Business Segment and Geographic Information (Tables)

The following table sets forth our segment information for revenue, measures of segment profit or loss, and significant expenses:



	Three Months Ended September 30,				Nine Months Ended September 30,
(In millions)	2026		2025		2026		2025
Revenue	$	1,344.5	$	1,209.3	$	3,844.8	$	3,402.4
Less:
Cost of sales (1)	480.1		477.9		1,400.1		1,393.2
Payroll related expenses	240.8		233.2		697.0		675.4
Stock-based compensation expense	34.1		44.1		110.5		116.4
Marketing expense	96.4		75.7		272.8		224.9
Travel related expenses	17.3		15.2		56.5		49.1
Supply expenses and clinical trials	14.8		17.7		38.5		45.8
Consulting & professional fees	41.3		33.1		117.3		100.9
Equipment, office & facility expenses	30.8		22.8		85.2		66.8
IT software and data	43.7		36.8		122.0		107.9
Depreciation and amortization	17.2		9.6		41.4		28.1
Other segment items (2)	0.8		0.7		2.7		5.1
Operating income	327.2		242.5		900.8		588.8
Other income, net	7.5		109.8		20.9		158.9
Income tax expense	59.6		68.5		198.0		178.7
Net income	$	275.1	$	283.8	$	723.7	$	569.0

(1) Includes amounts stated in other significant expense captions.
(2) Other segment items are primarily composed of bad debt expense and other miscellaneous operating expenses.



	Three Months Ended September 30,				Nine Months Ended September 30,
(In millions)	2026		2025		2026		2025
Other segment disclosures
Depreciation and amortization (1)	$	74.5	$	63.6	$	209.8	$	186.6
Expenditures for long-lived assets	$	52.9	$	80.5	$	214.2	$	261.6
Significant noncash items other than depreciation and amortization expense:
Deferred income tax expense (benefit)	$	(0.9)	$	118.0	$	(0.9)	$	103.3
Net (gains) losses on equity investments	$	—	$	(82.7)	$	10.0	$	(78.1)

(1) Includes depreciation and amortization recorded in both cost of sales and operating expenses.

The following table presents our revenue disaggregated by major sales channel and geographic region:



	Three Months Ended September 30,
	2026						2025
(In millions)	United States		International		Total		United States		International		Total
Distributor	$	933.1	$	214.9	$	1,148.0	$	818.1	$	207.9	$	1,026.0
Direct	36.7		159.8		196.5		33.8		149.5		183.3
Total revenue	$	969.8	$	374.7	$	1,344.5	$	851.9	$	357.4	$	1,209.3