v3.26.3
NET PRODUCT REVENUES - Schedule of Net Product Revenues (Detail) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Disaggregation of Revenue [Line Items]        
Total revenues $ 1,458,086 $ 1,249,026 $ 3,916,209 $ 2,616,904
Net product revenues        
Disaggregation of Revenue [Line Items]        
Total revenues 1,291,946 851,082 3,500,182 1,991,832
Total TTR        
Disaggregation of Revenue [Line Items]        
Total revenues 1,149,959 724,378 3,090,594 1,628,350
AMVUTTRA        
Disaggregation of Revenue [Line Items]        
Total revenues 1,130,363 685,303 3,032,056 1,487,248
ONPATTRO        
Disaggregation of Revenue [Line Items]        
Total revenues 19,596 39,075 58,538 141,102
Total Rare        
Disaggregation of Revenue [Line Items]        
Total revenues 141,987 126,704 409,588 363,482
GIVLAARI        
Disaggregation of Revenue [Line Items]        
Total revenues 89,487 73,874 253,645 221,691
OXLUMO        
Disaggregation of Revenue [Line Items]        
Total revenues 52,500 52,830 155,943 141,791
United States | AMVUTTRA        
Disaggregation of Revenue [Line Items]        
Total revenues 908,596 530,347 2,420,229 1,089,657
United States | ONPATTRO        
Disaggregation of Revenue [Line Items]        
Total revenues 9,705 12,480 29,734 50,105
United States | GIVLAARI        
Disaggregation of Revenue [Line Items]        
Total revenues 57,459 50,426 164,550 149,371
United States | OXLUMO        
Disaggregation of Revenue [Line Items]        
Total revenues 18,429 20,727 53,939 50,855
Europe | AMVUTTRA        
Disaggregation of Revenue [Line Items]        
Total revenues 130,718 111,944 363,041 284,900
Europe | ONPATTRO        
Disaggregation of Revenue [Line Items]        
Total revenues 4,762 19,678 17,835 67,465
Europe | GIVLAARI        
Disaggregation of Revenue [Line Items]        
Total revenues 20,872 18,706 65,485 58,216
Europe | OXLUMO        
Disaggregation of Revenue [Line Items]        
Total revenues 23,213 22,346 70,281 65,259
Rest of World | AMVUTTRA        
Disaggregation of Revenue [Line Items]        
Total revenues 91,049 43,012 248,786 112,691
Rest of World | ONPATTRO        
Disaggregation of Revenue [Line Items]        
Total revenues 5,129 6,917 10,969 23,532
Rest of World | GIVLAARI        
Disaggregation of Revenue [Line Items]        
Total revenues 11,156 4,742 23,610 14,104
Rest of World | OXLUMO        
Disaggregation of Revenue [Line Items]        
Total revenues $ 10,858 $ 9,757 $ 31,723 $ 25,677