v3.26.3
LIABILITIES RELATED TO THE SALE OF FUTURE ROYALTIES AND DEVELOPMENT FUNDING - Additional Information (Detail)
$ in Thousands
1 Months Ended
Sep. 30, 2026
USD ($)
Sep. 30, 2026
USD ($)
Jun. 30, 2026
USD ($)
Sep. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
payment
Sep. 30, 2023
USD ($)
payment
Aug. 31, 2020
USD ($)
program
Apr. 30, 2020
USD ($)
Jan. 01, 2030
Dec. 31, 2025
USD ($)
Liability Related To The Sale Of Future Royalties [Line Items]                    
Number of cardiometabolic programs | program             2      
Liabilities related to the sale of future royalties and development funding $ 272,037 $ 272,037               $ 220,068
Liabilities related to the sale of future royalties and development funding, net of current portion $ 1,462,828 $ 1,462,828               $ 1,470,341
Vutrisiran                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Effective interest rate 47.00% 47.00%               46.00%
Liabilities related to the sale of future royalties and development funding $ 76,000 $ 76,000               $ 94,500
Liabilities related to the sale of future royalties and development funding, net of current portion $ 94,400 $ 94,400               $ 99,700
Zilebesrian                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Effective interest rate 31.00% 31.00%               32.00%
Liabilities related to the sale of future royalties and development funding $ 6,900 $ 6,900               $ 6,800
Liabilities related to the sale of future royalties and development funding, net of current portion 18,300 18,300               10,300
Blackstone Life Sciences | Vutrisiran and ALN-AGT | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Maximum funding             $ 150,000      
Blackstone Life Sciences | HELIOS-B Phase 3 Clinical Trial | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Maximum funding   70,000                
Blackstone Life Sciences | ALN-AGT Phase 2 Clinical Trial                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Development milestone payable           $ 84,500        
Blackstone Life Sciences | ALN-AGT Phase 2 Clinical Trial | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Maximum funding   26,000                
Number of quarterly payments | payment           16        
Fixed payment, term (in years)           4 years        
Blackstone Life Sciences | ALN-AGT Phase 3 Clinical Trial | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Maximum funding 24,000   $ 36,000 $ 36,000            
Development milestone payable           $ 243,000        
Number of quarterly payments | payment           16        
Fixed payment, term (in years)           4 years        
Blackstone Life Sciences | Vutrisiran                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Development milestone payable         $ 175,000          
Blackstone Life Sciences | Vutrisiran | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Royalties payable, percent             1.00%      
Royalties payable, term (in years)             10 years      
Number of quarterly payments | payment         8          
Fixed payment, term (in years)         2 years          
Blackstone Life Sciences | Development Milestone                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Development milestone payable             $ 175,000      
Vutrisiran                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Royalty and development funding liability, fair value 479,300 479,300               541,300
Zilebesrian                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Royalty and development funding liability, fair value 120,100 120,100               116,200
Blackstone Group Inc.                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Liabilities related to the sale of future royalties and development funding 189,200 189,200               118,800
Liabilities related to the sale of future royalties and development funding, net of current portion $ 1,350,000 $ 1,350,000               $ 1,360,000
Blackstone Group Inc. | Net revenues from collaborations                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Collaborative arrangement, royalties and commercial milestones acquired by collaborator, percent               50.00%    
Commercial milestones acquired by collaborator, percent               75.00%    
Expected royalty interest payments               $ 1,000,000    
Consideration received               $ 1,000,000    
Interest rate 15.00% 15.00%               10.00%
Liabilities related to the sale of future royalties and development funding, net of current portion $ 1,539,305 $ 1,539,305               $ 1,479,209
Closing costs 7,700 7,700               8,300
Fair value of liability $ 2,030,000 $ 2,030,000               $ 1,610,000
Blackstone Group Inc. | Net revenues from collaborations | Forecast                    
Liability Related To The Sale Of Future Royalties [Line Items]                    
Collaborative arrangement, royalties and commercial milestones acquired by collaborator, percent                 55.00%