<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a135f6-34cf-732a-85dc-2a7b2992baa6,g:fe5e1f79-4d5f-4040-9746-6cb9ce37f748-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.fhlbdm.com/role/Cover" xlink:type="simple" xlink:href="fhlbdm-20261016.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.fhlbdm.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a135f6-34cf-7829-a272-3e71f9ad60ba" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_DocumentPeriodEndDate_01a135f6-34cf-7829-a272-3e71f9ad60ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a135f6-34cf-705d-8b62-455e1a4e712c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityRegistrantName_01a135f6-34cf-705d-8b62-455e1a4e712c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a135f6-34cf-7548-887e-9cd0820437fe" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a135f6-34cf-7548-887e-9cd0820437fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a135f6-34cf-733f-9a8b-3775c1a96f05" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityFileNumber_01a135f6-34cf-733f-9a8b-3775c1a96f05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a135f6-34cf-7dbd-9202-b163503eefa8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a135f6-34cf-7dbd-9202-b163503eefa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a135f6-34cf-7bdd-be0b-4c3f31480eea" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityAddressPostalZipCode_01a135f6-34cf-7bdd-be0b-4c3f31480eea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a135f6-34cf-7826-b514-f1831de4eeec" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_SolicitingMaterial_01a135f6-34cf-7826-b514-f1831de4eeec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a135f6-34cf-75a0-8264-f6653755497f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_PreCommencementTenderOffer_01a135f6-34cf-75a0-8264-f6653755497f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a135f6-34cf-7663-88de-46b0d5501bbb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a135f6-34cf-7663-88de-46b0d5501bbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a135f6-34cf-73fe-b64d-479a264d8ffb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a135f6-34cf-73fe-b64d-479a264d8ffb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a135f6-34cf-7c64-82e0-0b0e262e21fe" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_AmendmentFlag_01a135f6-34cf-7c64-82e0-0b0e262e21fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a135f6-34cf-73ee-a228-a2493a510cb7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityCentralIndexKey_01a135f6-34cf-73ee-a228-a2493a510cb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a135f6-34cf-748a-bcca-41dde7b9ba34" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityAddressAddressLine1_01a135f6-34cf-748a-bcca-41dde7b9ba34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a135f6-34cf-7a95-ade2-edbd2dd05d84" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityAddressStateOrProvince_01a135f6-34cf-7a95-ade2-edbd2dd05d84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a135f6-34cf-727e-a78a-db63056fec87" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_DocumentType_01a135f6-34cf-727e-a78a-db63056fec87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a135f6-34cf-7444-9bbb-7d92801dbeb6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_CityAreaCode_01a135f6-34cf-7444-9bbb-7d92801dbeb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a135f6-34cf-7e20-904b-9d0590cd5486" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_LocalPhoneNumber_01a135f6-34cf-7e20-904b-9d0590cd5486" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a135f6-34cf-76a8-b957-a41a91f48cdb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_EntityAddressCityOrTown_01a135f6-34cf-76a8-b957-a41a91f48cdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a135f6-34cf-7881-b3d0-d2fdcda4e6d8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a135f6-34cf-77e5-8e29-862a47cd9120" xlink:to="loc_dei_WrittenCommunications_01a135f6-34cf-7881-b3d0-d2fdcda4e6d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
