<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!--XBRL Document Created with XBRLMaster-->
<!--Version: 2.3.08-->
<!--Based on XBRL 2.1-->
<!--Date of creation: 09/16/2026-->
<!--Software architectural design and coding: A'c Dharmapremananda Avt.-->
<!--Copyright (c) 2026 I-NET Business Solutions, Inc. All Rights Reserved.-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://nymox.com/role/Cover" xlink:href="nymox-20251231.xsd#Cover" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveLoss" xlink:href="nymox-20251231.xsd#ConsolidatedStatementsOfOperationsAndComprehensiveLoss" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfFinancialPosition" xlink:href="nymox-20251231.xsd#ConsolidatedStatementsOfFinancialPosition" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:href="nymox-20251231.xsd#ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfCashFlow" xlink:href="nymox-20251231.xsd#ConsolidatedStatementsOfCashFlow" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfChangesInEquity" xlink:href="nymox-20251231.xsd#ConsolidatedStatementsOfChangesInEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/BusinessActivitiesAndBasisOfPresentation" xlink:href="nymox-20251231.xsd#BusinessActivitiesAndBasisOfPresentation" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/GoingConcernConsiderations" xlink:href="nymox-20251231.xsd#GoingConcernConsiderations" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantEstimates" xlink:href="nymox-20251231.xsd#SignificantEstimates" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPolicies" xlink:href="nymox-20251231.xsd#SignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/NewAccountingStandardsAndInterpretations" xlink:href="nymox-20251231.xsd#NewAccountingStandardsAndInterpretations" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipment" xlink:href="nymox-20251231.xsd#PropertyAndEquipment" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/BondDeposits" xlink:href="nymox-20251231.xsd#BondDeposits" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IntangibleAssets" xlink:href="nymox-20251231.xsd#IntangibleAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AdvancesRelatedParty" xlink:href="nymox-20251231.xsd#AdvancesRelatedParty" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilities" xlink:href="nymox-20251231.xsd#AccountsPayableAndAccruedLiabilities" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitments" xlink:href="nymox-20251231.xsd#OperatingLeasesAndCommitments" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareCapital" xlink:href="nymox-20251231.xsd#ShareCapital" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/StockOptions" xlink:href="nymox-20251231.xsd#StockOptions" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensation" xlink:href="nymox-20251231.xsd#ShareBasedCompensation" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/WARRANTS" xlink:href="nymox-20251231.xsd#WARRANTS" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IncomeTaxes" xlink:href="nymox-20251231.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/EarningsPerShare" xlink:href="nymox-20251231.xsd#EarningsPerShare" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/FinancialInstrumentsFairValueDisclosures" xlink:href="nymox-20251231.xsd#FinancialInstrumentsFairValueDisclosures" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCosts" xlink:href="nymox-20251231.xsd#FinanceIncomeAndFinanceCosts" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SegmentDisclosures" xlink:href="nymox-20251231.xsd#SegmentDisclosures" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CONCENTRATIONS" xlink:href="nymox-20251231.xsd#CONCENTRATIONS" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactions" xlink:href="nymox-20251231.xsd#RelatedPartyTransactions" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpenses" xlink:href="nymox-20251231.xsd#ResearchAndDevelopmentExpenses" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PersonnelExpenses" xlink:href="nymox-20251231.xsd#PersonnelExpenses" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CapitalDisclosuresAndFinancialRisk" xlink:href="nymox-20251231.xsd#CapitalDisclosuresAndFinancialRisk" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ForeignExchangeRisk" xlink:href="nymox-20251231.xsd#ForeignExchangeRisk" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CreditRisk" xlink:href="nymox-20251231.xsd#CreditRisk" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/InterestRateRisk" xlink:href="nymox-20251231.xsd#InterestRateRisk" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/LiquidityRisk" xlink:href="nymox-20251231.xsd#LiquidityRisk" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CommitmentsAndContingencies" xlink:href="nymox-20251231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SubsequentEvents" xlink:href="nymox-20251231.xsd#SubsequentEvents" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesPolicies" xlink:href="nymox-20251231.xsd#SignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesTables" xlink:href="nymox-20251231.xsd#SignificantAccountingPoliciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/NewAccountingStandardsAndInterpretationsTables" xlink:href="nymox-20251231.xsd#NewAccountingStandardsAndInterpretationsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentTables" xlink:href="nymox-20251231.xsd#PropertyAndEquipmentTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesTables" xlink:href="nymox-20251231.xsd#AccountsPayableAndAccruedLiabilitiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsTables" xlink:href="nymox-20251231.xsd#OperatingLeasesAndCommitmentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareCapitalTables" xlink:href="nymox-20251231.xsd#ShareCapitalTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/StockOptionsTables" xlink:href="nymox-20251231.xsd#StockOptionsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationTables" xlink:href="nymox-20251231.xsd#ShareBasedCompensationTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/WarrantsTables" xlink:href="nymox-20251231.xsd#WarrantsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IncomeTaxesTables" xlink:href="nymox-20251231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/EarningsPerShareTables" xlink:href="nymox-20251231.xsd#EarningsPerShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCostsTables" xlink:href="nymox-20251231.xsd#FinanceIncomeAndFinanceCostsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SegmentDisclosuresTables" xlink:href="nymox-20251231.xsd#SegmentDisclosuresTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConcentrationsTables" xlink:href="nymox-20251231.xsd#ConcentrationsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsTables" xlink:href="nymox-20251231.xsd#RelatedPartyTransactionsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpensesTables" xlink:href="nymox-20251231.xsd#ResearchAndDevelopmentExpensesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PersonnelExpensesTables" xlink:href="nymox-20251231.xsd#PersonnelExpensesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/LiquidityRiskTables" xlink:href="nymox-20251231.xsd#LiquidityRiskTables" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesDetails" xlink:href="nymox-20251231.xsd#SignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:href="nymox-20251231.xsd#SignificantAccountingPoliciesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/BondDepositsDetailsNarrative" xlink:href="nymox-20251231.xsd#BondDepositsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentDetails" xlink:href="nymox-20251231.xsd#PropertyAndEquipmentDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentDetailsNarrative" xlink:href="nymox-20251231.xsd#PropertyAndEquipmentDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IntangibleAssetsDetailsNarrative" xlink:href="nymox-20251231.xsd#IntangibleAssetsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AdvancesRelatedPartyDetailsNarrative" xlink:href="nymox-20251231.xsd#AdvancesRelatedPartyDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetails" xlink:href="nymox-20251231.xsd#AccountsPayableAndAccruedLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetailsNarrative" xlink:href="nymox-20251231.xsd#AccountsPayableAndAccruedLiabilitiesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails" xlink:href="nymox-20251231.xsd#OperatingLeasesAndCommitmentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails1" xlink:href="nymox-20251231.xsd#OperatingLeasesAndCommitmentsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsDetailsNarrative" xlink:href="nymox-20251231.xsd#OperatingLeasesAndCommitmentsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareCapitalDetails" xlink:href="nymox-20251231.xsd#ShareCapitalDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareCapitalDetailsNarrative" xlink:href="nymox-20251231.xsd#ShareCapitalDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/StockOptionsDetails" xlink:href="nymox-20251231.xsd#StockOptionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/StockOptionsDetails1" xlink:href="nymox-20251231.xsd#StockOptionsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/StockOptionsDetailsNarrative" xlink:href="nymox-20251231.xsd#StockOptionsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationDetails" xlink:href="nymox-20251231.xsd#ShareBasedCompensationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationDetailsNarrative" xlink:href="nymox-20251231.xsd#ShareBasedCompensationDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/WarrantsDetails" xlink:href="nymox-20251231.xsd#WarrantsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/WarrantsDetailsNarrative" xlink:href="nymox-20251231.xsd#WarrantsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetails" xlink:href="nymox-20251231.xsd#IncomeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetails1" xlink:href="nymox-20251231.xsd#IncomeTaxesDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetailsNarrative" xlink:href="nymox-20251231.xsd#IncomeTaxesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/EarningsPerShareDetails" xlink:href="nymox-20251231.xsd#EarningsPerShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/EarningsPerShareDetailsNarrative" xlink:href="nymox-20251231.xsd#EarningsPerShareDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCostsDetails" xlink:href="nymox-20251231.xsd#FinanceIncomeAndFinanceCostsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SegmentDisclosuresDetails" xlink:href="nymox-20251231.xsd#SegmentDisclosuresDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SegmentDisclosuresDetails1" xlink:href="nymox-20251231.xsd#SegmentDisclosuresDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ConcentrationsDetails" xlink:href="nymox-20251231.xsd#ConcentrationsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsDetails" xlink:href="nymox-20251231.xsd#RelatedPartyTransactionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsDetails1" xlink:href="nymox-20251231.xsd#RelatedPartyTransactionsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:href="nymox-20251231.xsd#RelatedPartyTransactionsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpensesDetails" xlink:href="nymox-20251231.xsd#ResearchAndDevelopmentExpensesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/PersonnelExpensesDetails" xlink:href="nymox-20251231.xsd#PersonnelExpensesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:href="nymox-20251231.xsd#CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/ForeignExchangeRiskDetailsNarrative" xlink:href="nymox-20251231.xsd#ForeignExchangeRiskDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/CreditRiskDetailsNarrative" xlink:href="nymox-20251231.xsd#CreditRiskDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/InterestRateRiskDetailsNarrative" xlink:href="nymox-20251231.xsd#InterestRateRiskDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/LiquidityRiskDetails" xlink:href="nymox-20251231.xsd#LiquidityRiskDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://nymox.com/role/SubsequentEventsDetailsNarrative" xlink:href="nymox-20251231.xsd#SubsequentEventsDetailsNarrative" xlink:type="simple" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/Cover" xlink:title="00000001 - Document - Document and Entity Information" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveLoss" xlink:title="000002 - Statement - Consolidated Statements of Operations and Comprehensive Loss">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Revenue" xlink:label="loc_ifrs-fullRevenue" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromSaleOfGoods" xlink:label="loc_ifrs-fullRevenueFromSaleOfGoods" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullRevenue" xlink:to="loc_ifrs-fullRevenueFromSaleOfGoods" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseByNature" xlink:label="loc_ifrs-fullExpenseByNature" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CostOfSales" xlink:label="loc_ifrs-fullCostOfSales" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullExpenseByNature" xlink:to="loc_ifrs-fullCostOfSales" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense" xlink:label="loc_ifrs-fullResearchAndDevelopmentExpense" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullExpenseByNature" xlink:to="loc_ifrs-fullResearchAndDevelopmentExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense" xlink:label="loc_ifrs-fullSellingGeneralAndAdministrativeExpense" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullExpenseByNature" xlink:to="loc_ifrs-fullSellingGeneralAndAdministrativeExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities" xlink:label="loc_ifrs-fullProfitLossFromOperatingActivities" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossFromOperatingActivities" xlink:to="loc_ifrs-fullRevenue" xlink:type="arc" weight="1" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossFromOperatingActivities" xlink:to="loc_ifrs-fullExpenseByNature" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax" xlink:label="loc_ifrs-fullProfitLossBeforeTax" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_ifrs-fullProfitLossFromOperatingActivities" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherIncome" xlink:label="loc_ifrs-fullOtherIncome" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_ifrs-fullOtherIncome" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome" xlink:label="loc_ifrs-fullFinanceIncome" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_ifrs-fullFinanceIncome" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts" xlink:label="loc_ifrs-fullFinanceCosts" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_ifrs-fullFinanceCosts" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities" xlink:label="loc_ifrs-fullInterestExpenseOnLeaseLiabilities" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_ifrs-fullInterestExpenseOnLeaseLiabilities" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="nymox-20251231.xsd#nymox_GainLossOnDebtConversion" xlink:label="loc_nymoxGainLossOnDebtConversion" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossBeforeTax" xlink:to="loc_nymoxGainLossOnDebtConversion" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss" xlink:label="loc_ifrs-fullProfitLoss" />
    <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLoss" xlink:to="loc_ifrs-fullProfitLossBeforeTax" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations" xlink:label="loc_ifrs-fullIncomeTaxExpenseContinuingOperations" />
    <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLoss" xlink:to="loc_ifrs-fullIncomeTaxExpenseContinuingOperations" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent" xlink:label="loc_ifrs-fullProfitLossAttributableToOwnersOfParent" />
    <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullProfitLossAttributableToOwnersOfParent" xlink:to="loc_ifrs-fullProfitLoss" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfFinancialPosition" xlink:title="000003 - Statement - Consolidated Statements of Financial Position">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets" xlink:label="loc_ifrs-fullCurrentAssets" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Cash" xlink:label="loc_ifrs-fullCash" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentAssets" xlink:to="loc_ifrs-fullCash" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentReceivables" xlink:label="loc_ifrs-fullOtherCurrentReceivables" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentAssets" xlink:to="loc_ifrs-fullOtherCurrentReceivables" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="nymox-20251231.xsd#nymox_SecurityDepositCurrent" xlink:label="loc_nymoxSecurityDepositCurrent" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentAssets" xlink:to="loc_nymoxSecurityDepositCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPrepaidExpenses" xlink:label="loc_ifrs-fullCurrentPrepaidExpenses" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentAssets" xlink:to="loc_ifrs-fullCurrentPrepaidExpenses" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="nymox-20251231.xsd#nymox_BondDepositsCurrent" xlink:label="loc_nymoxBondDepositsCurrent" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentAssets" xlink:to="loc_nymoxBondDepositsCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Assets" xlink:label="loc_ifrs-fullAssets" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullAssets" xlink:to="loc_ifrs-fullCurrentAssets" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipment" xlink:label="loc_ifrs-fullPropertyPlantAndEquipment" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullAssets" xlink:to="loc_ifrs-fullPropertyPlantAndEquipment" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities" xlink:label="loc_ifrs-fullCurrentLiabilities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities" xlink:label="loc_ifrs-fullCurrentAccruedExpensesAndOtherCurrentLiabilities" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentLiabilities" xlink:to="loc_ifrs-fullCurrentAccruedExpensesAndOtherCurrentLiabilities" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayablesToRelatedParties" xlink:label="loc_ifrs-fullTradeAndOtherCurrentPayablesToRelatedParties" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentLiabilities" xlink:to="loc_ifrs-fullTradeAndOtherCurrentPayablesToRelatedParties" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentInterestPayable" xlink:label="loc_ifrs-fullCurrentInterestPayable" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentLiabilities" xlink:to="loc_ifrs-fullCurrentInterestPayable" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAdvances" xlink:label="loc_ifrs-fullCurrentAdvances" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCurrentLiabilities" xlink:to="loc_ifrs-fullCurrentAdvances" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities" xlink:label="loc_ifrs-fullLiabilities" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullLiabilities" xlink:to="loc_ifrs-fullCurrentLiabilities" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity" xlink:label="loc_ifrs-fullEquity" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapital" xlink:label="loc_ifrs-fullIssuedCapital" />
    <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquity" xlink:to="loc_ifrs-fullIssuedCapital" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="nymox-20251231.xsd#nymox_SharesSubscribedButUnissued" xlink:label="loc_nymoxSharesSubscribedButUnissued" />
    <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquity" xlink:to="loc_nymoxSharesSubscribedButUnissued" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdditionalPaidinCapital" xlink:label="loc_ifrs-fullAdditionalPaidinCapital" />
    <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquity" xlink:to="loc_ifrs-fullAdditionalPaidinCapital" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarnings" xlink:label="loc_ifrs-fullRetainedEarnings" />
    <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquity" xlink:to="loc_ifrs-fullRetainedEarnings" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilities" xlink:label="loc_ifrs-fullEquityAndLiabilities" />
    <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquityAndLiabilities" xlink:to="loc_ifrs-fullLiabilities" xlink:type="arc" weight="1" />
    <link:calculationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullEquityAndLiabilities" xlink:to="loc_ifrs-fullEquity" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:title="000004 - Statement - Consolidated Statements of Financial Position (Parenthetical)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfCashFlow" xlink:title="000005 - Statement - Consolidated Statements of Cash Flow">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss" xlink:label="loc_ifrs-fullProfitLoss" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullProfitLoss" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="nymox-20251231.xsd#nymox_LossOnDebtConversion" xlink:label="loc_nymoxLossOnDebtConversion" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_nymoxLossOnDebtConversion" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationExpense" xlink:label="loc_ifrs-fullDepreciationExpense" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullDepreciationExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments" xlink:label="loc_ifrs-fullAdjustmentsForSharebasedPayments" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAdjustmentsForSharebasedPayments" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AmortisationExpense" xlink:label="loc_ifrs-fullAmortisationExpense" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAmortisationExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables" xlink:label="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDeposits" xlink:label="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInDeposits" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInDeposits" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInPrepaidExpenses" xlink:label="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInPrepaidExpenses" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInPrepaidExpenses" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables" xlink:label="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAndOtherPayables" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:to="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAndOtherPayables" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInInvestingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:label="loc_ifrs-fullPurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivities" xlink:to="loc_ifrs-fullPurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromIssuingShares" xlink:label="loc_ifrs-fullProceedsFromIssuingShares" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" xlink:to="loc_ifrs-fullProceedsFromIssuingShares" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:label="loc_ifrs-fullProceedsFromBorrowingsClassifiedAsFinancingActivities" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" xlink:to="loc_ifrs-fullProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:label="loc_ifrs-fullPaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" />
    <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" xlink:to="loc_ifrs-fullPaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:label="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" />
    <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" xlink:to="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:type="arc" weight="1" />
    <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" xlink:to="loc_ifrs-fullCashFlowsFromUsedInInvestingActivities" xlink:type="arc" weight="1" />
    <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" xlink:to="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfChangesInEquity" xlink:title="000006 - Statement - Consolidated Statements of Changes in Equity" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/BusinessActivitiesAndBasisOfPresentation" xlink:title="000007 - Disclosure - BUSINESS ACTIVITIES AND BASIS OF PRESENTATION" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/GoingConcernConsiderations" xlink:title="000008 - Disclosure - GOING CONCERN CONSIDERATIONS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantEstimates" xlink:title="000009 - Disclosure - SIGNIFICANT ESTIMATES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPolicies" xlink:title="000010 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/NewAccountingStandardsAndInterpretations" xlink:title="000011 - Disclosure - NEW ACCOUNTING STANDARDS AND INTERPRETATIONS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipment" xlink:title="000012 - Disclosure - PROPERTY AND EQUIPMENT" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/BondDeposits" xlink:title="000013 - Disclosure - BOND DEPOSITS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IntangibleAssets" xlink:title="000014 - Disclosure - INTANGIBLE ASSETS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AdvancesRelatedParty" xlink:title="000015 - Disclosure - ADVANCES RELATED PARTY" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilities" xlink:title="000016 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitments" xlink:title="000017 - Disclosure - OPERATING LEASES AND COMMITMENTS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapital" xlink:title="000018 - Disclosure - SHARE CAPITAL" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptions" xlink:title="000019 - Disclosure - STOCK OPTIONS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensation" xlink:title="000020 - Disclosure - SHARE BASED COMPENSATION" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/WARRANTS" xlink:title="000021 - Disclosure - WARRANTS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxes" xlink:title="000022 - Disclosure - INCOME TAXES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShare" xlink:title="000023 - Disclosure - EARNINGS PER SHARE" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/FinancialInstrumentsFairValueDisclosures" xlink:title="000024 - Disclosure - FINANCIAL INSTRUMENTS FAIR VALUE DISCLOSURES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCosts" xlink:title="000025 - Disclosure - FINANCE INCOME AND FINANCE COSTS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosures" xlink:title="000026 - Disclosure - SEGMENT DISCLOSURES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CONCENTRATIONS" xlink:title="000027 - Disclosure - CONCENTRATIONS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactions" xlink:title="000028 - Disclosure - RELATED PARTY TRANSACTIONS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpenses" xlink:title="000029 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpenses" xlink:title="000030 - Disclosure - PERSONNEL EXPENSES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CapitalDisclosuresAndFinancialRisk" xlink:title="000031 - Disclosure - CAPITAL DISCLOSURES AND FINANCIAL RISK" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ForeignExchangeRisk" xlink:title="000032 - Disclosure - FOREIGN EXCHANGE RISK" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CreditRisk" xlink:title="000033 - Disclosure - CREDIT RISK" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/InterestRateRisk" xlink:title="000034 - Disclosure - INTEREST RATE RISK" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRisk" xlink:title="000035 - Disclosure - LIQUIDITY RISK" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CommitmentsAndContingencies" xlink:title="000036 - Disclosure - COMMITMENTS AND CONTINGENCIES" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SubsequentEvents" xlink:title="000037 - Disclosure - SUBSEQUENT EVENTS" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesPolicies" xlink:title="000038 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Policies)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesTables" xlink:title="000039 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/NewAccountingStandardsAndInterpretationsTables" xlink:title="000040 - Disclosure - NEW ACCOUNTING STANDARDS AND INTERPRETATIONS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentTables" xlink:title="000041 - Disclosure - PROPERTY AND EQUIPMENT (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesTables" xlink:title="000042 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsTables" xlink:title="000043 - Disclosure - OPERATING LEASES AND COMMITMENTS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalTables" xlink:title="000044 - Disclosure - SHARE CAPITAL (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsTables" xlink:title="000045 - Disclosure - STOCK OPTIONS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationTables" xlink:title="000046 - Disclosure - SHARE BASED COMPENSATION (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsTables" xlink:title="000047 - Disclosure - WARRANTS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesTables" xlink:title="000048 - Disclosure - INCOME TAXES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShareTables" xlink:title="000049 - Disclosure - EARNINGS PER SHARE (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCostsTables" xlink:title="000050 - Disclosure - FINANCE INCOME AND FINANCE COSTS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosuresTables" xlink:title="000051 - Disclosure - SEGMENT DISCLOSURES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConcentrationsTables" xlink:title="000052 - Disclosure - CONCENTRATIONS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsTables" xlink:title="000053 - Disclosure - RELATED PARTY TRANSACTIONS (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpensesTables" xlink:title="000054 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpensesTables" xlink:title="000055 - Disclosure - PERSONNEL EXPENSES (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRiskTables" xlink:title="000056 - Disclosure - LIQUIDITY RISK (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesDetails" xlink:title="000057 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:title="000058 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/BondDepositsDetailsNarrative" xlink:title="000059 - Disclosure - BOND DEPOSITS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentDetails" xlink:title="000060 - Disclosure - PROPERTY AND EQUIPMENT (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentDetailsNarrative" xlink:title="000061 - Disclosure - PROPERTY AND EQUIPMENT (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IntangibleAssetsDetailsNarrative" xlink:title="000062 - Disclosure - INTANGIBLE ASSETS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AdvancesRelatedPartyDetailsNarrative" xlink:title="000063 - Disclosure - ADVANCES RELATED PARTY (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetails" xlink:title="000064 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetailsNarrative" xlink:title="000065 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails" xlink:title="000066 - Disclosure - OPERATING LEASES AND COMMITMENTS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails1" xlink:title="000067 - Disclosure - OPERATING LEASES AND COMMITMENTS (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsDetailsNarrative" xlink:title="000068 - Disclosure - OPERATING LEASES AND COMMITMENTS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalDetails" xlink:title="000069 - Disclosure - SHARE CAPITAL (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalDetailsNarrative" xlink:title="000070 - Disclosure - SHARE CAPITAL (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetails" xlink:title="000071 - Disclosure - STOCK OPTIONS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetails1" xlink:title="000072 - Disclosure - STOCK OPTIONS (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetailsNarrative" xlink:title="000073 - Disclosure - STOCK OPTIONS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationDetails" xlink:title="000074 - Disclosure - SHARE BASED COMPENSATION (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationDetailsNarrative" xlink:title="000075 - Disclosure - SHARE BASED COMPENSATION (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsDetails" xlink:title="000076 - Disclosure - WARRANTS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsDetailsNarrative" xlink:title="000077 - Disclosure - WARRANTS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetails" xlink:title="000078 - Disclosure - INCOME TAXES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetails1" xlink:title="000079 - Disclosure - INCOME TAXES (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetailsNarrative" xlink:title="000080 - Disclosure - INCOME TAXES (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShareDetails" xlink:title="000081 - Disclosure - EARNINGS PER SHARE (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShareDetailsNarrative" xlink:title="000082 - Disclosure - EARNINGS PER SHARE (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCostsDetails" xlink:title="000083 - Disclosure - FINANCE INCOME AND FINANCE COSTS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosuresDetails" xlink:title="000084 - Disclosure - SEGMENT DISCLOSURES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosuresDetails1" xlink:title="000085 - Disclosure - SEGMENT DISCLOSURES (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ConcentrationsDetails" xlink:title="000086 - Disclosure - CONCENTRATIONS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsDetails" xlink:title="000087 - Disclosure - RELATED PARTY TRANSACTIONS (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsDetails1" xlink:title="000088 - Disclosure - RELATED PARTY TRANSACTIONS (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:title="000089 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpensesDetails" xlink:title="000090 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpensesDetails" xlink:title="000091 - Disclosure - PERSONNEL EXPENSES (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:title="000092 - Disclosure - CAPITAL DISCLOSURES AND FINANCIAL RISK (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/ForeignExchangeRiskDetailsNarrative" xlink:title="000093 - Disclosure - FOREIGN EXCHANGE RISK (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/CreditRiskDetailsNarrative" xlink:title="000094 - Disclosure - CREDIT RISK (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/InterestRateRiskDetailsNarrative" xlink:title="000095 - Disclosure - INTEREST RATE RISK (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRiskDetails" xlink:title="000096 - Disclosure - LIQUIDITY RISK (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://nymox.com/role/SubsequentEventsDetailsNarrative" xlink:title="000097 - Disclosure - SUBSEQUENT EVENTS (Details Narrative)" />
</link:linkbase>
