| Schedule of Segment Profit or Loss and Significant Segment Expenses |
Additional information about segment profit or loss and significant segment expenses is as follows: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Three Months Ended September 30, | | Nine Months Ended September 30, | | | | | | | 2026 | | 2025 | | 2026 | | 2025 | | | | | | | Direct R&D program expense | | | | | | | | | | | | | | | | BHV-4157 (Troriluzole) | | $ | 1,300 | | | $ | 10,769 | | | $ | 15,926 | | | $ | 38,802 | | | | | | | | | BHV-2000 (Taldefgrobep Alfa) | | 6,354 | | | 4,489 | | | 21,417 | | | 18,719 | | | | | | | | | BHV-7000 & BHV-7010 (Kv7) | | 19,295 | | | 29,671 | | | 52,873 | | | 92,415 | | | | | | | | BHV-2100 & BHV-2110 (TRPM3 Antagonist) | | (1,178) | | | 2,720 | | | (1,708) | | | 26,314 | | | | | | | | | BHV-8000 (TYK2/JAK1) | | 4,208 | | | 4,134 | | | 13,520 | | | 29,722 | | | | | | | | | BHV-1300 (IgG Degrader) | | 9,818 | | | 8,628 | | | 20,821 | | | 28,980 | | | | | | | | | BHV-1310 (IgG Degrader) | | (149) | | | 369 | | | (168) | | | 5,055 | | | | | | | | | BHV-1400 (IgA Degrader) | | 10,067 | | | 8,049 | | | 26,913 | | | 19,646 | | | | | | | | | BHV-1600 (β1-AR AAB Degrader) | | 29 | | | 1,977 | | | (70) | | | 6,786 | | | | | | | | BHV-1510 (TROP-2) | | 2,166 | | | 9,327 | | | 8,668 | | | 19,200 | | | | | | | | | BHV-1530 (FGFR3) | | 2,576 | | | 2,437 | | | 5,985 | | | 21,006 | | | | | | | | | Other R&D program expense | | 9 | | | 562 | | | 72 | | | 2,177 | | | | | | | | Preclinical research programs R&D Expense | | 12,239 | | | 16,675 | | | 28,518 | | | 58,608 | | | | | | | | R&D personnel expense (excluding share-based compensation)(1) | | 18,234 | | | 20,473 | | | 58,667 | | | 62,100 | | | | | | | | R&D Share-based compensation expense | | 12,066 | | | 13,947 | | | 42,524 | | | 62,291 | | | | | | | | | | | | | | | | | | | | | | | G&A personnel expense (excluding share-based compensation)(1) | | 5,819 | | | 6,276 | | | 17,039 | | | 18,755 | | | | | | | | G&A Share-based compensation expense | | 6,558 | | | 7,588 | | | 23,550 | | | 33,118 | | | | | | | | Other segment items (2) | | 17,009 | | | 21,291 | | | 47,200 | | | 58,950 | | | | | | | | | Non-operating expense (income) | | 2,923 | | | 3,840 | | | 14,776 | | | (10,468) | | | | | | | | | (Benefit) provision for income taxes | | (64) | | | 221 | | | 599 | | | 1,091 | | | | | | | | Segment net loss | | 129,279 | | | 173,443 | | | 397,122 | | | 593,267 | | | | | | | | | | | | | | | | | | | | | | | | Reconciliation of profit or loss | | | | | | | | | | | | | | | Adjustments and reconciling items | | — | | | — | | | — | | | — | | | | | | | | Consolidated net loss | | $ | 129,279 | | | $ | 173,443 | | | $ | 397,122 | | | $ | 593,267 | | | | | | | |
(1) Personnel expense includes employee payroll, bonus, and employee benefits for medical care, retirement, insurances and other. (2) Other segment items included in Segment net loss include unallocated non-program R&D expense, legal, accounting and other professional service fees, rent and utilities expense, depreciation, and other corporate expenses.
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