<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f67af-44a6-750c-80a6-dec41f061743,g:3b2c0ea9-7dac-49c8-b91f-73c7d3480062-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CONDENSEDBALANCESHEETS" xlink:type="simple" xlink:href="nrix-20260831.xsd#CONDENSEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CONDENSEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019f67af-4564-749a-8898-d25a1b9a13fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:to="loc_us-gaap_AccountsPayableCurrent_019f67af-4564-749a-8898-d25a1b9a13fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_019f67af-4564-79d7-84b9-2fd6d0427a8f" xlink:href="nrix-20260831.xsd#nrix_AccruedExpensesAndOtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:to="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_019f67af-4564-79d7-84b9-2fd6d0427a8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019f67af-4564-7a48-a37d-b5ffca2d13ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019f67af-4564-7a48-a37d-b5ffca2d13ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019f67af-4564-7523-8c6d-9b9ac631e5fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019f67af-4564-7523-8c6d-9b9ac631e5fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_CollaborativeArrangementDeferredCollaborationFundingCurrent_01a10994-6ae4-7b7c-88e7-4bb0caf629d4" xlink:href="nrix-20260831.xsd#nrix_CollaborativeArrangementDeferredCollaborationFundingCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019f67af-4564-762c-9479-06a66b90ead8" xlink:to="loc_nrix_CollaborativeArrangementDeferredCollaborationFundingCurrent_01a10994-6ae4-7b7c-88e7-4bb0caf629d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f67af-4565-7f6f-977d-dec38d51ea50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f67af-4565-73a0-87d1-3447d7ee06f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f67af-4565-7f6f-977d-dec38d51ea50" xlink:to="loc_us-gaap_Liabilities_019f67af-4565-73a0-87d1-3447d7ee06f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019f67af-4565-70a6-ac63-fa4f22610ea7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f67af-4565-7f6f-977d-dec38d51ea50" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019f67af-4565-70a6-ac63-fa4f22610ea7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f67af-4565-7fa4-a311-c388a2936876" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019f67af-4565-7f6f-977d-dec38d51ea50" xlink:to="loc_us-gaap_StockholdersEquity_019f67af-4565-7fa4-a311-c388a2936876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f67af-4564-7a3c-97a2-2d638296dd4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f67af-4564-7ac1-aa58-124663cba064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f67af-4564-7a3c-97a2-2d638296dd4e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f67af-4564-7ac1-aa58-124663cba064" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019f67af-4565-7e08-ab56-d6c0b46177a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f67af-4564-7a3c-97a2-2d638296dd4e" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019f67af-4565-7e08-ab56-d6c0b46177a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019f67af-4565-712b-bb12-5fa3b8a0fd16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f67af-4564-7a3c-97a2-2d638296dd4e" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019f67af-4565-712b-bb12-5fa3b8a0fd16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a09d80-5fda-74dd-a611-28274ad7b4d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019f67af-4564-7a3c-97a2-2d638296dd4e" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_01a09d80-5fda-74dd-a611-28274ad7b4d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019f67af-4565-7e0e-8a42-950be4b41396" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_AssetsCurrent_019f67af-4565-7e0e-8a42-950be4b41396" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_019f67af-4565-7a7a-82ec-0fc8a164f899" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_019f67af-4565-7a7a-82ec-0fc8a164f899" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f67af-4565-7637-9fae-bb94f3a933e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019f67af-4565-7637-9fae-bb94f3a933e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019f67af-4565-75ce-8962-8dc16f9c13e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019f67af-4565-75ce-8962-8dc16f9c13e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019f67af-4565-7e14-84e7-f714bd201207" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019f67af-4565-7e14-84e7-f714bd201207" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_01a09d80-e93b-73ee-b056-4818f0c1f45f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019f67af-4565-7062-b6d5-dad20b438726" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_01a09d80-e93b-73ee-b056-4818f0c1f45f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019f67af-4565-7b99-a4e4-4900a5024ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019f67af-4565-7116-a62e-f533abb07cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f67af-4565-7b99-a4e4-4900a5024ea1" xlink:to="loc_us-gaap_LiabilitiesCurrent_019f67af-4565-7116-a62e-f533abb07cf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019f67af-4565-7a2d-a055-427aa9ccfa50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f67af-4565-7b99-a4e4-4900a5024ea1" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019f67af-4565-7a2d-a055-427aa9ccfa50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019f67af-4565-713e-9cd7-76f27489a8b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f67af-4565-7b99-a4e4-4900a5024ea1" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019f67af-4565-713e-9cd7-76f27489a8b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_CollaborativeArrangementDeferredCollaborationFundingNoncurrent_01a10995-9c68-7993-baea-acffce3b2b11" xlink:href="nrix-20260831.xsd#nrix_CollaborativeArrangementDeferredCollaborationFundingNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019f67af-4565-7b99-a4e4-4900a5024ea1" xlink:to="loc_nrix_CollaborativeArrangementDeferredCollaborationFundingNoncurrent_01a10995-9c68-7993-baea-acffce3b2b11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019f67af-4564-71c4-af88-1beff876e18e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:to="loc_us-gaap_PreferredStockValue_019f67af-4564-71c4-af88-1beff876e18e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019f67af-4564-726f-b13c-e1c8557b6dc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:to="loc_us-gaap_CommonStockValue_019f67af-4564-726f-b13c-e1c8557b6dc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019f67af-4564-73b2-be83-223f66f009c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019f67af-4564-73b2-be83-223f66f009c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f67af-4564-730b-b51c-850686e6007f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019f67af-4564-730b-b51c-850686e6007f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f67af-4564-7ae7-8fa5-2f765cbacc7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019f67af-4564-7d38-8dd2-ac1024c90eab" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019f67af-4564-7ae7-8fa5-2f765cbacc7d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="nrix-20260831.xsd#CONDENSEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019f67af-4565-72d6-94f4-50a1076cbe25" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019f67af-4565-7613-8a17-8fe56ad8a51f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019f67af-4565-72d6-94f4-50a1076cbe25" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019f67af-4565-7613-8a17-8fe56ad8a51f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019f67af-4565-7e2d-828f-199b9e9a670e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019f67af-4565-72d6-94f4-50a1076cbe25" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019f67af-4565-7e2d-828f-199b9e9a670e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019f67af-4565-7496-9795-4fda74a47cac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019f67af-4565-710d-8551-418a77313de7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f67af-4565-7496-9795-4fda74a47cac" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019f67af-4565-710d-8551-418a77313de7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019f67af-4565-7758-83e4-6d7d16b455de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019f67af-4565-7496-9795-4fda74a47cac" xlink:to="loc_us-gaap_OperatingExpenses_019f67af-4565-7758-83e4-6d7d16b455de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f67af-4565-7c8b-a69c-7fc275282291" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019f67af-4565-7ba3-84af-a2d606c0d140" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f67af-4565-7c8b-a69c-7fc275282291" xlink:to="loc_us-gaap_OperatingIncomeLoss_019f67af-4565-7ba3-84af-a2d606c0d140" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndOtherIncome_019f67af-4565-7d37-8151-00684cdb568b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestAndOtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f67af-4565-7c8b-a69c-7fc275282291" xlink:to="loc_us-gaap_InterestAndOtherIncome_019f67af-4565-7d37-8151-00684cdb568b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f67af-4565-79a9-b381-fd00f152a724" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f67af-4565-7d42-8619-248ecbfcc293" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f67af-4565-79a9-b381-fd00f152a724" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f67af-4565-7d42-8619-248ecbfcc293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019f67af-4565-706b-a25d-46955acd1281" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019f67af-4565-79a9-b381-fd00f152a724" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019f67af-4565-706b-a25d-46955acd1281" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="nrix-20260831.xsd#CONDENSEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f67af-4565-7c8b-a282-371db2f4462d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f67af-4565-750d-9e27-9deaab6aa66f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f67af-4565-7c8b-a282-371db2f4462d" xlink:to="loc_us-gaap_NetIncomeLoss_019f67af-4565-750d-9e27-9deaab6aa66f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019f67af-4565-7bf8-9fdb-ef2661867ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019f67af-4565-7c8b-a282-371db2f4462d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019f67af-4565-7bf8-9fdb-ef2661867ba9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="nrix-20260831.xsd#CONDENSEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CONDENSEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7d83-901a-4c89cfdcdc09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019f67af-4565-7e2c-bd21-323fc5f86987" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7d83-901a-4c89cfdcdc09" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019f67af-4565-7e2c-bd21-323fc5f86987" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019f67af-4565-7b83-92e3-82bce862dad5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7d83-901a-4c89cfdcdc09" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019f67af-4565-7b83-92e3-82bce862dad5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a0b399-c2e3-737d-9140-75b70599e283" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7d83-901a-4c89cfdcdc09" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_01a0b399-c2e3-737d-9140-75b70599e283" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f67af-4565-75e7-9b15-8ac2dbacbe8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019f67af-4565-78af-ad1d-38ebd3b42599" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f67af-4565-75e7-9b15-8ac2dbacbe8b" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019f67af-4565-78af-ad1d-38ebd3b42599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f67af-4565-7bfd-809d-16462018e461" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019f67af-4565-75e7-9b15-8ac2dbacbe8b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019f67af-4565-7bfd-809d-16462018e461" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f67af-4565-7d63-a860-8cfe622135b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_NetIncomeLoss_019f67af-4565-7d63-a860-8cfe622135b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_019f67af-4565-7db5-b62c-64da5242a94c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_DepreciationAndAmortization_019f67af-4565-7db5-b62c-64da5242a94c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019f67af-4565-7d63-9a2e-1ad334d5f9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_ShareBasedCompensation_019f67af-4565-7d63-9a2e-1ad334d5f9fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019f67af-4565-7ffa-993e-fbbdab2a8a8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019f67af-4565-7ffa-993e-fbbdab2a8a8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets_019f67af-4565-7d74-a398-43c1ca203d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets_019f67af-4565-7d74-a398-43c1ca203d2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f67af-4565-73ea-9a17-8404179528b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f67af-4565-73ea-9a17-8404179528b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f67af-4565-7061-8ae6-b6e8c43a7747" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019f67af-4565-7061-8ae6-b6e8c43a7747" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019f67af-4565-72c5-a21f-795737b0a003" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019f67af-4565-72c5-a21f-795737b0a003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f67af-4565-705b-9b12-cfb7eac83caa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f67af-4565-705b-9b12-cfb7eac83caa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_01a0b398-79cd-71d6-a649-5b1edc017e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_01a0b398-79cd-71d6-a649-5b1edc017e5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_01a0b398-79cd-7f4e-a998-29916a394bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_01a0b398-79cd-7f4e-a998-29916a394bc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_IncreaseDecreaseInDeferredCollaborationFunding_01a0b398-79cd-7a69-82a5-fb589480a48d" xlink:href="nrix-20260831.xsd#nrix_IncreaseDecreaseInDeferredCollaborationFunding"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_nrix_IncreaseDecreaseInDeferredCollaborationFunding_01a0b398-79cd-7a69-82a5-fb589480a48d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_01a10998-ea6e-7392-860f-a4dfe25c2cb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-77f3-a15f-28f3aa785408" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_01a10998-ea6e-7392-860f-a4dfe25c2cb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f67af-4565-7ec2-8451-92636781e6aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-7cdb-b799-6e68bbebe9e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f67af-4565-7ec2-8451-92636781e6aa" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f67af-4565-7cdb-b799-6e68bbebe9e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-726c-be72-27c900c34c97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f67af-4565-7ec2-8451-92636781e6aa" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-726c-be72-27c900c34c97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7dab-bd4a-58f78ff995b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019f67af-4565-7ec2-8451-92636781e6aa" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019f67af-4565-7dab-bd4a-58f78ff995b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-77a4-bed7-93c0f8c7544a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019f67af-4565-7390-89ae-b4f67e930972" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-77a4-bed7-93c0f8c7544a" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019f67af-4565-7390-89ae-b4f67e930972" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019f67af-4565-727e-9e69-7b55add229d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-77a4-bed7-93c0f8c7544a" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019f67af-4565-727e-9e69-7b55add229d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f67af-4565-706a-97ce-aefa48d8c6d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019f67af-4565-77a4-bed7-93c0f8c7544a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f67af-4565-706a-97ce-aefa48d8c6d4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedBalanceSheetComponentsScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="nrix-20260831.xsd#CondensedBalanceSheetComponentsScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedBalanceSheetComponentsScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019f67af-4609-7060-b7dc-c0397b0483e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019f67af-4609-76ed-88f5-53da0ab6bbf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019f67af-4609-7060-b7dc-c0397b0483e7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019f67af-4609-76ed-88f5-53da0ab6bbf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019f67af-4609-72e4-90d0-c93ffbe74c8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019f67af-4609-7060-b7dc-c0397b0483e7" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019f67af-4609-72e4-90d0-c93ffbe74c8f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="nrix-20260831.xsd#CondensedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:href="nrix-20260831.xsd#nrix_AccruedAndOtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019f67af-4609-7b95-9d8c-96b21196a2ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019f67af-4609-7b95-9d8c-96b21196a2ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019f67af-4609-71fa-adf5-d4aa72c66c7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019f67af-4609-71fa-adf5-d4aa72c66c7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedClinicalCurrent_019f67af-4609-78c0-8286-80bfe1883736" xlink:href="nrix-20260831.xsd#nrix_AccruedClinicalCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_nrix_AccruedClinicalCurrent_019f67af-4609-78c0-8286-80bfe1883736" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019f67af-4609-7008-bf4b-1beded46a7a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_us-gaap_TaxesPayableCurrent_019f67af-4609-7008-bf4b-1beded46a7a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019f67af-4609-7cc9-b59d-d7284785261e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019f67af-4609-7cc9-b59d-d7284785261e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedContractResearchAndLabSupplies_019f67af-4609-7946-88af-09f041f6dddf" xlink:href="nrix-20260831.xsd#nrix_AccruedContractResearchAndLabSupplies"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nrix_AccruedAndOtherLiabilitiesCurrent_019f67af-4609-7fe1-a119-f61ee6c9869d" xlink:to="loc_nrix_AccruedContractResearchAndLabSupplies_019f67af-4609-7946-88af-09f041f6dddf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/FairValueMeasurementsScheduleofInvestmentsFairValueMeasurementonRecurringBasisDetails" xlink:type="simple" xlink:href="nrix-20260831.xsd#FairValueMeasurementsScheduleofInvestmentsFairValueMeasurementonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/FairValueMeasurementsScheduleofInvestmentsFairValueMeasurementonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossNoncurrent_01a09db4-cac0-7132-9574-72b56d9a0863" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent_01a09db4-cac0-7cce-b676-11b49887f45b" xlink:href="nrix-20260831.xsd#nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossNoncurrent_01a09db4-cac0-7132-9574-72b56d9a0863" xlink:to="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent_01a09db4-cac0-7cce-b676-11b49887f45b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent_01a09db4-cac0-72e9-9909-018b1a2f397a" xlink:href="nrix-20260831.xsd#nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossNoncurrent_01a09db4-cac0-7132-9574-72b56d9a0863" xlink:to="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent_01a09db4-cac0-72e9-9909-018b1a2f397a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_01a09db4-cac0-7ade-9f3e-44709ec469ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossNoncurrent_01a09db4-cac0-7132-9574-72b56d9a0863" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_01a09db4-cac0-7ade-9f3e-44709ec469ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019f67af-4609-7a8e-86aa-aa463e6322c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019f67af-4609-7d82-8b2d-35fd50220b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019f67af-4609-7a8e-86aa-aa463e6322c8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019f67af-4609-7d82-8b2d-35fd50220b0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019f67af-4609-75ff-a2fe-a6341bb6c7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019f67af-4609-7a8e-86aa-aa463e6322c8" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019f67af-4609-75ff-a2fe-a6341bb6c7b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019f67af-4609-71b0-b209-7f8b292ddb5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019f67af-4609-7a8e-86aa-aa463e6322c8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019f67af-4609-71b0-b209-7f8b292ddb5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_019f67af-4609-7f6a-899b-a90cc929634c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent_019f67af-4609-73e1-87e9-903d15f0fddc" xlink:href="nrix-20260831.xsd#nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_019f67af-4609-7f6a-899b-a90cc929634c" xlink:to="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent_019f67af-4609-73e1-87e9-903d15f0fddc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent_019f67af-4609-7503-8280-2ce838968066" xlink:href="nrix-20260831.xsd#nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_019f67af-4609-7f6a-899b-a90cc929634c" xlink:to="loc_nrix_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent_019f67af-4609-7503-8280-2ce838968066" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019f67af-4609-7354-81c8-15f8c80bc9ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_019f67af-4609-7f6a-899b-a90cc929634c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019f67af-4609-7354-81c8-15f8c80bc9ea" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/FairValueMeasurementsScheduleofDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails" xlink:type="simple" xlink:href="nrix-20260831.xsd#FairValueMeasurementsScheduleofDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/FairValueMeasurementsScheduleofDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019f67af-4609-779b-b01a-ca8c2a25723b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019f67af-4609-7852-8659-5993eaaee016" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019f67af-4609-779b-b01a-ca8c2a25723b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019f67af-4609-7852-8659-5993eaaee016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019f67af-4609-7019-aae2-ac07eec7cf80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019f67af-4609-779b-b01a-ca8c2a25723b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019f67af-4609-7019-aae2-ac07eec7cf80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019f67af-4609-7e47-9e98-2bcc6bf11b6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019f67af-4609-7b85-925c-e18908d0d3b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019f67af-4609-7e47-9e98-2bcc6bf11b6f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019f67af-4609-7b85-925c-e18908d0d3b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019f67af-4609-7bc7-9482-efc1c6f2ad75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019f67af-4609-7e47-9e98-2bcc6bf11b6f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019f67af-4609-7bc7-9482-efc1c6f2ad75" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
