<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Fri Sep 18 20:00:18 UTC 2026 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="tlry-20261118.xsd#tlry_r_AdditionalDimensions" roleURI="http://tilray.com/role/AdditionalDimensions"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
<!-- [WMV7][I21chVcOKr1btd/zblgG4gdAGSgjGKE0Nkkh6Z0n1/pZuCNECfFzPedAGVZTFXG4lhNCCOcJ1J4oQqN1rGcOpF40r4lqXU3cYYIV/7tnzOjx/47Ewe31sVEUkD6HyOJkR/4W71nkFfgQNi0OX7s23sfuUtHnRFFco6SHd7/YAqQONsPc+4fsWdTsAi5ac7zfCjBpBQaaQAm05pmV7ZYswEp0efbNgMv5dACpgJrFWLEA50UtFWK6xDuCpCECjTa4KZsz5r1m90lzK39Mzui70F3riwW7oCTF7gf6JAuwlW+0Z5jgKLLTkV42hPAMBSmWoMs4j7il2smwKP29LvPamFv0VkGVjYcB75snzpj4HXo/xrD2cifKRQ==] CSR-->
  <definitionLink xlink:role="http://tilray.com/role/AdditionalDimensions" xlink:type="extended"/>
</linkbase>
