v3.26.3
NET PRODUCT REVENUES
 9 Months Ended
Sep. 30, 2026
Revenue from Contract with Customer [Abstract]  
NET PRODUCT REVENUES
3. NET PRODUCT REVENUES
Net product revenues, classified based on the geographic region in which the product is sold and by franchise (“TTR,” which includes AMVUTTRA and ONPATTRO, and “Rare,” which includes GIVLAARI and OXLUMO) consisted of the following:
Three Months Ended September 30,Nine Months Ended September 30,
(In thousands)2026202520262025
AMVUTTRA
United States$908,596 $530,347 $2,420,229 $1,089,657 
Europe130,718 111,944 363,041 284,900 
Rest of World91,049 43,012 248,786 112,691 
Total1,130,363 685,303 3,032,056 1,487,248 
ONPATTRO
United States9,705 12,480 29,734 50,105 
Europe4,762 19,678 17,835 67,465 
Rest of World5,129 6,917 10,969 23,532 
Total19,596 39,075 58,538 141,102 
Total TTR
1,149,959 724,378 3,090,594 1,628,350 
GIVLAARI
United States57,459 50,426 164,550 149,371 
Europe20,872 18,706 65,485 58,216 
Rest of World11,156 4,742 23,610 14,104 
Total89,487 73,874 253,645 221,691 
OXLUMO
United States18,429 20,727 53,939 50,855 
Europe23,213 22,346 70,281 65,259 
Rest of World10,858 9,757 31,723 25,677 
Total52,500 52,830 155,943 141,791 
Total Rare
141,987 126,704 409,588 363,482 
Total net product revenues$1,291,946 $851,082 $3,500,182 $1,991,832 
As of September 30, 2026 and December 31, 2025, net product revenue-related receivables of $906.2 million and $669.5 million, respectively, were included in accounts receivable, net on our condensed consolidated balance sheets.
The following table summarizes balances and activity in each product revenue allowance and reserve category:
(In thousands)Chargebacks and Rebates
Other Incentives and Allowances
Total
Beginning balance as of December 31, 2025
$399,853 $25,797 $425,650 
Provision related to current year sales
968,692 95,819 1,064,511 
Provision related to prior years’ sales
(6,045)(992)(7,037)
Credit or payments made during the period for current year sales
(598,591)(71,712)(670,303)
Credit or payments made during the period for prior years’ sales
(239,525)(16,323)(255,848)
Total as of September 30, 2026
$524,384 $32,589 $556,973