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  <xsd:element id="aytu_DebtInstrumentAmortizationPeriod" name="DebtInstrumentAmortizationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_DebtInstrumentTerminationFeeBetweenJune122025AndJune122026Percentage" name="DebtInstrumentTerminationFeeBetweenJune122025AndJune122026Percentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DebtInstrumentTerminationFeeBetweenJune122026AndJune122027Percentage" name="DebtInstrumentTerminationFeeBetweenJune122026AndJune122027Percentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DebtInstrumentTerminationFeeBetweenJune122026AndJune122028Percentage" name="DebtInstrumentTerminationFeeBetweenJune122026AndJune122028Percentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DebtInstrumentsFinalBalanceForEndOfPeriodicPayments" name="DebtInstrumentsFinalBalanceForEndOfPeriodicPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_December2020WarrantsJanuary2022WarrantsMarch2022WarrantsAndAugust2022WarrantsMember" name="December2020WarrantsJanuary2022WarrantsMarch2022WarrantsAndAugust2022WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_December2020WarrantsMember" name="December2020WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_DeferredTaxAssetsAccruedRebates" name="DeferredTaxAssetsAccruedRebates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DeferredTaxAssetsCapitalizedResearchAndDevelopment" name="DeferredTaxAssetsCapitalizedResearchAndDevelopment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DeferredTaxAssetsLeaseLiability" name="DeferredTaxAssetsLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_DisposalGroupIncludingDiscontinuedOperationRecognizedContingentConsideration" name="DisposalGroupIncludingDiscontinuedOperationRecognizedContingentConsideration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" name="DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_DisposalGroupMaximumRevenuebasedRoyaltyPaymentsToBeReceived" name="DisposalGroupMaximumRevenuebasedRoyaltyPaymentsToBeReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_EXXUAExclusiveCommercializationAgreementMember" name="EXXUAExclusiveCommercializationAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_EXXUAPortfolioMember" name="EXXUAPortfolioMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_EclipseBusinessCapitalLLCLoanAgreementMember" name="EclipseBusinessCapitalLLCLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_EclipseTermLoanMember" name="EclipseTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationGainOnDerivativeWarrantLiabilityAmount" name="EffectiveIncomeTaxRateReconciliationGainOnDerivativeWarrantLiabilityAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationGainOnDerivativeWarrantLiabilityPercent" name="EffectiveIncomeTaxRateReconciliationGainOnDerivativeWarrantLiabilityPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationInnovusSalesAdjustmentAmount" name="EffectiveIncomeTaxRateReconciliationInnovusSalesAdjustmentAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationInnovusSalesAdjustmentPercent" name="EffectiveIncomeTaxRateReconciliationInnovusSalesAdjustmentPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationPermanentDifferenceOtherAmount" name="EffectiveIncomeTaxRateReconciliationPermanentDifferenceOtherAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EffectiveIncomeTaxRateReconciliationPermanentDifferenceOtherPercent" name="EffectiveIncomeTaxRateReconciliationPermanentDifferenceOtherPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_EmployeeRetentionCredit" name="EmployeeRetentionCredit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_EmployeeRetentionCreditPolicyTextBlock" name="EmployeeRetentionCreditPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_EquityWarrantsMember" name="EquityWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ExercisePriceRangeFourMember" name="ExercisePriceRangeFourMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ExercisePriceRangeOneMember" name="ExercisePriceRangeOneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassificationOutOfLiabilityToEquity" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassificationOutOfLiabilityToEquity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_FiniteLivedIntangibleAssetUsefulLifeRenewablePeriod" name="FiniteLivedIntangibleAssetUsefulLifeRenewablePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_FiniteLivedIntangibleAssetsImpairedAccumulatedAmortization" name="FiniteLivedIntangibleAssetsImpairedAccumulatedAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_FiniteLivedIntangibleAssetsImpairedGross" name="FiniteLivedIntangibleAssetsImpairedGross" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_FirstFivePercentContributionByEmployeesMember" name="FirstFivePercentContributionByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_FirstThreePercentContributionByEmployeesMember" name="FirstThreePercentContributionByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_FixedPaymentArrangements" name="FixedPaymentArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_FixedPaymentArrangementsMeasurementInput" name="FixedPaymentArrangementsMeasurementInput" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_FloridaTaxAuthorityMember" name="FloridaTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_FurnitureAndEquipmentMember" name="FurnitureAndEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_GeorgiaTaxAuthorityMember" name="GeorgiaTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_GrandPrairieTexasManufacturingSiteMember" name="GrandPrairieTexasManufacturingSiteMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_IncomeTaxExpenseBenefitIntraperiodTaxAllocationTableTextBlock" name="IncomeTaxExpenseBenefitIntraperiodTaxAllocationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_IncreaseDecreaseInOperatingCapitalAttributableToDiscontinuedOperations" name="IncreaseDecreaseInOperatingCapitalAttributableToDiscontinuedOperations" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_IncrementalAdvanceMember" name="IncrementalAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_January2022WarrantsMember" name="January2022WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2023PrefundedWarrantsMember" name="June2023PrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2023TrancheAPrefundedWarrantsMember" name="June2023TrancheAPrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2023TrancheAWarrantsLiabilityClassifiedMember" name="June2023TrancheAWarrantsLiabilityClassifiedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2023TrancheAWarrantsMember" name="June2023TrancheAWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2023WarrantsTrancheAMember" name="June2023WarrantsTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2025EquityFinancingMember" name="June2025EquityFinancingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_June2025PrefundedWarrantsMember" name="June2025PrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_LeasesDisclosureTextBlock" name="LeasesDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_LesseeOperatingLeaseLiabilityToBePaidIncludingLeaseNotYetCommenced" name="LesseeOperatingLeaseLiabilityToBePaidIncludingLeaseNotYetCommenced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_LiabilityPrefundedWarrantsMember" name="LiabilityPrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_LiabilityWarrantsMember" name="LiabilityWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_LicensingAgreementsTextBlock" name="LicensingAgreementsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_LineOfCreditFacilityTerminationFeePercentageOfCommitmentTerminatedBetweenJune122025AndJune122026" name="LineOfCreditFacilityTerminationFeePercentageOfCommitmentTerminatedBetweenJune122025AndJune122026" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="aytu_LineOfCreditFacilityTerminationFeePercentageOfCommitmentTerminatedBetweenJune122026AndJune122028" name="LineOfCreditFacilityTerminationFeePercentageOfCommitmentTerminatedBetweenJune122026AndJune122028" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_ManufacturingAndLabEquipmentMember" name="ManufacturingAndLabEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_March2022WarrantsMember" name="March2022WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NeoMember" name="NeoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NeosPlanMember" name="NeosPlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NextFivePercentContributionByEmployeesMember" name="NextFivePercentContributionByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NextFourPercentAndFivePercentContributionByEmployeesMember" name="NextFourPercentAndFivePercentContributionByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NextFourPercentContributionByEmployeesMember" name="NextFourPercentContributionByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NonplanMember" name="NonplanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NorthCarolinaTaxAuthorityMember" name="NorthCarolinaTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_OceansideCaliforniaWarehouseMember" name="OceansideCaliforniaWarehouseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_OfficeEquipmentFurnitureAndOtherMember" name="OfficeEquipmentFurnitureAndOtherMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_OfficeSpaceInBerwynPennsylvaniaMember" name="OfficeSpaceInBerwynPennsylvaniaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_OperatingLeaseLiabilityIncludingLeaseNotYetCommenced" name="OperatingLeaseLiabilityIncludingLeaseNotYetCommenced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_OperatingLeaseUndiscountedMinimumMonthlyPayment" name="OperatingLeaseUndiscountedMinimumMonthlyPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_OperatingLossCarryforwardSubjectToExpire" name="OperatingLossCarryforwardSubjectToExpire" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_OperatingLossCarryforwardsLimitationsOnUseOwnershipChangePostchangeNetOperatingLossDisallowedRecognizedBuiltinLossCarriedForwardAsOperatingLoss" name="OperatingLossCarryforwardsLimitationsOnUseOwnershipChangePostchangeNetOperatingLossDisallowedRecognizedBuiltinLossCarriedForwardAsOperatingLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_OperatingLossCarryforwardsLimitationsOnUseOwnershipChangePostchangeNetOperatingLossFullyAvailableToOffsetCurrentFiscalYearPreChangeIncomeSubjectToLimitation" name="OperatingLossCarryforwardsLimitationsOnUseOwnershipChangePostchangeNetOperatingLossFullyAvailableToOffsetCurrentFiscalYearPreChangeIncomeSubjectToLimitation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_OperatingLossCarryforwardsNotSubjectToExpiration" name="OperatingLossCarryforwardsNotSubjectToExpiration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="aytu_OtherWarrantsMember" name="OtherWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_PaymentsOfFixedPaymentArrangements" name="PaymentsOfFixedPaymentArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_PolicyTable" name="PolicyTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_PolyTriAgreementsMember" name="PolyTriAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_PreFundedWarrantsMember" name="PreFundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_PrincipalOfficeDenverColoradoMember" name="PrincipalOfficeDenverColoradoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_ProceedsFromIssuanceOfCommonStockAndWarrants" name="ProceedsFromIssuanceOfCommonStockAndWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_ProceedsFromIssuanceOrSaleOfEquityNet" name="ProceedsFromIssuanceOrSaleOfEquityNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_PublicOfferingMember" name="PublicOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_RXSegmentMember" name="RXSegmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ReclassifiedFromDerivativeLiabilityToEquityMember" name="ReclassifiedFromDerivativeLiabilityToEquityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_RestrictedStockAndRestrictedStockUnitsRSUsMember" name="RestrictedStockAndRestrictedStockUnitsRSUsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ReturnReserveMember" name="ReturnReserveMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_SaleOfStockMaximumAmountOfEquityIssuable" name="SaleOfStockMaximumAmountOfEquityIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="aytu_ScheduleOfLeaseByBalanceSheetInformationTableTextBlock" name="ScheduleOfLeaseByBalanceSheetInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_ScheduleOfReturnReserveTableTextBlock" name="ScheduleOfReturnReserveTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_StockIssuedDuringPeriodSharesWarrantsExercised" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_StockIssuedDuringPeriodValueWarrantsExercised" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="aytu_SupplyAndDistributionAgreementExtensionTerm" name="SupplyAndDistributionAgreementExtensionTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_SupplyAndDistributionCommitmentPeriod" name="SupplyAndDistributionCommitmentPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_SupplyAndDistributionCommitmentRoyaltyPercentageOfNetSales" name="SupplyAndDistributionCommitmentRoyaltyPercentageOfNetSales" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_TRRPProprietaryTechnologyMember" name="TRRPProprietaryTechnologyMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_TennesseeTaxAuthorityMember" name="TennesseeTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_TexasTaxAuthorityMember" name="TexasTaxAuthorityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_The2015PlanMember" name="The2015PlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_The2020ShelfMember" name="The2020ShelfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_The2021ShelfMember" name="The2021ShelfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_The2023EquityIncentivePlanMember" name="The2023EquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_ThePediatricPortfolioMember" name="ThePediatricPortfolioMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_TrisKarbinalAgreementMember" name="TrisKarbinalAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_WarrantsExcludingPrefundedWarrantsMember" name="WarrantsExcludingPrefundedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="aytu_WarrantsOrRightsDisclosureTextBlock" name="WarrantsOrRightsDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-11-debt-future-principal-payments-details" name="statement-statement-note-11-debt-future-principal-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-11-debt-schedule-of-debt-details" name="statement-statement-note-11-debt-schedule-of-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-11-debt-tables" name="statement-statement-note-11-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-12-fair-value-measurements-recurring-fair-value-measurements-details" name="statement-statement-note-12-fair-value-measurements-recurring-fair-value-measurements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-12-fair-value-measurements-summary-of-level-3-changes-details" name="statement-statement-note-12-fair-value-measurements-summary-of-level-3-changes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-12-fair-value-measurements-tables" name="statement-statement-note-12-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-12-fair-value-measurements-valuation-assumptions-details" name="statement-statement-note-12-fair-value-measurements-valuation-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-effective-income-tax-rate-reconciliation-details" name="statement-statement-note-13-income-taxes-effective-income-tax-rate-reconciliation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-effective-income-tax-rate-reconciliation-details-parentheticals" name="statement-statement-note-13-income-taxes-effective-income-tax-rate-reconciliation-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-income-tax-expense-benefit-allocated-to-continuing-an-discontinued-operations-details" name="statement-statement-note-13-income-taxes-income-tax-expense-benefit-allocated-to-continuing-an-discontinued-operations-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-provision-for-income-taxes-details" name="statement-statement-note-13-income-taxes-provision-for-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" name="statement-statement-note-13-income-taxes-schedule-of-deferred-tax-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-schedule-of-unrecognized-tax-benefits-roll-forward-details" name="statement-statement-note-13-income-taxes-schedule-of-unrecognized-tax-benefits-roll-forward-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-13-income-taxes-tables" name="statement-statement-note-13-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plan-tables" name="statement-statement-note-15-equity-incentive-plan-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plans-restricted-stock-activity-details" name="statement-statement-note-15-equity-incentive-plans-restricted-stock-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plans-stock-compensation-expense-2-details" name="statement-statement-note-15-equity-incentive-plans-stock-compensation-expense-2-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plans-stock-compensation-expense-details" name="statement-statement-note-15-equity-incentive-plans-stock-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plans-stock-option-activity-details" name="statement-statement-note-15-equity-incentive-plans-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-15-equity-incentive-plans-stock-options-outstanding-details" name="statement-statement-note-15-equity-incentive-plans-stock-options-outstanding-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-16-warrants-schedule-of-warrants-outstanding-details" name="statement-statement-note-16-warrants-schedule-of-warrants-outstanding-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-16-warrants-tables" name="statement-statement-note-16-warrants-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-2-summary-of-significant-accounting-policies-allowance-for-credit-loss-details" name="statement-statement-note-2-summary-of-significant-accounting-policies-allowance-for-credit-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-2-summary-of-significant-accounting-policies-concentration-of-credit-risk-details" name="statement-statement-note-2-summary-of-significant-accounting-policies-concentration-of-credit-risk-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-2-summary-of-significant-accounting-policies-schedule-of-accounts-receivable-details" name="statement-statement-note-2-summary-of-significant-accounting-policies-schedule-of-accounts-receivable-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-2-summary-of-significant-accounting-policies-securities-excluded-from-calculation-of-earnings-per-share-details" name="statement-statement-note-2-summary-of-significant-accounting-policies-securities-excluded-from-calculation-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-2-summary-of-significant-accounting-policies-tables" name="statement-statement-note-2-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-20-discontinued-operations-schedule-of-discontinued-operations-details" name="statement-statement-note-20-discontinued-operations-schedule-of-discontinued-operations-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-20-discontinued-operations-tables" name="statement-statement-note-20-discontinued-operations-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-3-revenue-disaggregation-of-revenue-details" name="statement-statement-note-3-revenue-disaggregation-of-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-3-revenue-tables" name="statement-statement-note-3-revenue-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-4-inventories-schedule-of-inventories-details" name="statement-statement-note-4-inventories-schedule-of-inventories-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-4-inventories-tables" name="statement-statement-note-4-inventories-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-5-property-and-equipment-schedule-of-property-and-equipment-details" name="statement-statement-note-5-property-and-equipment-schedule-of-property-and-equipment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-5-property-and-equipment-tables" name="statement-statement-note-5-property-and-equipment-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-6-leases-lease-balance-sheet-information-details" name="statement-statement-note-6-leases-lease-balance-sheet-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-6-leases-lease-balance-sheet-information-details-parentheticals" name="statement-statement-note-6-leases-lease-balance-sheet-information-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-6-leases-lease-cost-details" name="statement-statement-note-6-leases-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-6-leases-schedule-of-lease-liability-maturity-details" name="statement-statement-note-6-leases-schedule-of-lease-liability-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-6-leases-tables" name="statement-statement-note-6-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-7-intangible-assets-future-amortization-expense-details" name="statement-statement-note-7-intangible-assets-future-amortization-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-7-intangible-assets-schedule-of-intangible-assets-details" name="statement-statement-note-7-intangible-assets-schedule-of-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-7-intangible-assets-summary-of-amortization-expense-details" name="statement-statement-note-7-intangible-assets-summary-of-amortization-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-7-intangible-assets-tables" name="statement-statement-note-7-intangible-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-8-accrued-liabilities-schedule-of-accrued-liabilities-details" name="statement-statement-note-8-accrued-liabilities-schedule-of-accrued-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-8-accrued-liabilities-schedule-of-return-reserve-details" name="statement-statement-note-8-accrued-liabilities-schedule-of-return-reserve-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-8-accrued-liabilities-tables" name="statement-statement-note-8-accrued-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-9-other-liabilities-schedule-of-other-liabilities-details" name="statement-statement-note-9-other-liabilities-schedule-of-other-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-note-9-other-liabilities-tables" name="statement-statement-note-9-other-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="aytu_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
