<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a0e958-19e7-70cb-bc95-023949e90a3c,g:26c0d259-cc31-4662-afde-6c7f6681883d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="zts-20261008.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a0e958-19e7-7b46-b460-2175664dbd3c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_DocumentType_01a0e958-19e7-7b46-b460-2175664dbd3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a0e958-19e7-7a95-854f-d870e69eb193" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_DocumentPeriodEndDate_01a0e958-19e7-7a95-854f-d870e69eb193" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a0e958-19e7-7163-9b1b-7a5316e3613b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityRegistrantName_01a0e958-19e7-7163-9b1b-7a5316e3613b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a0e958-19e7-7491-9ac8-4f25fb1024f2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityCentralIndexKey_01a0e958-19e7-7491-9ac8-4f25fb1024f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a0e958-19e7-7dbf-aa91-ea37c5d143c6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_AmendmentFlag_01a0e958-19e7-7dbf-aa91-ea37c5d143c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a0e958-19e7-7df9-9b45-bbd641574978" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a0e958-19e7-7df9-9b45-bbd641574978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a0e958-19e7-774a-846a-add70082458c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityFileNumber_01a0e958-19e7-774a-846a-add70082458c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a0e958-19e7-7f33-9edb-5fc69a0a4a43" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a0e958-19e7-7f33-9edb-5fc69a0a4a43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a0e958-19e7-7f58-8bf8-f717d3a10a81" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityAddressAddressLine1_01a0e958-19e7-7f58-8bf8-f717d3a10a81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a0e958-19e7-7c91-9936-6b20cc20f54c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityAddressCityOrTown_01a0e958-19e7-7c91-9936-6b20cc20f54c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a0e958-19e7-74ee-9deb-cf3dce530772" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityAddressStateOrProvince_01a0e958-19e7-74ee-9deb-cf3dce530772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a0e958-19e7-7f05-912d-390063b55cd6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityAddressPostalZipCode_01a0e958-19e7-7f05-912d-390063b55cd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a0e958-19e7-7f5f-8f6b-dde60162a42a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_CityAreaCode_01a0e958-19e7-7f5f-8f6b-dde60162a42a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a0e958-19e7-7cdb-9bfb-2183f66c4713" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_LocalPhoneNumber_01a0e958-19e7-7cdb-9bfb-2183f66c4713" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a0e958-19e7-7725-b0cb-a14630071c81" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_WrittenCommunications_01a0e958-19e7-7725-b0cb-a14630071c81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a0e958-19e7-72eb-9bf3-19b80513a230" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_SolicitingMaterial_01a0e958-19e7-72eb-9bf3-19b80513a230" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a0e958-19e7-76ac-b78a-83bdaecd2f84" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_PreCommencementTenderOffer_01a0e958-19e7-76ac-b78a-83bdaecd2f84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a0e958-19e7-74a5-9bf0-603fd4557e57" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a0e958-19e7-74a5-9bf0-603fd4557e57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a0e958-19e7-7d9c-bad8-656b188f104b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_Security12bTitle_01a0e958-19e7-7d9c-bad8-656b188f104b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a0e958-19e7-772f-a2a3-c1ef892f03a0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_TradingSymbol_01a0e958-19e7-772f-a2a3-c1ef892f03a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a0e958-19e7-76c8-b84f-5a7afc2f224c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_SecurityExchangeName_01a0e958-19e7-76c8-b84f-5a7afc2f224c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a0e958-19e7-724e-8286-fd41523cccb5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0e958-19e7-7ee6-bfa7-132d7cd0bd32" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a0e958-19e7-724e-8286-fd41523cccb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
