<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a01ab1-2cc6-754c-b36a-15e7834ffd73,g:5dd5e5ee-5e10-4aa8-b3a0-f3905dd60065-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.popular.com/role/Cover" xlink:type="simple" xlink:href="bpop-20261022.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.popular.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_01a01ab1-2cc6-77d0-b25d-89896ec30317" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_DocumentInformationTable_01a01ab1-2cc6-77d0-b25d-89896ec30317" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_01a01ab1-2cc6-77d0-b25d-89896ec30317" xlink:to="loc_us-gaap_StatementClassOfStockAxis_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca" xlink:to="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-75b4-b7ae-5f7ecc6f51dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_01a01ab1-2cc6-7b65-b48a-12ee5ff61bca" xlink:to="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-75b4-b7ae-5f7ecc6f51dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_01a01ab1-2cc6-7204-9d24-6edd70fe07b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-75b4-b7ae-5f7ecc6f51dc" xlink:to="loc_us-gaap_CommonStockMember_01a01ab1-2cc6-7204-9d24-6edd70fe07b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bpop_CumulativePreferredStockSixPointOneTwoFivePercentMember_01a01ab1-2cc6-79f5-918b-9097b0aa8901" xlink:href="bpop-20261022.xsd#bpop_CumulativePreferredStockSixPointOneTwoFivePercentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a01ab1-2cc6-75b4-b7ae-5f7ecc6f51dc" xlink:to="loc_bpop_CumulativePreferredStockSixPointOneTwoFivePercentMember_01a01ab1-2cc6-79f5-918b-9097b0aa8901" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a01ab1-2cc6-7070-a749-d16224997613" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_DocumentType_01a01ab1-2cc6-7070-a749-d16224997613" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a01ab1-2cc6-7af5-bfff-e69255be693f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_DocumentPeriodEndDate_01a01ab1-2cc6-7af5-bfff-e69255be693f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a01ab1-2cc6-7e80-9008-b8f3a5774cb6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityRegistrantName_01a01ab1-2cc6-7e80-9008-b8f3a5774cb6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a01ab1-2cc6-7da6-8844-64c06bdf3927" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a01ab1-2cc6-7da6-8844-64c06bdf3927" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a01ab1-2cc6-707f-9096-e924df69d20f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityFileNumber_01a01ab1-2cc6-707f-9096-e924df69d20f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a01ab1-2cc6-7818-a443-46670fab8396" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a01ab1-2cc6-7818-a443-46670fab8396" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a01ab1-2cc6-7678-b6b2-1de3a8cd15df" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityAddressAddressLine1_01a01ab1-2cc6-7678-b6b2-1de3a8cd15df" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a01ab1-2cc6-750a-bb83-679e7add65a6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityAddressCityOrTown_01a01ab1-2cc6-750a-bb83-679e7add65a6" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_01a01ab1-2cc6-735a-a6f4-11a6d8c9e2b1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCountry"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityAddressCountry_01a01ab1-2cc6-735a-a6f4-11a6d8c9e2b1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a01ab1-2cc6-774a-8b12-83233c9d15a0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityAddressPostalZipCode_01a01ab1-2cc6-774a-8b12-83233c9d15a0" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a01ab1-2cc6-7657-bc34-c09af09c20e8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_CityAreaCode_01a01ab1-2cc6-7657-bc34-c09af09c20e8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a01ab1-2cc6-76fc-a29a-7dc7ebfa5893" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_LocalPhoneNumber_01a01ab1-2cc6-76fc-a29a-7dc7ebfa5893" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a01ab1-2cc6-773a-8cb7-3b1ea8c2b114" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_WrittenCommunications_01a01ab1-2cc6-773a-8cb7-3b1ea8c2b114" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a01ab1-2cc6-7023-874f-879f77e6e9fa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_SolicitingMaterial_01a01ab1-2cc6-7023-874f-879f77e6e9fa" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a01ab1-2cc6-794d-8ce6-57804de5620f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_PreCommencementTenderOffer_01a01ab1-2cc6-794d-8ce6-57804de5620f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a01ab1-2cc6-7cd3-89f5-e7d9cf136f0a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a01ab1-2cc6-7cd3-89f5-e7d9cf136f0a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a01ab1-2cc6-7c3d-8175-90d1129bd1dd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_Security12bTitle_01a01ab1-2cc6-7c3d-8175-90d1129bd1dd" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a01ab1-2cc6-742f-9c2b-eb6c77ce9caa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_TradingSymbol_01a01ab1-2cc6-742f-9c2b-eb6c77ce9caa" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a01ab1-2cc6-7be0-a704-e4f463af92fa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_SecurityExchangeName_01a01ab1-2cc6-7be0-a704-e4f463af92fa" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a01ab1-2cc6-7578-b8cb-a30540da5cbc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a01ab1-2cc6-7578-b8cb-a30540da5cbc" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a01ab1-2cc6-721f-bb65-2ddef0797c2c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_EntityCentralIndexKey_01a01ab1-2cc6-721f-bb65-2ddef0797c2c" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a01ab1-2cc6-778d-933a-974f8dfdeb2d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_01a01ab1-2cc6-745d-a941-e6283f7a95d0" xlink:to="loc_dei_AmendmentFlag_01a01ab1-2cc6-778d-933a-974f8dfdeb2d" xlink:type="arc" order="21"/>
  </link:definitionLink>
</link:linkbase>
