v3.26.3
Shareholders' Equity - Changes in Shareholders' Deficit (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance     $ 52,072       $ 52,072  
Net loss $ (129,279)     $ (173,443)     (397,122) $ (593,267)
Ending balance $ (98,247)           $ (98,247)  
Common Shares                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance (in shares) 151,017,531 150,506,490 132,775,113 105,782,447 102,104,024 101,221,989 132,775,113 101,221,989
Beginning balance $ 2,138,861 $ 2,132,908 $ 1,934,276 $ 1,743,109 $ 1,689,346 $ 1,656,702 $ 1,934,276 $ 1,656,702
Issuance of common shares, net of offering costs (in shares)     17,164,940          
Issuance of common shares, net of offering costs     $ 178,884          
Issuance of common shares as payment under license and other agreements (in shares)     76,383   3,588,688 354,819    
Issuance of common shares as payment under license and other agreements     $ 858   $ 51,426 $ 13,398    
Issuance of common shares under 2022 Equity Incentive Plan (in shares) 37,629 511,041 490,054 21,208   527,216    
Issuance of common shares under 2022 Equity Incentive Plan $ 365 $ 5,953 $ 18,890 $ 631   $ 19,246    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan (in shares)         89,735      
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan         $ 2,337      
Ending balance (in shares) 151,055,160 151,017,531 150,506,490 105,803,655 105,782,447 102,104,024 151,055,160 105,803,655
Ending balance $ 2,139,226 $ 2,138,861 $ 2,132,908 $ 1,743,740 $ 1,743,109 $ 1,689,346 $ 2,139,226 $ 1,743,740
Additional Paid-in Capital                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance 220,365 203,358 193,984 157,019 137,467 112,369 193,984 112,369
Issuance of common shares as payment under license and other agreements           (8,554)    
Issuance of common shares under 2022 Equity Incentive Plan (154) (2,157) (18,912) (509)   (19,410)    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan         (1,260)      
Non-cash share-based compensation expense 18,624 19,164 28,286 21,535 20,812 53,062    
Ending balance 238,835 220,365 203,358 178,045 157,019 137,467 238,835 178,045
Accumulated Deficit                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance (2,352,379) (2,215,068) (2,084,536) (1,765,538) (1,567,391) (1,345,714) (2,084,536) (1,345,714)
Net loss (129,279) (137,311) (130,532) (173,443) (198,147) (221,677)    
Ending balance (2,481,658) (2,352,379) (2,215,068) (1,938,981) (1,765,538) (1,567,391) (2,481,658) (1,938,981)
Accumulated Other Comprehensive Income (Loss)                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance 5,375 8,302 8,348 (3) 73 79 8,348 79
Other comprehensive loss (25) (2,927) (46) 39 (76) (6) (2,998) (43)
Ending balance 5,350 5,375 8,302 36 (3) 73 5,350 36
Total Shareholders' Equity (Deficit)                
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Beginning balance 12,222 129,500 52,072 134,587 259,495 423,436 52,072 423,436
Net loss (129,279) (137,311) (130,532) (173,443) (198,147) (221,677)    
Issuance of common shares, net of offering costs     178,884          
Issuance of common shares as payment under license and other agreements     858   51,426 4,844    
Issuance of common shares under 2022 Equity Incentive Plan 211 3,796 (22) 122   (164)    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan         1,077      
Non-cash share-based compensation expense 18,624 19,164 28,286 21,535 20,812 53,062    
Other comprehensive loss (25) (2,927) (46) 39 (76) (6)    
Ending balance $ (98,247) $ 12,222 $ 129,500 $ (17,160) $ 134,587 $ 259,495 $ (98,247) $ (17,160)