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Commitments and contingencies - Censa agreement (Details) $ in Thousands			3 Months Ended			9 Months Ended
	Aug. 25, 2026 USD ($) D	Aug. 05, 2025 USD ($)	Sep. 30, 2026 USD ($)	Jun. 30, 2026 USD ($)	Sep. 30, 2025 USD ($)	Sep. 30, 2026 USD ($)	Sep. 30, 2025 USD ($)	Dec. 31, 2025 USD ($)	Jul. 31, 2025 USD ($)	Jun. 30, 2025 USD ($)	May 05, 2020 USD ($)
Commitments and contingencies
Revenue			$ 357,807		$ 211,007	$ 990,877	$ 1,565,978
Milestone Payable			80,000		32,500	80,000	32,500	$ 416
Sangamo asset acquisition
Commitments and contingencies
Milestone event notification period \| D	15
Maximum milestone payment due period \| D	20
Sangamo asset acquisition \| Upon Accelerated FDA Approval
Commitments and contingencies
Non-refundable payment	$ 80,000
Sangamo asset acquisition \| Upon Full FDA Approval
Commitments and contingencies
Non-refundable payment	20,000
Product
Commitments and contingencies
Revenue			275,894		$ 130,956	740,286	$ 402,711
Censa Merger Agreement
Commitments and contingencies
Maximum amount of upfront consideration			500,000	$ 250,000		500,000
Rights Satisfaction Agreement
Commitments and contingencies
Maximum amount of upfront consideration		$ 250,000
Maximum amount of additional milestone payable		100,000
Additional milestone payable for right holders		500,000
Payment of upfront consideration		225,100
Additional milestone obligated to be paid		$ 90,000
Rights Satisfaction Agreement \| Annual net sales less than or equal to $250 million
Commitments and contingencies
Percentage on annual net sales		8.00%
Rights Satisfaction Agreement \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Percentage on annual net sales		10.00%
Rights Satisfaction Agreement \| Annual net sales greater than $500 million
Commitments and contingencies
Percentage on annual net sales		12.00%
Rights Satisfaction Agreement \| First occurrence of a three or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period		3 years
Amount of net sales of product		$ 3,000,000
Rights Satisfaction Agreement \| First occurrence of a five or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period		5 years
Amount of net sales of product		$ 5,000,000
Rights Satisfaction Agreement \| First occurrence of a seven or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period		7 years
Amount of net sales of product		$ 7,000,000
Rights Satisfaction Agreement \| First occurrence of a nine or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period		9 years
Amount of net sales of product		$ 9,000,000
Rights Satisfaction Agreement \| First occurrence of a eleven or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period		11 years
Amount of net sales of product		$ 11,000,000
Minimum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Revenue		250,000
Minimum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $500 million
Commitments and contingencies
Revenue		500,000
Maximum \| Sangamo asset acquisition \| Upon Full FDA Approval
Commitments and contingencies
Non-refundable payment	$ 100,000
Maximum \| Rights Satisfaction Agreement \| Product \| Annual net sales less than or equal to $250 million
Commitments and contingencies
Revenue		250,000
Maximum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Revenue		$ 500,000
Censa
Commitments and contingencies
Asset acquisition, development and regulatory milestones											$ 109,000
Censa \| Censa Merger Agreement
Commitments and contingencies
Milestone payments triggered			50,000	30,000		50,000				$ 25,000
Milestone Payable									$ 32,500
Threshold revenue to milestone payment			$ 500,000	$ 250,000
Censa \| Maximum
Commitments and contingencies
Asset acquisition, milestone, amount											217,500
Asset acquisition, net sales milestone											$ 160,000
Former Censa Securityholders \| Development and Regulatory Milestones
Commitments and contingencies
Milestone obligation payments made						152,500
Potential milestone payments due						217,500
Former Censa Securityholders \| Rights Satisfaction Agreement
Commitments and contingencies
Ownership percentage prior to merger		90.00%
Sephience \| Censa
Commitments and contingencies
Royalty payments						4,100
Tegsedi \| Censa
Commitments and contingencies
Royalty payments						4,300
Waylivra \| Censa
Commitments and contingencies
Royalty payments						$ 3,400