<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a01947-1a19-7ce5-b812-c017a14a09f3,g:b608ef1f-a554-459e-9383-b33b9b3484a6-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.novocure.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="nvcr-20260930.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-746e-ad8a-9f56452be1dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01a01947-1ad9-77f3-a1c3-e55f6aa96643" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-746e-ad8a-9f56452be1dd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_01a01947-1ad9-77f3-a1c3-e55f6aa96643" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_FieldEquipmentNetNoncurrent_01a01947-1ad9-79b0-91b8-47766e3be0fc" xlink:href="nvcr-20260930.xsd#nvcr_FieldEquipmentNetNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-746e-ad8a-9f56452be1dd" xlink:to="loc_nvcr_FieldEquipmentNetNoncurrent_01a01947-1ad9-79b0-91b8-47766e3be0fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a01947-1ad9-7f63-8701-0a41afe0afdb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-746e-ad8a-9f56452be1dd" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_01a01947-1ad9-7f63-8701-0a41afe0afdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_01a01947-1ad9-7ec2-9f8f-0b8a2a70e7c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-746e-ad8a-9f56452be1dd" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_01a01947-1ad9-7ec2-9f8f-0b8a2a70e7c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_01a01947-1ad9-75c1-a051-16e13f99fb82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7951-9762-b49697532b10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_01a01947-1ad9-75c1-a051-16e13f99fb82" xlink:to="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7951-9762-b49697532b10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-747c-a9dd-ca44e55b8a27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_01a01947-1ad9-75c1-a051-16e13f99fb82" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-747c-a9dd-ca44e55b8a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a01947-1ad9-71f0-a2d6-52fcd24947e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_01a01947-1ad9-7d40-ba02-bcd4a29b476b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a01947-1ad9-71f0-a2d6-52fcd24947e4" xlink:to="loc_us-gaap_Liabilities_01a01947-1ad9-7d40-ba02-bcd4a29b476b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_01a01947-1ad9-74de-8f54-c47346344f0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a01947-1ad9-71f0-a2d6-52fcd24947e4" xlink:to="loc_us-gaap_CommitmentsAndContingencies_01a01947-1ad9-74de-8f54-c47346344f0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a01947-1ad9-72c6-8c46-e5eea357d7e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_01a01947-1ad9-71f0-a2d6-52fcd24947e4" xlink:to="loc_us-gaap_StockholdersEquity_01a01947-1ad9-72c6-8c46-e5eea357d7e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7d87-bd6f-ef24968d15fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_01a01947-1ad9-7767-b36a-b562358d7934" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7d87-bd6f-ef24968d15fd" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_01a01947-1ad9-7767-b36a-b562358d7934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_OtherAccountsPayableLeaseLiabilitiesAndAccruedExpensesCurrent_01a01947-1ad9-7c24-abeb-08d3da5e7f9d" xlink:href="nvcr-20260930.xsd#nvcr_OtherAccountsPayableLeaseLiabilitiesAndAccruedExpensesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7d87-bd6f-ef24968d15fd" xlink:to="loc_nvcr_OtherAccountsPayableLeaseLiabilitiesAndAccruedExpensesCurrent_01a01947-1ad9-7c24-abeb-08d3da5e7f9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_01a134c6-9e01-7585-9482-6dc02261bbca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_01a01947-1ad9-7d87-bd6f-ef24968d15fd" xlink:to="loc_us-gaap_LongTermDebtCurrent_01a134c6-9e01-7585-9482-6dc02261bbca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_01a01947-1ad9-7059-b405-5db895f8d55e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_01a01947-1ad9-7ab2-ab18-50298b709da6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a01947-1ad9-7059-b405-5db895f8d55e" xlink:to="loc_us-gaap_CommonStockValue_01a01947-1ad9-7ab2-ab18-50298b709da6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_01a01947-1ad9-74a4-9bca-6da2b4f3235d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a01947-1ad9-7059-b405-5db895f8d55e" xlink:to="loc_us-gaap_AdditionalPaidInCapital_01a01947-1ad9-74a4-9bca-6da2b4f3235d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a01947-1ad9-7610-b259-4badc7ebab93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a01947-1ad9-7059-b405-5db895f8d55e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_01a01947-1ad9-7610-b259-4badc7ebab93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a01947-1ad9-7926-8274-3c3e312396d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_01a01947-1ad9-7059-b405-5db895f8d55e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_01a01947-1ad9-7926-8274-3c3e312396d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_01a01947-1ad9-75d4-8acf-06d368401da3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_01a01947-1ad9-74ed-9b0f-fb50c9452678" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a01947-1ad9-75d4-8acf-06d368401da3" xlink:to="loc_us-gaap_AssetsCurrent_01a01947-1ad9-74ed-9b0f-fb50c9452678" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-782f-bfa2-5f3f3ca1374c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_01a01947-1ad9-75d4-8acf-06d368401da3" xlink:to="loc_us-gaap_AssetsNoncurrent_01a01947-1ad9-782f-bfa2-5f3f3ca1374c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a01947-1ad9-7fe4-989d-590e3dfe4a06" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a01947-1ad9-7fe4-989d-590e3dfe4a06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesCurrent_01a01947-1ad9-7b74-9f5b-57c57404d4a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesCurrent_01a01947-1ad9-7b74-9f5b-57c57404d4a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_01a01947-1ad9-7084-a61f-3deb189cb29f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_us-gaap_RestrictedCashCurrent_01a01947-1ad9-7084-a61f-3deb189cb29f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_01a01947-1ad9-7188-ae87-ea2d18864397" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_01a01947-1ad9-7188-ae87-ea2d18864397" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_ReceivablesAndPrepaidExpenses_01a01947-1ad9-7fb2-b2ea-ac3cbd29aa3e" xlink:href="nvcr-20260930.xsd#nvcr_ReceivablesAndPrepaidExpenses"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_nvcr_ReceivablesAndPrepaidExpenses_01a01947-1ad9-7fb2-b2ea-ac3cbd29aa3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_01a01947-1ad9-7649-aab8-2c4b7080af1b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_01a01947-1ad9-75b3-a79a-f7a3529ade47" xlink:to="loc_us-gaap_InventoryNet_01a01947-1ad9-7649-aab8-2c4b7080af1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-7857-b906-2354f50d9b07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a01947-1ad9-7893-81e7-fa7bdc371194" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-7857-b906-2354f50d9b07" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a01947-1ad9-7893-81e7-fa7bdc371194" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_EmployeeRelatedLiabilitiesNonCurrent_01a01947-1ad9-786d-a426-a5dc02289e7b" xlink:href="nvcr-20260930.xsd#nvcr_EmployeeRelatedLiabilitiesNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-7857-b906-2354f50d9b07" xlink:to="loc_nvcr_EmployeeRelatedLiabilitiesNonCurrent_01a01947-1ad9-786d-a426-a5dc02289e7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermLineOfCredit_01a01947-1ad9-73d0-aeb0-e7d4ec879354" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermLineOfCredit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_01a01947-1ad9-7857-b906-2354f50d9b07" xlink:to="loc_us-gaap_LongTermLineOfCredit_01a01947-1ad9-73d0-aeb0-e7d4ec879354" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="nvcr-20260930.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7433-8669-02ee2f959967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a01947-1ad9-7cfc-97c4-590f27fe48dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7433-8669-02ee2f959967" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a01947-1ad9-7cfc-97c4-590f27fe48dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_01a01947-1ad9-7b5e-9d00-45e73986d72c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7433-8669-02ee2f959967" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_01a01947-1ad9-7b5e-9d00-45e73986d72c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a01947-1ad9-78c1-a24f-ec66e2a21be4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a01947-1ad9-78e4-997f-1f134eac5d35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a01947-1ad9-78c1-a24f-ec66e2a21be4" xlink:to="loc_us-gaap_OperatingIncomeLoss_01a01947-1ad9-78e4-997f-1f134eac5d35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_01a01947-1ad9-750c-bec1-f0acd50f016c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_01a01947-1ad9-78c1-a24f-ec66e2a21be4" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_01a01947-1ad9-750c-bec1-f0acd50f016c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_01a01947-1ad9-799e-a043-cd1ef1f2aeb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_01a01947-1ad9-7722-b3d0-2d42c11eb7f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_01a01947-1ad9-799e-a043-cd1ef1f2aeb5" xlink:to="loc_us-gaap_Revenues_01a01947-1ad9-7722-b3d0-2d42c11eb7f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_01a01947-1ad9-7091-9d6a-0b8b677c8711" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_01a01947-1ad9-799e-a043-cd1ef1f2aeb5" xlink:to="loc_us-gaap_CostOfRevenue_01a01947-1ad9-7091-9d6a-0b8b677c8711" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_01a01947-1ad9-79d0-a135-ffd04dd2744f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_01a01947-1ad9-709e-a8e8-065dcf80ccf2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_01a01947-1ad9-79d0-a135-ffd04dd2744f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_01a01947-1ad9-709e-a8e8-065dcf80ccf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_01a01947-1ad9-7b3a-99b4-dafaa2fef890" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_01a01947-1ad9-79d0-a135-ffd04dd2744f" xlink:to="loc_us-gaap_SellingAndMarketingExpense_01a01947-1ad9-7b3a-99b4-dafaa2fef890" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_01a01947-1ad9-7b63-91d5-d68c234094a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_01a01947-1ad9-79d0-a135-ffd04dd2744f" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_01a01947-1ad9-7b63-91d5-d68c234094a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a01947-1ad9-76ff-b883-414c01dfe181" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_01a01947-1ad9-7000-a9ab-c7bb94709cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_01a01947-1ad9-76ff-b883-414c01dfe181" xlink:to="loc_us-gaap_GrossProfit_01a01947-1ad9-7000-a9ab-c7bb94709cd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_01a01947-1ad9-75f0-b66b-882e7c2278db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_01a01947-1ad9-76ff-b883-414c01dfe181" xlink:to="loc_us-gaap_OperatingExpenses_01a01947-1ad9-75f0-b66b-882e7c2278db" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="nvcr-20260930.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a01947-1ad9-7660-ae76-f9b7aeb19cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_01a01947-1ad9-7520-a2ad-847a09b66311" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a01947-1ad9-7660-ae76-f9b7aeb19cd6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_01a01947-1ad9-7520-a2ad-847a09b66311" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_01a01947-1ad9-7af5-8ac6-7053e5d1a537" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a01947-1ad9-7660-ae76-f9b7aeb19cd6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_01a01947-1ad9-7af5-8ac6-7053e5d1a537" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7c8b-9846-80a9d180870d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_01a01947-1ad9-7660-ae76-f9b7aeb19cd6" xlink:to="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7c8b-9846-80a9d180870d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="nvcr-20260930.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_01a01947-1ad9-7c81-9d28-7ba0c9ca06db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_01a01947-1ad9-7c81-9d28-7ba0c9ca06db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_01a01947-1ad9-7fe0-9843-9336fd069cc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_01a01947-1ad9-7fe0-9843-9336fd069cc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a01947-1ad9-7398-85ed-d3041b43e7ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a01947-1ad9-7398-85ed-d3041b43e7ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_01a01947-1ad9-784d-b81d-76abc8eb842b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_01a01947-1ad9-784d-b81d-76abc8eb842b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_PaymentsTaxRelatedToNetSettlementOnEquityAwards_01a01947-1ad9-7a6b-85e2-ef42d6ed59c3" xlink:href="nvcr-20260930.xsd#nvcr_PaymentsTaxRelatedToNetSettlementOnEquityAwards"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e02-b63e-500b85a141c3" xlink:to="loc_nvcr_PaymentsTaxRelatedToNetSettlementOnEquityAwards_01a01947-1ad9-7a6b-85e2-ef42d6ed59c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a01947-1ad9-702f-81a0-b91e631da8cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7ede-bba7-6bfd2e4c0ae0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a01947-1ad9-702f-81a0-b91e631da8cc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7ede-bba7-6bfd2e4c0ae0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7af7-9a22-4ce5ce5b6ab4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a01947-1ad9-702f-81a0-b91e631da8cc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7af7-9a22-4ce5ce5b6ab4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e24-9136-4b786ea59149" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a01947-1ad9-702f-81a0-b91e631da8cc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_01a01947-1ad9-7e24-9136-4b786ea59149" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a01947-1ad9-7b61-9b34-1a9b6fb0a0bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_01a01947-1ad9-702f-81a0-b91e631da8cc" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a01947-1ad9-7b61-9b34-1a9b6fb0a0bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a01947-1ad9-7e13-8c88-e4cd7fbe7b25" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a01947-1ad9-7637-add3-aef756cc1928" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a01947-1ad9-7e13-8c88-e4cd7fbe7b25" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_01a01947-1ad9-7637-add3-aef756cc1928" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_01a01947-1ad9-7c2d-a6a3-8eb3c9a8dd3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_01a01947-1ad9-7e13-8c88-e4cd7fbe7b25" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_01a01947-1ad9-7c2d-a6a3-8eb3c9a8dd3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_01a01947-1ad9-7c83-b8bb-41421bc491cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_01a01947-1ad9-7c83-b8bb-41421bc491cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_01a01947-1ad9-70c8-bbf1-1947d602d0d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_01a01947-1ad9-70c8-bbf1-1947d602d0d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_01a01947-1ad9-799e-88d8-4ea4667dd371" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_DepreciationAndAmortization_01a01947-1ad9-799e-88d8-4ea4667dd371" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_01a01947-1ad9-7b09-b27b-2c58573f43d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_AssetImpairmentCharges_01a01947-1ad9-7b09-b27b-2c58573f43d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a01947-1ad9-7b05-b32b-0f970c5d6e9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_01a01947-1ad9-7b05-b32b-0f970c5d6e9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_01a01947-1ad9-7bd3-8956-5c82a37b2fe8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_01a01947-1ad9-7bd3-8956-5c82a37b2fe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_01a01947-1ad9-7704-8031-9d10098bc3bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_01a01947-1ad9-7704-8031-9d10098bc3bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_01a01947-1ad9-7b7b-813d-7819be01616b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_01a01947-1ad9-7b7b-813d-7819be01616b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7009-ac2e-8b29b08d614c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_NetIncomeLoss_01a01947-1ad9-7009-ac2e-8b29b08d614c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01a01947-1ad9-72ed-b0c0-22fd815610ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01a01947-1ad9-72ed-b0c0-22fd815610ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_01a01947-1ad9-7907-be09-5f867d7b6e5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_us-gaap_ShareBasedCompensation_01a01947-1ad9-7907-be09-5f867d7b6e5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_IncreaseDecreaseInAccountsReceivablesAndPrepaidExpenses_01a01947-1ad9-70cc-beda-5c5d47258782" xlink:href="nvcr-20260930.xsd#nvcr_IncreaseDecreaseInAccountsReceivablesAndPrepaidExpenses"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_01a01947-1ad9-7c22-a179-be37dd5dc44d" xlink:to="loc_nvcr_IncreaseDecreaseInAccountsReceivablesAndPrepaidExpenses_01a01947-1ad9-70cc-beda-5c5d47258782" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7e65-82dc-9fac084a9cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a01947-1ad9-789f-af06-75856856befd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7e65-82dc-9fac084a9cb6" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_01a01947-1ad9-789f-af06-75856856befd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_01a01947-1ad9-7d7f-b2f4-b72a4297d7f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7e65-82dc-9fac084a9cb6" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_01a01947-1ad9-7d7f-b2f4-b72a4297d7f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_01a01947-1ad9-7a6c-b9d8-910fa52f7549" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_01a01947-1ad9-7e65-82dc-9fac084a9cb6" xlink:to="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_01a01947-1ad9-7a6c-b9d8-910fa52f7549" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/CASHCASHEQUIVALENTSANDSHORTTERMINVESTMENTSDetails" xlink:type="simple" xlink:href="nvcr-20260930.xsd#CASHCASHEQUIVALENTSANDSHORTTERMINVESTMENTSDetails"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/CASHCASHEQUIVALENTSANDSHORTTERMINVESTMENTSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities_01a01947-1ad9-7420-89d7-74468ea2c17d" xlink:href="nvcr-20260930.xsd#nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-790a-b0bb-fce9e88855c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities_01a01947-1ad9-7420-89d7-74468ea2c17d" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-790a-b0bb-fce9e88855c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-7455-b11f-81c1b9e4f01e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities_01a01947-1ad9-7420-89d7-74468ea2c17d" xlink:to="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-7455-b11f-81c1b9e4f01e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-77eb-af5e-cd3fb5a99886" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_01a01947-1ad9-77d5-9d55-2780e21f016f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-77eb-af5e-cd3fb5a99886" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_01a01947-1ad9-77d5-9d55-2780e21f016f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_01a01947-1ad9-7fb1-a458-8dcb22bd55e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-77eb-af5e-cd3fb5a99886" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_01a01947-1ad9-7fb1-a458-8dcb22bd55e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_01a01947-1ad9-7f6a-afcf-e1e138657555" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-77eb-af5e-cd3fb5a99886" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_01a01947-1ad9-7f6a-afcf-e1e138657555" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost_01a01947-1ad9-741d-804f-ef8ec2fd7e1b" xlink:href="nvcr-20260930.xsd#nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-75e8-a618-35d2d359846d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost_01a01947-1ad9-741d-804f-ef8ec2fd7e1b" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-75e8-a618-35d2d359846d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-7dab-b0ab-8f3c257c9142" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost_01a01947-1ad9-741d-804f-ef8ec2fd7e1b" xlink:to="loc_us-gaap_HeldToMaturitySecurities_01a01947-1ad9-7dab-b0ab-8f3c257c9142" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedLoss_01a01947-1ad9-7333-9bec-2038406bc52f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_01a01947-1ad9-7a28-8767-a9b1bc6bb418" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedLoss_01a01947-1ad9-7333-9bec-2038406bc52f" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_01a01947-1ad9-7a28-8767-a9b1bc6bb418" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedGain_01a01947-1ad9-71aa-a289-1568d99f1c5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedGain"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_01a01947-1ad9-7f98-a5b1-28234b9b48a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAndHeldToMaturityCumulativeUnrecognizedGain_01a01947-1ad9-71aa-a289-1568d99f1c5d" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_01a01947-1ad9-7f98-a5b1-28234b9b48a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue_01a01947-1ad9-72ef-94a9-a759180cbf73" xlink:href="nvcr-20260930.xsd#nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-7d47-a2fc-9a8b1720717b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue_01a01947-1ad9-72ef-94a9-a759180cbf73" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_01a01947-1ad9-7d47-a2fc-9a8b1720717b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_01a01947-1ad9-72b7-af0b-5615814d2256" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue_01a01947-1ad9-72ef-94a9-a759180cbf73" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_01a01947-1ad9-72b7-af0b-5615814d2256" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/INVENTORIESDetails" xlink:type="simple" xlink:href="nvcr-20260930.xsd#INVENTORIESDetails"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/INVENTORIESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_01a01947-1ad9-7c7e-9573-8fc6e24c1b31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_01a01947-1ad9-7544-a89c-c34b313188d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_01a01947-1ad9-7c7e-9573-8fc6e24c1b31" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_01a01947-1ad9-7544-a89c-c34b313188d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_01a01947-1ad9-7241-875a-a82c328faff0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_01a01947-1ad9-7c7e-9573-8fc6e24c1b31" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_01a01947-1ad9-7241-875a-a82c328faff0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_01a01947-1ad9-73ea-9e91-f93a0d18674d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_01a01947-1ad9-7c7e-9573-8fc6e24c1b31" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_01a01947-1ad9-73ea-9e91-f93a0d18674d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/LONGTERMDEBTNETScheduleofLiabilityandEquityComponentsoftheSeniorSecuredCreditFacilityDetails" xlink:type="simple" xlink:href="nvcr-20260930.xsd#LONGTERMDEBTNETScheduleofLiabilityandEquityComponentsoftheSeniorSecuredCreditFacilityDetails"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/LONGTERMDEBTNETScheduleofLiabilityandEquityComponentsoftheSeniorSecuredCreditFacilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_01a01947-1b7e-7608-99ca-399f9e068b12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_01a01947-1b7e-7922-bc92-d8742e9a9fc0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_01a01947-1b7e-7608-99ca-399f9e068b12" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_01a01947-1b7e-7922-bc92-d8742e9a9fc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_01a01947-1b7e-7f9c-8e51-8f047b056ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_01a01947-1b7e-7608-99ca-399f9e068b12" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_01a01947-1b7e-7f9c-8e51-8f047b056ce0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.novocure.com/role/LONGTERMDEBTNETAmortizationofFinanceExpenseSeniorSecuredCreditFacilityDetails" xlink:type="simple" xlink:href="nvcr-20260930.xsd#LONGTERMDEBTNETAmortizationofFinanceExpenseSeniorSecuredCreditFacilityDetails"/>
  <link:calculationLink xlink:role="http://www.novocure.com/role/LONGTERMDEBTNETAmortizationofFinanceExpenseSeniorSecuredCreditFacilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_01a01947-1b7e-793e-8f7c-6e81a754a583" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseLongTermDebt_01a01947-1b7e-7f5f-b7f2-543ca56454b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_01a01947-1b7e-793e-8f7c-6e81a754a583" xlink:to="loc_us-gaap_InterestExpenseLongTermDebt_01a01947-1b7e-7f5f-b7f2-543ca56454b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_01a01947-1b7e-7db3-bc20-3fdc55504f4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_01a01947-1b7e-793e-8f7c-6e81a754a583" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_01a01947-1b7e-7db3-bc20-3fdc55504f4c" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
