<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fc7b4-92f2-775e-beea-bf3c19cde8cd,g:d81a4c81-273a-4730-a7a9-d33587d7015c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.enterprisebank.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="efsc-20261021.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://www.enterprisebank.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019fc7b4-92f2-7b5e-b680-8cb1fea6e605" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019fc7b4-92f2-7b65-91fe-46492750009f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_019fc7b4-92f2-7b5e-b680-8cb1fea6e605" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019fc7b4-92f2-7b65-91fe-46492750009f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019fc7b4-92f2-7cdf-9dd1-a9648d960aef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019fc7b4-92f2-7b65-91fe-46492750009f" xlink:to="loc_us-gaap_ClassOfStockDomain_019fc7b4-92f2-7cdf-9dd1-a9648d960aef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019fc7b4-92f2-7c96-bfe5-d98ce75de81d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019fc7b4-92f2-7cdf-9dd1-a9648d960aef" xlink:to="loc_us-gaap_CommonStockMember_019fc7b4-92f2-7c96-bfe5-d98ce75de81d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_DepositarySharesMember_019fc7b4-92f2-79ae-9e29-fd1b448eaa88" xlink:href="efsc-20261021.xsd#efsc_DepositarySharesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_019fc7b4-92f2-7cdf-9dd1-a9648d960aef" xlink:to="loc_efsc_DepositarySharesMember_019fc7b4-92f2-79ae-9e29-fd1b448eaa88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_019fc7b4-92f2-7b5e-b680-8cb1fea6e605" xlink:to="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019fc7b4-92f2-7646-841a-9c9da1b33c98" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_DocumentType_019fc7b4-92f2-7646-841a-9c9da1b33c98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fc7b4-92f2-73a1-bef8-85f51888ac98" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_DocumentPeriodEndDate_019fc7b4-92f2-73a1-bef8-85f51888ac98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019fc7b4-92f2-7a1a-a59a-e06f1a86cd00" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityRegistrantName_019fc7b4-92f2-7a1a-a59a-e06f1a86cd00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019fc7b4-92f2-7493-942e-4f441f4f35d6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019fc7b4-92f2-7493-942e-4f441f4f35d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019fc7b4-92f2-704c-8660-70c0e97d9041" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityFileNumber_019fc7b4-92f2-704c-8660-70c0e97d9041" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019fc7b4-92f2-7cc5-9859-ec510a4a52d1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityTaxIdentificationNumber_019fc7b4-92f2-7cc5-9859-ec510a4a52d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019fc7b4-92f2-75d4-9c86-1f49f5a2c1cd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityAddressAddressLine1_019fc7b4-92f2-75d4-9c86-1f49f5a2c1cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019fc7b4-92f2-7d19-8f34-cd8a4af8e184" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityAddressCityOrTown_019fc7b4-92f2-7d19-8f34-cd8a4af8e184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019fc7b4-92f2-78ff-992a-8a0c34cdc5e1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityAddressStateOrProvince_019fc7b4-92f2-78ff-992a-8a0c34cdc5e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019fc7b4-92f2-7bdf-8b4e-1960e777ed87" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityAddressPostalZipCode_019fc7b4-92f2-7bdf-8b4e-1960e777ed87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019fc7b4-92f2-7f28-8b0f-dc3749888fad" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_CityAreaCode_019fc7b4-92f2-7f28-8b0f-dc3749888fad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019fc7b4-92f2-7d65-8b44-197d3aa317b2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_LocalPhoneNumber_019fc7b4-92f2-7d65-8b44-197d3aa317b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019fc7b4-92f2-79de-8c8c-05b3fc824654" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_WrittenCommunications_019fc7b4-92f2-79de-8c8c-05b3fc824654" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019fc7b4-92f2-78c3-9219-f66c7679e41f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_SolicitingMaterial_019fc7b4-92f2-78c3-9219-f66c7679e41f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019fc7b4-92f2-7e5a-a2f9-a4fa4d1cdca5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_PreCommencementTenderOffer_019fc7b4-92f2-7e5a-a2f9-a4fa4d1cdca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019fc7b4-92f2-7274-b949-dca65a3ccd05" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019fc7b4-92f2-7274-b949-dca65a3ccd05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019fc7b4-92f2-7513-9081-a015711a2ae3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_Security12bTitle_019fc7b4-92f2-7513-9081-a015711a2ae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019fc7b4-92f2-796b-8579-51e8457200c1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_TradingSymbol_019fc7b4-92f2-796b-8579-51e8457200c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019fc7b4-92f2-7572-bdf1-35ad04c349e1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_SecurityExchangeName_019fc7b4-92f2-7572-bdf1-35ad04c349e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019fc7b4-92f2-72f4-825d-542c28b9d5b5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityEmergingGrowthCompany_019fc7b4-92f2-72f4-825d-542c28b9d5b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019fc7b4-92f2-7f2a-a089-305b1a48453c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_EntityCentralIndexKey_019fc7b4-92f2-7f2a-a089-305b1a48453c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019fc7b4-92f2-74ae-987f-671ef785c526" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_019fc7b4-92f2-7d3e-88a9-98163b5d611b" xlink:to="loc_dei_AmendmentFlag_019fc7b4-92f2-74ae-987f-671ef785c526" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
