<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a17dce-cd30-7453-a478-19e39a9ef729,g:ba990bbb-84be-4659-b572-62fe18663cd1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.fhlbdm.com/role/Cover" xlink:type="simple" xlink:href="fhlbdm-20261021.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.fhlbdm.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a17dce-cd30-7c06-8180-a434a7437592" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_DocumentPeriodEndDate_01a17dce-cd30-7c06-8180-a434a7437592" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a17dce-cd30-768e-aa65-0cc4c4d729e3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityRegistrantName_01a17dce-cd30-768e-aa65-0cc4c4d729e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a17dce-cd30-78a2-b05c-4d3129181260" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a17dce-cd30-78a2-b05c-4d3129181260" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a17dce-cd30-724e-b6d1-df71985b11ac" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityFileNumber_01a17dce-cd30-724e-b6d1-df71985b11ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a17dce-cd30-7a1f-93e4-cfde79586c3f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a17dce-cd30-7a1f-93e4-cfde79586c3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a17dce-cd30-7ad9-b4a2-ff4b5c1f9a0a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityAddressPostalZipCode_01a17dce-cd30-7ad9-b4a2-ff4b5c1f9a0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a17dce-cd30-7b98-b975-2a76be51cc8d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_SolicitingMaterial_01a17dce-cd30-7b98-b975-2a76be51cc8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a17dce-cd30-708f-a75b-3850867ff0f7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_PreCommencementTenderOffer_01a17dce-cd30-708f-a75b-3850867ff0f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a17dce-cd30-7ade-b5d7-e9942e9f3051" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a17dce-cd30-7ade-b5d7-e9942e9f3051" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a17dce-cd30-727e-b9f4-e4300b250de2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a17dce-cd30-727e-b9f4-e4300b250de2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a17dce-cd30-74ac-a41c-31fc0a92ab5d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_AmendmentFlag_01a17dce-cd30-74ac-a41c-31fc0a92ab5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a17dce-cd30-756b-a199-cda5ae988072" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityCentralIndexKey_01a17dce-cd30-756b-a199-cda5ae988072" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a17dce-cd30-79e3-8ac6-3b442c55ff60" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityAddressAddressLine1_01a17dce-cd30-79e3-8ac6-3b442c55ff60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a17dce-cd30-7fbd-a2be-51f100682f72" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityAddressStateOrProvince_01a17dce-cd30-7fbd-a2be-51f100682f72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a17dce-cd30-7bda-8bda-8f605950c24f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_DocumentType_01a17dce-cd30-7bda-8bda-8f605950c24f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a17dce-cd30-7710-859f-057eb87c0207" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_CityAreaCode_01a17dce-cd30-7710-859f-057eb87c0207" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a17dce-cd30-70f0-a279-a9be108c7dff" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_LocalPhoneNumber_01a17dce-cd30-70f0-a279-a9be108c7dff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a17dce-cd30-70e4-89a6-ef607ba6c459" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_EntityAddressCityOrTown_01a17dce-cd30-70e4-89a6-ef607ba6c459" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a17dce-cd30-75bb-9967-cf83e1e6d488" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a17dce-cd30-796e-8595-bce75df6f244" xlink:to="loc_dei_WrittenCommunications_01a17dce-cd30-75bb-9967-cf83e1e6d488" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
