v3.26.3
Segments and geographic information - Significant segment expenses (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
Segments and geographic information                
Collaboration revenue $ 34,057     $ 11,734     $ 35,573 $ 24,631
Research and development:                
Total research and development 33,422     58,426     123,483 188,513
General and administrative:                
Total general and administrative 14,112     18,859     45,608 58,475
Total operating expenses 47,534     77,285     169,091 246,988
Net loss (10,478) $ (50,333) $ (60,825) (59,100) $ (78,952) $ (60,754) (121,636) (198,806)
Single reportable segment                
Segments and geographic information                
Collaboration revenue 34,057     11,734     35,573 24,631
Research and development:                
Discovery, platform and other expense 9,506     11,969     26,371 33,113
Employee and contractor related expenses 12,441     18,375     42,586 53,919
Share-based compensation 1,873     3,645     7,446 12,150
Facility expenses 1,344     1,814     4,606 5,345
Research and development incentives and government grants (4,840)     (7,617)     (17,388) (28,455)
Total research and development 33,422     58,426     123,483 188,513
General and administrative:                
Personnel-related costs 4,670     7,305     17,942 21,411
Professional and consulting fees 3,691     4,113     9,820 15,114
Other general and administrative costs 2,200     2,473     6,710 6,993
Share-based compensation 3,545     5,126     11,306 15,661
Effect of foreign exchange rates 6     (158)     (170) (704)
Total general and administrative 14,112     18,859     45,608 58,475
Total operating expenses 47,534     77,285     169,091 246,988
Other segment items 2,999     6,451     11,882 23,551
Net loss $ (10,478)     $ (59,100)     $ (121,636) $ (198,806)
Segment Reporting, Other Segment Item, Composition, Description Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.     Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.     Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes. Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.
Single reportable segment | Zelenectide pevedotin (Nectin-4 BDC)                
Research and development:                
Project specific costs $ 10,186     $ 27,461     $ 50,815 $ 104,204
Single reportable segment | Nuzefatide pevedotin (EphA2 BDC)                
Research and development:                
Project specific costs 2,065     2,295     6,751 6,641
Single reportable segment | BT1702 (MT1-MMP BRC)                
Research and development:                
Project specific costs 791           1,349  
Single reportable segment | Bicycle tumor-targeted immune cell agonists                
Research and development:                
Project specific costs $ 56     $ 484     $ 947 $ 1,596