0001636282 2026-10-06 2026-10-06 0001636282 1 2026-10-06 2026-10-06 iso4217:USD pure shares S-3 424B5 EX-FILING FEES 333-297063 0001636282 Spyre Therapeutics, Inc. N/A N/A false S-3 Spyre Therapeutics, Inc. false Equity Common stock, $0.0001 par value per share true 4735295 85.00 402500075.00 0.000087 35017.51 402500075.00 35017.51 0.00 0.00 35017.51 Calculated in accordance with Rule 457(r) under the Securities Act of 1933, as amended (the "Securities Act"). The fee payable in connection with the offering pursuant to this prospectus supplement has been paid in accordance with Rule 456(b) under the Securities Act, and represents deferred payment of the registration fees in connection with the registrant's Registration Statement on Form S-3ASR (Registration No. 333-297063). Assumes exercise in full of the underwriters' option to purchase up to 617,647 shares of common stock.