<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a14021-38ca-772f-a1a0-319b4f79a04a,g:87a41474-ce12-48e4-8749-1a690d179b16-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.zymeworks.com/role/Cover" xlink:type="simple" xlink:href="zyme-20261022.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.zymeworks.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a14021-38ca-751d-ad0d-d377dfc1b9a7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_DocumentType_01a14021-38ca-751d-ad0d-d377dfc1b9a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a14021-38ca-79d5-8ddb-e196ecbf966e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_DocumentPeriodEndDate_01a14021-38ca-79d5-8ddb-e196ecbf966e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a14021-38ca-7a1a-bd2f-1576188231fd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityRegistrantName_01a14021-38ca-7a1a-bd2f-1576188231fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a14021-38ca-795c-a64f-524b7d79bdf7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a14021-38ca-795c-a64f-524b7d79bdf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a14021-38ca-7d18-9ae7-07bb13d6049f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityFileNumber_01a14021-38ca-7d18-9ae7-07bb13d6049f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a14021-38ca-7c7f-a16c-b5f39df10ce9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a14021-38ca-7c7f-a16c-b5f39df10ce9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a14021-38ca-77d5-a44c-485e358ef868" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityAddressAddressLine1_01a14021-38ca-77d5-a44c-485e358ef868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a14021-38ca-79d7-b682-43e9fca1847b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityAddressCityOrTown_01a14021-38ca-79d7-b682-43e9fca1847b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a14021-38ca-722c-a20f-ff4dd07ab5fc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityAddressStateOrProvince_01a14021-38ca-722c-a20f-ff4dd07ab5fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a14021-38ca-7636-9810-c99bf539a21d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityAddressPostalZipCode_01a14021-38ca-7636-9810-c99bf539a21d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a14021-38ca-7c18-b5c5-7d42c7ebfe9f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_CityAreaCode_01a14021-38ca-7c18-b5c5-7d42c7ebfe9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a14021-38ca-720f-86c9-f578898b0e15" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_LocalPhoneNumber_01a14021-38ca-720f-86c9-f578898b0e15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a14021-38ca-7b96-a012-45d476a4472b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_WrittenCommunications_01a14021-38ca-7b96-a012-45d476a4472b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a14021-38ca-7585-a7f8-95b120930267" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_SolicitingMaterial_01a14021-38ca-7585-a7f8-95b120930267" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a14021-38ca-770b-a75c-cfac431cbd53" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_PreCommencementTenderOffer_01a14021-38ca-770b-a75c-cfac431cbd53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a14021-38ca-794c-9f46-16fa1a830d7b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a14021-38ca-794c-9f46-16fa1a830d7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a14021-38ca-78fe-b947-a976ffe947b5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_Security12bTitle_01a14021-38ca-78fe-b947-a976ffe947b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a14021-38ca-709c-986c-4051f9a483ac" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_TradingSymbol_01a14021-38ca-709c-986c-4051f9a483ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a14021-38ca-7d31-b01a-0a5376d97561" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_SecurityExchangeName_01a14021-38ca-7d31-b01a-0a5376d97561" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a14021-38ca-703b-920d-1c89645cfce2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a14021-38ca-703b-920d-1c89645cfce2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a14021-38ca-7074-9a94-bbcbad1af0b1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_AmendmentFlag_01a14021-38ca-7074-9a94-bbcbad1af0b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a14021-38ca-7982-91bc-5bd9b7275efb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a14021-38ca-7ca3-9db2-a1d72e33750c" xlink:to="loc_dei_EntityCentralIndexKey_01a14021-38ca-7982-91bc-5bd9b7275efb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
