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Intangible assets and goodwill - Definite-lived Intangibles (Details) - USD ($) $ in Thousands	3 Months Ended			9 Months Ended
	Sep. 30, 2026	Jun. 30, 2026	Sep. 30, 2025	Sep. 30, 2026	Sep. 30, 2025	Dec. 31, 2025	Aug. 05, 2025
Definite-lived intangibles
Amortization	$ (12,595)		$ (7,534)	$ (36,017)	$ (15,393)
Total definite-lived intangibles, net	443,686			443,686
Accrued royalties	$ 16,970			$ 16,970		$ 9,574
Weighted Average
Definite-lived intangibles
Remaining amortization period	10 years 9 months 18 days			10 years 9 months 18 days
Censa Merger Agreement
Definite-lived intangibles
Maximum Upfront Consideration Agreed To Be Paid	$ 500,000	$ 250,000		$ 500,000
Rights Satisfaction Agreement
Definite-lived intangibles
Maximum Upfront Consideration Agreed To Be Paid							$ 250,000
Akcea \| Waylivra
Definite-lived intangibles
Royalty payments				3,400
Akcea \| Waylivra \| Accounts payable and accrued expenses
Definite-lived intangibles
Accrued royalties	500			500
Akcea \| Tegsedi
Definite-lived intangibles
Royalty payments				4,300
Akcea \| Tegsedi \| Accounts payable and accrued expenses
Definite-lived intangibles
Accrued royalties	1,100			1,100
Censa \| Waylivra
Definite-lived intangibles
Royalty payments				3,400
Censa \| Tegsedi
Definite-lived intangibles
Royalty payments				4,300
Censa \| Sephience
Definite-lived intangibles
Royalty payments				4,100
Censa \| Sephience \| Accounts payable and accrued expenses
Definite-lived intangibles
Accrued royalties	3,100			3,100
Censa \| Censa Merger Agreement
Definite-lived intangibles
Milestone obligation payments recorded	50,000	$ 30,000		30,000
Definite-lived intangible assets
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				444,591
Additions				91,764
Foreign currency translation				(1,593)
Ending balance - Definite-lived assets, Gross	534,762			534,762
Beginning balance - Accumulated amortization				(55,838)
Amortization	(12,600)		$ (7,500)	(36,017)	$ (15,400)
Foreign currency translation - Accumulated amortization				779
Ending balance - Accumulated amortization	(91,076)			(91,076)
Total definite-lived intangibles, net	443,686			443,686
Definite-lived intangible assets \| Waylivra
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				18,598
Additions				3,414
Foreign currency translation				(691)
Ending balance - Definite-lived assets, Gross	21,321			21,321
Beginning balance - Accumulated amortization				(8,689)
Amortization				(2,848)
Foreign currency translation - Accumulated amortization				353
Ending balance - Accumulated amortization	(11,184)			(11,184)
Definite-lived intangible assets \| Tegsedi
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				24,825
Additions				4,297
Foreign currency translation				(902)
Ending balance - Definite-lived assets, Gross	28,220			28,220
Beginning balance - Accumulated amortization				(10,295)
Amortization				(3,877)
Foreign currency translation - Accumulated amortization				426
Ending balance - Accumulated amortization	(13,746)			(13,746)
Definite-lived intangible assets \| Kebilidi
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				10,731
Ending balance - Definite-lived assets, Gross	10,731			10,731
Beginning balance - Accumulated amortization				(1,006)
Amortization				(1,459)
Ending balance - Accumulated amortization	(2,465)			(2,465)
Definite-lived intangible assets \| Upstaza
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				106,937
Ending balance - Definite-lived assets, Gross	106,937			106,937
Beginning balance - Accumulated amortization				(27,437)
Amortization				(11,925)
Ending balance - Accumulated amortization	(39,362)			(39,362)
Definite-lived intangible assets \| Sephience
Definite-lived intangibles
Beginning balance - Definite-lived assets, Gross				283,500
Additions				84,053
Ending balance - Definite-lived assets, Gross	367,553			367,553
Beginning balance - Accumulated amortization				(8,411)
Amortization				(15,908)
Ending balance - Accumulated amortization	$ (24,319)			$ (24,319)