| Schedule of disaggregation of net product revenue |
| | | | | | | | | | | | | | | | | | Three Months Ended September 30, | | | | 2026 | | | 2025 | (in thousands) | | | United States | | International | | Total | | | | United States | | International | | Total | Sephience | | $ | 144,795 | $ | 37,090 | $ | 181,885 | | | $ | 14,365 | $ | 5,198 | $ | 19,563 | Translarna | | | — | | 48,511 | | 48,511 | | | | — | | 50,665 | | 50,665 | Emflaza | | | 25,094 | | — | | 25,094 | | | | 35,160 | | — | | 35,160 | Upstaza/Kebilidi | | | 3,960 | | 10,593 | | 14,553 | | | | 6,898 | | 8,837 | | 15,735 | All other products | | | — | | 5,851 | | 5,851 | | | | — | | 9,833 | | 9,833 | Total net product revenue | | $ | 173,849 | $ | 102,045 | $ | 275,894 | | | $ | 56,423 | $ | 74,533 | $ | 130,956 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Nine Months Ended September 30, | | | 2026 | | | 2025 | | | | United States | | International | | Total | | | | United States | | International | | Total | Sephience | | $ | 384,385 | $ | 73,361 | $ | 457,746 | | | $ | 14,365 | $ | 5,198 | $ | 19,563 | Translarna | | | — | | 149,704 | | 149,704 | | | | — | | 196,289 | | 196,289 | Emflaza | | | 71,206 | | — | | 71,206 | | | | 119,303 | | — | | 119,303 | Upstaza/Kebilidi | | | 6,958 | | 28,351 | | 35,309 | | | | 6,898 | | 29,385 | | 36,283 | All other products | | | — | | 26,321 | | 26,321 | | | | — | | 31,273 | | 31,273 | Total net product revenue | | $ | 462,549 | $ | 277,737 | $ | 740,286 | | | $ | 140,566 | $ | 262,145 | $ | 402,711 |
| | | | | | | | | | | | | | | | Three Months Ended September 30, | | Nine Months Ended September 30, | (in thousands) | | 2026 | | 2025 | | | 2026 | | 2025 | United States | | $ | 173,849 | | $ | 56,423 | | | $ | 462,549 | | $ | 140,566 | Russia | | | 33,011 | | | 25,107 | | | | 61,841 | | | 81,745 | Brazil | | | 1,590 | | | 9,222 | | | | 51,012 | | | 59,678 | All other countries | | | 67,444 | | | 40,204 | | | | 164,884 | | | 120,722 | Total net product revenue | | $ | 275,894 | | $ | 130,956 | | | $ | 740,286 | | $ | 402,711 |
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