Non-Cash Share-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2026

Share-Based Payment Arrangement [Abstract]

Schedule of non-cash share-based compensation expense

Non-cash share-based compensation expense, consisting of expense for share options, restricted share units ("RSUs"), performance share options, and the Employee Share Purchase Plan, was classified in the condensed consolidated statements of operations and comprehensive loss as follows:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2026		2025		2026		2025
Research and development expenses	$	12,066	$	13,947	$	42,524	$	62,291
General and administrative expenses	6,558		7,588		23,550		33,118
Total non-cash share-based compensation expense	$	18,624	$	21,535	$	66,074	$	95,409

Schedule of stock option activity

The following table is a summary of the Company's share option activity for the nine months ended September 30, 2026:


	Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term	Aggregate Intrinsic Value
				(in years)
Outstanding as of December 31, 2025	15,649,514	$	21.06
Granted	5,225,025	$	11.35
Exercised	(343,814)	$	7.12
Forfeited	(265,819)	$	28.25
Outstanding as of September 30, 2026	20,264,906	$	18.70	7.39	$	55,762
Options exercisable as of September 30, 2026	13,968,344	$	17.77	6.74	$	47,589
Vested and expected to vest as of September 30, 2026	20,264,906	$	18.70	7.39	$	55,762

Schedule of RSU activity

The following table is a summary of the RSU activity for the nine months ended September 30, 2026:


	Number of shares	Weighted Average Grant Date Fair Value
Unvested as of December 31, 2025	1,402,696	$	38.48
Granted	15,850	$	11.02
Vested	(482,437)	$	39.01
Forfeited	(47,873)	$	39.02
Unvested as of September 30, 2026	888,236	$	37.68