<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a13ba0-7572-7f07-9c5e-6b4ce0d60422,g:495d07f0-eba3-4827-890e-e6c9105996e7-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://quantum-si.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="qsi-20261014.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://quantum-si.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a13ba0-7572-7621-9745-8d55b09194a7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_DocumentType_01a13ba0-7572-7621-9745-8d55b09194a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a13ba0-7572-7560-99b9-eecacbeacfa3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_DocumentPeriodEndDate_01a13ba0-7572-7560-99b9-eecacbeacfa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a13ba0-7572-78d2-bab0-48447f2de964" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityRegistrantName_01a13ba0-7572-78d2-bab0-48447f2de964" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a13ba0-7572-729d-8e4b-3cade0eb0d6d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a13ba0-7572-729d-8e4b-3cade0eb0d6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a13ba0-7572-77d7-9f62-3edc75f386ee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityFileNumber_01a13ba0-7572-77d7-9f62-3edc75f386ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a13ba0-7572-76fc-a121-888900175f40" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a13ba0-7572-76fc-a121-888900175f40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a13ba0-7572-70b6-8eea-e0e68c5cb6da" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityAddressAddressLine1_01a13ba0-7572-70b6-8eea-e0e68c5cb6da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a13ba0-7572-7265-9fd3-cf417c42abf5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityAddressCityOrTown_01a13ba0-7572-7265-9fd3-cf417c42abf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a13ba0-7572-7fd2-abcc-f59c772252de" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityAddressStateOrProvince_01a13ba0-7572-7fd2-abcc-f59c772252de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a13ba0-7572-7175-907a-0aeaed196bb8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityAddressPostalZipCode_01a13ba0-7572-7175-907a-0aeaed196bb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a13ba0-7572-73df-8d0e-cd2dbc5fbb21" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_CityAreaCode_01a13ba0-7572-73df-8d0e-cd2dbc5fbb21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a13ba0-7572-71de-9e9f-4ea73055f5f5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_LocalPhoneNumber_01a13ba0-7572-71de-9e9f-4ea73055f5f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a13ba0-7572-7672-bcfa-4da1c7ee933b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_WrittenCommunications_01a13ba0-7572-7672-bcfa-4da1c7ee933b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a13ba0-7572-79c1-a4e9-5c9e3d280ae4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_SolicitingMaterial_01a13ba0-7572-79c1-a4e9-5c9e3d280ae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a13ba0-7572-702a-a472-75faa4e7ed77" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_PreCommencementTenderOffer_01a13ba0-7572-702a-a472-75faa4e7ed77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a13ba0-7572-703c-ba49-b051b8dc8285" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a13ba0-7572-703c-ba49-b051b8dc8285" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a13ba0-7572-74dc-93bd-c2a82057cb62" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_Security12bTitle_01a13ba0-7572-74dc-93bd-c2a82057cb62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a13ba0-7572-765f-8b1c-b2c39e4cc469" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_TradingSymbol_01a13ba0-7572-765f-8b1c-b2c39e4cc469" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a13ba0-7572-7372-a6ab-f7113c50fdea" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_SecurityExchangeName_01a13ba0-7572-7372-a6ab-f7113c50fdea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a13ba0-7572-7256-8286-7ae2a59e0f45" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a13ba0-7572-7256-8286-7ae2a59e0f45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a13ba0-7572-7343-9f26-21a85a995f92" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_EntityCentralIndexKey_01a13ba0-7572-7343-9f26-21a85a995f92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a13ba0-7572-7ece-b027-4133e8ad8d07" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a13ba0-7572-7eeb-b787-1289b0397dfd" xlink:to="loc_dei_AmendmentFlag_01a13ba0-7572-7ece-b027-4133e8ad8d07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
