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  <xs:element name="EmployeeStockOwnershipPlanPurchasePricePercent" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="howl_EmployeeStockOwnershipPlanPurchasePricePercent"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationPeriodUponTermination" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationPeriodUponTermination"/>
  <xs:element name="LesseeOperatingLeaseAreaOfRentableSpace" type="dtr:areaItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="howl_LesseeOperatingLeaseAreaOfRentableSpace"/>
  <xs:element name="LesseeOperatingLeaseLeaseNotYetCommencedAreaOfRentableSpace" type="dtr:areaItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="howl_LesseeOperatingLeaseLeaseNotYetCommencedAreaOfRentableSpace"/>
  <xs:element name="LesseeOperatingLeaseLeaseNotYetCommencedTenantImprovements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="howl_LesseeOperatingLeaseLeaseNotYetCommencedTenantImprovements"/>
  <xs:element name="LesseeOperatingLeaseDeposit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LesseeOperatingLeaseDeposit"/>
  <xs:element name="LicensingAgreementMaximumLegalCostsToBeReimbursed" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicensingAgreementMaximumLegalCostsToBeReimbursed"/>
  <xs:element name="LicensingAgreementMinimumAnnualRoyaltiesToBePaidUponFirstCommercialSale" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicensingAgreementMinimumAnnualRoyaltiesToBePaidUponFirstCommercialSale"/>
  <xs:element name="PaymentOfLicenseAgreementUpfrontFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_PaymentOfLicenseAgreementUpfrontFee"/>
  <xs:element name="LicenseAgreementTerminationPriorWrittenNotice" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_LicenseAgreementTerminationPriorWrittenNotice"/>
  <xs:element name="LicenseAgreementUpfrontFeeAndFinalFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicenseAgreementUpfrontFeeAndFinalFee"/>
  <xs:element name="LicenseAgreementResearchProgramMilestoneFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicenseAgreementResearchProgramMilestoneFee"/>
  <xs:element name="LicenseAgreementExercisedTargetOptionFeePerTargetOption" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicenseAgreementExercisedTargetOptionFeePerTargetOption"/>
  <xs:element name="LicenseAgreementExercisedOptionMilestoneFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_LicenseAgreementExercisedOptionMilestoneFee"/>
  <xs:element name="CapitalizedResearchAndExperimentationExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="howl_CapitalizedResearchAndExperimentationExpenses"/>
  <xs:element name="OperatingLossCarryforwardsNotSubjectToExpiration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="howl_OperatingLossCarryforwardsNotSubjectToExpiration"/>
  <xs:element name="SubleaseCashPaymentsReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="howl_SubleaseCashPaymentsReceived"/>
  <xs:element name="LesseeOperatingLeasesNoticePeriodToTerminate" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="howl_LesseeOperatingLeasesNoticePeriodToTerminate"/>
  <xs:element name="DebtInstrumentCovenantPeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="howl_DebtInstrumentCovenantPeriodAxis"/>
  <xs:element name="A2017StockIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_A2017StockIncentivePlanMember"/>
  <xs:element name="A2021StockEmployeeStockPurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_A2021StockEmployeeStockPurchasePlanMember"/>
  <xs:element name="A2021StockIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_A2021StockIncentivePlanMember"/>
  <xs:element name="A2026RestructuringPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_A2026RestructuringPlanMember"/>
  <xs:element name="ATMOfferingBabyShelfLimitationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_ATMOfferingBabyShelfLimitationMember"/>
  <xs:element name="ATMOfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_ATMOfferingMember"/>
  <xs:element name="AdimabLLCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_AdimabLLCMember"/>
  <xs:element name="AssignmentAndLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_AssignmentAndLicenseAgreementMember"/>
  <xs:element name="CommonStockIssuedUnderThe2021ESPPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_CommonStockIssuedUnderThe2021ESPPMember"/>
  <xs:element name="CommonStockToBeIssuedUnderThe2021ESPPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_CommonStockToBeIssuedUnderThe2021ESPPMember"/>
  <xs:element name="DebtInstrumentCovenantPeriodFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_DebtInstrumentCovenantPeriodFourMember"/>
  <xs:element name="DebtInstrumentCovenantPeriodOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_DebtInstrumentCovenantPeriodOneMember"/>
  <xs:element name="DebtInstrumentCovenantPeriodThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_DebtInstrumentCovenantPeriodThreeMember"/>
  <xs:element name="DebtInstrumentCovenantPeriodTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_DebtInstrumentCovenantPeriodTwoMember"/>
  <xs:element name="DevelopmentAndOptionAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_DevelopmentAndOptionAgreementMember"/>
  <xs:element name="EmployeeRetentionBonusesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_EmployeeRetentionBonusesMember"/>
  <xs:element name="FurnitureAndOfficeEquipmentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_FurnitureAndOfficeEquipmentMember"/>
  <xs:element name="HarpoonTherapeuticsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_HarpoonTherapeuticsMember"/>
  <xs:element name="InducementStockOptionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_InducementStockOptionMember"/>
  <xs:element name="K2HVConversionFeatureMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_K2HVConversionFeatureMember"/>
  <xs:element name="LeaseContractualTermOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_LeaseContractualTermOneMember"/>
  <xs:element name="LeaseContractualTermThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_LeaseContractualTermThreeMember"/>
  <xs:element name="LoanAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_LoanAgreementMember"/>
  <xs:element name="MarketOfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_MarketOfferingMember"/>
  <xs:element name="MeasurementInputVolatilityMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_MeasurementInputVolatilityMember"/>
  <xs:element name="ReportableSegmentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_ReportableSegmentMember"/>
  <xs:element name="SubleaseAgreementYearOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_SubleaseAgreementYearOneMember"/>
  <xs:element name="TermLoansMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_TermLoansMember"/>
  <xs:element name="StrategicReviewAndLiquidityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="howl_StrategicReviewAndLiquidityAbstract"/>
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</xs:schema>
