v3.26.3
Schedule of reconciliation of income tax expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Tax Disclosure [Abstract]    
Tax computed at the federal statutory rate $ (12,518) $ (14,653)
Tax computed at the federal statutory rate, Percentage 21.00%  
State income taxes, net of federal tax benefit $ 0 [1] (49)
State and local income taxes, net of federal income tax effect, Percentage [1] 0.00%  
Research and development credit, Amount $ (1,279)  
Research and development credit, Percentage 2.10%  
Orphan drug credit, Amount $ (533)  
Orphan drug credit, Percentage 0.90%  
Valuation allowance $ 12,829 17,013
Change in valuation allowance, Percentage (21.50%)  
Permanent items, Amount $ 117  
Permanent items, Percentage (0.20%)  
Nondeductible executive compensation $ 403 369
Equity compensation, Percentage (0.70%)  
Nondeductible officers compensation, Amount $ 981  
Nondeductible officers compensation, Percentage (1.60%)  
Changes in unrecognized tax benefits, Amount $ 0  
Changes in unrecognized tax benefits, Percentage 0.00%  
Other, net $ 0 (132)
Other, net, Percentage 0.00%  
Income tax expense $ 0
Provision for income taxes, Percentage 0.00%  
Stock-based compensation   294
Research and development and orphan drug credits   (3,789)
Uncertain tax positions   $ 947
[1] The state that contributes to the majority (greater than 50%) of the tax effect in this category was California for year ending December 31, 2025.