<?xml version="1.0" encoding="utf-8"?>
<!--XBRL document created with Toppan Merrill Bridge  11.5.0.6 -->
<!--Based on XBRL 2.1-->
<!--Created on: 9/28/2026 10:05:38 AM-->
<!--Modified on: 9/28/2026 10:05:38 AM-->
<xsd:schema targetNamespace="http://addextherapeutics.com/20260630" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:adxn="http://addextherapeutics.com/20260630" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:srt="http://fasb.org/srt/2025" xmlns:currency="http://xbrl.sec.gov/currency/2025" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:ifrs-full="https://xbrl.ifrs.org/taxonomy/2025-03-27/ifrs-full" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:country="http://xbrl.sec.gov/country/2025" xmlns:attributeFormDefault="unqualified" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:deprecated="http://www.xbrl.org/2009/role/deprecated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:dei="http://xbrl.sec.gov/dei/2025" xmlns:us-roles="http://fasb.org/us-roles/2025" xmlns:dtr="http://www.xbrl.org/2009/dtr" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://addextherapeutics.com/role/StatementCondensedConsolidatedBalanceSheets" id="StatementCondensedConsolidatedBalanceSheets">
        <link:definition>00100 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveLoss" id="StatementCondensedConsolidatedStatementsOfComprehensiveLoss">
        <link:definition>00200 - Statement - Condensed Consolidated Statements of Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureConsolidatedStatementsOfComprehensiveProfitOrLossCalc2" id="DisclosureConsolidatedStatementsOfComprehensiveProfitOrLossCalc2">
        <link:definition>00300 - Disclosure - Consolidated Statements of Comprehensive Profit or Loss (Calc 2)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" id="StatementCondensedConsolidatedStatementsOfCashFlows">
        <link:definition>00400 - Statement - Condensed Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureSegmentInformationDetails" id="DisclosureSegmentInformationDetails">
        <link:definition>40501 - Disclosure - Segment information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureCashAndCashEquivalentsDetails" id="DisclosureCashAndCashEquivalentsDetails">
        <link:definition>40601 - Disclosure - Cash and cash equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOtherCurrentAssetsDetails" id="DisclosureOtherCurrentAssetsDetails">
        <link:definition>40701 - Disclosure - Other current assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureNonCurrentFinancialAssetsDetails" id="DisclosureNonCurrentFinancialAssetsDetails">
        <link:definition>41101 - Disclosure - Non-current financial assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosurePayablesAccrualsAndOtherCurrentLiabilitiesDetails" id="DisclosurePayablesAccrualsAndOtherCurrentLiabilitiesDetails">
        <link:definition>41201 - Disclosure - Payables, accruals and other current liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRetirementBenefitsObligationsComprehensiveLossDetails" id="DisclosureRetirementBenefitsObligationsComprehensiveLossDetails">
        <link:definition>41501 - Disclosure - Retirement benefits obligations - Comprehensive loss (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOperatingCostsDetails" id="DisclosureOperatingCostsDetails">
        <link:definition>41801 - Disclosure - Operating costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureStaffCostsDetails" id="DisclosureStaffCostsDetails">
        <link:definition>41901 - Disclosure - Staff costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinanceResultNetDetails" id="DisclosureFinanceResultNetDetails">
        <link:definition>42001 - Disclosure - Finance result, net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRelatedPartyTransactionsDetails" id="DisclosureRelatedPartyTransactionsDetails">
        <link:definition>42601 - Disclosure - Related party transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>00090 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/StatementCondensedConsolidatedStatementsOfChangesInEquity" id="StatementCondensedConsolidatedStatementsOfChangesInEquity">
        <link:definition>00300 - Statement - Condensed Consolidated Statements of Changes in Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/StatementCondensedConsolidatedStatementsOfCashFlowsParenthetical" id="StatementCondensedConsolidatedStatementsOfCashFlowsParenthetical">
        <link:definition>00405 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureGeneralInformationDetails" id="DisclosureGeneralInformationDetails">
        <link:definition>40101 - Disclosure - General information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureMaterialAccountingEstimatesAndJudgmentsDetails" id="DisclosureMaterialAccountingEstimatesAndJudgmentsDetails">
        <link:definition>40301 - Disclosure - Material accounting estimates and judgments - (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRightOfUseAssetsDetails" id="DisclosureRightOfUseAssetsDetails">
        <link:definition>40801 - Disclosure - Right-of-use assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureEquipmentDetails" id="DisclosureEquipmentDetails">
        <link:definition>40901 - Disclosure - Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureIntangibleAssetsDetails" id="DisclosureIntangibleAssetsDetails">
        <link:definition>41001 - Disclosure - Intangible assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareCapitalDetails" id="DisclosureShareCapitalDetails">
        <link:definition>41301 - Disclosure - Share capital (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareBasedCompensationDetails" id="DisclosureShareBasedCompensationDetails">
        <link:definition>41401 - Disclosure - Share-based compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareBasedCompensationShareOptionsOrSharesOutstandingDetails" id="DisclosureShareBasedCompensationShareOptionsOrSharesOutstandingDetails">
        <link:definition>41402 - Disclosure - Share-based compensation - Share options or shares outstanding (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRetirementBenefitsObligationsBalanceSheetDetails" id="DisclosureRetirementBenefitsObligationsBalanceSheetDetails">
        <link:definition>41502 - Disclosure - Retirement benefits obligations - Balance sheet (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRevenueFromContractWithCustomerDetails" id="DisclosureRevenueFromContractWithCustomerDetails">
        <link:definition>41601 - Disclosure - Revenue from contract with customer (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOtherIncomeDetails" id="DisclosureOtherIncomeDetails">
        <link:definition>41701 - Disclosure - Other income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOperatingCostsAdditionalInformationDetails" id="DisclosureOperatingCostsAdditionalInformationDetails">
        <link:definition>41802 - Disclosure - Operating costs - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureStaffCostsAdditionalInformationDetails" id="DisclosureStaffCostsAdditionalInformationDetails">
        <link:definition>41902 - Disclosure - Staff costs - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDiscontinuedOperationsGeneralDetails" id="DisclosureDiscontinuedOperationsGeneralDetails">
        <link:definition>42101 - Disclosure - Discontinued operations - General (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureInterestsInAssociatesDetails" id="DisclosureInterestsInAssociatesDetails">
        <link:definition>42201 - Disclosure - Interests in associates (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeDetails" id="DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeDetails">
        <link:definition>42301 - Disclosure - Financial assets at fair value through other comprehensive income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDerivativeFinancialInstrumentsDetails" id="DisclosureDerivativeFinancialInstrumentsDetails">
        <link:definition>42401 - Disclosure - Derivative financial instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDerivativeFinancialInstrumentsInputsDetails" id="DisclosureDerivativeFinancialInstrumentsInputsDetails">
        <link:definition>42402 - Disclosure - Derivative financial instruments - inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureLossPerShareDetails" id="DisclosureLossPerShareDetails">
        <link:definition>42501 - Disclosure - Loss per share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureEventsAfterBalanceSheetDateDetails" id="DisclosureEventsAfterBalanceSheetDateDetails">
        <link:definition>42701 - Disclosure - Events after the balance sheet date (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureGeneralInformation" id="DisclosureGeneralInformation">
        <link:definition>10101 - Disclosure - General information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureBasisOfPreparation" id="DisclosureBasisOfPreparation">
        <link:definition>10201 - Disclosure - Basis of preparation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureMaterialAccountingEstimatesAndJudgments" id="DisclosureMaterialAccountingEstimatesAndJudgments">
        <link:definition>10301 - Disclosure - Material accounting estimates and judgments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureInterimMeasurementNote" id="DisclosureInterimMeasurementNote">
        <link:definition>10401 - Disclosure - Interim measurement note</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureSegmentReporting" id="DisclosureSegmentReporting">
        <link:definition>10501 - Disclosure - Segment reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureCashAndCashEquivalents" id="DisclosureCashAndCashEquivalents">
        <link:definition>10601 - Disclosure - Cash and cash equivalents</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOtherCurrentAssets" id="DisclosureOtherCurrentAssets">
        <link:definition>10701 - Disclosure - Other current assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRightOfUseAssets" id="DisclosureRightOfUseAssets">
        <link:definition>10801 - Disclosure - Right-of-use assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureEquipment" id="DisclosureEquipment">
        <link:definition>10901 - Disclosure - Equipment</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureIntangibleAssets" id="DisclosureIntangibleAssets">
        <link:definition>11001 - Disclosure - Intangible assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureNonCurrentFinancialAssets" id="DisclosureNonCurrentFinancialAssets">
        <link:definition>11101 - Disclosure - Non-current financial assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosurePayablesAccrualsAndOtherCurrentLiabilities" id="DisclosurePayablesAccrualsAndOtherCurrentLiabilities">
        <link:definition>11201 - Disclosure - Payables, accruals and other current liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareCapital" id="DisclosureShareCapital">
        <link:definition>11301 - Disclosure - Share capital</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareBasedCompensation" id="DisclosureShareBasedCompensation">
        <link:definition>11401 - Disclosure - Share-based compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRetirementBenefitsObligations" id="DisclosureRetirementBenefitsObligations">
        <link:definition>11501 - Disclosure - Retirement benefits obligations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRevenueFromContractWithCustomer" id="DisclosureRevenueFromContractWithCustomer">
        <link:definition>11601 - Disclosure - Revenue from contract with customer</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOtherIncome" id="DisclosureOtherIncome">
        <link:definition>11701 - Disclosure - Other income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOperatingCosts" id="DisclosureOperatingCosts">
        <link:definition>11801 - Disclosure - Operating costs</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureStaffCosts" id="DisclosureStaffCosts">
        <link:definition>11901 - Disclosure - Staff costs</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinanceResultNet" id="DisclosureFinanceResultNet">
        <link:definition>12001 - Disclosure - Finance result, net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDiscontinuedOperations" id="DisclosureDiscontinuedOperations">
        <link:definition>12101 - Disclosure - Discontinued operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureInterestsInAssociates" id="DisclosureInterestsInAssociates">
        <link:definition>12201 - Disclosure - Interests in associates</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncome" id="DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncome">
        <link:definition>12301 - Disclosure - Financial assets at fair value through other comprehensive income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDerivativeFinancialInstruments" id="DisclosureDerivativeFinancialInstruments">
        <link:definition>12401 - Disclosure - Derivative financial instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureLossPerShare" id="DisclosureLossPerShare">
        <link:definition>12501 - Disclosure - Loss per share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRelatedPartyTransactions" id="DisclosureRelatedPartyTransactions">
        <link:definition>12601 - Disclosure - Related party transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureEventsAfterBalanceSheetDate" id="DisclosureEventsAfterBalanceSheetDate">
        <link:definition>12701 - Disclosure - Events after the balance sheet date</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureBasisOfPreparationPolicies" id="DisclosureBasisOfPreparationPolicies">
        <link:definition>20202 - Disclosure - Basis of preparation (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureSegmentReportingTables" id="DisclosureSegmentReportingTables">
        <link:definition>30503 - Disclosure - Segment reporting (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureCashAndCashEquivalentsTables" id="DisclosureCashAndCashEquivalentsTables">
        <link:definition>30603 - Disclosure - Cash and cash equivalents (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOtherCurrentAssetsTables" id="DisclosureOtherCurrentAssetsTables">
        <link:definition>30703 - Disclosure - Other current assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRightOfUseAssetsTables" id="DisclosureRightOfUseAssetsTables">
        <link:definition>30803 - Disclosure - Right-of-use assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureEquipmentTables" id="DisclosureEquipmentTables">
        <link:definition>30903 - Disclosure - Equipment (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureIntangibleAssetsTables" id="DisclosureIntangibleAssetsTables">
        <link:definition>31003 - Disclosure - Intangible assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureNonCurrentFinancialAssetsTables" id="DisclosureNonCurrentFinancialAssetsTables">
        <link:definition>31103 - Disclosure - Non-current financial assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosurePayablesAccrualsAndOtherCurrentLiabilitiesTables" id="DisclosurePayablesAccrualsAndOtherCurrentLiabilitiesTables">
        <link:definition>31203 - Disclosure - Payables, accruals and other current liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureShareCapitalTables" id="DisclosureShareCapitalTables">
        <link:definition>31303 - Disclosure - Share capital (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRetirementBenefitsObligationsTables" id="DisclosureRetirementBenefitsObligationsTables">
        <link:definition>31503 - Disclosure - Retirement benefits obligations (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureOperatingCostsTables" id="DisclosureOperatingCostsTables">
        <link:definition>31803 - Disclosure - Operating costs (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureStaffCostsTables" id="DisclosureStaffCostsTables">
        <link:definition>31903 - Disclosure - Staff costs (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinanceResultNetTables" id="DisclosureFinanceResultNetTables">
        <link:definition>32003 - Disclosure - Finance result, net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureInterestsInAssociatesTables" id="DisclosureInterestsInAssociatesTables">
        <link:definition>32203 - Disclosure - Interests in associates (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeTables" id="DisclosureFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeTables">
        <link:definition>32303 - Disclosure - Financial assets at fair value through other comprehensive income (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureDerivativeFinancialInstrumentsTables" id="DisclosureDerivativeFinancialInstrumentsTables">
        <link:definition>32403 - Disclosure - Derivative financial instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureLossPerShareTables" id="DisclosureLossPerShareTables">
        <link:definition>32503 - Disclosure - Loss per share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureRelatedPartyTransactionsTables" id="DisclosureRelatedPartyTransactionsTables">
        <link:definition>32603 - Disclosure - Related party transactions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="adxn-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="adxn-20260630_cal.xml" xlink:title="Calculation Links, all" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="adxn-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="adxn-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:roleType roleURI="http://addextherapeutics.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
        <link:definition>99900 - Disclosure - Standard And Custom Axis Domain Defaults</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="https://xbrl.org/2023/calculation-1.1" schemaLocation="https://www.xbrl.org/2023/calculation-1.1.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-roles-2025.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2025" schemaLocation="https://xbrl.sec.gov/country/2025/country-2025.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd" />
  <xsd:import namespace="https://xbrl.ifrs.org/taxonomy/2025-03-27/ifrs-full" schemaLocation="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/currency/2025" schemaLocation="https://xbrl.sec.gov/currency/2025/currency-2025.xsd" />
  <xsd:element name="NumberOfOtherEquityInstrumentsSubjectToStrikePriceReduction" id="adxn_NumberOfOtherEquityInstrumentsSubjectToStrikePriceReduction" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfOptionsSubjectToStrikePriceReduction" id="adxn_NumberOfOptionsSubjectToStrikePriceReduction" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedArrangementIncreaseInFairValueFromModification" id="adxn_ShareBasedArrangementIncreaseInFairValueFromModification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInExternalResearchDevelopmentAndPatentCosts" id="adxn_IncreaseDecreaseInExternalResearchDevelopmentAndPatentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInExpensesRecognizedForServicesReceivedAtZeroCost" id="adxn_IncreaseDecreaseInExpensesRecognizedForServicesReceivedAtZeroCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SignificantAccountingPoliciesAbstract" id="adxn_SignificantAccountingPoliciesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GeneralInformationAbstract" id="adxn_GeneralInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CriticalAccountingEstimatesAndJudgmentsAbstract" id="adxn_CriticalAccountingEstimatesAndJudgmentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherCurrentAssetsAbstract" id="adxn_OtherCurrentAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PayablesAccrualsAbstract" id="adxn_PayablesAccrualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueFromContractsWithCustomersAbstract" id="adxn_RevenueFromContractsWithCustomersAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsOtherIncomeAbstract" id="adxn_IfrsOtherIncomeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingCostsAbstract" id="adxn_OperatingCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FinanceCostsAbstract" id="adxn_FinanceCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfNonCurrentFinancialAssetsTextBlock" id="adxn_DisclosureOfNonCurrentFinancialAssetsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfDetailedInformationAboutCashAndCashEquivalentsTableTextBlock" id="adxn_DisclosureOfDetailedInformationAboutCashAndCashEquivalentsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfCashAndCashEquivalentsByCurrencyTableTextBlock" id="adxn_DisclosureOfCashAndCashEquivalentsByCurrencyTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfDetailedInformationAboutOtherCurrentAssetsTableTextBlock" id="adxn_DisclosureOfDetailedInformationAboutOtherCurrentAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfDetailedInformationAboutNonCurrentFinancialAssetsTableTextBlock" id="adxn_DisclosureOfDetailedInformationAboutNonCurrentFinancialAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfDetailedInformationAboutPayablesAndAccrualsTableTextBlock" id="adxn_DisclosureOfDetailedInformationAboutPayablesAndAccrualsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfStaffCostsTableTextBlock" id="adxn_DisclosureOfStaffCostsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfAmountsRecognizedInBalanceSheetForEmploymentBenefitObligationsTableTextBlock" id="adxn_DisclosureOfAmountsRecognizedInBalanceSheetForEmploymentBenefitObligationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfAmountsRecognizedInProfitOrLossForEmploymentBenefitObligationsTableTextBlock" id="adxn_DisclosureOfAmountsRecognizedInProfitOrLossForEmploymentBenefitObligationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherReserveMember" id="adxn_OtherReserveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MovementInTreasurySharesAbstract" id="adxn_MovementInTreasurySharesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NetSalesPurchasesOfTreasurySharesUnderLiquidityAgreement" id="adxn_NetSalesPurchasesOfTreasurySharesUnderLiquidityAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="NumberOfSegments" id="adxn_NumberOfSegments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IndiviorPlcMember" id="adxn_IndiviorPlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashAndCashEquivalentsTable" id="adxn_CashAndCashEquivalentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashAndCashEquivalentLineItems" id="adxn_CashAndCashEquivalentLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PercentageOfCashAndCashEquivalents" id="adxn_PercentageOfCashAndCashEquivalents" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="P1Or1Member" id="adxn_P1Or1Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsEquipmentMember" id="adxn_IfrsEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MaturityPeriodOfPayables" id="adxn_MaturityPeriodOfPayables" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="JanssenPharmaceuticalsInc.Member" id="adxn_JanssenPharmaceuticalsInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SharesHeldInTreasuryMember" id="adxn_SharesHeldInTreasuryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="KeplerCapitalMarketsSaMember" id="adxn_KeplerCapitalMarketsSaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsBalanceSheetLocationAxis" id="adxn_IfrsBalanceSheetLocationAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BalanceSheetLocationMember" id="adxn_BalanceSheetLocationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherFinancialAssetsMember" id="adxn_OtherFinancialAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherIncomeTable" id="adxn_OtherIncomeTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherIncomeLineItems" id="adxn_OtherIncomeLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExternalResearchAndDevelopmentCosts" id="adxn_ExternalResearchAndDevelopmentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PatentMaintenanceAndRegistrationCosts" id="adxn_PatentMaintenanceAndRegistrationCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="NumberOfCategoriesOfDilutivePotentialShares" id="adxn_NumberOfCategoriesOfDilutivePotentialShares" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SubscriptionAndFloorPriceAxis" id="adxn_SubscriptionAndFloorPriceAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SubscriptionAndFloorPriceMember" id="adxn_SubscriptionAndFloorPriceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfRightOfUseAssetsTextBlock" id="adxn_DisclosureOfRightOfUseAssetsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfSwissBanksUsed" id="adxn_NumberOfSwissBanksUsed" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="DisclosureOfOtherCurrentAssetsTable" id="adxn_DisclosureOfOtherCurrentAssetsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfOtherCurrentAssetsLineItems" id="adxn_DisclosureOfOtherCurrentAssetsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfTreasurySharesSoldPurchased" id="adxn_NumberOfTreasurySharesSoldPurchased" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseThroughIssuanceOfWarrantsAndPreFundedWarrants" id="adxn_IncreaseDecreaseThroughIssuanceOfWarrantsAndPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInOperatingExpenses" id="adxn_IncreaseDecreaseInOperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInEmployeeBenefitsExpenses" id="adxn_IncreaseDecreaseInEmployeeBenefitsExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfFinanceIncomeExpenseTableTextBlock" id="adxn_DisclosureOfFinanceIncomeExpenseTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareSalePrice" id="adxn_ShareSalePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DateOfGrantAxis" id="adxn_DateOfGrantAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DateOfGrantMember" id="adxn_DateOfGrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EmployeeShareOptionPlansMember" id="adxn_EmployeeShareOptionPlansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredStrikePricePaymentPlanMember" id="adxn_DeferredStrikePricePaymentPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ContractAssetsAndTradeAndOtherReceivablesMember" id="adxn_ContractAssetsAndTradeAndOtherReceivablesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncreaseDecreaseInOtherCurrentAsset" id="adxn_IncreaseDecreaseInOtherCurrentAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NumberOfSharesReclassedAsTreasurySharesUnderIfrs2TreasuryShares" id="adxn_NumberOfSharesReclassedAsTreasurySharesUnderIfrs2TreasuryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfSharesReclassedAsTreasurySharesUnderIfrs2SharesOutstanding" id="adxn_NumberOfSharesReclassedAsTreasurySharesUnderIfrs2SharesOutstanding" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfSharesIssuedIncludingIfrs2Shares" id="adxn_NumberOfSharesIssuedIncludingIfrs2Shares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfTreasurySharesIncludingIfrs2Shares" id="adxn_NumberOfTreasurySharesIncludingIfrs2Shares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfSharesOutstandingIncludingIfrs2Shares" id="adxn_NumberOfSharesOutstandingIncludingIfrs2Shares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TypesOfEquityIncentiveUnitsByTimingAxis" id="adxn_TypesOfEquityIncentiveUnitsByTimingAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TypesOfEquityIncentiveUnitsByTimingDomain" id="adxn_TypesOfEquityIncentiveUnitsByTimingDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InterimMeasurementNoteAbstract" id="adxn_InterimMeasurementNoteAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BasisOfPreparationAbstract" id="adxn_BasisOfPreparationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AcquisitionOfSharesForfeitedFromDeferredStrikePricePaymentPlan" id="adxn_AcquisitionOfSharesForfeitedFromDeferredStrikePricePaymentPlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="KeyManagementPersonnelCompensationSalariesOtherShortTermEmployeeBenefitsAndPostEmploymentBenefits" id="adxn_KeyManagementPersonnelCompensationSalariesOtherShortTermEmployeeBenefitsAndPostEmploymentBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisclosureOfInterimMeasurementNoteTextBlock" id="adxn_DisclosureOfInterimMeasurementNoteTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NeurosterixPharmaSarlMember" id="adxn_NeurosterixPharmaSarlMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlansContinuingOperations" id="adxn_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlansContinuingOperations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AdjustmentsForGainLossOnDiscontinuanceNetOfTax" id="adxn_AdjustmentsForGainLossOnDiscontinuanceNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="GainLossOnDiscontinuanceNetOfTax" id="adxn_GainLossOnDiscontinuanceNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NeurosterixUsHoldingsLlcMember" id="adxn_NeurosterixUsHoldingsLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ServiceAgreementMember" id="adxn_ServiceAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AllostericModulatorDrugDiscoveryTechnologyPlatformAndPortfolioOfPreclinicalProgramsDisposalGroupDiscontinuedOperationsMember" id="adxn_AllostericModulatorDrugDiscoveryTechnologyPlatformAndPortfolioOfPreclinicalProgramsDisposalGroupDiscontinuedOperationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AmountOfCommitmentFundingReceived" id="adxn_AmountOfCommitmentFundingReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsForDecreaseIncreaseInMiscellaneousOtherCurrentAssets" id="adxn_AdjustmentsForDecreaseIncreaseInMiscellaneousOtherCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PercentageOfEquityInterestReceived" id="adxn_PercentageOfEquityInterestReceived" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GrossProceedsFromDisposalOfDiscontinuedOperation" id="adxn_GrossProceedsFromDisposalOfDiscontinuedOperation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AmountOfEquityInterestReceivedOnDisposalOfDiscontinuedOperation" id="adxn_AmountOfEquityInterestReceivedOnDisposalOfDiscontinuedOperation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="FairValueOfServiceAgreementProvidedAfterDisposalOfDiscontinuedOperation" id="adxn_FairValueOfServiceAgreementProvidedAfterDisposalOfDiscontinuedOperation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NeurosterixGroupMember" id="adxn_NeurosterixGroupMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncreaseDecreaseInProfessionalFees" id="adxn_IncreaseDecreaseInProfessionalFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ExpensesRecognisedForServicesReceivedAtZeroCosts" id="adxn_ExpensesRecognisedForServicesReceivedAtZeroCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncomeRecognisedForServicesReceivedAtZeroCosts" id="adxn_IncomeRecognisedForServicesReceivedAtZeroCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TabularDisclosureOfInformationAboutFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeTableTextBlock" id="adxn_TabularDisclosureOfInformationAboutFinancialAssetsAtFairValueThroughOtherComprehensiveIncomeTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExercisePeriodOfWarrants" id="adxn_ExercisePeriodOfWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CostOfSaleOfTreasurySharesEquity" id="adxn_CostOfSaleOfTreasurySharesEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsForCostOfFairValueOfServicesReceivedAtZeroCost" id="adxn_AdjustmentsForCostOfFairValueOfServicesReceivedAtZeroCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsForIncomeOfFairValueOfServicesReceivedAtZeroCost" id="adxn_AdjustmentsForIncomeOfFairValueOfServicesReceivedAtZeroCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CostsPaidOnSaleOfTreasuryShares" id="adxn_CostsPaidOnSaleOfTreasuryShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SaleOfTreasuryShares" id="adxn_SaleOfTreasuryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TypeOfTreasuryShareTransactionAxis" id="adxn_TypeOfTreasuryShareTransactionAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TypeOfTreasuryShareTransactionDomain" id="adxn_TypeOfTreasuryShareTransactionDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TreasurySharesSoldUnderSaleAgencyAgreementMember" id="adxn_TreasurySharesSoldUnderSaleAgencyAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreferredSharesReceivedOnInvestment" id="adxn_PreferredSharesReceivedOnInvestment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncreaseDecreaseInPayablesAccrualsAndOtherCurrentLiabilities" id="adxn_IncreaseDecreaseInPayablesAccrualsAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StaliclaSaMember" id="adxn_StaliclaSaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PurchaseOfDerivativeFinancialInstruments" id="adxn_PurchaseOfDerivativeFinancialInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PurchaseOfInvestmentsInOtherEntitiesIncludingRelatedFinancialInstruments" id="adxn_PurchaseOfInvestmentsInOtherEntitiesIncludingRelatedFinancialInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisclosureOfFairValueMeasurementOfDerivativeFinancialInstrumentsTextBlock" id="adxn_DisclosureOfFairValueMeasurementOfDerivativeFinancialInstrumentsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PhantomSharesReceivedOnInvestment" id="adxn_PhantomSharesReceivedOnInvestment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsReceivedOnInvestment" id="adxn_WarrantsReceivedOnInvestment" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StrikePriceOfWarrantsReceivedOnInvestment" id="adxn_StrikePriceOfWarrantsReceivedOnInvestment" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsReceivedOnInvestmentsClassOneMember" id="adxn_WarrantsReceivedOnInvestmentsClassOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantsReceivedOnInvestmentsClassTwoMember" id="adxn_WarrantsReceivedOnInvestmentsClassTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfOrdinarySharesToWhoseProceedsPhantomSharesEntitlephantomSharesReceivedOnInvestment" id="adxn_NumberOfOrdinarySharesToWhoseProceedsPhantomSharesEntitlephantomSharesReceivedOnInvestment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfOrdinarySharesToWhosePurchaseWarrantsEntitle" id="adxn_NumberOfOrdinarySharesToWhosePurchaseWarrantsEntitle" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfPreferredSharesToWhosePurchaseWarrantsEntitle" id="adxn_NumberOfPreferredSharesToWhosePurchaseWarrantsEntitle" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AmountNotRecordedAsPhantomSharesDueToCapOnFairValue" id="adxn_AmountNotRecordedAsPhantomSharesDueToCapOnFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PhantomSharesMember" id="adxn_PhantomSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AntiDilutionProtectionMember" id="adxn_AntiDilutionProtectionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnderlyingSharePriceMember" id="adxn_UnderlyingSharePriceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SalePriceOfSharesMember" id="adxn_SalePriceOfSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfTreasuryShare" id="adxn_SaleOfTreasuryShare" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInKeyManagementPersonnelCompensation" id="adxn_IncreaseDecreaseInKeyManagementPersonnelCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromSalePaymentsForPurchaseOfTreasurySharesUnderLiquidityAgreement" id="adxn_ProceedsFromSalePaymentsForPurchaseOfTreasurySharesUnderLiquidityAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TradeAndOtherCurrentPayablesAndOtherCurrentLiabilities" id="adxn_TradeAndOtherCurrentPayablesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TreasurySharesSoldThroughAtMarketAgreementUnderFormOfAdsMember" id="adxn_TreasurySharesSoldThroughAtMarketAgreementUnderFormOfAdsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncreaseDecreaseInInvestmentsInAssociatesAccountedForUsingEquityMethod" id="adxn_IncreaseDecreaseInInvestmentsInAssociatesAccountedForUsingEquityMethod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
