvcCstMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PnsnAdjsPrrSvcCstMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PnsnAdjsPrrSvcCstMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AggtPnsnAdjsSvcCstMember" xlink:to="loc_ecd_PnsnAdjsPrrSvcCstMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_EqtyAwrdsAdjsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_EqtyAwrdsAdjsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_ecd_EqtyAwrdsAdjsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_EqtyAwrdsInSummryCompstnTblForAplblYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_EqtyAwrdsInSummryCompstnTblForAplblYrMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsMember" xlink:to="loc_ecd_EqtyAwrdsInSummryCompstnTblForAplblYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsMember" xlink:to="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="loc_ecd_DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MeasureAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_MeasureAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PvpTable" xlink:to="loc_ecd_MeasureAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PvpTableTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PvpTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PvpTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CoSelectedMeasureName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CoSelectedMeasureName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CoSelectedMeasureName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NamedExecutiveOfficersFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NamedExecutiveOfficersFnTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_NamedExecutiveOfficersFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeerGroupIssuersFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeerGroupIssuersFnTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PeerGroupIssuersFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_ChangedPeerGroupFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_ChangedPeerGroupFnTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_ChangedPeerGroupFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeoTotalCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeoTotalCompAmt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PeoTotalCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeoActuallyPaidCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeoActuallyPaidCompAmt"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PeoActuallyPaidCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToPeoCompFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AdjToPeoCompFnTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_AdjToPeoCompFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonPeoNeoAvgTotalCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonPeoNeoAvgTotalCompAmt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_NonPeoNeoAvgTotalCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonPeoNeoAvgCompActuallyPaidAmt"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_NonPeoNeoAvgCompActuallyPaidAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToNonPeoNeoCompFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AdjToNonPeoNeoCompFnTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_AdjToNonPeoNeoCompFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_EquityValuationAssumptionDifferenceFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_EquityValuationAssumptionDifferenceFnTextBlock"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_EquityValuationAssumptionDifferenceFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CompActuallyPaidVsNetIncomeTextBlock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CompActuallyPaidVsNetIncomeTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TotalShareholderRtnVsPeerGroupTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TotalShareholderRtnVsPeerGroupTextBlock"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_TotalShareholderRtnVsPeerGroupTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CompActuallyPaidVsOtherMeasureTextBlock"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CompActuallyPaidVsOtherMeasureTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TabularListTableTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TabularListTableTextBlock"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_TabularListTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TotalShareholderRtnAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TotalShareholderRtnAmt"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_TotalShareholderRtnAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeerGroupTotalShareholderRtnAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeerGroupTotalShareholderRtnAmt"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PeerGroupTotalShareholderRtnAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_CoSelectedMeasureAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_CoSelectedMeasureAmt"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_CoSelectedMeasureAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_OtherPerfMeasureAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_OtherPerfMeasureAmt"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_OtherPerfMeasureAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AdjToCompAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AdjToCompAmt"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_AdjToCompAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PeoName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PeoName"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PeoName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MeasureName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_MeasureName"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_MeasureName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonGaapMeasureDescriptionTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonGaapMeasureDescriptionTextBlock"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_NonGaapMeasureDescriptionTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_Additional402vDisclosureTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_Additional402vDisclosureTextBlock"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_Additional402vDisclosureTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_PnsnBnftsAdjFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_PnsnBnftsAdjFnTextBlock"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_PnsnBnftsAdjFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_EqtyAwrdsAdjFnTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_EqtyAwrdsAdjFnTextBlock"/>
    <link:presentationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_PayVsPerformanceDisclosureLineItems" xlink:to="loc_ecd_EqtyAwrdsAdjFnTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/InsiderTradingArrangements" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#InsiderTradingArrangements"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/InsiderTradingArrangements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTradingArrLineItems" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_InsiderTradingArrLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TradingArrByIndTable" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TradingArrByIndTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TradingArrByIndTable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TradingArrAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TradingArrAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_TradingArrByIndTable" xlink:to="loc_ecd_TradingArrAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllTradingArrangementsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllTradingArrangementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_TradingArrAxis" xlink:to="loc_ecd_AllTradingArrangementsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_IndividualAxis" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_IndividualAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_TradingArrByIndTable" xlink:to="loc_ecd_IndividualAxis" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_IndividualAxis" xlink:to="loc_ecd_AllIndividualsMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_alny_TolgaTangulerMember" xlink:href="alny-20260930.xsd#alny_TolgaTangulerMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_alny_TolgaTangulerMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_MtrlTermsOfTrdArrTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_MtrlTermsOfTrdArrTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_MtrlTermsOfTrdArrTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrIndName" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrIndName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrIndName" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrIndTitle" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrIndTitle"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrIndTitle" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_Rule10b51ArrAdoptedFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_Rule10b51ArrAdoptedFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_Rule10b51ArrAdoptedFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonRule10b51ArrAdoptedFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonRule10b51ArrAdoptedFlag"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_NonRule10b51ArrAdoptedFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrAdoptionDate" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrAdoptionDate"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrAdoptionDate" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_Rule10b51ArrTrmntdFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_Rule10b51ArrTrmntdFlag"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_Rule10b51ArrTrmntdFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_NonRule10b51ArrTrmntdFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_NonRule10b51ArrTrmntdFlag"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_NonRule10b51ArrTrmntdFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrTerminationDate" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrTerminationDate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrTerminationDate" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrExpirationDate" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrExpirationDate"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrExpirationDate" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrDuration" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrDuration"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrDuration" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_TrdArrSecuritiesAggAvailAmt" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_TrdArrSecuritiesAggAvailAmt"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingArrLineItems" xlink:to="loc_ecd_TrdArrSecuritiesAggAvailAmt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/InsiderTradingPoliciesProc" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#InsiderTradingPoliciesProc"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/InsiderTradingPoliciesProc" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTradingPoliciesProcLineItems" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_InsiderTradingPoliciesProcLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTrdPoliciesProcAdoptedFlag" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_InsiderTrdPoliciesProcAdoptedFlag"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingPoliciesProcLineItems" xlink:to="loc_ecd_InsiderTrdPoliciesProcAdoptedFlag" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_ecd_InsiderTrdPoliciesProcNotAdoptedTextBlock" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_InsiderTrdPoliciesProcNotAdoptedTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_InsiderTradingPoliciesProcLineItems" xlink:to="loc_ecd_InsiderTrdPoliciesProcNotAdoptedTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
